Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: Relationship to 'bypass Sec14p' and inositol auxotrophy

Molecular Biology of the Cell

Volumn 10, Issue 7, 1999, Pages 2235-2250

  Rivas, Marcos P ^a   Kearns, Brian G ^a   Xie, Zhigang ^a   Guo, Shuling ^c   Sekar, M Chandra ^b   Hosaka, Kohei ^d   Kagiwada, Satoshi ^e   York, John D ^c   Bankaitis, Vytas A ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d GUNMA UNIVERSITY   (Japan)

^e NARA WOMEN'S UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CITICOLINE; DIACYLGLYCEROL KINASE; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PHOSPHOLIPASE D;

ARTICLE; AUXOTROPHY; CELL GROWTH; CELL VIABILITY; ENZYME ACTIVITY; ENZYME INACTIVATION; FUNGUS MUTANT; GENE EXPRESSION REGULATION; GENE MUTATION; GOLGI COMPLEX; METHYLATION; NONHUMAN; PHENOTYPE; PHOSPHOINOSITIDE METABOLISM; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; YEAST;

BACTERIA (MICROORGANISMS); FUNGI;

EID: 0032874292     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.10.7.2235     Document Type: Article

References (41)

1. Aitken, J.F., van Heusden, G.P.H., Temkin, M., and Dowhan, W. (1990). The gene encoding the phosphatidylinositol transfer protein is essential for cell growth. J. Biol. Chem. 265, 4711-4717.
2. Alb, J.G., Jr., Kearns, M.A., and Bankaitis, V.A. (1996). Phospholipid metabolism and membrane dynamics. Curr. Opin. Cell Biol. 8, 534-541.
3. Atkinson, K.D. (1984). Saccharomyces cerevisiae recessive suppressor that circumvents phosphatidylserine deficiency. Genetics 108, 533-543.
4. Bankaitis, V.A., Aitken, J.R., Cleves, A.E., and Dowhan, W. (1990). An essential role for a phospholipid transfer protein in yeast Golgi function. Nature 347, 561-562.
5. Bankaitis, V.A., Malehorn, D.E., Emr, S.D., and Greene, R. (1989). The Saccharomyces cerevisiae SEC14 gene encodes a cytosolic factor that is required for transport of secretory proteins from the yeast Golgi complex. J. Cell Biol. 208, 1271-1281.
6. Buttke, T.M., and Pyle, A.L. (1982). Effects of unsarurated fatty acid deprivation on neutral lipid synthesis in Saccharomyces cerevisiae. J. Bacteriol. 152, 747-756.
7. Carman, G.A., and Henry, S.A. (1989). Phospholipid biosynthesis in yeast. Annu. Rev. Biochem. 58, 635-667.
8. Cleves, A.E., McGee, T.P., and Bankaitis, V.A. (1991a). Phospholipid transfer proteins: a biological debut. Trends Cell Biol. 1, 30-34.
9. Cleves, A.E., McGee, T.P., Whitters, E.A., Champion, K.M., Aitken, J.R., Dowhan, W., Goebl, M., and Bankaitis, V.A. (1991b). Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. Cell 64, 789-800.
10. Cleves, A.E., Novick, P.J., and Bankaitis, V.A. (1989). Mutations in the SAC1 gene suppress defects in yeast Golgi and yeast actin function. J. Cell Biol. 109, 2939-2950.
11. +) cells. J. Bacteriol. 126, 232-242.
12. Culbertson, M., Donahue, T.F., and Henry, S. (1976b). Selection of spontaneous mutants by inositol starvation in yeast. J. Bacteriol. 126, 243-250.
13. Cutler, N.S., Heitman, J., and Cardenas, M.E. (1997). STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. J. Biol. Chem. 272, 27671-27677.
14. Fang, M., Kearns, B.G., Gedvilaite, A., Kagiwada, S., Kearns, M., Fung, M.K.Y., and Bankaitis, V.A. (1996). Kes1p shares homology with human oxysterol binding ptrotein and participates in a novel regulatory pathway for yeast Golgi-derived transport vesicle biogenesis. EMBO J. 15, 6447-6459.
15. Fang, M., Rivas, M.P., and Bankaitis, V.A. (1998). The contribution of lipids and lipid metabolism to cellular functions of the Golgi complex. Biochim. Biophys. Acta 1404, 85-100.
16. Franzusoff, A., and Schekman, R. (1989). Functional compartments of the Golgi complex are defined by the sec7 mutation. EMBO J. 8, 2695-2702.
17. Gary, J.D., Wurmser, A.E., Bonangelino, C.J., Weisman, L.S., and Emr, S.D. (1998). Fablp is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis. J. Cell Biol. 143, 65-79.
18. Guo, S., Stolz, L.E., Lemrow, S., and York, J.D. (1999). SAC1-like domains of yeast SAC1, INP52 and INP53, and human synaptojanin encode polyphosphoinositide phosphatases. J. Biol. Chem. 274, 12990-12995.
19. Hosaka, K., Nikawa, J., Kodaki, T., and Yamashita, S. (1992). A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae. J. Biochem. 116, 1317-1321.
20. Ito, H., Fukuda, Y., Murata, K., and Kimura, A. (1983). Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 253, 163-168.
21. Kagiwada, S., Kearns, E.G., McGee, T.P., Fang, M., Hosaka, K., and Bankaitis, V.A. (1996). The yeast BSD2-1 mutation influences both the requirement for phosphatidylinositol transfer protein function and derepression of phospholipid biosynthetic gene expression in yeast. Genetics 143, 685-697.
22. Kearns, B.G., Alb, J.G., Jr., and Bankaitis, V.A. (1998). Phosphatidylinositol transfer proteins: the long and winding road to physiological function. Trends Cell Biol. 8, 276-282.
23. Kearns, B.G., McGee, T.P., Mayinger, P., Gedvilaite, A., Phillips, S.E., Kagiwada, S., and Bankaitis, V.A. (1997). An essential role for diacylglycerol in protein transport from the yeast Golgi complex. Nature 387, 101-105.
24. Kochendörfer, K.-U., Then, A., Kearns, B.C., Bankaitis, V.A., and Mayinger, P. (1999). The role for Saclp in microsomal ATP transport is distinct from its function in inositol phospholipid metabolism. EMBO J. 18, 1506-1515.
25. Lips, D.L., Majerus, P.W., Gorga, F.R., Young, A.T., and Benjamin, T.L. (1989). Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II. J. Biol Chem. 264, 8759-8763.
26. Mayinger, P., Bankaitis, V.A., and Meyer, D.I. (1996). SacIp mediates the adenosine triphosphate transport into yeast endoplasmic reticulum that is required for protein translocation. J. Cell Biol. 131, 1377-1386.
27. McGee, T.P., Skinner, H.B., Whitters, E.A., Henry, S.A., and Bankaitis, V.A. (1994). A phosphatidylinositol transfer protein controls the phosphatidylcholine content of yeast Golgi membranes. J. Cell Biol. 124, 273-287.
28. Novick, P., Field, C, and Schekman, R. (1980). Identification of 23 complementation groups required for posttranslational events in the yeast secretory pathway. Cell 21, 205-215.
29. Novick, P., Osmond, B.C., and Botstein, D.D. (1989). Suppressors of yeast actin mutations. Genetics 121, 659-674.
30. Rothstein, R.J. (1983). One step gene disruption in yeast. Methods Enzymol. 101, 202-211.
31. Salama, S.R., Cleves, A.E., Malehorn, D.E., Whitters, E.A., and Bankaitis, V.A. (1990). Cloning and characterization of Kluyveromyces lactis SEC14, a gene whose product stimulates Golgi secretory function in Saccharomyces cerevisiae. J. Bacteriol. 172, 4510-4521.
32. Sherman, F., Fink, G.R., and Hicks, J.B. (1983). Methods in Yeast Genetics, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory, 1-113.
33. Skinner, H.B., McGee, T.P., McMaster, C.R., Fry, M.R., Bell, R.M., and Bankaitis, V.A. (1995). Phosphatidylinositol transfer protein stimulates yeast Golgi function by inhibiting choline-phosphate cytidylyltransferase activity. Proc. Natl. Acad. Sci. USA 92, 112-116.
34. Sreenivas, A., Patton-Vogt, J.L., Bruno, V., Griac, P., and Henry, S.A. (1998). A role for phospholipase D in growth, secretion, and regulation of membrane lipid synthesis in yeast. J. Biol. Chem. 273, 16635-16638.
35. Steiner, M.R., and Lester, R.L. (1972). In vitro studies of phospholipid biosynthesis in Saccharomyces cerevisiae. Biochim. Biophys. Acta 260, 222-243.
36. Stock, S.D., Hama, H., DeWald, D.B., and Takemoto, J.Y. (1999). SEC14-dependent secretion in Saccharomyces cerevisiae: nondependence on sphingolipid-coupled diacyglycerol synthesis. J. Biol. Chem. 274, 12979-12983.
37. Stolz, L.E., Kuo, W.J., Longchamps, J., Sekhon, M.K., and York, J.D. (1998). Inp51, a yeast inositol polyphosphate 5-phosphatase required for phosphatidylinositol 4,5-bisphosphate homeostasis and whose absence confers a cold-resistant phenotype. J. Biol. Chem. 273, 11852-11861.
38. Whitters, E.A., Cleves, A.E., McGee, T.P., Skinner, H.B., and Bankaitis, V.A. (1993). SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. J. Cell Biol. 122, 79-94.
39. Xie, Z., Fang, M., Rivas, M.P., Faulkner, A., Sternweis, P.C., Engebrecht, J., and Bankaitis, V.A. (1998). Phospholipase D activity is required for suppression of yeast phosphatidylinositol transfer protein defects. Proc. Natl. Acad. Sci. USA 95, 12346-12351.
40. York, J.D., Chen, Z., Ponder, J.W., Chauhan, A.K., Mathews, F.S., and Majerus, P.W. (1994). Crystallization and initial crystallographic characterization of recombinant inositol polyphosphate 1-phosphatase produced in Spodoptera frugiperda cells. J. Mol. Biol. 236, 584-589.
41. York, J.D., and Majerus, P.W. (1994). Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells. J. Biol. Chem. 269, 7847-7850.