Functions of SR and Tra2 proteins in pre-mRNA splicing regulation

Proceedings of the Society for Experimental Biology and Medicine

Volumn 220, Issue 2, 1999, Pages 59-63

  Tacke, Roland ^a   Manley, James L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENE PRODUCT; PROTEIN; RNA BINDING PROTEIN;

CELL DIFFERENTIATION; CELL FUNCTION; CONFERENCE PAPER; GENE EXPRESSION REGULATION; LETHAL GENE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FAMILY; REGULATORY MECHANISM; RNA BINDING; RNA SPLICING; SEX DIFFERENCE;

EID: 0032914520     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.1999.d01-10.x     Document Type: Conference Paper

References (29)

1. Burtis KC. The regulation of sex determination and sexually dimorphic differentiation in Drosophila. Curr Op Cell Biol 5:1006-1004, 1993.
2. Yeakley JM, Morfin J-P, Rosenfeld MG, Fu XD. A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer. Proc Natl Acad Sci USA 93:7582-7587, 1996.
3. Black DL. Splicing in the inner ear: A familiar tune, but what are the instruments? Neuron 20:165-168, 1998.
4. Min H, Turck CW, Nicolic JM, Black DL. A new regulatory protein, KSRP mediates exon inclusion through an intronic splicing enhancer. Genes Dev 15:1023-1036, 1997.
5. Grabowski PJ. Splicing regulation in neurons: Tinkering with cell-specific control. Cell 92:709-712, 1998.
6. Ge H, Manley JL. A protein factor, ASF, controls cells-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell 62:25-34, 1990.
7. Manley JL, Tacke R. SR proteins and splicing control. Genes Dev 10:1569-1579, 1996.
8. Krainer AR, Conway GC, Kozak D. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites. Cell 62:35-42, 1990.
9. Wang J, Takagaki Y, Manley JL. Targeted disruption of an essential vertebrate gene, ASF/SF2 is required for cell viability. Genes Dev 10:2588-2599, 1996.
10. Zahler AM, Roth MB. Distinct functions of SR proteins in recruitment of U1 small nuclear ribonucleoprotein to alternative 5′ splice sites. Proc Natl Acad Sci 92:2642-2646, 1995.
11. Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL. Protein-protein interactions and 5′-splice-site recognition in mammalian mRNA precursors. Nature 368:119-124, 1994.
12. Xiao SH, Manley JL. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein interactions and protein-RNA interactions and is necessary for splicing. Genes Dev 11:334-344, 1997.
13. Wang J, Xiao SH, Manley JL. Genetic analysis of the SR protein ASF/SF2: Interchangeability of RS domain and negative control of splicing. Genes Dev 12:2222-2233, 1998.
14. Ramchatesingh J, Zahler AM, Neugebauer KM, Roth MB, Cooper TA. A subset of SR proteins activates splicing of the cardiac troponin T alternative exon by direct interactions with an exonic enhancer. Mol Cell Biol 15:4898-4907, 1995.
15. Tacke R, Manley JL. The human splicing factors ASF/SF2 and SC35 possess different, functionally significant RNA binding specificities. EMBO J 14:3540-3551, 1995.
16. Tacke R, Chen Y, Manley JL. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: Creation of an SRp40-specific splicing enhancer. Proc Natl Acad Sci USA 94:1148-1153, 1997.
17. Tian M, Maniatis T. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74:105-114, 1993.
18. Heinrichs V, Baker BS. The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences. EMBO J 14:3987-4000, 1995.
19. Lynch KW, Maniatis T. Synergistic interactions between two distinct elements of a regulated splicing enhancer. Genes Dev 9:284-293, 1995.
20. 35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. Genes Dev 10:1356-1368, 1996.
21. Heinrichs V, Ryner LC, Baker B. Regulation of sex-specific selection of fruitless 5′ splice sites by transformer and transformer-2. Mol Cell Biol 18:450-458, 1998.
22. Mattox W, McGuffin ME, Baker BS. A negative feedback mechanism revealed by functional analysis of the alternative isoforms of the Drosophila splicing regulator transformer-2. Genetics 143:303-314, 1996.
23. Dauwalder B, Amaya-Manzanares F, Mattox W. A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. Proc Natl Acad Sci USA 93:9004-9009, 1996.
24. Matsuo N, Ogawa S, Imai Y, Takagi T, Tohyama M, Stern D, Wanaka A. Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation. J Biol Chem 270:28216-28222, 1995.
25. Segade F, Hurlé B, Claudio E, Ramos S, Lazo PS. Molecular cloning of a mouse homologue for the Drosophila splicing regulator Tra2. FEBS Lett 387:152-156, 1996.
26. Beil B, Screaton G, Stamm S. Molecular cloning of htra2β-1 and htra2β-2, two human homologs of tra-2 generated by alternative splicing. DNA Cell Biol 16:679-690, 1997.
27. Tacke R, Tohyama M, Ogawa S, Manley JL. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93:139-148, 1998.
28. Ryan KJ, Cooper TA. Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol 16:4014-4023, 1996.
29. Lynch KW, Maniatis T. Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer. Genes Dev 10:2089-2101, 1996.