The role of DNA polymerase β in determining sensitivity to ionizing radiation in human tumor cells

Nucleic Acids Research

Volumn 30, Issue 13, 2002, Pages 2995-3004

  Vens, Conchita ^a   Dahmen Mooren, Els ^a   Verwijs Janssen, Manon ^a   Blyweert, Wim ^a   Graversen, Lise ^a   Bartelink, Harry ^a   Begg, Adrian C ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BASE; DNA DIRECTED DNA POLYMERASE BETA; RETROVIRUS VECTOR;

BINDING SITE; CARCINOMA CELL; CELL CLONE; CELL CYCLE G1 PHASE; CELL LINE; CELL POPULATION; CELL SELECTION; CONTROLLED STUDY; DNA DAMAGE; EXCISION REPAIR; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RADIATION DOSE; RADIOSENSITIVITY; RADIOSENSITIZATION; REVIEW; TUMOR CELL;

CELL CYCLE; CELL DIVISION; CELL NUCLEUS; CELL SURVIVAL; DNA POLYMERASE BETA; G1 PHASE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; METHYLNITRONITROSOGUANIDINE; RECOMBINANT FUSION PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

UNIDENTIFIED RETROVIRUS;

EID: 0036640294     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (65)

1. Rejoining of DNA double-strand breaks in Ku80-deficient mouse fibroblasts
2. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination
3. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival and development
4. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity and inability to support V(D)J recombination
5. The repair of ionising radiation-induced damage to DNA
6. In vivo repair of methylation damage in Aag 3-methyladenine DNA glycosylase null mouse cells
7. Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase
8. Initiation of base excision repair: Glycosylase mechanisms and structures
9. A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity
10. Genome maintenance mechanisms for preventing cancer
11. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
12. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand break repair and sister chromatid exchange
13. XRCC1 keeps DNA from getting stranded
14. Biological response to ionizing radiation in mouse embryo fibroblasts with a targeted disruption of the DNA polymerase beta gene
15. Requirement of mammalian DNA polymerase-beta in base-excision repair
16. Mammalian base excision repair and DNA polymerase beta
17. XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair
18. Passing the baton in base excision repair
19. DNA polymerase beta conducts the gap-filling step in uracil-initiated base excision repair in a bovine testis nuclear extract
20. Different DNA polymerases are involved in the short-and long-patch base excision repair in mammalian cells
21. Two pathways for base excision repair in mammalian cells
22. Second pathway for completion of human DNA base excision-repair: Reconstitution with purified proteins and requirement for DNase IV (FEN1)
23. Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage
24. Specific inhibition of DNA polymerase beta by its 14 kDa domain: Role of single- and double-stranded DNA binding and 5′-phosphate recognition
25. Differential repair of radiation-induced DNA damage in cells of human squamous cell carcinoma and the effect of caffeine and cysteamine on induction and repair of DNA double-strand breaks
26. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus
27. Green fluorescent protein as a selectable marker of fibronectin-facilitated retroviral gene transfer in primary human T lymphocytes
28. Deregulation of DNA polymerase beta by sense and antisense RNA expression in mouse 3T3 cells alters cell growth
29. Production of high-titer helper-free retroviruses by transient transfection
30. Improved immunodetection of nuclear antigens after sodium dodecyl sulfate treatment of formaldehyde-fixed cells
31. Cell kinetic analysis of mixed populations using three-color fluorescence flow cytometry
32. Lack of correlation between G1 arrest and radiation age-response in three synchronized human tumour cell lines
33. A role for p53 in base excision repair
34. Factors affecting human tumor cell radiosensitivity: Molecular studies
35. Paclitaxel as a radiosensitiser: A proposed schedule of administration based on in vitro data and pharmacokinetic calculations
36. The exogenous wild-type p14ARF gene induces growth arrest and promotes radiosensitivity in human lung cancer cell lines
37. U5 region of the human immunodeficiency virus type 1 long terminal repeat contains TRE-like cAMP-responsive elements that bind both AP-1 and CREB/ATF proteins
38. Ionizing radiation activates nuclear factor kappa B but fails to produce an increase in human immunodeficiency virus gene expression in stably transfected human cells
39. The Pol beta-14 dominant negative rat DNA polymerase beta mutator mutant commits errors during the gap-filling step of base excision repair in Saccharomyces cerevisiae
40. Dominant negative rat DNA polymerase beta mutants interfere with base excision repair in Saccharomyces cerevisiae
41. A variant of DNA polymerase beta acts as a dominant negative mutant
42. Repair-deficient 3-methyladenine DNA glycosylase homozygous mutant mouse cells have increased sensitivity to alkylation-induced chromosome damage and cell killing
43. HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
44. Combined mismatch and nucleotide excision repair defects in a human cell line: Mismatch repair processes methylation but not UV-or ionizing radiation-induced DNA damage
45. Comparative repair of the endogenous lesions 8-oxo-7,8-dihydroguanine (8-oxoG), uracil and abasic site by mammalian cell extracts: 8-oxoG is poorly repaired by human cell extracts
46. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts
47. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps
48. DNA synthesis and dRPase activities of polymerase beta are both essential for single-nucleotide patch base excision repair in mammalian cell extracts
49. Comparison of biological effects of DNA damage induced by ionizing radiation and hydrogen peroxide in CHO cells
50. DNA polymerase beta is required for efficient DNA strand break repair induced by methyl methanesulfonate but not by hydrogen peroxide
51. 5′-Nicked apurinic/apyrimidinic sites are resistant to beta-elimination by beta-polymerase and are persistent in human cultured cells after oxidative stress
52. Amino acid substitution variants of APE1 and XRCC1 genes associated with ionizing radiation sensitivity
53. Nuclear expression of human apurinic/apyrimidinic endonuclease (HAP1/Ref-1) in head-and-neck cancer is associated with resistance to chemoradiotherapy and poor outcome
54. Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers
55. Trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N'-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon
56. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation
57. A Ku80 fragment with dominant negative activity imparts a radiosensitive phenotype to CHO-K1 cells
58. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development
59. DNA polymerase alpha and beta activities during the cell cycle and their role in heat radiosensitization in Chinese hamster ovary cells
60. Induction of DNA polymerase beta during proliferation of mitogen-stimulated human lymphocytes
61. Characterization of DNA polymerase β mRNA: Cell-cycle and growth response in cultured human cells
62. Human DNA polymerase ε is expressed during cell proliferation in a manner characteristic of replicative DNA polymerases
63. DNA damage control by novel DNA polymerases: Translesion replication and mutagenesis
64. Repair of chromosomal abasic sites in vivo involves at least three different repair pathways
65. A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair