Phosphoinositides and the Golgi complex

Current Opinion in Cell Biology

Volumn 14, Issue 4, 2002, Pages 434-447

  De Matteis, Maria Antonietta ^a   Godi, Anna ^a   Corda, Daniela ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4-PHOSPHATE; POLYPHOSPHOINOSITIDE; LIGAND; PHOSPHATASE; PHOSPHATIDYLINOSITIDE;

ANIMAL; BIOLOGICAL MODEL; GOLGI COMPLEX; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; YEAST; CELL MEMBRANE; CELL ORGANELLE; PRECURSOR; PRIORITY JOURNAL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; GOLGI APPARATUS; HUMANS; MODELS, BIOLOGICAL; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHATIDYLINOSITOLS; YEASTS;

EID: 0036701574     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(02)00357-5     Document Type: Review

References (115)

1. Martin T.F. Phosphoinositide lipids as signaling molecules: common themes for signal transduction, cytoskeletal regulation, and membrane trafficking. Annu Rev Cell Dev Biol. 14:1998;231-264.
2. Cullen P.J., Cozier G.E., Banting G., Mellor H. Modular phosphoinositide-binding domains-their role in signalling and membrane trafficking. Curr Biol. 11:2001;R882-R893. A comprehensive review on phosphoinositide-binding domains, with particular reference to proteins involved in membrane traffic pathways.
3. Cockcroft S., De Matteis M.A. Inositol lipids as spatial regulators of membrane traffic. J Membr Biol. 180:2001;187-194.
4. Batty I.H., Currie R.A., Downes C.P. Evidence for a model of integrated inositol phospholipid pools implies an essential role for lipid transport in the maintenance of receptor-mediated phospholipase C activity in 1321N1 cells. Biochem J. 330:1998;1069-1077.
5. Wirtz K.W. Phospholipid transfer proteins revisited. Biochem J. 324:1997;353-360.
6. Cockcroft S. Phosphatidylinositol transfer proteins couple lipid transport to phosphoinositide synthesis. Semin Cell Dev Biol. 12:2001;183-191. An extensive review on the role of phosphatidylinositol transfer proteins in phospholipid metabolism, signalling and membrane trafficking in mammal cells.
7. Li X., Xie Z., Bankaitis V.A. Phosphatidylinositol/phosphatidylcholine transfer proteins in yeast. Biochim Biophys Acta. 1486:2000;55-71. Yeast provides a very powerful system for analysing the physiology and mechanism of the phosphatidylinositol transfer protein (PITP) function in vivo. The review highlights the recent progress and the remaining questions in the area of PITP functions in yeast.
8. Kavran J.M., Klein D.E., Lee A., Falasca M., Isakoff S.J., Skolnik E.Y., Lemmon M.A. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem. 273:1998;30497-30508.
9. Corda D., Iurisci C., Berrie C.P. Biological activities and metabolism of the lysophosphatidylinositol and glycerophosphoinositols. Biochem Biophys Acta. 1582:2002;52-69.
10. Eberhard D.A., Cooper C.L., Low M.G., Holz R.W. Evidence that the inositol phospholipids are necessary for exocytosis, Loss of inositol phospholipids and inhibition of secretion in permeabilized cells caused by a bacterial phospholipase C and removal of ATP. Biochem J. 268:1990;15-25.
11. Bankaitis V.A., Aitken J.R., Cleves A.E., Dowhan W. An essential role for a phospholipid transfer protein in yeast Golgi function. Nature. 347:1990;561-562.
12. Simonsen A., Wurmser A.E., Emr S.D., Stenmark H. The role of phosphoinositides in membrane transport. Curr Opin Cell Biol. 13:2001;485-492. A complete review on the subcellular distribution of the phosphoinositides and their role in endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.
13. Cremona O., De Camilli P. Phosphoinositides in membrane traffic at the synapse. J Cell Sci. 114:2001;1041-1052. A comprehensive review with an historical perspective on the role of the phosphatidylinositides in membrane and actin cytoskeleton dynamics at the synapse. The authors propose that the reversible phosphorylation of inositol phospholipids may be one of the mechanisms governing the vectorial progression of synaptic vesicle membranes during their exocytic-endocytic cycle.
14. Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2:2001;330-335.
15. Ono F., Nakagawa T., Saito S., Owada Y., Sakagami H., Goto K., Suzuki M., Matsuno S., Kondo H. A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. J Biol Chem. 273:1998;7731-7736.
16. Domin J., Gaidarov I., Smith M.E., Keen J.H., Waterfield M.D. The class II phosphoinositide 3-kinase PI3K-C2 alpha is concentrated in the trans-Golgi network and present in clathrin-coated vesicles. J Biol Chem. 275:2000;11943-11950.
17. Schu P.V., Takegawa K., Fry M.J., Stack J.H., Waterfield M.D., Emr S.D. Phosphatidylinositol 3-kinase encoded by yeast vps34 gene essential for protein sorting. Science. 260:1993;88-91.
18. Jones S.M., Howell K.E. Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN. J Cell Biol. 139:1997;339-349.
19. Jones S.M., Alb J.G. Jr, Phillips S.E., Bankaitis V.A., Howell K.E. A phosphatidylinositol 3-kinase and phosphatidylinositol transfer protein act synergistically in formation of constitutive transport vesicles from the trans-Golgi network. J Biol Chem. 273:1998;10349-10354.
20. Davidson H.W. Wortmannin causes mistargeting of procathepsin D. evidence for the involvement of a phosphatidylinositol 3-kinase in vesicular transport to lysosomes. J Cell Biol. 130:1995;797-805.
21. Brown W.J., DeWald D.B., Emr S.D., Plutner H., Balch W.E. Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells. J Cell Biol. 130:1995;781-796.
22. Gaffet P., Jones A.T., Clague M.J. Inhibition of calcium-independent mannose 6-phosphate receptor incorporation into trans-Golgi network-derived clathrin-coated vesicles by wortmannin. J Biol Chem. 272:1997;24170-24175.
23. Gaidarov I., Smith M.E., Domin J., Keen J.H. The class II phosphoinositide 3-kinase C2 alpha is activated by clathrin and regulates clathrin-mediated membrane trafficking. Mol Cell. 7:2001;443-449. The first report of a physical and functional interaction between a coat component (clathrin) and a phosphoinositide-metabolising enzyme (PI3KC2α), providing a mechanistic basis for localised phosphoinositide generation at sites of clathrin-coated bud formation (the plasma membrane and trans-Golgi network), which may regulate coated vesicle formation and uncoating.
24. Robinson M.S., Bonifacino J.S. Adaptor-related proteins. Curr Opin Cell Biol. 13:2001;444-453.
25. Stack J.H., Herman P.K., Schu P.V., Emr S.D. A membrane-associated complex containing the Vps15 protein kinase and the Vps34 PI 3-kinase is essential for protein sorting to the yeast lysosome-like vacuole. EMBO J. 12:1993;2195-2204.
26. Volinia S., Dhand R., Vanhaesebroeck B., MacDougall L.K., Stein R., Zvelebil M.J., Domin J., Panaretou C., Waterfield M.D. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J. 14:1995;3339-3348.
27. Kihara A., Noda T., Ishihara N., Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol. 152:2001;519-530.
28. Audhya A., Foti M., Emr S.D. Distinct roles for the yeast phosphatidylinositol 4-kinases, Stt4p and Pik1p, in secretion, cell growth, and organelle membrane dynamics. Mol Biol Cell. 11:2000;2673-2689. Analysis of the functions in yeast of the two phosphatidylinositol 4-kinases, Stt4p and Pik1p, demonstrating that they produce distinct pools of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate that act on different intracellular membranes to recruit or activate as yet uncharacterised effector proteins.
29. Flanagan C.A., Schnieders E.A., Emerick A.W., Kunisawa R., Admon A., Thorner J. Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science. 262:1993;1444-1448.
30. Walch-Solimena C., Novick P. The yeast phosphatidylinositol-4-OH kinase pik1 regulates secretion at the Golgi. Nat Cell Biol. 1:1999;523-525.
31. Hama H., Schnieders E.A., Thorner J., Takemoto J.Y., DeWald D.B. Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem. 274:1999;34294-34300.
32. Wong K., Meyers R., Cantley L.C. Subcellular locations of phosphatidylinositol 4-kinase isoforms. J Biol Chem. 272:1997;13236-13241.
33. Godi A., Pertile P., Meyers R., Marra P., Di Tullio G., Iurisci C., Luini A., Corda D., De Matteis M.A. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. Nat Cell Biol. 1:1999;280-287.
34. Nakagawa T., Goto K., Kondo H. Cloning, expression, and localisation of 230-kDa phosphatidylinositol 4-kinase. J Biol Chem. 271:1996;12088-12094.
35. Whitters E.A., Cleves A.E., McGee T.P., Skinner H.B., Bankaitis V.A. SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J Cell Biol. 122:1993;79-94.
36. Foti M., Audhya A., Emr S.D. Sac1 lipid phosphatase and Stt4 phosphatidylinositol 4-kinase regulate a pool of phosphatidylinositol 4-phosphate that functions in the control of the actin cytoskeleton and vacuole morphology. Mol Biol Cell. 12:2001;2396-2411. Analysis of the primary role of Sac1p using temperature-sensitive mutants. The authors demonstrate that Sac1p primarily turns over Stt4p-generated phosphatidylinositol 4-phosphate and that the regulation of this phosphatidylinositol 4-phosphate pool appears to be crucial for the maintenance of vacuole morphology, regulation of lipid storage, Golgi function and actin cytoskeleton organisation.
37. Minagawa T., Ijuin T., Mochizuki Y., Takenawa T. Identification and characterization of a sac domain-containing phosphoinositide 5-phosphatase. J Biol Chem. 276:2001;22011-22015.
38. Nemoto Y., Kearns B.G., Wenk M.R., Chen H., Mori K., Alb J.G. Jr, De Camilli P., Bankaitis V.A. Functional characterization of a mammalian Sac1 and mutants exhibiting substrate-specific defects in phosphoinositide phosphatase activity. J Biol Chem. 275:2000;34293-34305.
39. Schorr M., Then A., Tahirovic S., Hug N., Mayinger P. The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase. Curr Biol. 11:2001;1421-1426. This paper reports on the role of Sac1p and Pik1p in chitin synthase transport in yeast, indicating that Sac1p acts as an antagonist of Pik1p. The authors suggest that the generation of phosphatidylinositol 4-phosphate is sufficient to trigger forward transport from the Golgi complex to the plasma membrane.
40. Trotter P.J., Wu W.I., Pedretti J., Yates R., Voelker D.R. A genetic screen for aminophospholipid transport mutants identifies the phosphatidylinositol 4-kinase, STT4p, as an essential component in phosphatidylserine metabolism. J Biol Chem. 273:1998;13189-13196.
41. Cleves A.E., Novick P.J., Bankaitis V.A. Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J Cell Biol. 109:1989;2939-2950.
42. Rivas M.P., Kearns B.G., Xie Z., Guo S., Sekar M.C., Hosaka K., Kagiwada S., York J.D., Bankaitis V.A. Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to 'bypass Sec14p' and inositol auxotrophy. Mol Biol Cell. 10:1999;2235-2250.
43. Li X., Rivas M.P., Fang M., Marchena J., Mehrotra B., Chaudhary A., Feng L., Prestwich G.D., Bankaitis V.A. Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex. J Cell Biol. 157:2002;63-78. This study demonstrates that Kes1p, one of the seven members of the yeast oxysterol-binding protein (OSBP) family, associates with the Golgi complex by binding to a Pik1p-generated phosphatidylinositol 4-phosphate pool via a conserved motif found in all members of the OSBP family. The authors also show that Kes1p may regulate ADP-ribosylation factor (ARF) function in yeast. They suggest that Kes1p interfaces with Sec14p in controlling Golgi secretory function through an altered regulation of ARF.
44. Konrad G., Schlecker T., Faulhammer F., Mayinger P. Retention of the yeast sac1p phosphatase in the endoplasmic reticulum causes distinct changes in cellular phosphoinositide levels and stimulates microsomal ATP transport. J Biol Chem. 277:2002;10547-10554.
45. Hughes W.E., Woscholski R., Cooke F.T., Patrick R.S., Dove S.K., McDonald N.Q., Parker P.J. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases. J Biol Chem. 275:2000;801-808.
46. Ha S.A., Bunch J.T., Hama H., DeWald D.B., Nothwehr S.F. A novel mechanism for localizing membrane proteins to yeast trans-Golgi network requires function of synaptojanin-like protein. Mol Biol Cell. 12:2001;3175-3190.
47. Levine T.P., Munro S. The pleckstrin homology domain of oxysterol-binding protein recognises a determinant specific to Golgi membranes. Curr Biol. 8:1998;729-739.
48. Levine T.P., Munro S. Targeting of Golgi-specific pleckstrin homology domains involves both PtdIns 4-kinase-dependent and-independent components. Curr Biol. 12:2002;695-704. This work studies the distribution of green fluorescent protein fused pleckstrin homology (PH) domains of oxysterol-binding protein and related domains in yeast strains carrying mutations in individual phosphoinositide kinases. The authors demonstrate that the Golgi targeting of this PH domain depends on the activity of the phosphatidylinositol 4-kinase Pik1p, and on a second determinant regulated by ADP-ribosylation factor.
49. Bruns J.R., Ellis M.A., Jeromin A., Weisz O.A. Multiple roles for phosphatidylinositol 4-kinase in biosynthetic transport in polarized Madin-Darby canine kidney cells. J Biol Chem. 277:2002;2012-2018.
50. Jones D.H., Morris J.B., Morgan C.P., Kondo H., Irvine R.F., Cockcroft S. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the Golgi compartment. J Biol Chem. 275:2000;13962-13966.
51. Liljedahl M., Maeda Y., Colanzi A., Ayala I., Van Lint J., Malhotra V. Protein kinase D regulates the fission of cell surface destined transport carriers from the trans-Golgi network. Cell. 104:2001;409-420.
52. Nishikawa K., Toker A., Wong K., Marignani P.A., Johannes F.J., Cantley L.C. Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type I phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 273:1998;23126-23133.
53. Hendricks K.B., Wang B.Q., Schnieders E.A., Thorner J. Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase. Nat Cell Biol. 1:1999;234-241.
54. Zhao X., Varnai P., Tuymetova G., Balla A., Toth Z.E., Oker-Blom C., Roder J., Jeromin A., Balla T. Interaction of neuronal calcium sensor-1 (NCS-1) with phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and affects membrane trafficking in COS-7 cells. J Biol Chem. 276:2001;40183-40189.
55. Weisz O.A., Gibson G.A., Leung S.M., Roder J., Jeromin A. Overexpression of frequenin, a modulator of phosphatidylinositol 4-kinase, inhibits biosynthetic delivery of an apical protein in polarized Madin-Darby canine kidney cells. J Biol Chem. 275:2000;24341-24347.
56. Siddhanta A., Backer J.M., Shields D. Inhibition of phosphatidic acid synthesis alters the structure of the Golgi apparatus and inhibits secretion in endocrine cells. J Biol Chem. 275:2000;12023-12031.
57. Attree O., Olivos I.M., Okabe I., Bailey L.C., Nelson D.L., Lewis R.A., McInnes R.R., Nussbaum R.L. The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate- 5-phosphatase. Nature. 358:1992;239-242.
58. Olivos-Glander I.M., Janne P.A., Nussbaum R.L. The oculocerebrorenal syndrome gene product is a 105-kD protein localized to the Golgi complex. Am J Hum Genet. 57:1995;817-823.
59. Bascom R.A., Srinivasan S., Nussbaum R.L. Identification and characterization of golgin-84, a novel Golgi integral membrane protein with a cytoplasmic coiled-coil domain. J Biol Chem. 274:1999;2953-2962.
60. Dressman M.A., Olivos-Glander I.M., Nussbaum R.L., Suchy S.F. Ocrl1, a PtdIns(4,5)P(2) 5-phosphatase, is localized to the trans-Golgi network of fibroblasts and epithelial cells. J Histochem Cytochem. 48:2000;179-190.
61. Zhang X., Hartz P.A., Philip E., Racusen L.C., Majerus P.W. Cell lines from kidney proximal tubules of a patient with Lowe syndrome lack OCRL inositol polyphosphate 5-phosphatase and accumulate phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 273:1998;1574-1582.
62. Godi A., Santone I., Pertile P., Devarajan P., Stabach P.R., Morrow J.S., Di Tullio G., Polishchuk R., Petrucci T.C., Luini A., et al. ADP ribosylation factor regulates spectrin binding to the Golgi complex. Proc Natl Acad Sci USA. 95:1998;8607-8612.
63. Sweeney D.A., Siddhanta A., Shields D. Fragmentation and re-assembly of the Golgi apparatus in vitro. A requirement for phosphatidic acid and phosphatidylinositol 4,5-bisphosphate synthesis. J Biol Chem. 277:2002;3030-3039.
64. De Matteis M.A., Morrow J.S. The role of ankyrin and spectrin in membrane transport and domain formation. Curr Opin Cell Biol. 10:1998;542-549.
65. Lorra C., Huttner W.B. The mesh hypothesis of Golgi dynamics. Nat Cell Biol. 1:1999;E113-115.
66. Rozelle A.L., Machesky L.M., Yamamoto M., Driessens M.H., Insall R.H., Roth M.G., Luby-Phelps K., Marriott G., Hall A., Yin H.L. Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol. 10:2000;311-320.
67. Kozlov M.M. Fission of biological membranes: interplay between dynamin and lipids. Traffic. 2:2001;51-65.
68. Martin T.F. PI(4,5)P(2) regulation of surface membrane traffic. Curr Opin Cell Biol. 13:2001;493-499. This is a review on the recent progress in localizing phosphatidylinositol 4,5-bisphosphate and elucidating mechanisms for its localised synthesis. The roles of phosphatidylinositol 4,5-bisphosphate as a signal for coordinating membrane trafficking and cytoskeletal events are delineated.
69. Stefan C.J., Audhya A., Emr S.D. The yeast synaptojanin-like proteins control the cellular distribution of phosphatidylinositol (4,5)-bisphosphate. Mol Biol Cell. 13:2002;542-557. This study demonstrates that synaptojanins control the distribution of phosphatidylinositol 4,5-bisphosphate in yeast and are responsible for its restricted plasma membrane localisation. The study also provides evidence for the compartmentalisation of the different phosphoinositides in yeast.
70. Watt S.A., Kular G., Fleming I.N., Downes C.P., Lucocq J.M. Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase Cδ1. Biochem J. 363:2002;657-666.
71. Pertile P., Liscovitch M., Chalifa V., Cantley L.C. Phosphatidylinositol 4,5-bisphosphate synthesis is required for activation of phospholipase D in U937 cells. J Biol Chem. 270:1995;5130-5135.
72. Divecha N., Roefs M., Halstead J.R., D'Andrea S., Fernandez-Borga M., Oomen L., Saqib K.M., Wakelam M.J., D'Santos C. Interaction of the type I alpha PIP kinase with phospholipase D: a role for the local generation of phosphatidylinositol 4, 5-bisphosphate in the regulation of PLD2 activity. EMBO J. 19:2000;5440-5449.
73. Donaldson J.G., Jackson C.L. Regulators and effectors of the ARF GTPases. Curr Opin Cell Biol. 12:2000;475-482.
74. Simon J.P., Morimoto T., Bankaitis V.A., Gottlieb T.A., Ivanov I.E., Adesnik M., Sabatini D.D. An essential role for the phosphatidylinositol transfer protein in the scission of coatomer-coated vesicles from the trans-Golgi network. Proc Natl Acad Sci USA. 95:1998;11181-11186.
75. Buccione R., Bannykh S., Santone I., Baldassarre M., Facchiano F., Bozzi Y., Di Tullio G., Mironov A., Luini A., De Matteis M.A. Regulation of constitutive exocytic transport by membrane receptors. A biochemical and morphometric study. J Biol Chem. 271:1996;3523-3533.
76. Baron C.L., Malhotra V. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science. 295:2002;325-328.
77. De Matteis M.A., Morrow J.S. Spectrin tethers and mesh in the biosynthetic pathway. J Cell Sci. 113:2000;2331-2343.
78. Dowler S., Currie R.A., Campbell D.G., Deak M., Kular G., Downes C.P., Alessi D.R. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J. 351:2000;19-31.
79. van Meer G. Lipids of the Golgi membrane. Trends Cell Biol. 8:1998;29-33.
80. Jin T.G., Satoh T., Liao Y., Song C., Gao X., Kariya K., Hu C.D., Kataoka T. Role of the CDC25 homology domain of phospholipase C epsilon in amplification of Rap1-dependent signaling. J Biol Chem. 276:2001;30301-30307.
81. Barker S.A., Caldwell K.K., Pfeiffer J.R., Wilson B.S. Wortmannin-sensitive phosphorylation, translocation, and activation of PLCgamma1, but not PLCgamma2, in antigen-stimulated RBL-2H3 mast cells. Mol Biol Cell. 9:1998;483-496.
82. Evans J.H., Spencer D.M., Zweifach A., Leslie C.C. Intracellular calcium signals regulating cytosolic phospholipase A2 translocation to internal membranes. J Biol Chem. 276:2001;30150-30160.
83. 2+ store, with functional properties distinct from those of the endoplasmic reticulum. EMBO J. 17:1998;5298-5308.
84. 2+ storage in the Golgi. J Cell Biol. 145:1999;279-289.
85. Ahluwalia J.P., Topp J.D., Weirather K., Zimmerman M., Stamnes M. A role for calcium in stabilizing transport vesicle coats. J Biol Chem. 276:2001;34148-34155.
86. de Graaf P., Klapisz E.E., Schulz T.K., Cremers A.F.M., Verkleij A.J., van Bergen en Henegouwen P.M.P. Nuclear localization of phosphatidylinositol 4-kinase β J Cell Sci. 115:2002;1769-1775.
87. Cocco L., Martelli A.M., Barnabei O., Manzoli F.A. Nuclear inositol lipid signaling. Adv Enzyme Regul. 41:2001;361-384.
88. Daniele N., Rajas F., Payrastre B., Mauco G., Zitoun C., Mithieux G. Phosphatidylinositol 3-kinase translocates onto liver endoplasmic reticulum and may account for the inhibition of glucose-6-phosphatase during refeeding. J Biol Chem. 274:1999;3597-3601.
89. Barylko B., Gerber S.H., Binns D.D., Grichine N., Khvotchev M., Sudhof T.C., Albanesi J.P. A novel family of phosphatidylinositol 4-kinases conserved from yeast to humans. J Biol Chem. 276:2001;7705-7708.
90. Walker S.M., Downes C.P., Leslie N.R. TPIP: a novel phosphoinositide 3-phosphatase. Biochem J. 360:2001;277-283.
91. Jones S.M., Howell K.E., Henley J.R., Cao H., McNiven M.A. Role of dynamin in the formation of transport vesicles from the trans-Golgi network. Science. 279:1998;573-577.
92. Lee S.Y., Mansour M., Pohajdak B. B2-1, a Sec7- and pleckstrin homology domain-containing protein, localizes to the Golgi complex. Exp Cell Res. 256:2000;515-521.
93. Monier S., Chardin P., Robineau S., Goud B. Overexpression of the ARF1 exchange factor ARNO inhibits the early secretory pathway and causes the disassembly of the Golgi complex. J Cell Sci. 111 (Pt 22):1998;3427-3436.
94. Franco M., Boretto J., Robineau S., Monier S., Goud B., Chardin P., Chavrier P. ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function. Proc Natl Acad Sci USA. 95:1998;9926-9931.
95. Andreev J., Simon J.P., Sabatini D.D., Kam J., Plowman G., Randazzo P.A., Schlessinger J. Identification of a new Pyk2 target protein with Arf-GAP activity. Mol Cell Biol. 19:1999;2338-2350.
96. Miura K., Jacques K.M., Stauffer S., Kubosaki A., Zhu K., Hirsch D.S., Resau J., Zheng Y., Randazzo P.A. ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell. 9:2002;109-119. The identification of two members of the ARAPs family that contain the ADP ribosylation factor (ARF) GAP, the Rho GAP and five pleckstrin homology domains, as components of signalling pathways regulating cell movement. ARAP1 has Rho GAP and phosphatidylinositol 3,4,5-trisphosphate-dependent ARF GAP activities, and induces changes in the Golgi complex and the actin cytoskeleton when overexpressed. Thus, ARAP1 is a point of convergence for ARF, Rho and the phosphoinositides, and could coordinate membrane trafficking and actin remodelling.
97. Estrada L., Caron E., Gorski J.L. Fgd1, the Cdc42 guanine nucleotide exchange factor responsible for faciogenital dysplasia, is localized to the subcortical actin cytoskeleton and Golgi membrane. Hum Mol Genet. 10:2001;485-495.
98. Nagaya H., Wada I., Jia Y.J., Kanoh H. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Mol Biol Cell. 13:2002;302-316.
99. Freyberg Z., Sweeney D., Siddhanta A., Bourgoin S., Frohman M., Shields D. Intracellular localization of phospholipase D1 in mammalian cells. Mol Biol Cell. 12:2001;943-955.
100. Krappa R., Nguyen A., Burrola P., Deretic D., Lemke G. Evectins: vesicular proteins that carry a pleckstrin homology domain and localize to post-Golgi membranes. Proc Natl Acad Sci USA. 96:1999;4633-4638.
101. Ridley S.H., Ktistakis N., Davidson K., Anderson K.E., Manifava M., Ellson C.D., Lipp P., Bootman M., Coadwell J., Nazarian A., et al. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci. 114:2001;3991-4000.
102. Kerkhoff E., Simpson J.C., Leberfinger C.B., Otto I.M., Doerks T., Bork P., Rapp U.R., Raabe T., Pepperkok R. The Spir actin organizers are involved in vesicle transport processes. Curr Biol. 11:2001;1963-1968.
103. Shisheva A., Rusin B., Ikonomov O.C., DeMarco C., Sbrissa D. Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIK FYVE in 3T3-L1 adipocytes. J Biol Chem. 276:2001;11859-11869.
104. Nielsen E., Christoforidis S., Uttenweiler-Joseph S., Miaczynska M., Dewitte F., Wilm M., Hoflack B., Zerial M. Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain. J Cell Biol. 151:2000;601-612.
105. Fukuda M., Ibata K., Mikoshiba K. A unique spacer domain of synaptotagmin IV is essential for Golgi localization. J Neurochem. 77:2001;730-740.
106. Mehrotra B., Myszka D.G., Prestwich G.D. Binding kinetics and ligand specificity for the interactions of the C2B domain of synaptogmin II with inositol polyphosphates and phosphoinositides. Biochemistry. 39:2000;9679-9686.
107. Chaudhary A., Gu Q.M., Thum O., Profit A.A., Qi Y., Jeyakumar L., Fleischer S., Prestwich G.D. Specific interaction of Golgi coatomer protein alpha-COP with phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem. 273:1998;8344-8350.
108. Hao W., Tan Z., Prasad K., Reddy K.K., Chen J., Prestwich G.D., Falck J.R., Shears S.B., Lafer E.M. Regulation of AP-3 function by inositides. Identification of phosphatidylinositol 3,4,5-trisphosphate as a potent ligand. J Biol Chem. 272:1997;6393-6398.
109. Randazzo P.A. Functional interaction of ADP-ribosylation factor 1 with phosphatidylinositol 4,5-bisphosphate. J Biol Chem. 272:1997;7688-7692.
110. Dong J., Radau B., Otto A., Muller E., Lindschau C., Westermann P. Profilin I attached to the Golgi is required for the formation of constitutive transport vesicles at the trans-Golgi network. Biochim Biophys Acta. 1497:2000;253-260.
111. Mazaki Y., Hashimoto S., Okawa K., Tsubouchi A., Nakamura K., Yagi R., Yano H., Kondo A., Iwamatsu A., Mizoguchi A., et al. An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization. Mol Biol Cell. 12:2001;645-662.
112. Vitale N., Patton W.A., Moss J., Vaughan M., Lefkowitz R.J., Premont R.T. GIT proteins, a novel family of phosphatidylinositol 3,4, 5-trisphosphate-stimulated GTPase-activating proteins for ARF6. J Biol Chem. 275:2000;13901-13906.
113. Sciorra V.A., Rudge S.A., Prestwich G.D., Frohman M.A., Engebrecht J., Morris A.J. Identification of a phosphoinositide binding motif that mediates activation of mammalian and yeast phospholipase D isoenzymes. EMBO J. 18:1999;5911-5921.
114. Irvine R.F., Schell M.J. Back in the water: the return of the inositol phosphates. Nat Rev Mol Cell Biol. 2:2001;327-338. This is a comprehensive review on the metabolism and roles of the inositol phosphates in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.
115. Ching T.T., Wang D.S., Hsu A.L., Lu P.J., Chen C.S. Identification of multiple phosphoinositide-specific phospholipases D as new regulatory enzymes for phosphatidylinositol 3,4, 5-trisphosphate. J Biol Chem. 274:1999;8611-8617.