Islet abnormalities in the pathogenesis of autoimmune diabetes

Trends in Endocrinology and Metabolism

Volumn 13, Issue 5, 2002, Pages 209-214

  Rosmalen, Judith G M ^a   Leenen, Pieter J M ^a   Pelegri, Carme ^b   Drexhage, Hemmo A ^a   Homo Delarche, Françoise ^b  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; INSULIN;

ANIMAL MODEL; AUTOIMMUNITY; CELL DIFFERENTIATION; CELL FUNCTION; GENETIC ANALYSIS; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN SYNTHESIS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; ANIMAL; CONGENITAL MALFORMATION; FEMALE; GENETIC PREDISPOSITION; GENETICS; HUMAN; IMMUNOLOGY; IMPAIRED GLUCOSE TOLERANCE; NEWBORN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PREGNANCY;

ANIMALS; ANIMALS, NEWBORN; AUTOANTIGENS; DIABETES MELLITUS, TYPE 1; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; ISLETS OF LANGERHANS; MICE; MICE, INBRED NOD; PREDIABETIC STATE; PREGNANCY;

EID: 0036634124     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1043-2760(02)00600-8     Document Type: Review

References (64)

1. Delovitch, T.L. and Singh, B. (1997) The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 7, 727-738
2. Redondo, M.J. et al. (2001) Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United States. Diabetologia 44, 354-362
3. Patterson, C.C. et al. (2001) Is childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates. Diabetologia 44, B9-B16
4. Greiner, D.L. et al. (2001) Translating data from animal models into methods for preventing human autoimmune diabetes mellitus: caveat emptor and primum non nocere. Clin. Immunol. 100, 134-143
5. Todd, J.A. and Wicker, L.S. (2001) Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models. Immunity 15, 387-395
6. Nerup, J. et al. (1994) On the pathogenesis of IDDM. Diabetologia 37, S82-S89
7. McDuffie, M. (1998) Genetics of autoimmune diabetes in animal models. Curr. Opin. Immunol. 10, 704-709
8. She, J.X. and Marron, M.P. (1998) Genetic susceptibility factors in type 1 diabetes: linkage, disequilibrium and functional analyses. Curr Opin. Immunol. 10, 682-689
9. Metcalfe, K.A. et al. (2001) Concordance for type 1 diabetes in identical twins is affected by insulin genotype. Diabetes Care 24, 838-842
10. Naya, F.J. et al. (1997) Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/neuroD-deficient mice. Genes Dev. 11, 2323-2334
11. Tamimi, R. et al. (1996) The NEUROD gene maps to human chromosome 2q32 and mouse chromosome 2. Genomics 34, 418-421
12. Owerbach, D. et al. (1997) Analysis of candidate genes for susceptibility to type 1 diabetes: a case-control and family-association study of genes on chromosome 2q31-35. Diabetes 46, 1069-1074
13. Iwata, I. et al. (1999) Association of polymorphism in the NeuroD/BETA2 gene with type 1 diabetes in the Japanese. Diabetes 48, 416-419
14. Hansen, L. et al. (2000) NeuroD/BETA2 gene variability and diabetes: no associations to late-onset type 2 diabetes but an A45 allele may represent a susceptibility marker for type 1 diabetes among Danes. Danish Study Group of Diabetes in Childhood, and the Danish IDDM Epidemiology and Genetics Group. Diabetes 49,876-878
15. Formby, B. et al. (1987) The offspring of the female diabetic nonobese diabetic (NOD) mouse are large for gestational age and have elevated pancreatic insulin content: a new animal model of human diabetic pregnancy. Proc. Soc. Exp. Biol. Med. 184, 291-294
16. Trudeau, J.D. et al. (2000) Neonatal β-cell apoptosis: a trigger for autoimmune diabetes? Diabetes 49, 1-7
17. Lindberg, B. et al. (1999) Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia 42, 181-187
18. Ziegler, A.G. et al. (1999) Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 48, 460-468
19. Podar, T. et al. (1999) Neonatal anthropometric measurements and risk of childhood-onset type 1 diabetes. DiMe Study Group. Diabetes Care 22, 2092-2094
20. Stene, L.C. et al. (2001) Birth weight and childhood onset type 1 diabetes: population based cohort study. Br. Med. J. 322, 889-892
21. Bruining, G.J. (2000) Association between infant growth before onset of juvenile type-1 diabetes and autoantibodies to IA-2. Lancet 356, 655-656
22. Amrani, A. et al. (1998) Glucose homeostasis in the nonobese diabetic mouse at the prediabetic stage. Endocrinology 139, 1115-1124
23. Homo-Delarche, F. (1997) β-Cell behaviour during the prediabetic stage. Part II. Non-insulin-dependent and insulin-dependent diabetes mellitus. Diabetes Metab. 23, 473-505
24. Girard, J. et al. (1992) Adaptations of glucose and fatty acid metabolism during perinatal period and suckling-weaning transition. Physiol. Rev. 72, 507-562
25. Fujimoto, S. et al. (2000) Augmentation of basal insulin release from rat islets by preexposure to a high concentration of glucose. Am. J. Physiol. 279, E927-E940
26. Finegood, D.T. et al. (1995) Dynamics of β-cell mass in the growing rat pancreas. Estimation with a simple mathematical model. Diabetes 44, 249-256
27. Fernandes, A. et al. (1997) Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 138, 1750-1762
28. O'Reilly, L.A. et al. (1997) α-Cell neogenesis in an animal model of IDDM. Diabetes 46, 599-606
29. Sreenan, S. et al. (1999) Increased β-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48, 989-996
30. Wogensen, L.D. et al. (1990) Functional and morphological effects of interleukin-1β on the perfused rat pancreas. Diabetologia 33, 15-23
31. Zumsteg, U. et al. (1993) Differential interleukin-1 receptor antagonism on pancreatic β and α cells. Studies in rodent and human islets and in normal rats. Diabetologia 36, 759-766
32. Samols, E. and Stagner, J.I. (1991) The Endocrine Pancreas (Samols, E., ed.), pp. 93-124, Raven Press Ltd
33. Honeyman, M.C. and Harrison, L.C. (1993) The immunologic insult in type 1 diabetes. Springer Semin. Immunopathol. 14, 253-274
34. Ohneda, A. et al. (1984) Insulin and glucagon in spontaneously diabetic non-obese mice. Diabetologia 27, 460-463
35. Pelegri, C. et al. (2001) Islet endocrine-cell behavior from birth onward in mice with the nonobese diabetic genetic background. Mol. Med. 7, 311-319
36. Tisch, R. et al. (1993) Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366, 72-75
37. Sorenson, R.L. et al. (1991) Structural and functional considerations of GABA in islets of Langerhans. β-Cells and nerves. Diabetes 40, 1365-1374
38. Saravia-Fernandez, F. et al. (1996) Localization of γ-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse. Endocrinology 137, 3497-3506
39. Rosmalen, J.G.M. et al. (2000) Islet abnormalities associated with an early influx of dendritic cells and macrophages in NOD and NODscid mice. Lab. Invest. 80, 769-777
40. Rosmalen, J.G.M. et al. (2001) Sex steroids influence pancreatic islet hypertrophy and subsequent autoimmune infiltration in nonobese diabetic (NOD) and NODscid mice. Lab. Invest. 81, 231-239
41. Karounos, D.G. et al. (1997) Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. J. Clin. Invest. 100, 1344-1348
42. Hoorens, A. et al. (1996) Glucose promotes survival of rat pancreatic β cells by activating synthesis of proteins which suppress a constitutive apoptotic program. J. Clin. Invest. 98, 1568-1574
43. Kano, Y. et al. (1986) Defect of the first-phase insulin secretion to glucose stimulation in the perfused pancreas of the Nonobese Diabetic (NOD) mouse. Diabetes, 35, 486-490
44. Yu, L. et al. (2000) Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc. Natl. Acad. Sci. U. S. A. 97, 1701-1706
45. Alarcon, C. et al. (1995) Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus. J. Clin. Invest. 95, 1032-1039
46. Kahn, S.E. and Halban, P.A. (1997) Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46, 1725-1732
47. Rodriguez-Villar, C. et al. (1997) High proinsulin levels in late PRE-IDDM stage. Diabetes Res. Clin. Pract. 37, 145-148
48. Heaton, D.A. et al. (1987) Evidence of β cell dysfunction which does not lead on to diabetes: a study of identical twins of insulin dependent diabetics. BMJ 294, 145-146
49. Kjos, S.L. and Buchanan, T.A. (1999) Gestational diabetes mellitus. N. Engl. J. Med. 341, 1749-1756
50. Damm, P. et al. (1994) Prevalence and predictive value of islet cell antibodies and insulin autoantibodies in women with gestational diabetes. Diabet. Med. 11, 558-563
51. Carel, J.C. and Bougneres, P.F. (1996) Treatment of prediabetic patients with insulin: experience and future. European Prediabetes Study Group. Horm. Res. 45, 44-47
52. Ziegler, A.G. et al. (1993) Prophylactic insulin treatment in relatives at high risk for type 1 diabetes. Diabetes Metab. Rev. 9, 289-293
53. Rodriguez-Villar, C. et al. (1999) Effects of insulin administration in a group of high-risk, non-diabetic, first-degree relatives of type 1 diabetic patients: an open pilot trial. Diabet. Med. 16, 160-163
54. Homo-Delarche, F. and Boitard, C. (1996) Autoimmune diabetes: the role of the islets of Langerhans. Immunol. Today 17, 456-460
55. Buschard, K. (1991) The functional state of the β cells in the pathogenesis of insulin-dependent diabetes mellitus. Autoimmunity 10, 65-69
56. Bjork, E. et al. (1992) Glucose regulation of the autoantigen GAD65 in human pancreatic islets. J. Clin. Endocrinol. Metab. 75, 1574-1576
57. Roep, B.O. et al. (1990) T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature 345, 632-634
58. Rudy, G. et al. (1995) Similar peptides from two β cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol. Med. 1, 625-633
59. Chen, W. et al. (2001) Evidence that a peptide spanning the B-C junction of proinsulin is an early autoantigen epitope in the pathogenesis of type 1 diabetes. J. Immunol. 167, 4926-4935
60. French, M.B. et al. (1997) Transgenic expression of mouse proinsulin II prevents diabetes in nonobese diabetic mice. Diabetes 46, 34-39
61. Charre, S. et al. (2002) Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period. Histol. Histopathol. 17, 393-401
62. Notkins, A.L. and Lernmark, A. (2001) Autoimmune type 1 diabetes: resolved and unresolved issues. J. Clin. Invest. 108, 1247-1252
63. Andre, I. et al. (1996) Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc. Natl. Acad. Sci. U. S. A. 93, 2260-2263
64. Robinson, C.P. et al. (1996) Genetically programmed development of salivary gland abnormalities in the NOD (nonobese diabetic)-scid mouse in the absence of detectable lymphocytic infiltration: a potential trigger for sialoadenitis of NOD mice. Clin. Immunol. Immunopathol. 79, 50-59