The endocrinology of obesity

Endocrinology and Metabolism Clinics of North America

Volumn 25, Issue 4, 1996, Pages 921-942

  Smith, S R ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOCRIPTINE; FENFLURAMINE; FLUOXETINE; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; INSULIN; LEPTIN; NALOXONE; OPIATE ANTAGONIST; PROLACTIN; RECOMBINANT GROWTH HORMONE; SOMATOMEDIN C; THYROTROPIN; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ADULT; CHILD; CLINICAL TRIAL; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL REGULATION; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MALE; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS FUNCTION; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; REVIEW; WEIGHT GAIN;

EID: 0030460782     PISSN: 08898529     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0889-8529(05)70362-5     Document Type: Article

References (186)

1. W.G. Abbott P. Thuillez B.V. Howard Body composition, adipocyte size, free fatty acid concentration, and glucose tolerance in children of diabetic pregnancies Diabetes 35 1986 1077 1080
2. F. Ahmad B.J. Goldstein Increased abundance of specific skeletal muscle protein-tyrosine phosphatases in a genetic model of insulin-resistant obesity and diabetes mellitus Metabolism 44 1995 1175 1184
3. L. Altomonte A. Zoli F. Alessi Effect of fenfluramine on growth hormone and prolactin secretion in obese subjects Horm Res 27 1987 190 194
4. A.C. Andreotti R. Lanzi M.F. Manzoni Acute pharmacologic blockade of lipolysis normalizes nocturnal growth hormone levels and pulsatility in obese subjects Metabolism 43 1994 1207 1213
5. G. Argenio G. Bernini M.S. Vivaldi Effect of fenfluramine on prolactin and thyroid-stimulating-hormone response to thyrotropin-releasing-hormone in obese and normal women Eur J Clin Pharmacol 39 1990 13 16
6. G.F. Argenio G.P. Bernini M.S. Vivaldi Naloxone does not modify fenfluramine-induced prolactin increase in obese patients Clin Endocrinol (Oxf) 35 1991 505 508
7. A. Astrup B. Buemann N.J. Christensen The contribution of body composition, substrates, and hormones to the variability in energy expenditure and substrate utilization in premenopausal women J Clin Endocrinol Metab 74 1992 279 286
8. P. Auberger L. Falquerho J.O. Contreres Characterization of a natural inhibitor of the insulin receptor tyrosine kinase: cDNA cloning, purification, and anti-mitogenic activity Cell 58 1989 631 640
9. R. Azziz Reproductive endocrinologic alterations in female asymptomatic obesity Fertil Steril 52 1989 703 725
10. C.M. Bamberger G.P. Chrousos The glucocorticoid receptor and RU 486 in man [review] Ann NY Acad Sci 761 1995 296 310
11. H.A. Barakat N. Mooney K. O'Brien Coronary heart disease risk factors in morbidly obese women with normal glucose tolerance Diabetes Care 16 1993 144 149
12. B. Baranowska S.P. Singh P. Soszynski The role of opiate, dopaminergic, and adrenergic systems in the hypothalamo-pituitary dysfunction in obesity Acta Endocrinol (Copenh) 116 1987 221 228
13. E. Barrett-Connor K.T. Khaw Endogenous sex hormones and cardiovascular disease in men: A prospective population-based study Circulation 78 1988 539 545
14. R.C. Baxter Insulin-like growth factor binding proteins as glucoregulators [review] Metabolism 44 1995 12 17
15. B.A. Bengtsson S. Eden L. Lonn Treatment of adults with growth hormone (GH) deficiency with recombinant human GH J Clin Endocrinol Metab 76 1993 309 317
16. G.P. Bernini G.F. Argenio M.S. Vivaldi Effects of fenfluramine and ritanserin on prolactin response to insulin-induced hypoglycemia in obese patients: Evidence for failure of the serotoninergic system Horm Res 31 1989 133 137
17. K.I. Birkeland K.F. Hanssen P.A. Torjesen Level of sex hormone-binding globulin is positively correlated with insulin sensitivity in men with type 2 diabetes [see comments] J Clin Endocrinol Metab 76 1993 275 278
18. P. Bjorntorp Insulin resistance: The consequence of a neuroendocrine disturbance? [review]? Int J Obes Relat Metab Disord 19 suppl 1 1995 S6 10
19. P. Bjorntorp Neuroendocrine abnormalities in human obesity [review] Metabolism 44 1995 38 41
20. W.G. Blackard J.N. Clore P.S. Glickman Insulin sensitivity of splanchnic and peripheral adipose tissue in vivo in morbidly obese man Metabolism 42 1993 1195 1200
21. J. Bolinder L. Kager J. Ostman Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis Diabetes 32 1983 117 123
22. R.C. Bonadonna L. Groop N. Kraemer Obesity and insulin resistance in humans: A dose-response study Metabolism 39 1990 452 459
23. C.M. Boney B.M. Moats-Staats A.D. Stiles Expression of insulin-like growth factor-I (IGF-I) and IGF-binding proteins during adipogenesis Endocrinology 135 1994 1863 1868
24. G.A. Bray K.E. Melvin I.J. Chopra Effect of triiodothyronine on some metabolic responses of obese patients Am J Clin Nutr 26 1973 715 721
25. G.A. Bray M.S. Raben J. Londono Effects of triiodothyroine, growth hormone and anabolic steroids on nitrogen excretion and oxygen consumption of obese patients J Clin Endocrinol Metab 33 1971 293 300
26. P.J. Campbell J.E. Gerich Impact of obesity on insulin action in volunteers with normal glucose tolerance: Demonstration of a threshold for the adverse effect of obesity J Clin Endocrinol Metab 70 1990 1114 1118
27. L.A. Campfield F.J. Smith G. Mackie Insulin normalization as an approach to the pharmacological treatment of obesity Obes Res 3 1995 591S 603S
28. J.F. Caro L.G. Dohm W.J. Pories Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes [review] Diabetes Metab Rev 5 1989 665 689
29. F.F. Casanueva L. Villanueva C. Dieguez Free fatty acids block growth hormone (GH) releasing hormone-stimulated GH secretion in man directly at the pituitary J Clin Endocrinol Metab 65 1987 634 642
30. S. Chalew H. Nagel S. Shore The hypothalamic-pituitary-adrenal axis in obesity [review] Obes Res 3 1995 371 382
31. A.H. Cincotta A.H. Meier Bromocriptine inhibits in vivo free fatty acid oxidation and hepatic glucose output in seasonally obese hamsters (Mesocricetus auratus) Metabolism 44 1995 1349 1355
32. S.D. Clarke D.B. Jump Regulation of gene transcription by polyunsaturated fatty acids (review) Prog Lipid Res 32 1993 139 149
33. D.R. Clemmons D.K. Snyder R. Williams Growth hormone administration conserves lean body mass during dietary restriction in obese subjects J Clin Endocrinol Metab 64 1987 878 883
34. L. Cohn A.G. Feller M.W. Draper Carpal tunnel syndrome and gynaecomastia during growth hormone treatment of elderly men with low circulating IGF-I concentrations Clin Endocrinol (Oxf) 39 1993 417 425
35. V. Coiro M. Passeri L. Capretti Serotonergic control of TSH and PRL secretion in obese men Psychoneuroendocrinology 15 1990 261 268
36. G.A. Colditz W.C. Willett A. Rotnitzky Weight gain as a risk factor for clinical diabetes mellitus in women [see comments] Ann Intern Med 122 1995 481 486
37. F. Cordido A. Penalva C. Dieguez Massive growth hormone (GH) discharge in obese subjects after the combined administration of GH-releasing hormone and GHRP-6: Evidence for a marked somatotroph secretory capability in obesity [see comments] J Clin Endocrinol Metab 76 1993 819 823
38. I. Cusin A. Sainsbury P. Doyle The ob gene and insulin: A relationship leading to clues to the understanding of obesity Diabetes 44 1995 1467 1470
39. P.O. Dale T. Tanbo S. Vaaler Body weight, hyperinsulinemia, and gonadotropin levels in the polycystic ovarian syndrome: Evidence of two distinct populations Fertil Steril 58 1992 487 491
40. P. De Meyts C.T. Christoffersen B. Urso Role of the time factor in signaling specificity: Application to mitogenic and metabolic signaling by the insulin and insulin-like growth factor-I receptor tyrosine kinases [review] Metabolism 44 1995 2 11
41. G. De Pergola V. Triggiani F. Giorgino The free testosterone to dehydroepiandrosterone sulphate molar ratio as a marker of visceral fat accumulation in premenopausal obese women Int J Obes Relat Metab Disord 18 1994 659 664
42. C. Dieguez M.D. Page M.F. Scanlon Growth hormone neuroregulation and its alterations in disease states [review] Clin Endocrinol (Oxf) 28 1988 109 143
43. R.J. Distel G.S. Robinson B.M. Spiegelman Fatty acid regulation of gene expression: Transcriptional and post-transcriptional mechanisms J Biol Chem 267 1992 5937 5941
44. M.L. Drent L.D. Wever H.J. Ader Growth hormone administration in addition to a very low calorie diet and an exercise program in obese subjects Eur J Endocrinol 132 1995 565 572
45. G.P. Eberhart D.B. West C.N. Boozer Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity Am J Physiol 266 1994 R1423 R1428
46. D.J. Evans J.H. Barth C.W. Burke Body fat topography in women with androgen excess Int J Obes 12 1988 157 162
47. D.J. Evans R.G. Hoffman R.K. Kalkhoff Relationship of androgenic activity to body fat topography, fat cell morphology, and metabolic aberrations in premenopausal women J Clin Endocrinol Metab 57 1983 304 310
48. L. Falquerho G. Patey L. Paquereau Primary structure of the rat gene encoding an inhibitor of the insulin receptor tyrosine kinase Gene 98 1991 209 216
49. R. Feinstein H. Kanety M.Z. Papa Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates J Biol Chem 268 1993 26055 26058
50. K.M. Feldkircher A.M. Mistry D.R. Romsos Adrenalectomy reverses pre-existing obesity in adult genetically obese (ob/ob) mice Int J Obes 20 1996 232 235
51. E. Ferrannini E.J. Barrett S. Bevilacqua Effect of fatty acids on glucose production and utilization in man J Clin Invest 72 1983 1737 1747
52. N. Finer P. Price A. Grossman The effect of enkephalin analogue on pituitary hormone release in human obesity Horm Metab Res 19 1987 68 70
53. R.C. Frederich A. Hamann S. Anderson Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action Nat Med 1 1995 1311 1314
54. G.R. Freidenberg D. Reichart J.M. Olefsky Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus: Effect of weight loss J Clin Invest 82 1988 1398 1406
55. J. Frystyk E. Vestbo C. Skjaerbaek Free insulin-like growth factors in human obesity Metabolism 44 1995 37 44
56. G.T. Galasko Y. Bao S.J. Broomfield Circulating factors and insulin resistance. I. A novel myoinositol 1,2-cyclic phosphate phosphoglycan insulin antagonist from human plasma is elevated in noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 80 1995 2419 2429
57. V.A. Giagulli G. De Pergola F. Giorgino Increased free testosterone but normal 5 alpha-reduced testosterone metabolites in obese premenopausal women Clin Endocrinol (Oxf) 36 1992 553 558
58. V.A. Giagulli J.M. Kaufman A. Vermeulen Pathogenesis of the decreased androgen levels in obese men J Clin Endocrinol Metab 79 1994 997 1000
59. A.R. Glass Endocrine aspects of obesity Med Clin North Am 73 1989 139 160
60. A.R. Glass K.D. Burman W.T. Dahms Endocrine function in human obesity [review] Metabolism 30 1981 89 104
61. A. Golay N. Chen Y.D. Chen Effect of central obesity on regulation of carbohydrate metabolism in obese patients with varying degrees of glucose tolerance J Clin Endocrinol Metab 71 1990 1299 1304
62. A. Golay Y.D. Chen G.M. Reaven Effect of differences in glucose tolerance on insulin's ability to regulate carbohydrate and free fatty acid metabolism in obese individuals J Clin Endocrinol Metab 62 1986 1081 1088
63. D. Goodman-Gruen E. Barrett-Connor Total but not bioavailable testosterone is a predictor of central adiposity in postmenopausal women Int J Obes Relat Metab Disord 19 1995 293 298
64. D.K. Granner R.M. O'Brien Molecular physiology and genetics of NIDDM Diabetes Care 15 1992 369 395
65. S. Grenman T. Ronnemaa K. Irjala Sex steroid, gonadotropin, cortisol, and prolactin levels in healthy, massively obese women: Correlation with abdominal fat cell size and effect of weight reduction J Clin Endocrinol Metab 63 1986 1257 1261
66. S.M. Haffner M.S. Katz M.P. Stern The relationship of sex hormones to hyperinsulinemia and hyperglycemia Metabolism 37 1988 683 688
67. S.M. Haffner R.A. Valdez M.P. Stern Obesity, body fat distribution and sex hormones in men Int J Obes Relat Metab Disord 17 1993 643 649
68. B.S. Hamilton D. Paglia A.Y. Kwan Increased obese mRNA expression in omental fat cells from massively obese humans Nat Med 1 1995 953 956
69. S.E. Hankinson W.C. Willett J.E. Manson Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women J Natl Cancer Inst 87 1995 1297 1302
70. R.R. Henry P. Wallace J.M. Olefsky Effects of weight loss on mechanisms of hyperglycemia in obese non-insulin-dependent diabetes mellitus Diabetes 35 1986 990 998
71. K.K. Ho D.M. Hoffman Defining growth hormone deficiency in adults [review] Metabolism 44 1995 91 96
72. K.Y. Ho W.S. Evans R.M. Blizzard Effects of sex and age on the 24-hour profile of growth hormone secretion in man: Importance of endogenous estradiol concentrations J Clin Endocrinol Metab 64 1987 51 58
73. D.M. Hoffman A.J. O'Sullivan R.C. Baxter Diagnosis of growth-hormone deficiency in adults [see comments] [published erratum appears in Lancet 1994 Jul 16;344(8916):206] Lancet 343 1994 1064 1068
74. G.S. Hotamisligil P. Arner J.F. Caro Increased adipose tissue expression of tumor-necrosis factor alpha in human obesity and insulin resistance J Clin Invest 95 1995 2409 2415
75. G.S. Hotamisligil D.L. Murray L.N. Choy Tumor necrosis factor alpha inhibits signaling from the insulin receptor Proc Natl Acad Sci USA 91 1994 4854 4858
76. G.S. Hotamisligil P. Peraldi A. Budavari IRS-1 mediated inhibition of insulin receptor tyrosine kinase activity in TNF-a and obesity induced insulin resistance Science 271 1996 665 668
77. S. Inoue G.A. Bray Y.S. Mullen Transplantation of pancreatic beta-cells prevents development of hypothalamic obesity in rats Am J Physiol 235 1978 E266 E271
78. B. Jeanrenaud Central nervous system and peripheral abnormalities: Clues to the understanding of obesity and NIDDM [review] Diabetologia 37 suppl 2 1994 S170 S178
79. J.O. Jorgensen S.B. Pedersen J. Borglum Serum concentrations of insulin-like growth factors (IGFs), IGF binding proteins 1 and 3 and growth hormone binding protein in obese women and the effects of growth hormone administration: A double-blind, placebo-controlled study Eur J Endocrinol 133 1995 65 70
80. J.O. Jorgensen S.B. Pedersen J. Borglum Fuel metabolism, energy expenditure, and thyroid function in growth hormone-treated obese women: A double-blind placebo-controlled study Metabolism 43 1994 872 877
81. E.M. Kaptein J.S. Fisler M.J. Duda Relationship between the changes in serum thyroid hormone levels and protein status during prolonged protein supplemented caloric deprivation Clin Endocrinol (Oxf) 22 1985 1 15
82. M. Kelijman L.A. Frohman Enhanced growth hormone (GH) responsiveness to GH-releasing hormone after dietary manipulation in obese and nonobese subjects J Clin Endocrinol Metab 66 1988 489 494
83. D.E. Kelley M. Mokan J.A. Simoneau Interaction between glucose and free fatty acid metabolism in human skeletal muscle J Clin Invest 92 1993 91 98
84. P.A. Kern M. Saghizad J.M. Ong The expression of tumor-necrosis factor in human adipose tissue: Regulation by obesity, weight loss and relationship to lipoprotein-lipase J Clin Invest 95 1995 2111 2119
85. K.T. Khaw E. Barrett-Connor Lower endogenous androgens predict central adiposity in men Ann Epidemiol 2 1992 675 682
86. A.H. Kissebah Insulin resistance in visceral obesity [review] Int J Obes 15 suppl 2 1991 109 115
87. O.A. Kletzky M. Vermesh Effectiveness of vaginal bromocriptine in treating women with hyperprolactinemia Fertil Steril 51 1989 269 272
88. V.R. Lala A. Ray P. Jamias Prolactin and thyroid status in prepubertal children with mild to moderate obesity J Am Coll Nutr 7 1988 361 366
89. C.H. Lang Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor Am J Physiol 264 1993 R984 R991
90. C.H. Lang C. Dobrescu G.J. Bagby Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output Endocrinology 130 1992 43 52
91. E.J. Lee K.R. Kim K.M. Lee Reduced growth hormone response to L-dopa and pyridostigmine in obesity Int J Obes Relat Metab Disord 18 1994 465 468
92. E.J. Lee S.Y. Nam K.R. Kim Acipimox potentiates growth hormone (GH) response to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty acid in normal and obese subjects J Clin Endocrinol Metab 80 1995 2495 2498
93. G.H. Lee R. Proenca J.M. Montez Abnormal splicing of the leptin receptor in diabetic mice Nature 379 1996 632 635
94. R. Leenen K. van der Kooy J.C. Seidell Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy J Clin Endocrinol Metab 78 1994 1515 1520
95. G. Lindstedt P.A. Lundberg L. Lapidus Low sex-hormone-binding globulin concentration as independent risk factor for development of NIDDM: 12-yr follow-up of population study of women in Gothenburg, Sweden Diabetes 40 1991 123 128
96. R.A. Lobo O.A. Kletzky E.M. Kaptein Prolactin modulation of dehydroepiandrosterone sulfate secretion Am J Obstet Gynecol 138 1980 632 636
97. H.J. Londono T.F. Gallagher Jr G.A. Bray Effect of weight reduction, triiodothyronine, and diethylstilbestrol on growth hormone in obesity Metabolism 18 1969 986 992
98. F. Lonnqvist P. Arner L. Nordfors Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nat Med 1 1995 950 953
99. F. Lonnqvist A. Thome K. Nilsell A pathogenic role of visceral fat beta 3-adrenoceptors in obesity [see comments] J Clin Invest 95 1995 1109 1116
100. F. Lonnqvist A. Thorne K. Nilsell A pathogenic role of visceral fat beta(3)-adrenoceptors in obesity J Clin Invest 95 1995 1109 1116
101. J.S. LoPresti D. Gray J.T. Nicoloff Influence of fasting and refeeding on 3,3′,5′-triiodothyronine metabolism in man J Clin Endocrinol Metab 72 1991 130 136
102. J.C. Lovejoy G.A. Bray C.S. Greeson Oral anabolic steroid treatment, but not parenteral androgen treatment, decreases abdominal fat in obese, older men Int J Obes 19 1995 614 624
103. O.A. MacDougald C.S. Hwang H. Fan Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes Proc Natl Acad Sci USA 92 1995 9034 9037
104. O.A. MacDougald M.D. Lane Transcriptional regulation of gene-expression during adipocyte differentiation Annu Rev Biochem 64 1995 345 373
105. B.A. Maddux P. Sbraccia S. Kumakura Membrane glycoprotein PC-1 and insulin resistance in non-insulin dependent diabetes mellitus Nature 373 1995 448 451
106. M. Maffei J. Halaas E. Ravussin Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects Nat Med 1 1995 1155 1161
107. P. Marin N. Darin T. Amemiya Cortisol secretion in relation to body fat distribution in obese premenopausal women Metabolism 41 1992 882 886
108. P. Marin S. Holmang L. Jonsson The effects of testosterone treatment on body composition and metabolism in middle-aged obese men Int J Obes Relat Metab Disord 16 1992 991 997
109. P. Marin M. Krotkiewski P. Bjorntorp Androgen treatment of middle-aged, obese men: Effects on metabolism, muscle and adipose tissues Eur J Med 1 1992 329 336
110. P. Marin B. Oden P. Bjorntorp Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: Effects of androgens J Clin Endocrinol Metab 80 1995 239 243
111. D.R. Matthews B.A. Naylor R.G. Jones Pulsatile insulin has greater hypoglycemic effect than continuous delivery Diabetes 32 1983 617 621
112. G. Medeiros-Neto N. Lima L. Perozim The effect of hypocaloric diet with and without D-fenfluramine treatment on growth hormone release after growth hormone-releasing factor stimulation in patients with android obesity Metabolism 43 1994 969 973
113. A.H. Meier A.H. Cincotta W.C. Lovell Timed bromocriptine administration reduces body fat stores in obese subjects and hyperglycemia in type II diabetics Experientia 48 1992 248 253
114. N. Moller J.O. Jorgensen J. Moller Metabolic effects of growth hormone in humans [review] Metabolism 44 1995 33 36
115. A. Mota A. Bento A. Penalva Role of the serotonin receptor subtype 5-HT1D on basal and stimulated growth hormone secretion J Clin Endocrinol Metab 80 1995 1973 1977
116. S. Nader M.A. Charles M.F. Saad Serum androgens in hyperinsulinemic Pima Indian and obese Caucasian women and their response to short-term insulin infusion J Endocrinol Invest 16 1993 403 406
117. J.E. Nestler J.F. Strauss 3d Insulin as an effector of human ovarian and adrenal steroid metabolism. [review] Endocrinol Metab Clin North Am 20 1991 807 823
118. R.A. Norman C. Bogardus E. Ravussin Linkage between obesity and a marker near the tumor necrosis factor-alpha locus in Pima Indians J Clin Invest 96 1995 158 162
119. J. Nougues Y. Reyne B. Barenton Differentiation of adipocyte precursors in a serum-free medium is influenced by glucocorticoids and endogenously produced insulin-like growth factor-I Int J Obes 17 1993 159 167
120. S. O'Rahilly R.C. Turner D.R. Matthews Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes N Engl J Med 318 1988 1225 1230
121. S. Okada D.A. York G.A. Bray Mifepristone (RU 486), a blocker of type II glucocorticoid and progestin receptors, reverses a dietary form of obesity Am J Physiol 262 1992 R1106 R1110
122. G. Paolisso A.J. Scheen D. Giugliano Pulsatile insulin delivery has greater metabolic effects than continuous hormone administration in man: Importance of pulse frequency J Clin Endocrinol Metab 72 1991 607 615
123. D. Papalia M. Lunetta M. Di Mauro Effects of naloxone on prolactin, growth hormone and cortisol response to insulin hypoglycemia in obese subjects J Endocrinol Invest 12 1989 777 782
124. R. Pasquali S. Cantobelli F. Casimirri The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution [see comments] J Clin Endocrinol Metab 77 1993 341 346
125. R. Pasquali F. Casimirri S. Cantobelli Effect of obesity and body fat distribution on sex hormones and insulin in men Metabolism 40 1991 101 104
126. R. Pasquali F. Casimirri R. De Iasio Insulin regulates testosterone and sex hormone-binding globulin concentrations in adult normal weight and obese men J Clin Endocrinol Metab 80 1995 654 658
127. A.N. Peiris J.I. Stagner S.R. Plymate Relationship of insulin secretory pulses to sex hormone-binding globulin in normal men [see comments] J Clin Endocrinol Metab 76 1993 279 282
128. A.N. Peiris J.I. Stagner R.L. Vogel Body fat distribution and peripheral insulin sensitivity in healthy men: Role of insulin pulsatility J Clin Endocrinol Metab 75 1992 290 294
129. M.A. Permutt Genetics of NIDDM Diabetes Care 13 1990 1150 1153
130. M.A. Peter K.H. Winterhalter M. Boni-Schnetzler Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding proteins by growth hormone in rat white adipose tissue Endocrinology 133 1993 2624 2631
131. H. Pijl H.P. Koppeschaar F.L. Willekens The influence of serotonergic neurotransmission on pituitary hormone release in obese and non-obese females Acta Endocrinol (Copenh) 128 1993 319 324
132. G. Plewe U. Schneider U. Krause Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans J Endocrinol Invest 10 1987 137 141
133. K.S. Polonsky The b-cell in diabetes: From molecular genetics to clinical research Diabetes 44 1995 705 720
134. K.S. Polonsky B.D. Given L.J. Hirsch Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus N Engl J Med 318 1988 1231 1239
135. K.S. Polonsky B.D. Given E. Van Cauter Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects J Clin Invest 81 1988 442 448
136. A.E. Pontiroli R. Lanzi L.D. Monti Growth hormone (GH) autofeedback on GH response to GH-releasing hormone: Role of free fatty acids and somatostatin J Clin Endocrinol Metab 72 1991 492 495
137. P. Preziosi E. Barrett-Connor L. Papoz Interrelation between plasma sex hormone-binding globulin and plasma insulin in healthy adult women: The telecom study [see comments] J Clin Endocrinol Metab 76 1993 283 287
138. M.H. Rasmussen J. Frystyk T. Andersen The impact of obesity, fat distribution, and energy restriction on insulin-like growth factor-1 (IGF-1), IGF-binding protein-3, insulin, and growth hormone Metabolism 43 1994 315 319
139. M.H. Rasmussen A. Hvidberg A. Juul Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I levels in obese subjects [published erratum appears in J Clin Endocrinol Metab 1995 Aug;80(8):2446] J Clin Endocrinol Metab 80 1995 1407 1415
140. G.M. Reaven Role of insulin resistance in the pathophysiology of non-insulin dependent diabetes mellitus [review] Diabetes Metab Rev 9 suppl 1 1993 5S 12S
141. M. Rebuffe-Scrive P. Marin P. Bjorntorp Effect of testosterone on abdominal adipose tissue in men Int J Obes 15 1991 791 795
142. A.T. Reutens D.M. Hoffman K.C. Leung Evaluation and application of a highly sensitive assay for serum growth hormone (GH) in the study of adult GH deficiency J Clin Endocrinol Metab 80 1995 480 485
143. J. Rissanen R. Hudson R. Ross Visceral adiposity, androgens, and plasma lipids in obese men Metabolism 43 1994 1318 1323
144. S. Rojdmark A. Berg S. Rossner Nocturnal melatonin secretion in thyroid-disease and in obesity Clin Endocrinol 35 1991 61 65
145. S. Rojdmark S. Rossner Decreased dopaminergic control of prolactin secretion in male obesity: Normalization by fasting Metabolism 40 1991 191 195
146. R. Saladin P. De Vos M. Guerre-Millo Transient increase in obese gene expression after food intake or insulin administration Nature 377 1995 527 529
147. L.B. Salans G.A. Bray S.W. Cushman Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity: Effects of dietary composition and adipose cell size J Clin Invest 53 1974 848 856
148. L.B. Salans J.W. Dougherty The effect of insulin upon glucose metabolism by adipose cells of different size: Influence of cell lipid and protein content, age, and nutritional state J Clin Invest 50 1971 1399 1410
149. J.F. Sassin A.G. Frantz E.D. Weitzman Human prolactin: 24-hour pattern with increased release during sleep Science 177 1972 1205 1207
150. J.C. Seidell P. Bjorntorp L. Sjostrom Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels Metabolism 39 1990 897 901
151. J.C. Seidell M. Cigolini J. Charzewska Androgenicity in relation to body fat distribution and metabolism in 38-year-old women—the European Fat Distribution Study J Clin Epidemiol 43 1990 21 34
152. J.C. Seidell M. Cigolini P. Deurenberg Fat distribution, androgens, and metabolism in nonobese women Am J Clin Nutr 50 1989 269 273
153. J. Sjogren M. Li P. Bjorntorp Androgen hormone binding to adipose tissue in rats Biochim Biophys Acta 1244 1995 117 120
154. D.K. Snyder D.R. Clemmons L.E. Underwood Dietary carbohydrate content determines responsiveness to growth hormone in energy-restricted humans J Clin Endocrinol Metab 69 1989 745 752
155. D.K. Snyder L.E. Underwood D.R. Clemmons Persistent lipolytic effect of exogenous growth hormone during caloric restriction Am J Med 98 1995 129 134
156. G.E. Sonnenberg R.G. Hoffman R.A. Mueller Splanchnic insulin dynamics and secretion pulsatilities in abdominal obesity Diabetes 43 1994 468 477
157. G.E. Sonnenberg R.G. Hoffmann C.P. Johnson Low- and high-frequency insulin secretion pulses in normal subjects and pancreas transplant recipients: Role of extrinsic innervation J Clin Invest 90 1992 545 553
158. P.R. Srinivas G. Grunberger Inhibitors of the insulin receptor tyrosine kinase [review] Pharmacol Ther 64 1994 23 35
159. P.R. Srinivas A.S. Wagner L.V. Reddy Serum alpha 2-HS-glycoprotein is an inhibitor of the human insulin receptor at the tyrosine kinase level Mol Endocrinol 7 1993 1445 1455
160. H.H. Steineger H.N. Sorensen J.D. Tugwood Dexamethasone and insulin demonstrate marked and opposite regulation of the steady-state mRNA level of the peroxisomal proliferator-activated receptor (PPAR) in hepatic cells: Hormonal modulation of fatty-acid-induced transcription Eur J Biochem 225 1994 967 974
161. G. Strain B. Zumoff W. Rosner The relationship between serum levels of insulin and sex hormone-binding globulin in men: The effect of weight loss J Clin Endocrinol Metab 79 1994 1173 1176
162. G.W. Strain B. Zumoff L.K. Miller Effect of massive weight loss on hypothalamic-pituitary-gonadal function in obese men J Clin Endocrinol Metab 66 1988 1019 1023
163. J.S. Strobl M.J. Thomas Human growth hormone [review] Pharmacol Rev 46 1994 1 34
164. J. Sturis W.L. Pugh J. Tang Alterations in pulsatile insulin secretion in the Zucker diabetic fatty rat Am J Physiol 267 1994 E250 E259
165. O.S. Svendsen C. Hassager C. Christiansen Impact of regional and total body composition and hormones on resting energy expenditure in overweight postmenopausal women Metabolism 42 1993 1588 1591
166. G.S. Tannenbaum H.J. Guyda B.I. Posner Insulin-like growth factors: A role in growth hormone negative feedback and body weight regulation via brain Science 220 1983 77 79
167. A. Tchernof J.P. Despres A. Belanger Reduced testosterone and adrenal C19 steroid levels in obese men Metabolism 44 1995 513 519
168. J.P. Thissen J.M. Ketelslegers L.E. Underwood Nutritional regulation of the insulin-like growth factors Endocr Rev 15 1994 80 101
169. T.L. Thomas L.D. Devenport R.D. Stith Relative contribution of type I and II corticosterone receptors in VMH lesion-induced obesity and hyperinsulinemia Am J Physiol 266 1994 R1623 R1629
170. R.H. Unger Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications [review] Diabetes 44 1995 863 870
171. J.D. Veldhuis A. Iranmanesh G. Lizarralde Combined deficits in the somatotropic and gonadotropic axes in healthy aging men: An appraisal of neuroendocrine mechanisms by deconvolution analysis Neurobiol Aging 15 1994 509 517
172. J.D. Veldhuis A.Y. Liem S. South Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay J Clin Endocrinol Metab 80 1995 3209 3222
173. A. Vermeulen J.M. Kaufman J.P. Deslypere Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men J Clin Endocrinol Metab 76 1993 1140 1146
174. M. Wabitsch H. Hauner E. Heinze The role of growth hormone/insulin-like growth factors in adipocyte differentiation [review] Metabolism 44 1995 45 49
175. J.U. Weaver K. Noonan P.G. Kopelman An association between hypothalamic-pituitary dysfunction and peripheral endocrine function in extreme obesity Clin Endocrinol (Oxf) 35 1991 97 102
176. J.U. Weaver K. Noonan P.G. Kopelman Impaired prolactin secretion and body fat distribution in obesity Clin Endocrinol (Oxf) 32 1990 641 646
177. A. Weltman J.Y. Weltman M.L. Hartman Relationship between age, percentage body fat, fitness, and 24-hour growth hormone release in healthy young adults: Effects of gender J Clin Endocrinol Metab 78 1994 543 548
178. H.A. Wollmann M.B. Ranke Metabolic effects of growth hormone in children [review] Metabolism 44 1995 97 102
179. G.H. Wolters J.B. Wiegman W. Konijnendijk Effect of glucose stimulation on 45-calcium uptake and total calcium content of pancreatic islets of fed and fasted rats and obese hyperglycemic mice Diabetes 32 1983 124 129
180. C.K. Wolverton M.J. Azain J.Y. Duffy Influence of somatotropin on lipid metabolism and IGF gene expression in porcine adipose tissue Am J Physiol 263 1992 E637 E645
181. H. Yki-Jarvinen Glucose toxicity [review] Endocr Rev 13 1992 415 431
182. D.A. York G.A. Bray Dependence of hypothalamic obesity on insulin, the pituitary and the adrenal gland Endocrinology 90 1972 885 894
183. Y.Y. Zhang R. Proenca M. Maffei Positional cloning of the mouse obese gene and its human homolog Nature 372 1994 425 432
184. B. Zumoff Hormonal abnormalities in obesity [review] Acta Med Scand Suppl 723 1988 153 160
185. B. Zumoff G.W. Strain A perspective on the hormonal abnormalities of obesity: Are they cause or effect? Obes Res 2 1994 56 67
186. B. Zumoff G.W. Strain L.K. Miller Partial reversal of the hypogonadotropic hypogonadism of obese men by administration of corticosuppressive doses of dexamethasone Int J Obes 12 1988 525 531