Control of hnRNP A1 alternative splicing: An intron element represses use of the common 3' splice site

Molecular and Cellular Biology

Volumn 20, Issue 19, 2000, Pages 7353-7362

  Simard, M J ^a   Chabot, B ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; ISOPROTEIN; MESSENGER RNA; RNA PRECURSOR; TRANS ACTING FACTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; CONTROLLED STUDY; EXON; GENE FUNCTION; GENE INSERTION; GENE REPRESSION; GLOBIN GENE; HUMAN; HUMAN CELL; INTRON; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SPLICEOSOME; TRANSCRIPTION REGULATION;

ALTERNATIVE SPLICING; BASE SEQUENCE; EXONS; GENE EXPRESSION REGULATION; GENE SILENCING; GTP-BINDING PROTEINS; HELA CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMAN; INTRONS; MOLECULAR SEQUENCE DATA; REGULATORY SEQUENCES, NUCLEIC ACID; RIBONUCLEOPROTEINS; RNA PRECURSORS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS;

EID: 0033835026     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.19.7353-7362.2000     Document Type: Article

References (63)

1. Presence of negative and positive cis-acting RNA splicing elements within and flanking the first tat coding exon of human immunodeficiency virus type 1
2. Presence of exon splicing silencers within human immunodeficiency virus type 1 tat exon 2 and tat-rev exon 3: Evidence for inhibition mediated by cellular factors
3. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: Evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart
4. Activation of c-src neuron-specific splicing by an unusual RNA element in vivo and in vitro
5. Finding splice sites within a wilderness of RNA
6. U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing
7. A highly stable duplex structure sequesters the 5' splice site region of hnRNP A1 alternative exon 7B
8. Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization
9. Identification of a bidirectional splicing enhancer: Differential involvement of SR proteins in 5' or 3' splice site activation
10. A novel bipartite splicing enhancer modulates the differential processing of the human fibronectin EDA exon
11. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing
12. An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing
13. Directing alternative splicing: Cast and scenarios
14. Synthesis and purification of RNA substrates
15. An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1
16. An exonic splicing silencer in the testes-specific DNA ligase III beta exon
17. RNA secondary structure repression of a muscle-specific exon in HeLa cell nuclear extracts
18. SR protein and snRNP requirements for assembly of the Rous sarcoma virus negative regulator of splicing complex in vitro
19. Natural base-pairing interactions between 5' splice site and branch site sequences affect mammalian 5' splice site selection
20. An element in the 5' common exon of the NCAM alternative splicing unit interacts with SR proteins and modulates 5' splice site selection
21. Resolution of the mammalian E complex and the ATP-dependent spliceosomal complexes on native agarose mini-gels
22. Exon and intron sequences, respectively, repress and activate splicing of a fibroblast growth factor receptor 2 alternative exon
23. Multiple interdependent sequence elements control splicing of a fibroblast growth factor receptor 2 alternative exon
24. hnRNP A1 recruited to an exon in vivo can function as an exon splicing silencer
25. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
26. Cooperation of pre-mRNA sequence elements in splice site selection
27. Selection of splice sites in pre-mRNAs with short internal exons
28. A short sequence within two purine-rich enhancers determines 5' splice site specificity
29. Pathways for selection of 5' splice sites by U1 snRNPs and SF2/ASF
30. A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms
31. cis-Acting sequences involved in exon selection in the chicken β-tropomyosin gene
32. Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing
33. Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon
34. The function of multisite splicing enhancers
35. Elements regulating an alternatively spliced exon of the rat fibronectin gene
36. A 32-nucleotide exon-splicing enhancer regulates usage of competing 5' splice sites in a differential internal exon
37. Association of missense and 5'-splice-site mutations in tan with the inherited dementia FTDP-17
38. Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor
39. Inhibition by SR proteins of splicing of a regulated adenovirus pre-mRNA
40. Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors
41. Accurate selection of a 5' splice site requires sequences within fibronectin alternative exon B
42. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding
43. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation
44. Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon
45. SR proteins and splicing control
46. G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection
47. An RNA splicing enhancer-like sequence is a component of a splicing inhibitor element from Rous sarcoma virus
48. Combinatorial control of a neuron-specific exon
49. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon
50. Regulation of fibronectin EDA exon alternative splicing: Possible role of RNA secondary structure for enhancer display
51. Identification of cis-acting intron and exon regions in influenza virus NS1 mRNA that inhibit splicing and cause the formation of aberrantly sedimenting presplicing complexes
52. Intron sequences involved in lariat formation during pre-mRNA splicing
53. Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle
54. The exon splicing silencer in human immunodeficiency virus type 1 tat exon 3 is bipartite and acts early in spliceosome assembly
55. The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: Multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding
56. Identification of positive and negative splicing regulatory elements within the terminal tat-rev exon of human immunodeficiency virus type 1
57. SR proteins promote the first specific recognition of pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex
58. Post-transcriptional regulation: The dawn of PTB
59. Two different sequence elements within exon 4 are necessary for calcitonin-specific splicing of the human calcitonin/calcitonin gene-related peptide I pre-mRNA
60. Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity
61. The A1 and A1(B) proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo
62. Control of calcitonin/calcitonin gene-related peptide pre-mRNA processing by constitutive intron and exon elements
63. Coordinate repression of a trio of neuron-specific splicing events by the splicing regulator PTB