A novel mechanism for localizing membrane proteins to yeast trans-Golgi network requires function of synaptojanin-like protein

Molecular Biology of the Cell

Volumn 12, Issue 10, 2001, Pages 3175-3190

  Ha, S A ^a   Bunch, J T ^a   Hama, H ^a   DeWald, D B ^a   Nothwehr, S F ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; MEMBRANE PROTEIN; PHOSPHATASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL; SYNAPTOJANIN;

ARTICLE; CELL FRACTIONATION; GENE MUTATION; GOLGI COMPLEX; IMMUNOPRECIPITATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; YEAST;

EID: 0035172475     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.10.3175     Document Type: Article

References (68)

1. Protein sorting by directed maturation of Golgi compartments
2. Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
3. Synthetic genetic interactions with temperature-sensitive clathrin Saccharomyces cerevisiae: Roles for synaptojanin-like Inp53p and dynamin-related Vps1p in clathrin-dependent protein sorting at the trans-Golgi network
4. Ric1p and the Ypt6p GTPase function in a common pathway required for localization of trans-Golgi network membrane proteins
5. A selective transport route nfrom Golgi to late endosomes that requires the yeast GGA proteins
6. Procollagen traverses the Golgi stack without leaving the lumen of cisternae: Evidence for cisternal maturation
7. SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals
8. Two separate signals act independently to localize a yeast late Golgi membrane protein through a combination of retrieval and retention
9. Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to ring FYVE domains
10. The cytoplasmic tail domain of the vacuolar protein sorting receptor Vps10p and a subset of VPS gene products regulate receptor stability, function, and localization
11. The functioning of the yeast Golgi apparatus requires an ER protein encoded by ANP1, a member of a new family of genes affecting the secretory pathway
12. Yeast Kex1p is a Golgi-associated membrane protein: Deletions in a cytoplasmic targeting domain result in mislocalization to the vacuolar membrane
13. Vps10p cycles between the late-Golgi and prevacuolar compartments in its function as the sorting receptor for multiple yeast vacuolar hydrolases
14. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole
15. Novel Golgi to vacuole delivery pathway in yeast - Identification of a sorting determinant and required transport component
16. Essential role of phosphoinositide metabolism in synaptic vesicle recycling
17. The VPS4 gene is involved in protein transport out of a yeast prevacuolar endosome-like compartment
18. 2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes
19. Intracellular targeting and structural conservation of a prohormone-processing endoprotease
20. Enzymes required for yeast prohormone processing
21. Signal-mediated retrieval of a membrane protein from the Golgi to the ER in yeast
22. A cisternal maturation mechanism can explain the asymmetry of the Golgi stack
23. SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases
24. Analysis of phosphoinositides in protein trafficking
25. The extraction of inositol-containing phospholipids and phosphatidylcholine from Saccharomyces cerevisiae and Neurospora crassa
26. Mutations in synaptojanin disrupt synaptic vesicle recycling
27. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor
28. On global sequence alignment
29. Sac phosphatase domain proteins
30. SAC1 encodes a regulated lipid phosphoinositide phosphatase, defects in which can be suppressed by the homologous Inp52p and Inp53p phosphatases
31. Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis
32. Essential role for diacylglycerol in protein transport from the yeast Golgi complex
33. Specific retrieval of the exocytic SNARE Snc1p from early yeast endosomes
34. Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant
35. The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene
36. A synthetic model of intra-Golgi traffic
37. Distinct domains within Vps35p mediate the retrieval of two different cargo proteins from the yeast prevacuolar/endosomal compartment
38. The newly identified yeast GRD genes are required for retention of late-Golgi membrane proteins
39. Golgi and vacuolar membrane proteins reach the vacuole in vps1 mutant yeast cells via the plasma membrane
40. Sorting of yeast membrane proteins into an endosome-to-Golgi pathway involves direct interaction of their cytosolic domains with Vps35p
41. The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi
42. Membrane protein retention in the yeast Golgi apparatus: Dipeptidyl aminopeptidase A is retained by a cytoplasmic signal containing aromatic residues
43. Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body
44. The yeast inositol polyphosphate 5-phosphatases Inp52p and Inp53p translocate to actin patches following hyperosmotic stress: Mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations
45. Genetic applications of yeast transformation with linear and gapped plasmids
46. The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the vps-dependent pathway
47. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae
48. Morphology of the yeast endocytic pathway
49. Morphological classification of the yeast vacuolar protein sorting mutants: Evidence for a prevacuolar compartment in class E vps mutants
50. Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae
51. Membrane protein sorting in the yeast secretory pathway: Evidence that the vacuole may be the default compartment
52. Methods for studying the yeast vacuole
53. Protein sorting in Saccharomyces cerevisiae: Isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
54. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector
55. Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the Vps29, Vps30, and Vps35 gene products
56. A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast
57. Identification and quantification of polyphosphoinositides produced in response to platelet-derived growth factor stimulation
58. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
59. EEA1 links PI(3)kinase function to rab5 regulation of endosome fusion
60. Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins
61. Synaptojanin family members are implicated in endocytic membrane traffic in yeast
62. The yeast GRD20 gene is required for protein sorting in the trans-Golgi network/endosomal system and for polarization of the actin cytoskeleton
63. Disruption of three phosphatidylinositol-polyphosphate 5-phosphatase genes from Saccharomyces cerevisiae results in pleiotropic abnormalities of vacuole morphology, cell shape, and osmohomeostasis
64. Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger
65. Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole
66. Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP53, INP52, and INP53 gene products) in the yeast Saccharomyces cerevisiae
67. The VPS1 protein, a homolog of dynamin required for vacuolar protein sorting in Saccharomyces cerevisiae, is a GTPase with two functionally separable domains
68. Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole