Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age

Diabetologia

Volumn 42, Issue 2, 1999, Pages 181-187

  Lindberg, B ^a,b   Ivarsson, S A ^a   Landin Olsson, M ^b   Sundkvist, G ^a   Svanberg, L ^a   Lernmark, A ^c  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Autoimmunity; GAD65 antibodies; ICA512 antibodies; Insulin autoantibodies; Islet cell antibodies

Indexed keywords

AUTOANTIBODY;

ADOLESCENT; ADULT; ANTIBODY DETECTION; ANTIBODY PRODUCTION; ANTIGEN PRESENTATION; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CHILD; FEMALE; GENETIC SUSCEPTIBILITY; HLA SYSTEM; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MATERNAL BLOOD; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; UMBILICAL CORD BLOOD;

ADOLESCENT; ADULT; AUTOANTIBODIES; AUTOANTIGENS; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; FEMALE; FETAL BLOOD; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GLUTAMATE DECARBOXYLASE; HUMANS; INFANT; INSULIN; ISLETS OF LANGERHANS; MALE; MATERNAL AGE; MEMBRANE PROTEINS; PROTEIN-TYROSINE-PHOSPHATASE;

EID: 0032925805     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051137     Document Type: Article

References (62)

1. 1. Gepts W (1965) Pathologic anatomy of the pancreas in juvenile diabetes mellius. Diabetes 14: 613-633
2. 2. Bottazzo GF, Dean BM, McNally JM, Mac Kay EH, Swift PGF, Gamble DR (1985) In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulinitis. N Engl J Med 313: 353-360
3. 3. Lernmark Å, Klöppel G, Stenger D et al. (1995) Heterogeneity of human islet pathology in newly diagnosed childhood insulin-dependent diabetes mellitus. Macrophage infiltrations and expression of HLA-DQ and glutamic acid decarboxylase. Virchows Arch 425: 631-640
4. 4. Roep B, Kalian A, Hazenbos W et al. (1991) T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet 337: 1439-1441
5. 5. Atkinson M, Bowman M, Campbell L, Darrow B, Kaufman D, Maclaren N (1994) Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest 94: 2125-2129
6. 6. Honeyman M, Stone N, de Aizpurua H, Rowley M, Harrison L (1997) High T-cell responses to the glutamic acid decarboxylase (GAD) isoform 67 reflect a hyperimmune state that precedes the onset of insulin-dependent diabetes. J Autoimmunity 10: 165-173
7. 7. Riley WJ, Maclaren NK, Krischer J et al. (1990) A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 323: 1167-1172
8. 8. Bingley PJ, Christie MR, Bonifacio E et al. (1994) Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 43: 1304-1310
9. 9. Verge C, Gianani R, Yu L et al. (1995) Late progression to diabetes and evidence for chronic beta-cell autoimmunity in identical twins of patients with type 1 diabetes. Diabetes 55: 1176-1179
10. 10. Tuomilehto J, Zimmet P, Mackay I et al. (1994) Antibodies to glutamic acid decarboxylase as predictors of insulin-dependent diabetes mellitus before clinical onset of disease. Lancet 343: 1383-1385
11. 11. Ivarsson SA, Ackefors M, Carlsson A et al. (1997) Glutamate decarboxylase antibodies in non-diabetic pregnancies precedes insulin-dependent diabetes in the mother but not necessarily in the offspring. Autoimmunity 26: 261-269
12. 12. Landin-Olsson M, Karlsson A, Dahlquist G, Blom L, Lernmark Å, Sundkvist G (1989) Islet cell and other organspecific autoantibodies in all children developing type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched controls. Diabetologia 32: 387-395
13. 13. Levy-Marchal C, Tichet J, Fajardy I, Gu XF, Dubois F, Czernichow P (1992) Islet cell antibodies in normal French school-children. Diabetologia 35: 577-582
14. 14. Schatz D, Krischer J, Horne G et al. (1994) Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerful as in unaffected relatives. J Clin Invest 93: 2403-2407
15. 15. Verge CF, Gianani R, Kawasaki E et al. (1996) Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD, and ICA512bdc/IA-2 autoantibodies. Diabetes 45: 926-933
16. 16. Cantor A, Krischer J, Cuthbertson DD et al. (1995) Age and family relationship accentuate the risk of insulin-dependent diabetes mellitus (IDDM) in relatives of patients with IDDM. J Clin Endocrinol Metab 80: 3739-3743
17. 17. Bingley P (1996) Interactions of age, islet cell antibodies, insulin antibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA( + ) relatives: The ICARUS data set. Diabetes 45: 1720-1728
18. 18. McCulloch D, Klaff L, Kahn S et al. (1990) Nonprogression of subclinical beta-cell dysfunction among first degree relatives of IDDM patients: 5-yr. follow-up of the Seattle family study. Diabetes 39: 549-556
19. 19. Bärmeier H, McCulloch D, Neifing J et al. (1991) Risk for developing type 1 (insulin-dependent) diabetes mellitus and the presence of islet 64 K antibodies. Diabetologia 34: 727-733
20. 20. Yu L, Gianani R, Eisenbarth G (1994) Quantitation of glutamic acid decarboxylase autoantibody levels in prospectively evaluated relatives of patients with type 1 diabetes. Diabetes 43: 1229-1233
21. 21. Baekkeskov S, Nielsen JH, Marner B, Bilde T, Ludvigsson J, Lernmark Å (1982) Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins. Nature 298: 167-169
22. 22. Baekkeskov S, Aanstoot H-K, Christgau S et al. (1990) Identification of the 64 k autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347: 151-156
23. 23. Grubin CE, Daniels T, Toivola B et al. (1994) A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 37: 344-350
24. 24. Schmidli RS, Colman PG, Bonnifacio E (1995) Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The Second International Glutamic Acid Decarboxylase Workshop. Diabetes 44: 636-640
25. 25. Vandevalle C, Falorni A, Svanholm S, Lernmark Å, Pipeleers D, Gorus F (1995) High diagnostic sensitivity of glutamate decarboxylase autoantibodies in insulin-dependent diabetes mellitus with clinical onset between age 20 and 40 years. The Belgian Diabetes Registry. J Clin Endocrinol Metab 80: 846-851
26. 3H recombinant human ligands. J Immunol Methods 186: 89-99
27. 27. Hagopian W, Sanjeevi C, Kockum I et al. (1995) Glutamate decarboxylase-, insulin- and islet cell antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children. J Clin Invest 95: 1505-1511
28. 28. Lan M, Lu J, Goto Y, Notkins A (1994) Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 13: 505-514
29. 29. Payton MA, Hawkes CJ, Christie MR (1995) Relationship of the 37,000- and 40,000-Mr tryptic fragments of islet antigens in insulin-dependent diabetes to the protein tyrosine phosphatase-like molecule IA-2 (ICA512). J Clin Invest 96: 1506-1511
30. 30. Rabin DU, Pleasic SM, Shapiro JA et al. (1994) Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol 152: 3183-3187
31. 31. Greenbaum C, Palmer J, Kuglin B, Kolb H (1992) Insulin autoantibodies measured by radioimmunoassay methodology are more related to insulin-dependent diabetes mellitus than those measured by enzyme-linked immunosorbent assay: Results of the Fourth International Workshop on the Standardization of Insulin Autoantibody measurement. J Clin Endocrinol Metab 74: 1040-1044
32. 32. Palmer JP, Asplin CM, Clemons P et al. (1983) Insulin antibodies in insulin-dependent diabetics before insulin treatment. Science 222: 1337-1339
33. 33. Landin-Olsson M, Palmer J, Lernmark Å et al. (1992) Predictive value of islet cell and insulin autoantibodies for type 1 (insulin-dependent) diabetes mellitus in a population-based study of newly-diagnosed diabetic and matched control children. Diabetologia 35: 1068-1073
34. 34. Lernmark Å (1987) Islet cell antibodies-theoretical and practical implications. Diabetic Medicine 4: 285-292
35. 35. Greenbaum CJ, Palmer JP, Nagataki S et al. (1992) Improved specificity of ICA assays in the fourth international immunology of diabetes serum exchange workshop. Diabetes 42: 1570-1574
36. 36. Lendrum R, Walker G, Cudworth AG et al. (1976) Islet cell antibodies in diabetes mellitus. Lancet ii: 1273-1276
37. 37. Bonifacio E, Genovese S, Braghi S et al. (1995) Islet autoantibody markers in IDDM: risk assessment strategies yielding high sensitivity. Diabetologia 38: 816-822
38. 38. Wiest-Ladenburger U, Hartmann R, Hartmann U, Berling K, Böhm B, Richter W (1997) Combined analysis and single-step detection of GAD65 and IA2 autoantibodies in IDDM can replace the histochemical islet cell antibody test. Diabetes 46: 565-571
39. 39. Roll U, Christie M, Standl E, Ziegler AG (1994) Association of anti-GAD antibodies with islet cell antibodies and insulin autoantibodies in first-degree relatives of type 1 diabetic patients. Diabetes 43: 154-160
40. 40. Martikainen A, Saukkonen T, Kulmala PK et al. (1996) Disease-associated antibodies in offspring of mothers with IDDM. Diabetes 45: 1706-1710
41. 41. Ahlfors K, Ivarsson S-A, Johnsson I, Svanberg I (1982) Primary and secondary maternal cytomegalovirus infections and their relation to congenital infection. Acta Paediatr Scand 71: 109-113
42. 42. Kawasaki E, Yu L, Gianani R et al. (1997) Evaluation of islet cell antigen (ICA) 512/IA-2 autoantibody radioassays using overlapping ICA512/IA-2 constructs. J Clin Endocrino Metab 82: 375-380
43. 43. Palmer JP, Wilkin TJ, Kurtz AB, Bonifacio E (1990) The third international workshop on the standardization of insulin antibody measurement. Diabetologia 33: 60-61
44. 44. Landin-Olsson M, Sundkvist G, Lernmark A (1987) Prolonged incubation in the two-colour immunofluorescence test increases the prevalence and titres of islet cell antibodies in Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 30: 327-332
45. 45. Madsen OD, Landin-Olsson M, Bille G et al. (1986) A two-colour immunofluorescence test with a monoclonal human proinsulin antibody improves the assay for islet cell antibodies. Diabetologia 29: 115-118
46. 46. Bonifacio E, Lernmark Å, Dawkins et al. (1988) Serum exchange and use of dilutions have improved precision of measurement of islet cell antibodies. J Immunol Methods 106: 83-88
47. 47. Gorsuch AN, Spencer KM, Lister J et al. (1981) Evidence for a long prediabetic period in Type 1 (insulin-dependent) diabetes mellitus. Lancet 26: 1363-1364
48. 48. Norris J, Beaty B, Klingensmith G et al. (1996) Lack of association between early exposure to cow's milk protein and beta-cell autoimmunity. Diabetes Autoimmunity Study in the Young (DAISY). JAMA 276: 609-614
49. 49. Hayward AR (1981) Development of immunity mechanism. In: Soothill JF, Hayward AR, Wood CBS (eds.) Paediatric Immunology. Blackwell scientific publications Oxford, pp 48-55
50. 50. McIntosh S, Pearson HA (1973) Isoimmune neonatal purpura. J Pediatr 82: 1020
51. 51. Hollingsworth DR (1985) Neonatal hyperthyroidism. In: Delange F, Fisher DA, Malvaux P (eds.) Pediatric thyroidology. Karger Basel, New York, pp 210-222
52. 52. Ziegler AG, Hillebrand B, Rabl W et al. (1993) On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 36: 402-408
53. 53. Roll U, Christie MR, Fuchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG (1996) Perinatal autoimmunity in offspring of diabetic parents. The German Multicenter BABY-DIAB study: detection of humoral immune responses to islet antigens in early childhood. Diabetes 45: 967-973
54. 54. Sundkvist G, Bergqvist A, Weibull H et al. (1991) Islet cell antibody reactivity with human fetal pancreatic islets. Diabetes Res Clin Pract 14:1-8
55. 55. Yokota I, Matsuda J, Naito E, Ito M, Shima K, Kuroda Y (1998) Comparison of GAD and ICA512/IA-2 antibodies at and after the onset of IDDM. Diabetes Care 21: 49-52
56. 56. Genovese S, Bonfanti R, Bazzigaluppiu E et al. (1996) Association of IA-2 autoantibodies with HLA DR4 phenotypes in IDDM. Diabetologia 39: 1223-1226
57. 57. Forrest JM, Menser MA, Burgess JA (1971) High frequency of diabetes mellitus in young adults with congenital rubella. Lancet ii: 332-334
58. 58. Ginsberg-Fellner F, Witt ME, Fedun B et al. (1985) Diabetes mellitus and autoimmunity in patients with congenital rubella syndrome. Rev Infect Dis 7 [Suppl 1]: 170-176
59. 59. Dahlquist G, Ivarsson S, Lindberg B, Forsgren M (1995) Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. Diabetes 44: 408-413
60. 60. Hyöty H, Hiltunen M, Knip M et al. (1995) A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study. Diabetes 44: 652-657
61. 61. Oldstone MBA (1987) Molecular mimicry and autoimmune disease. Cell 50: 819-820
62. 62. Kaufman D, Erlander M, Clare-Salzler M, Atkinson M, Maclaren N, Tobin A (1992) Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 89: 283-292