Activation of the recombinant human α7 nicotinic acetylcholine receptor significantly raises intracellular free calcium

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 1, 1997, Pages 428-438

  Delbono, O ^a   Gopalakrishnan, M ^b   Renganathan, M ^a   Monteggia, L M ^b   Messi, M L ^a   Sullivan, J P ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIMETHYL 4 PHENYLPIPERAZINIUM IODIDE; BUNGAROTOXIN; EPIBATIDINE; NICOTINE; NICOTINIC RECEPTOR;

ARTICLE; AUTONOMIC GANGLION; BINDING AFFINITY; CALCIUM CELL LEVEL; CELL MEMBRANE PERMEABILITY; CELL SYNCHRONIZATION; DRUG RECEPTOR BINDING; EVOKED RESPONSE; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ASSEMBLY; VOLTAGE CLAMP;

BASE SEQUENCE; CALCIUM; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MOLECULAR SEQUENCE DATA; NICOTINE; NICOTINIC AGONISTS; RECEPTORS, NICOTINIC; RECOMBINANT PROTEINS;

EID: 0031000154     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. AKAIKE, A.: Nicotine-induced proection of cultured cortical neurons against n-methyl-D-aspartate receptor-mediated glutamate cytotoxicity. Brain Res. 644: 181-187, 1994.
2. ALKONDON, M. AND ALBUQUERQUE, E. X.: Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes. J. Pharmacol. Exp. Ther. 265: 1455-1473, 1993.
3. ALKONDON M., REINHARDT, S., LOBRON, C., HERMSEN, B., MAELICKE, A. AND ALBUQUERQUE, E. X.: Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. II. Rundown and inward rectification of agonist-elicited whole-cell currents and identification of receptor subunits by in situ hybridization. J. Pharmacol. Exp. Ther. 271: 494-506, 1994.
4. AMADOR, M. AND DANI, J.: Mechanism for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission. J. Neurosci. 15: 4525-4532, 1995.
5. ANAND, R., BASON, L., SAEDI, M. S., GERANICH, V., PENG, X. AND LINDSTROM, J.: Reporter epitopes: a novel approach to examine trans-membrane topology of integral membrane proteins applied to the α1 subunit of the nicotinic acetylcholine receptor. Biochemistry 32: 9975-9984, 1993.
6. 7 nicotinic receptor. Proc. Natl. Acad. Sci. U.S.A. 90: 6971-6975, 1993.
7. BOULTER, J., CONNOLLY, J., DENERIS, E., GOLDMAN, D., HEINEMANN, S. AND PATRICK, J.: Functional expression of the two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family. Proc. Natl. Acad. Sci. U.S.A. 84: 7763-7767, 1987.
8. BURNASHEV, N., ZHOU, Z., NEHER, E. AND SAKMANN, B.: Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J. Physiol. 485: 403-418, 1995.
9. CASTRO, N. G. AND ALBUQUERQUE, E. X.: α-Bungarotoxin-sensitive hippocampal nicotinic receptor channel has a high calcium permeability. Biophys. J. 68: 516-524, 1995.
10. CHAN, J. AND QUIK, M.: A role for the nicotinic alpha-bungarotoxin receptor in neurite outgrowth in PC12 cells. Neuroscience 56: 441-451, 1993.
11. COSTA, A. C. S., PATRICK, J. W. AND DANI, J. A.: Improved technique for studying ion channels expressed in Xenopus oocytes, including fast perfusion. Biophys. J. 67: 395-401, 1994.
12. 7) is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX. Neuron 5: 847-856, 1990.
13. 125I]α-bungarotoxin receptor subtypes. Mol. Pharmacol. 47: 164-171, 1995.
14. 2+ release channels in rat denervated skeletal muscles. Exp. Physiol. 80: 561-574, 1995.
15. DELBONO, O. AND STEFANI, E.: Calcium transients in single mammalian skeletal muscle fibres. J. Physiol. 463: 689-707, 1993.
16. DENERIS, E. S., CONNOLLY, J., ROGERS, S. W. AND DUVOISIN, R.: Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. Trends Pharmacol. Sci. 12: 34-40, 1991.
17. DINGELDINE, R., HUME, R. I. AND HEINEMANN, S. F.: Structural determinants of barium permeation and rectification in non-NMDS glutamate receptor channels. J. Neurosci. 12: 4080-4087, 1992.
18. DONNELLY-ROBERTS, D. L., XUE, I. C., ARNERIC, S. P. AND SULLIVAN, J. P.: In Vitro neuroprotective properties of the novel cholinergic channel activator, ABT-418. Brain Res. 719: 36-44, 1996.
19. 7 nicotinic acetylcholine receptor. Drug Dev. Res. 30: 252-256, 1993.
20. FIEBER, L. A. AND ADAMS, D. J.: Acetylcholine-evoked currents in cultured neurones dissociated from rat parasympathetic cardiac ganglia. J. Physiol. 434: 215-237, 1991.
21. FRANKLIN, J. L. AND JOHNSON, E. M. JR.: Supression of programmed neuronal death by sustained elevation of cytoplasmic calcium. Trends Neurol. Sci. 15: 501-508, 1992.
22. GALZI, J-L., DEVILLERS-THIÉRY, A., HUSSY, N., BERTRAND, S. AND CHANGEAUX, J-P.: Mutations in the channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature 359: 500-505, 1992.
23. 7 nicotinic acetylcholine receptor. Eur. J. Pharmacol (Mol. Pharmacol.) 290: 237-246, 1995.
24. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260: 3440-3450, 1985.
25. HAMILL, O. P., MARTY, A., NEHER, E., SACKMANN, B. AND SIGWORTH, F. J.: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391: 85-100, 1981.
26. HORCH, H. L. AND SARGENT, P. B.: Perisynaptic surface distribution of multiple classes of nicotinic acetylcholine receptors on neurons in the chicken ciliary ganglion. J. Neurosci. 15: 7778-7795, 1995.
27. JONAS, P.: Fast application of agonists to isolated membrane patches. In Single Channel Recording, ed. by B. Sakmann and E. Neher, pp. 231-242, Plenum Press, New York, 1995.
28. KARLIN, A. AND AKABAS, M. H.: Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins. Neuron 15: 1231-1244, 1995.
29. KATER, S. B., MATTSON, M. P., COHAN, CH. AND CONNOR, J.: Calcium regulation of the neuronal growth cone. Trends Neurol. Sci. 11: 315-321, 1988.
30. KYROZIS, A., GOLDSTEIN, P. A., HEATH, M. J. S. AND MACDERMOTT, A. B.: Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons. J. Physiol. 485: 373-381, 1995.
31. LESTER, R. A. J. AND DANI, J. A.: Time-dependent changes in central nicotinic acetylcholine channel kinetics in excised patches. Neuro pharmacology 33: 27-34, 1994.
32. LINDSTROM, J., ANAND, R., PENG, X., GERZANICH, V., WANG, F. AND LI, Y.: Neuronal nicotinic receptor subtypes. Ann. NY Acad. Sci. 757: 100-116, 1995.
33. LUETJE, C. W. AND PATRICK, J.: Both alpha- and beta-subunits contribute to the agonist sensitivity of neuronal nicotinic acetylcholine receptor. J. Neurosci. 11: 837-845, 1991.
34. MCGEHEE, D. S. AND ROLE, L. W.: Physiological diversity of nicotinic acetylcholine receptors expressed by vertebrate neurons. Annu. Rev. Physiol. 57: 521-546, 1995.
35. MCGEHEE, D. S., HEATH, M. J. S., GELBER, S., DEVAY, P. AND ROLE, L. W.: Nicotinic enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269: 1692-1696, 1995.
36. 7-nicotinic acetylcholine receptor (nAChR) stably expressed in K28 cells. Biophys. J. 70: A252, 1996.
37. MESSING, R. O., STEVENS, A. M., KIYASU, E. AND SNEADE, A. B.: Nicotinic and muscarinic agonist stimulate rapid protein kinase C translocation in PC12 cells. J. Neurosci. 9: 507-512, 1989.
38. MEYER, E. M., DE FIEBRE, C. M., HUNTER, B. E., SIMPKINS, C. E., FRAUWORTH, N. AND DE FIEBRE, N. E. C.: Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev. Res. 31: 127-134, 1994.
39. 2+ images obtained by optical sectioning of fura-2 loaded mast cells. J. Cell Biol. 116: 745-759, 1992.
40. MULLE, CH., CHOQUET, D., KORN, H. AND CHANGEAUX, J-P.: Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation. Neuron 8: 135-143, 1992.
41. NEHER, E. AND AUGUSTINE, G. J.: Calcium gradients and buffers in bovine chromaffin cells. J. Physiol. 450: 273-301, 1992.
42. 7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional homomers expressed in Xenopus oocytes. Mol. Pharmacol. 45: 546-554, 1994.
43. 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells. J. Pharmacol. Exp. Ther. 270: 768-778, 1994.
44. 7 subunits in human SH-SY5Y neuroblastoma cells. FEBS Lett. 354: 155-159, 1994.
45. PUGH, P. C. AND BERG, D. K.: Neuronal acetylcholine receptors that bind α-bungarotoxin mediates neurite retraction in a calcium-dependent manner. J. Neurosci. 14: 889, 1994.
46. PUGH, P. C., CORRIVEAU, R. A., CONROY, W. G. AND BERG, D. K.: Novel subpopulaton of neuronal acetylcholine receptors among those binding α-bungarotoxin. Mol. Pharmacol. 47: 717-725, 1995.
47. 5 subunit to neuronal acetylcholine receptor channels. Nature 380: 347-351, 1996.
48. RATHOUZ, M. M. AND BERG, D. K.: Synaptic-type acetylcholine receptors raise intracellular calcium levels in neurons by two mechanisms. J. Neurosci. 14: 6935-6945, 1994.
49. ROGERS, M. AND DANI, J. A.: Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels. Biophys. J. 68: 501-507, 1995.
50. 2+ release channel. Am. J. Physiol. 243: C364-C368, 1987.
51. SALA, F. AND HERNANDEZ-CRUZ, A.: Calcium diffusion modeling in a spherical neuron. Relevance of buffering properties. Biophys. J. 57: 313-324, 1990.
52. SANDS, S. B. AND BARISH, M. E.: Calcium permeability of neuronal nicotinic channels in PC12 cells. Brain Res. 560: 38-42, 1991.
53. 7 expressed in Xenopus oocytes. Biophys. J. 65: 2614-2621, 1993.
54. SCHNEGGENBURGER, R., KONNERTH, Z. AND NEHER, E.: Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron 11: 133-143, 1993.
55. 7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13: 595-604, 1993.
56. THAYER, S. A. AND MILLER, R. J.: Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro. J. Physiol. 425: 85-115, 1990.
57. VERNINO, S., AMADOR, M., LUETJE, C. W., PATRICK, J. AND DANI, J.: Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8: 127-134, 1992.
58. VERNINO, S., ROGERS, M., RADCLIFFE, K. A. AND DANI, J. A.: Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors. J. Neurosci. 14: 5541-5524, 1994.
59. 2+. Neuron 8: 353-362, 1992.
60. VIZI, E. S. AND SOMOGYI, G. T.: Prejunctional modulation of acetylcholine release from the skeletal neuromuscular junction: Link between positive(nicotine)-and negative (muscarinic)-feedback mechanisms. Br. J. Pharmacol. 97: 66-70, 1989.
61. WADA, E. MCKINNON, D., HEINEMANN, S., PATRICK, J. AND SWANSON, L. W.: The distribution of mRNA encoded by a new member of the neuronal nicotinic acetylcholine receptor gene family (alpha 5) in the rat central nervous system. Brain Res. 526: 45-53, 1990.
62. WHITING, P., SCHOEPFER, R., LINDSTROM, J. AND PRIESTLEY, T.: Structural and pharmacological characterization of the major brain nicotinic acetylcholine receptor subtype stably expressed in mouse fibroblasts. Mol. Pharmacol. 40: 463-472, 1991.
63. 2+ channel. Science 257: 389-395, 1992.
64. WONG, L. A. AND GALLAGHER, J. P.: Pharmacology of nicotinic receptor-mediated inhibition in rat dorsolateral septal neurones. J. Physiol. (Lond.) 436: 325-346, 1991.
65. WONNACOTT, S., ALBUQUERQUE, E. X. AND BERTRAND, D.: Methyllycaconitine: A new probe that discriminates between nicotinic acetylcholine receptor subclasses. Meth. Neurosci. 12: 263-275, 1993.
66. ZAREI, M. M. AND DANI, J. A.: Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel. J. Gen. Physiol. 103: 231-248, 1994.
67. ZHANG, Z., VIJAYARAGHAVAN, S. AND BERG, D. K.: Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels. Neuron. 12: 167-177, 1994.
68. ZHOU, Z. AND NEHER, E.: Calcium permeability of nicotinic acetylcholine receptor channels in bovine chromaffin cells. Pflügers Arch. 425: 513-517, 1998.