Subcutaneous vaccination with irradiated, cytokine-producing tumor cells stimulates CD8+ cell-mediated immunity against tumors located in the "immunologically privileged" central nervous system

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 19, 1996, Pages 10399-10404

  Sampson, John H ^a   Archer, Gerald E ^a   Ashley, David M ^a   Fuchs, Herbert E ^a   Hale, Laura P ^a   Dranoff, Glenn ^b   Bigner, Darell D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Central nervous system neoplasms; Immunotherapy; Melanoma

Indexed keywords

CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CENTRAL NERVOUS SYSTEM TUMOR; CONTROLLED STUDY; DRUG POTENCY; FEMALE; LEWIS CARCINOMA; LYMPHOCYTE DEPLETION; MELANOMA B16; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN CELL; SUBCUTANEOUS DRUG ADMINISTRATION; VACCINATION;

ANIMALS; BRAIN NEOPLASMS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INJECTIONS, SUBCUTANEOUS; INTERFERON TYPE II; INTERLEUKIN-2; INTERLEUKIN-3; INTERLEUKIN-4; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; SPLEEN; T-LYMPHOCYTES; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 0029841918     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.19.10399     Document Type: Article

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