XRCC1 keeps DNA from getting stranded

Mutation Research - DNA Repair

Volumn 459, Issue 1, 2000, Pages 1-18

  Thompson, Larry H ^a   West, Mary G ^a  

^a LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

Author keywords

DNA; Single strand breaks; XRCC1

Indexed keywords

DNA; MUTAGENIC AGENT;

ANIMAL CELL; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND; DNA STRAND BREAKAGE; GENE; GENE EXPRESSION; GENE STRUCTURE; GENETIC VARIABILITY; MOUSE; MUTANT; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SITE DIRECTED MUTAGENESIS; X RAY;

ANIMALS; BASE SEQUENCE; DNA; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; HUMANS; MOLECULAR SEQUENCE DATA; REACTIVE OXYGEN SPECIES; SEQUENCE HOMOLOGY, NUCLEIC ACID; SISTER CHROMATID EXCHANGE;

ANIMALIA;

EID: 0033955346     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(99)00058-0     Document Type: Review

References (149)

1. J.F. Ward, Nature of lesions formed by ionizing radiation, in: J.A. Nickoloff, M. Hoekstra (Eds.), DNA Damage and Repair, Vol. 2: DNA Repair in Higher Eukaryotes, Humana Press, Totowa, NJ, 1998, pp. 65-84.
2. Wallace S.S. Enzymatic processing of radiation-induced free radical damage in DNA. Radiat. Res. 150:1998;S60-S79.
3. Lindahl T. Instability and decay of the primary structure of DNA. Nature. 362:1993;709-715.
4. Wallace S.S. AP endonucleases and DNA glycosylases that recognize oxidative DNA damage. Environ. Mol. Mutagen. 12:1988;431-477.
5. E.C. Friedberg, G.C. Walker, W. Siede, DNA Repair and Mutagenesis, American Soc. Microbiol., Washington, DC, 1995.
6. S.H. Wilson, R.K. Singhal, Mammalian DNA repair and the cellular DNA polymerases, in: J.A. Nickoloff, M. Hoekstra (Eds.), DNA Damage and Repair, Vol. 2: DNA Repair in Higher Eukaryotes, Humana Press, Totowa, NJ, pp. 161-180.
7. Beckman K.B., Ames B.N. Oxidative decay of DNA. J. Biol. Chem. 272:1997;19633-19636.
8. Helbock H.J., Beckman K.B., Shigenaga M.K., Walter P.B., Woodall A.A., Yeo H.C., Ames B.N. DNA oxidation matters: the HPLC-electrochemical detection assay of 8-oxo-deoxyguanosine and 8-oxo-guanine. Proc. Natl. Acad. Sci. U. S. A. 95:1998;288-293.
9. Ward J.F. DNA damage produced by ionizing radiation in mammalian cells: Identities, mechanisms of formation, and reparability. Prog. Nucl. Acids Res. Mol. Biol. 35:1988;95-125.
10. Henner W.D., Grunberg S.M., Haseltine W.A. Sites and structure of gamma radiation-induced DNA strand breaks. J. Biol. Chem. 257:1982;11750-11754.
11. Henner W.D., Grunberg S.M., Haseltine W.A. Enzyme action at 3′ termini of ionizing radiation-induced DNA strand breaks. J. Biol. Chem. 258:1983;15198-15205.
12. Chaudhry M., Weinfeld M.A. Reactivity of human apurinic/apyrimidinic endonuclease and Escherichia coli exonuclease III with bistranded abasic sites in DNA. J. Biol. Chem. 272:1997;15650-15655.
13. Harrison L., Hatahet Z., Purmal A.A., Wallace S.S. Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII. Nucleic Acids Res. 26:1998;932-941.
14. Collins A.R. Mutant rodent cell lines sensitive to ultraviolet light, ionizing radiation and cross-linking agents: a comprehensive survey of genetic and biochemical characteristics. Mutat. Res. 293:1993;99-118.
15. Thompson L.H., Fong S., Brookman K. Validation of conditions for efficient detection of HPRT and APRT mutations in suspension-cultured Chinese hamster cells. Mutat. Res. 74:1980;21-36.
16. Thompson L.H., Brookman K.W., Dillehay L.E., Carrano A.V., Mazrimas J.A., Mooney C.L., Minkler J.L. A CHO-cell strain having hypersensitivity to mutagens, a defect in strand-break repair, and an extraordinary baseline frequency of sister chromatid exchange. Mutat. Res. 95:1982;427-440.
17. Zdzienicka M.Z., van der Schans G.P., Natarajan A.T., Thompson L.H., Neuteboom I., Simons J.W. A Chinese hamster ovary cell mutant (EM-C11) with sensitivity to simple alkylating agents and a very high level of sister chromatid exchanges. Mutagenesis. 7:1992;265-269.
18. Siciliano M.J., Stallings R.L., Adair G.M., Humphrey R.M., Siciliano J. Provisional assignment of TPI, GPI, and PEPD to Chinese hamster autosomes 8 and 9: a cytogenetic basis for functional haploidy of an autosomal linkage group in CHO cells. Cytogenet. Cell Genet. 35:1983;15-20.
19. Shen M.R., Zdzienicka M.Z., Mohrenweiser H., Thompson L.H., Thelen M.P. Mutations in hamster single-strand break repair gene XRCC1 causing defective DNA repair. Nucleic Acids Res. 26:1998;1032-1037.
20. Tebbs R.S., Flannery M.L., Meneses J.J., Hartmann A., Tucker J.D., Thompson L.H., Cleaver J.E., Pedersen R.A. Requirement for the Xrcc1 DNA base excision repair gene during early mouse development. Dev. Biol. 208:1999;513-529.
21. Caldecott K.W., McKeown C.K., Tucker J.D., Stanker L., Thompson L.H. Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells. Nucleic Acids Res. 23:1995;4836-4843.
22. Churchill M.E., Peak J.G., Peak M.J. Correlation between cell survival and DNA single-strand break repair proficiency in the Chinese hamster ovary cell lines AA8 and EM9 irradiated with 365-nm ultraviolet-A radiation. Photochem. Photobiol. 53:1991;229-236.
23. Thompson L.H., Brookman K.W., Jones N.J., Allen S.A., Carrano A.V. Molecular cloning of the human XRCC1 gene, which corrects defective DNA strand-break repair and sister chromatid exchange. Mol. Cell. Biol. 10:1990;6160-6171.
24. Cantoni O., Murray D., Meyn R.E. Induction and repair of DNA single-strand breaks in EM9 mutant CHO cells treated with hydrogen peroxide. Chem. Biol. Interact. 63:1987;29-38.
25. Caldecott K., Jeggo P. Cross-sensitivity of gamma-ray-sensitive hamster mutants to cross-linking agents. Mutat. Res. 255:1991;111-121.
26. Barrows L.R., Holden J.A., Anderson M., D'Arpa P. The CHO XRCC1 mutant, EM9, deficient in DNA ligase III activity, exhibits hypersensitivity to camptothecin independent of DNA replication. Mutat. Res. 408:1998;103-110.
27. Dillehay L.E., Thompson L.H., Carrano A.V. DNA-strand breaks associated with halogenated pyrimidine incorporation. Mutat. Res. 131:1984;129-136.
28. Schwartz J.L., Giovanazzi S., Weichselbaum R.R. Recovery from sublethal and potentially lethal damage in an X-ray-sensitive CHO cell. Radiat. Res. 111:1987;58-67.
29. van Ankeren S.C., Murray D., Meyn R.E. Induction and rejoining of γ-ray-induced DNA single- and double-strand breaks in Chinese hamster AA8 cells and in two radiosensitive clones. Radiat. Res. 116:1988;511-525.
30. Dillehay L.E., Thompson L.H., Minkler J.L., Carrano A.V. The relationship between sister-chromatid exchange and perturbations in DNA replication in mutant EM9 and normal CHO cells. Mutat. Res. 109:1983;283-296.
31. R.M. Taylor, D.J. Moore, J. Whitehouse, P. Johnson, K.W. Caldecott, A cell cycle-specific requirement for the XRCC1 BRCT II domain during mammalian DNA strand break repair, Mol. Cell. Biol. (2000) in press.
32. Nocentini S. Rejoining kinetics of DNA single- and double-strand breaks in normal and DNA ligase-deficient cells after exposure to ultraviolet C and gamma radiation: an evaluation of ligating activities involved in different DNA repair processes. Radiat. Res. 151:1999;423-432.
33. Chaganti R.S.K., Schonberg S., German J. A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc. Natl. Acad. Sci. U. S. A. 71:1974;4508-4512.
34. Pinkel D., Thompson L.H., Gray J.W., Vanderlaan M. Measurement of sister chromatid exchanges at very low bromodeoxyuridine substitution levels using a monoclonal antibody in Chinese hamster ovary cells. Cancer Res. 45:1985;5795-5798.
35. Berry S.E., Garces C., Hwang H.S., Kunugi K., Meyers M., Davis T.W., Boothman D.A., Kinsella T.J. The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells. Cancer Res. 59:1999;1840-1845.
36. Sonoda E., Sasaki M.S., Morrison C., Yamaguchi-Iwai Y., Takata M., Takeda S. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19:1999;5166-5169.
37. Painter R.B. A replication model for sister-chromatid exchange. Mutat. Res. 70:1980;337-341.
38. Carrano A.V., Minkler J.L., Dillehay L.E., Thompson L.H. Incorporated bromodeoxyuridine enhances the sister-chromatid exchange and chromosomal aberration frequencies in an EMS-sensitive Chinese hamster cell line. Mutat. Res. 162:1986;233-239.
39. Domínguez I., Daza P., Natarajan A.T., Cortes F. A high yield of translocations parallels the high yield of sister chromatid exchanges in the CHO mutant EM9. Mutat. Res. 398:1998;67-73.
40. Op het Veld C.W., Zdzienicka M.Z., Vrieling H., Lohman P.H., van Zeeland A.A. Molecular analysis of ethyl methanesulfonate-induced mutations at the hprt gene in the ethyl methanesulfonate-sensitive Chinese hamster cell line EM-C11 and its parental line CHO9. Cancer Res. 54:1994;3001-3006.
41. Op het Veld C.W., Jansen J., Zdzienicka M.Z., Vrieling H., van Zeeland A.A. Methyl methanesulfonate-induced hprt mutation spectra in the Chinese hamster cell line CHO9 and its xrcc1-deficient derivative EM-C11. Mutat. Res. 398:1998;83-92.
42. Chu G. Double strand break repair. J. Biol. Chem. 272:1997;24097-24100.
43. Lieber M.R., Grawunder U., Wu X., Yaneva M. Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks. Curr. Opin. Genet. Dev. 7:1997;99-104.
44. Critchlow S.E., Jackson S.P. DNA end-joining: from yeast to man. Trends Biochem. Sci. 23:1998;394-398.
45. Jeggo P.A. Identification of genes involved in repair of DNA double-strand breaks in mammalian cells. Radiat. Res. 150:1998;S80-S91.
46. Jeggo P.A. DNA breakage and repair. Adv. Genet. 38:1998;185-218.
47. Tomkinson A.E., Mackey Z.B. Structure and function of mammalian DNA ligases. Mutat. Res. 407:1998;1-9.
48. Ljungquist S., Kenne K., Olsson L., Sandstrom M. Altered DNA ligase III activity in the CHO EM9 mutant. Mutat. Res. 314:1994;177-186.
49. Caldecott K.W., McKeown C.K., Tucker J.D., Ljungquist S., Thompson L.H. An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III. Mol. Cell. Biol. 14:1994;68-76.
50. Cappelli E., Taylor R., Cevasco M., Abbondandolo A., Caldecott K., Frosina G. Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair. J. Biol. Chem. 272:1997;23970-23975.
51. Critchlow S.E., Bowater R.P., Jackson S.P. Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV. Curr. Biol. 7:1997;588-598.
52. Grawunder U., Wilm M., Wu X., Kulesza P., Wilson T.E., Mann M., Lieber M.R. Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells. Nature. 388:1997;492-495.
53. Bryans M., Valenzano M.C., Stamato T.D. Absence of DNA ligase IV protein in XR-1 cells: evidence for stabilization by XRCC4. Mutat. Res. 433:1999;53-58.
54. Pinz K.G., Bogenhagen D.F. Efficient repair of abasic sites in DNA by mitochondrial enzymes. Mol. Cell. Biol. 18:1998;1257-1265.
55. Lakshmipathy U., Campbell C. The human DNA ligase III gene encodes nuclear and mitochondrial proteins. Mol. Cell. Biol. 19:1999;3869-3876.
56. Kubota Y., Nash R.A., Klungland A., Schar P., Barnes D.E., Lindahl T. Reconstitution of DNA base excision-repair with purified human proteins: interaction between DNA polymerase beta and the XRCC1 protein. EMBO J. 15:1996;6662-6670.
57. Manley J.L., Fire A., Samuels M., Sharp P.A. In vitro transcription: whole-cell extract. Methods Enzymol. 101:1983;568-582.
58. Fortini P., Pascucci B., Parlanti E., Sobol R.W., Wilson S.H., Dogliotti E. Different DNA polymerases are involved in the short- and long-patch base excision repair in mammalian cells. Biochemistry. 37:1998;3575-3580.
59. Biade S., Sobol R.W., Wilson S.H., Matsumoto Y. Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J. Biol. Chem. 273:1998;898-902.
60. Stucki M., Pascucci B., Parlanti E., Fortini P., Wilson S.H., Hubscher U., Dogliotti E. Mammalian base excision repair by DNA polymerases delta and epsilon. Oncogene. 17:1998;835-843.
61. Xanthoudakis S., Smeyne R.J., Wallace J.D., Curran T. The redox/DNA repair protein, Ref.-1, is essential for early embryonic development in mice. Proc. Natl. Acad. Sci. U. S. A. 93:1996;8919-8923.
62. Ludwig D.L., MacInnes M.A., Takiguchi Y., Purtymun P.E., Henrie M., Flannery M., Meneses J., Pedersen R.A., Chen D.J. A murine AP-endonuclease gene-targeted deficiency with post-implantation embryonic progression and ionizing radiation sensitivity. Mutat. Res. 409:1998;17-29.
63. Brookman K.W., Tebbs R.S., Allen S.A., Tucker J.D., Swiger R.R., Lamerdin J.E., Carrano A.V., Thompson L.H. Isolation and characterization of mouse Xrcc-1, a DNA repair gene affecting ligation. Genomics. 22:1994;180-188.
64. Zhou Z.Q., Walter C.A. Cloning and characterization of the promoter of baboon XRCC1, a gene involved in DNA strand-break repair. Somatic Cell Mol. Genet. 24:1998;23-39.
65. Siciliano M.J., Carrano A.V., Thompson L.H. Assignment of a human DNA-repair gene associated with sister-chromatid exchange to chromosome 19. Mutat. Res. 174:1986;303-308.
66. Mohrenweiser H.W., Carrano A.V., Fertitta A., Perry B., Thompson L.H., Tucker J.D., Weber C.A. Refined mapping of the three DNA repair genes, ERCC1, ERCC2, and XRCC1, on human chromosome 19. Cytogenet. Cell Genet. 52:1989;11-14.
67. Lamerdin J.E., Montgomery M.A., Stilwagen S.A., Scheidecker L.K., Tebbs R.S., Brookman K.W., Thompson L.H., Carrano A.V. Genomic sequence comparison of the human and mouse XRCC1 DNA repair gene regions. Genomics. 25:1995;547-554.
68. Mighell A.J., Markham A.F., Robinson P.A. Alu sequences. FEBS Lett. 417:1997;1-5.
69. Yoo H., Li L., Sacks P.G., Thompson L.H., Becker F.F., Chan J.Y. Alterations in expression and structure of the DNA repair gene XRCC1. Biochem. Biophys. Res. Commun. 186:1992;900-910.
70. Walter C.A., Lu J., Bhakta M., Zhou Z.-Q., Thompson L.H., McCarrey J.R. Testis and somatic Xrcc-1 DNA repair gene expression. Somatic Cell Mol. Genet. 20:1994;451-461.
71. Zhou Z.Q., Walter C.A. Expression of the DNA repair gene XRCC1 in baboon tissues. Mutat. Res. 348:1995;111-116.
72. Walter C.A., Trolian D.A., McFarland M.B., Street K.A., Gurram G.R., McCarrey J.R. Xrcc-1 expression during male meiosis in the mouse. Biol. Reprod. 55:1996;630-635.
73. Chen J., Tomkinson A.E., Ramos W., Mackey Z.B., Danehower S., Walter C.A., Schultz R.A., Besterman J.M., Husain I. Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination. Mol. Cell. Biol. 15:1995;5412-5422.
74. Alcivar A.A., Hake L.E., Hecht N.B. DNA polymerase-beta and poly(ADP)ribose polymerase mRNAs are differentially expressed during the development of male germinal cells. Biol. Reprod. 46:1992;201-207.
75. Plug A.W., Clairmont C.A., Sapi E., Ashley T., Sweasy J.B. Evidence for a role for DNA polymerase beta in mammalian meiosis. Proc. Natl. Acad. Sci. U. S. A. 94:1997;1327-1331.
76. L.H. Thompson, A.J. Fornace, K.W. Caldecott, K.W. Brookman, C.A. Weber, E.P. Salazar, K. Takayama, Recent developments with the human repair genes ERCC2, ERCC4, and XRCC1, in: The Alfred Benzon Symposium, Vol. 35, Munksgaard, Copenhagen, 1993, pp. 42-55.
77. Shung B., Miyakoshi J., Takebe H. X-ray-induced transcriptional activation of c-myc and XRCC1 genes in ataxia telangiectasia cells. Mutat. Res. 307:1994;43-51.
78. Labudova O., Hardmeier R., Golej J., Rink H., Lubec G. The transcription of the XRCC1 gene in spleen following ionizing irradiation in radiosensitive and radioresistant mice. Life Sci. 61:1997;2417-2423.
79. Labudova O., Hardmeier R., Rink H., Lubec G. The transcription of the XRCC1 gene in the heart of radiation-resistant and radiation-sensitive mice after ionizing irradiation. Pediatr. Res. 41:1997;435-439.
80. Labudova O., Hardmeier R., Kitzmuller E., Rink H., Lubec G. Transcription of the XRCC1 gene in kidneys of radiosensitive and radioresistant mice following whole-body irradiation. Nephron. 79:1998;61-66.
81. Caldecott K.W., Aoufouchi S., Johnson P., Shall S. XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly(ADP-ribose) polymerase, and DNA ligase III is a novel 'nick-sensor' in vitro. Nucleic Acids Res. 24:1996;4387-4394.
82. Marintchev A., Mullen M.A., Maciejewski M.W., Pan B., Gryk M.R., Mullen G.P. Solution structure of the single-strand break repair protein XRCC1 N-terminal domain. Nat. Struct. Biol. 6:1999;884-893.
83. Sharief F.S., Vojta P.J., Ropp P.A., Copeland W.C. Cloning and chromosomal mapping of the human DNA polymerase theta (POLQ), the eighth human DNA polymerase. Genomics. 59:1999;90-96.
84. Wilson S.H. Mammalian base excision repair and DNA polymerase beta. Mutat. Res. 407:1998;203-215.
85. Matsumoto K., Kim Y. Excision of deoxyribose phosphate residues by DNA polymerase beta during DNA repair. Science. 269:1995;699-702.
86. Sobol R.W., Horton J.K., Kuhn R., Gu H., Singhal R.K., Prasad R., Rajewsky K., Wilson S.H. Requirement of mammalian DNA polymerase-beta in base-excision repair. Nature. 379:1996;183-186.
87. Ochs K., Sobol R.W., Wilson S.H., Kaina B. Cells deficient in DNA polymerase beta are hypersensitive to alkylating agent-induced apoptosis and chromosomal breakage. Cancer Res. 59:1999;1544-1551.
88. Masson M., Niedergang C., Schreiber V., Muller S., Menissier-de Murcia J., de Murcia G. XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage. Mol. Cell. Biol. 18:1998;3563-3571.
89. Jeggo P.A. DNA repair: PARP - another guardian angel? Curr. Biol. 8:1998;R49-R51.
90. Dantzer F., Schreiber V., Niedergang C., Trucco C., Flatter E., De La Rubia G., Oliver J., Rolli V., Menissier-de Murcia J., de Murcia G. Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie. 81:1999;69-75.
91. Lindahl T., Satoh M.S., Poirier G.G., Klungland A. Post-translational modification of poly(APD-ribose) polymerase induced by DNA strand breaks. TIBS. 20:1995;405-411.
92. Bork P., Hofmann K., Bucher P., Neuwald A.F., Altschul S.F., Koonin E.V. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11:1997;68-76.
93. Callebaut I., Mornon J.P. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400:1997;25-30.
94. Lehmann A.R. Duplicated region of sequence similarity to the human XRCC1 DNA repair gene in the Schizosaccharomyces pombe rad4/cut5 gene. Nuclei Acids Res. 21:1993;5274.
95. Mackey Z.B., Ramos W., Levin D.S., Walter C.A., McCarrey J.R., Tomkinson A.E. An alternative splicing event which occurs in mouse pachytene spermatocytes generates a form of DNA ligase III with distinct biochemical properties that may function in meiotic recombination. Mol. Cell. Biol. 17:1997;989-998.
96. Nash R.A., Caldecott K.W., Barnes D.E., Lindahl T. XRCC1 protein interacts with one of two distinct forms of DNA ligase III. Biochemistry. 36:1997;5207-5211.
97. Taylor R.M., Wickstead B., Cronin S., Caldecott K.W. Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1. Curr. Biol. 8:1998;877-880.
98. Sakaguchi K., Boyd J.B. Purification and characterization of a DNA polymerase beta from Drosophila. J. Biol. Chem. 260:1985;10406-10411.
99. Miwa M., Hanai S., Poltronieri P., Uchida M., Uchida K. Functional analysis of poly(ADP-ribose) polymerase in Drosophila melanogaster. Mol. Cell. Biochem. 193:1999;103-107.
100. Zhang X., Morera S., Bates P.A., Whitehead P.C., Coffer A.I., Hainbucher K., Nash R.A., Sternberg M.J., Lindahl T., Freemont P.S. Structure of an XRCC1 BRCT domain: a new protein-protein interaction module. EMBO J. 17:1998;6404-6411.
101. Sawaya M.R., Prasad R., Wilson S.H., Kraut J., Pelletier H. Crystal structures of human DNA polymerase beta complexed with gapped and nicked DNA: evidence for an induced fit mechanism. Biochemistry. 36:1997;11205-11215.
102. Canitrot Y., Cazaux C., Frechet M., Bouayadi K., Lesca C., Salles B., Hoffmann J.S. Overexpression of DNA polymerase beta in cell results in a mutator phenotype and a decreased sensitivity to anticancer drugs. Proc. Natl. Acad. Sci. U. S. A. 95:1998;12586-12590.
103. Lunn R.M., Langlois R.G., Hsieh L.L., Thompson C.L., Bell D.A. XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res. 59:1999;2557-2561.
104. Price E.A., Bourne S.L., Radbourne R., Lawton P.A., Lamerdin J., Thompson L.H., Arrand J.E. Rare microsatellite polymorhisms linked to the DNA repair genes XRCC1, XRCC3, and XRCC5 associated with cancer in patients of varying radiosensitivity. Somatic Cell Mol. Genet. 23:1997;237-247.
105. Gradwohl G., Menissier de Murcia J.M., Molinete M., Simonin F., Koken M., Hoeijmakers J.H., de Murcia G. The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA. Proc. Natl. Acad. Sci. U. S. A. 87:1990;2990-2994.
106. D'Silva I., Pelletier J.D., Lagueux J., D'Amours D., Chaudhry M.A., Weinfeld M., Lees-Miller S.P., Poirier G.G. Relative affinities of poly(ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochim. Biophys. Acta. 1430:1999;119-126.
107. de Murcia G., de Murcia J.M. Poly(ADP-ribose) polymerase: a molecular nick-sensor. Trends Biochem. Sci. 19:1994;172-176.
108. Lindahl T., Satoh M.S., Dianov G. Enzymes acting at strand interruptions in DNA. Philos. Trans. R. Soc. Lond., Ser. B. 347:1995;57-62.
109. Weinfeld M., Chaudhry M.A., D'Amours D., Pelletier J.D., Poirier G.G., Povirk L.F., Lees-Miller S.P. Interaction of DNA-dependent protein kinase and poly(ADP-ribose) polymerase with radiation-induced DNA strand breaks. Radiat. Res. 148:1997;22-28.
110. de Murcia J.M., Niedergang C., Trucco C., Ricoul M., Dutrillaux B., Mark M., Oliver F.J., Masson M., Dierich A., LeMeur M., Walztinger C., Chambon P., de Murcia G. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. Proc. Natl. Acad. Sci. U. S. A. 94:1997;7303-7307.
111. Wang Z.Q., Stingl L., Morrison C., Jantsch M., Los M., Schulze-Osthoff K., Wagner E.F. PARP is important for genomic stability but dispensable in apoptosis. Genes Dev. 11:1997;2347-2358.
112. Masutani M., Nozaki T., Nishiyama E., Shimokawa T., Tachi Y., Suzuki H., Nakagama H., Wakabayashi K., Sugimura T. Function of poly(ADP-ribose) polymerase in response to DNA damage: gene-disruption study in mice. Mol. Cell. Biochem. 193:1999;149-152.
113. Shall S. ADP-Ribose in DNA repair: a new component of DNA excision repair. Adv. Radiat. Biol. 11:1984;1-69.
114. Chatterjee S., Berger S.J., Berger N.A. Poly(ADP-ribose) polymerase: a guardian of the genome that facilitates DNA repair by protecting against DNA recombination. Mol. Cell. Biochem. 193:1999;23-30.
115. Durkacz B.W., Omidiji O., Gray D.A., Shall S. (ADP-ribose)n participates in DNA excision repair. Nature. 283:1980;593-596.
116. Jacobson E.L., Smith J.Y., Wielckens K., Hilz H., Jacobson M.K. Cellular recovery of dividing and confluent C3H10T1/2 cells from N-methyl-N′-nitro-N-nitrosoguanidine in the presence of ADP-ribosylation inhibitors. Carcinogenesis. 6:1985;715-718.
117. Schreiber V., Hunting D., Trucco C., Gowans B., Grunwald D., De Murcia G., De Murcia J.M. A dominant-negative mutant of human poly(ADP-ribose) polymerase affects cell recovery, apoptosis, and sister chromatid exchange following DNA damage. Proc. Natl. Acad. Sci. U. S. A. 92:1995;4753-4757.
118. Chatterjee S., Berger N.A. Growth-phase-dependent response to DNA damage in poly(ADP-ribose) polymerase deficient cell lines: basis for a new hypothesis describing the role of poly(ADP-ribose) polymerase in DNA replication and repair. Mol. Cell. Biochem. 138:1994;61-69.
119. Küpper J.-H., Müller M., Jacobson M.K., Tatsumi-Miyajima J., Coyle D.L., Jacobson E.L., Bürkle A. trans-Dominant inhibition of Poly(ADP-ribosyl)ation sensitizes cells against γ-irradiation and N-methyl-N′-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyomavirus replicon. Mol. Cell. Biol. 15:1995;3154-3163.
120. Trucco C., Oliver F.J., de Murcia G., Menissier-de Murcia J. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Nucleic Acids Res. 26:1998;2644-2649.
121. Ding R., Pommier Y., Kang V.H., Smulson M. Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. J. Biol. Chem. 267:1992;12804-12812.
122. Oikawa A., Tohda H., Kanai M., Miwa M., Sugimura T. Inhibitors of poly(adenosine diphosphate ribose) polymerase induce sister chromatid exchanges. Biochem. Biophys. Res. Commun. 97:1980;1311-1316.
123. Morgan W.F., Bodycote J., Doida Y., Fero M.L., Hahn P., Kapp L.N. Spontaneous and 3-aminobenzamide-induced sister-chromatid exchange frequencies estimated by ring chromosome analysis [published erratum appears in Mutagenesis 3 (3) (May 1988) 286]. Mutagenesis. 1:1986;453-459.
124. Chatterjee S., Hirschler N.V., Petzold S.J., Berger S.J., Berger N.A. Mutant cells defective in poly(ADP-ribose) synthesis due to stable alterations in enzyme activity or substrate availability. Exp. Cell Res. 184:1989;1-15.
125. Ikejima M., Bohannon D.M., Gill D.M., Thompson L.H. Poly(ADP-ribose) metabolism appears normal in EM9, a mutagen-sensitive mutant of CHO cells. Mutat. Res. 128:1984;213-220.
126. Eki T. Poly (ADP-ribose) polymerase inhibits DNA replication by human replicative DNA polymerase alpha, delta and epsilon in vitro. FEBS Lett. 356:1994;261-266.
127. Simbulan-Rosenthal C.M., Rosenthal D.S., Boulares A.H., Hickey R.J., Malkas L.H., Coll J.M., Smulson M.E. Regulation of the expression or recruitment of components of the DNA synthesome by poly(ADP-ribose) polymerase. Biochemistry. 37:1998;9363-9370.
128. Li S., Chen P.L., Subramanian T., Chinnadurai G., Tomlinson G., Osborne C.K., Sharp Z.D., Lee W.H. Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage. J. Biol. Chem. 274:1999;11334-11338.
129. Satoh M.S., Poirier G.G., Lindahl T. Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage. Biochemistry. 33:1994;7099-7113.
130. Prasad R., Singhal R.K., Srivastava D.K., Molina J.T., Tomkinson A.E., Wilson S.H. Specific interaction of DNA polymerase beta and DNA ligase I in a multiprotein base excision repair complex from bovine testis. J. Biol. Chem. 271:1996;16000-16007.
131. Shen M.R., Jones I.M., Mohrenweiser H. Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 58:1998;604-608.
132. Johnson P.A., Clements P., Hudson K., Caldecott K.W. A mitotic spindle requirement for DNA damage-induced apoptosis in Chinese hamster ovary cells. Cancer Res. 59:1999;2696-2700.
133. Sedivy, A J.M. Dutriaux, gene targeting and somatic cell genetics - a rebirth or a coming of age? Trends Genet. 15:1999;88-90.
134. Schwartz J.L., Shadley J.D., Atcher R.W., Tang J., Whitlock J.L., Rotmensch J. Comparison of radon-daughter-induced effects in repair-proficient and repair-deficient CHO cell lines. Environ. Mol. Mutagen. 16:1990;178-184.
135. Gu H., Marth J.D., Orban P.C., Mossmann H., Rajewsky K. Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science. 265:1994;103-106.
136. Klungland T., Lindahl A. Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1). EMBO J. 16:1997;3341-3348.
137. Dianov G.L., Prasad R., Wilson S.H., Bohr V.A. Role of DNA polymerase beta in the excision step of long patch mammalian base excision repair. J. Biol. Chem. 274:1999;13741-13743.
138. Winters T.A., Russell P.S., Kohli M., Dar M.E., Neumann R.D., Jorgensen T.J. Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate. Nucleic Acids Res. 27:1999;2423-2433.
139. Matsumoto Y., Kim K., Bogenhagen D.F. Proliferating cell nuclear antigen-dependent abasic site repair in Xenopus laevis oocytes: an alternative pathway of base excision DNA repair. Mol. Cell. Biol. 14:1994;6187-6197.
140. Frosina G., Fortini P., Rossi O., Carrozzino F., Raspaglio G., Cox L.S., Lane D.P., Abbondandolo A., Dogliotti E. Two pathways for base excision repair in mammalian cells. J. Biol. Chem. 271:1996;9573-9578.
141. Bennett R.A., Wilson D.M.3., Wong D., Demple B. Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway. Proc. Natl. Acad. Sci. U. S. A. 94:1997;7166-7169.
142. Chen D.S., Herman T., Demple B. Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA. Nucleic Acids Res. 19:1991;5907-5914.
143. Dianov G., Bischoff C., Piotrowski J., Bohr V.A. Repair pathways for processing of 8-oxoguanine in DNA by mammalian cell extracts. J. Biol. Chem. 273:1998;33811-33816.
144. Fortini P., Parlanti E., Sidorkina O.M., Laval J., Dogliotti E. The type of DNA glycosylase determines the base excision repair pathway in mammalian cells. J. Biol. Chem. 274:1999;15230-15236.
145. Nakamura J., Swenberg J.A. Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues. Cancer Res. 59:1999;2522-2526.
146. Srivastava D.K., Berg B.J., Prasad R., Molina J.T., Beard W.A., Tomkinson A.E., Wilson S.H. Mammalian abasic site base excision repair. Identification of the reaction sequence and rate-determining steps. J. Biol. Chem. 273:1998;21203-21209.
147. Cooper P.K., Nouspikel T., Clarkson S.G., Leadon S.A. Transcription-coupled repair of oxidative base damage in Cockayne syndrome patients from XP group G. Science. 275:1997;990-993.
148. G.P. Mullen, A. Marintchev, M.W. Maciejewski, B. Pan, XRCC1(1-183) interaction with the thumb/palm of DNA polymerase beta, Frontiers of NMR in Molecular Biology VI, Breckenridge, USA, Jan. 9-15, 1999, abstract.
149. Schuler G.D., Altschul S.F., Lipman D.J. A workbench for multiple alignment construction and analysis. Proteins. 9:1991;180-190.