An ADP-ribosylation factor GTPase-activating protein Git2-short/KIAA0148 is involved in subcellular localization of paxillin and actin cytoskeletal organization

Molecular Biology of the Cell

Volumn 12, Issue 3, 2001, Pages 645-662

  Mazaki, Y ^a   Hashimoto, S ^a   Okawa, K ^a   Tsubouchi, A ^a   Nakamura, K ^a   Yagi, R ^a   Yano, H ^a   Kondo, A ^a   Iwamatsu, A ^a   Mizoguchi, A ^a   Sabe, H ^a  

^a OSAKA BIOSCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; COAT PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; PAXILLIN; PROTEIN GIT2 SHORT; UNCLASSIFIED DRUG;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ADHESION; COMPLEX FORMATION; CYTOSKELETON; GOLGI COMPLEX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

EID: 0035173058     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.3.645     Document Type: Article

References (79)

1. Involvement of NH2-terminal sequences in the negative regulation of Vav signaling and transforming activity
2. Identification of a new Pyk2 target protein with Arf-GAP activity
3. A tyrosine-phosphorylated protein that binds to an important regulatory region on the Cool family of p21-activated kinase-binding proteins
4. ADP-ribosylation factor is required for vesicular trafficking between the endoplasmic reticulum and the cis-Golgi compartment
5. Arf proteins: The membrane traffic police?
6. Pre-Golgi degradation of newly synthesized T-cell antigen receptor chains: Intrinsic sensitivity and the role of subunit assembly
7. Paxillin LD. Motifs may define a new family of protein recognition domains
8. Focal adhesions, contractility, and signaling
9. Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
10. p95-APP1 links membrane transport to Rac-mediated reorganization of actin
11. Brefeldin A: The advantage of being incompetitive
12. Integrins and signal transduction pathways: The road taken
13. ARF-regulated phospholipase D, a potential role in membrane traffic
14. The ARF1 GTPase-activating protein: Zinc finger motif and Golgi complex localization
15. Dominant inhibitory mutants of ARF1 block endoplasmic reticulum to Golgi transport and trigger disassembly of the Golgi apparatus
16. ADP-ribosylation factor, a small GTP-binding protein, is required for binding of the coatomer protein beta-COP to Golgi membranes
17. Binding of ARF and β-COP to Golgi membranes: Possible regulation by a trimeric G proteins
18. ARF: A key regulatory switch in membrane traffic and organelle structure
19. Aluminum fluoride acts on the reversibility of ARF1-dependent coat protein binding to Golgi membranes
20. Structural and functional analysis of the ARF1-ARFGAP complex reveals a role for coatomer in GTP hydrolysis
21. Complement receptor 3 (CR3, Mac-1, integrin alpha M beta 2, CD11b/CD18) is required for tyrosine phosphorylation of paxillin in adherent and nonadherent neutrophils
22. Rho GTPases and the actin cytoskeleton
23. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6)
24. Integrins: Versatility, modulation, and signaling in cell adhesion
25. S-carboxymethylation of proteins transferred onto polyvinylidene difluoride membranes followed by in situ protease digestion and amino acid microsequencing
26. The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein
27. The amino terminus of ADP-ribosylation factor (ARF) is a critical determinant of ARF activities and is a potent and specific inhibitor of protein transport
28. ARF signaling: A potential role for phospholipase D in membrane traffic
29. A new paxillin-binding protein, PAG3/Papα/KIAA0400, bearing an Arf GTPase-activating protein activity is involved in paxillin recruitment to focal adhesions and cell migration
30. COPs regulating membrane traffic
31. Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion
32. Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum
33. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
34. Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases
35. Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins
36. Paxillin isoforms in mouse: Lack of the gamma isoform and developmentally specific beta isoform expression
37. Integrin function: Molecular hierarchies of cytoskeletal and signaling molecules
38. Localization of rabphilin-3A on the synaptic vesicle
39. Advanced mammalian gene transfer: High titer retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
40. Structure, and function of ARF proteins: Activators of cholera toxin and critical components of intracellular vesicular transport processes
41. Molecules in the ARF orbit
42. Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1
43. Tyrosine phosphorylation of paxillin is involved in temporospatial regulation of paxillin-containing focal adhesion formation and F-actin organization in motile cells
44. Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
45. Rho GTPases, control polarity, protrusion, and adhesion during cell movement
46. ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts
47. GTPases: Multifunctional molecular switches regulating vesicular traffic
48. ADP-ribosylation factor 1 (ARF1) regulates recruitment of the AP-3 adaptor complex to membranes
49. Production of high-titer helper-free retroviruses by transient transfection
50. Overexpression of wild-type and mutant ARF1 and ARF6: Distinct perturbations of non-overlapping membrane compartments
51. Saccharomyces cerevisiae Gcs1 is an ADP-ribosylation factor GTPase-activating protein
52. beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein
53. The GIT family of ADP-ribosylation factor GTPase-activating proteins
54. ARF6 requirement for Rac ruffiing suggests a role for membrane trafficking in cortical actin rearrangements
55. Aluminum fluoride stimulates surface protrusions in cells overexpressing the ARF6 GTPase
56. Snapshots of ARF1: Implications for mechanisms of activation and inactivation
57. Analysis of the binding of the Src homology 2 domain of Csk to tyrosine-phosphorylated proteins in the suppression and mitotic activation of c-Src
58. Coat proteins and vesicle budding
59. ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: A novel role for a GTP-binding protein
60. Localization of endogenous ARF6 to sites of cortical actin rearrangement and involvement of ARF6 in cell spreading
61. A primer on vesicle budding
62. The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein
63. ADP-ribosylation factor is functionalty and physically associated with the Golgi complex
64. Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK
65. A target of phosphatidytinositol 3,4,5-trisphosphate with a zinc finger motif similar to that of the ADP-ribosylation-factor GTPase-activating protein and two pleckstrin homology domains
66. The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton
67. The bovine papiliomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase
68. Paxillin
69. Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling
70. Interaction of GTP-binding and GTPase-activating domains of ARD1 involves the effector region of the ADP-ribosylation factor domain
71. GIT proteins, a novel family of phosphatidylinositol 3,4,5-triphosphate-stimulated GTPase-activating proteins for ARF6
72. The role of ADP-ribosylation factor and phospholipase D in adaptor recruitment
73. Characterization of the paxillin-binding site and the C-terminal focal adhesion targeting sequence in vinculin
74. ADP-ribosylation factor-1 is sensitive to N-ethylmaleimide
75. The Ras target AF-6 interacts with ZO-1 and serves as a peripheral component of tight junction in epithelial cell
76. Paxillin a and Crk-associated substrate exert opposing effects on cell migration and contact inhibition of growth through tyrosine phosphorylation
77. Expression of a dominant allele of human ARF1 inhibits membrane traffic in vivo
78. A requirement of ARF6 in Fcγ receptor-mediated phagocytosis in macrophages