Homologues of twisted gastrulation am extracellular cofactors in antagonism of BMP signalling

Nature

Volumn 410, Issue 6827, 2001, Pages 475-478

  Scott, Ian C ^a   Blitz, Ira L ^b   Pappano, William N ^c   Maas, Sarah A ^c   Cho, Ken W Y ^b   Greenspan, Daniel S ^a,c  

^a Department of Pathology and Laboratory Medicine ^*  (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; DNA; PROTEIN; PROTEIN TSG; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; DNA DETERMINATION; FLUORESCENCE IN SITU HYBRIDIZATION; GASTRULATION; GENE MAPPING; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ZEBRA FISH;

AMINO ACID SEQUENCE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CHICK EMBRYO; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 18; DROSOPHILA PROTEINS; GASTRULA; GENE EXPRESSION PROFILING; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; XENOPUS; ZEBRAFISH;

DANIO RERIO; HEXAPODA; VERTEBRATA;

EID: 0035932443     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35068572     Document Type: Article

References (27)

1. Dorsal midline fate in Drosophila embryos requires twisted gastrulation, a gene encoding a secreted protein rebated to human connective tissue growth factor
2. Dorsal-ventral patterning of the Drosophila embryo depends on a putative negative growth factor encoded by the short gastrulation gene
3. Production of a DPP activity gradient in the early Drosophila embryo through the opposing actions of the SOG and TLD proteins
4. The evolutionarily conserved BMP-binding protein twisted gastrulation promotes BMP signalling
5. Processing of the Drosophila Sog protein creates a novel BMP inhibitory activity
6. Mammalian BMP-1/Tolloid-related metalloproteinases, including novel family member mammalian tolloid-like 2, have differential enzymatic activities and distributions of expression relevant to patterning and skeletogenesis
7. Twisted gastrulation can function as a BMP antagonist
8. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
9. Dorsoventral patterning in Xenopus: Inhibition of ventral signals by direct binding of Chordin to BMP-4
10. Is Chordin a long-range or short-range acting factor? Roles for BMP1-related metalloproteases in regulating chordin action
11. BMP-binding modules in chordin: A model for signalling regulation in the extracellular space
12. The screw gene encodes a ubiquilously expressed member of the TGF-β family required for specification of dorsal cell fates in the Drosophila embryo
13. Localized enhancement and repression of the activity of the TGF-β family member, decapentaplegic, is necessary for dorsal-ventral pattern formation in the Drosophila embryo
14. Altered mitotic domains reveal fate map changes in Drosophila embryos mutant for zygotic dorsoventral patterning genes
15. An activity gradient of decapentaplegic is necessary for the specification of dorsal pattern elements in the Drosophila embryo
16. The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor
17. A conserved system for dorsal-ventral patterning in insects and vertebrates involving sog and chordin
18. Short gastrulation, a mutation causing delays in stage specific cell shape changes during gastrulation in Drosophila melanogaster
19. Twisted gastrulation is a conserved extracellular BMP antagonist
20. Properties of the extracellular calcium binding module of the proteoglycan testican
21. Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta 1 and BMP-2
22. Coding sequence and expression patterns o f mouse Chordin and mapping of the cognate mouse Chrd and human CHRD genes
23. Transforming growth factor-β regulation of bone morphogenetic protein-1/procollagen C-proteinase and related proteins in fibrogenic cells and keratinocytes
24. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
25. Bone morphogenetic protein-1 and a mammalian tolloid homologue (mTld) are encoded by alternatively spliced transcripts which are differentially expressed in some tissues
26. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development