Sexual dimorphism in 11 β hydroxysteroid dehydrogenase activity and its relation to fat distribution and insulin sensitivity; a study in hypopituitary subjects

Clinical Endocrinology

Volumn 49, Issue 1, 1998, Pages 13-20

  Weaver, Jolanta U ^a   Taylor, Norman F ^c   Monson, John P ^e   Wood, Peter J ^d   Kelly, William F ^b  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b JAMES COOK UNIVERSITY HOSPITAL   (United Kingdom)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

^d ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^e SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE;

ADULT; AGED; ARTICLE; BIOAVAILABILITY; BODY COMPOSITION; BODY FAT; CLINICAL ARTICLE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEEDBACK SYSTEM; FEMALE; HOMEOSTASIS; HUMAN; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL; REGRESSION ANALYSIS; SEX DIFFERENCE; SUBSTITUTION THERAPY; TISSUE DISTRIBUTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASES; ADULT; AGED; BODY COMPOSITION; CARRIER PROTEINS; CORTISONE; FEMALE; GONADAL STEROID HORMONES; HUMANS; HYDROCORTISONE; HYDROXYSTEROID DEHYDROGENASES; HYPOPITUITARISM; INSULIN RESISTANCE; ISOENZYMES; MALE; MIDDLE AGED; REGRESSION ANALYSIS; SEX CHARACTERISTICS;

EID: 0031869516     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1998.00494.x     Document Type: Article

References (23)

1. Albiston, A.L., Smith, R.E. & Krozowski, Z.S. (1995) Sex- and tissue specific regulation of 11 β-hydroxysteroid dehydrogenase. Molecular Cellular Endocrinology, 109, 183-188.
2. Best, R. & Walker, B.R. (1997) Additional value of measurement of urinary cortisone and unconjugated cortisol metabolites in assessing the activity of 11 β hydroxysteroid dehydrogenase in vivo. Clinical Endocrinology, 47, 231-236.
3. Bevan, B.R., Savvas, M., Jenkins, J.M., Baker, K., Pennington, G.W. & Taylor, N.F. (1986) Abnormal steroid excretion in gestational trophoblastic disease complicated by the presence of ovarian thecalutein cysts. Journal of Clinical Pathology, 39, 627-634.
4. Bujalska, I.J., Kumar, S. & Stewart, P.M. (1997) Does central obesity reflect 'Cushing disease of the omentum'? Lancet, 349, 1210-1213.
5. Dullaart, R.B., Ubels, F.L., Hoogenberg, K., Smit, A.J., Pratt, J.J., Muntinga, J.H.J., Sluiter, W.J. & Wolthers, B.G. (1995) Alterations in cortisol metabolism in Insulin-Dependent Diabetes Mellitus: Relationship with metabolic control and estimated blood volume and effect of angiotensin-converting enzyme inhibition. Journal of Clinical Endocrinology and Metabolism., 80, 3002-3008.
6. Gordon, G.G. & Southern, A.L. (1977) Thyroid hormone effects on steroid metabolism. Bulletin of the New York Academy of Sciences, 53, 241-259.
7. Hammami, M.M. & Siiteri, P.K. (1991) Regulation of 11 β -hydroxysteroid dehydrogenase activity in human skin fibroblasts: enzymatic modulation of glucocorticoid action. Journal of Clinical Endocrinology and Metabolism., 73, 326-334.
8. Jamicson, P.M., Chapman dwards, K.E., C.R.W. & Seckl, J. (1995) 11 β-Hydroxysteroid Dehydrogenase is an exclusive 11 β - reductase in primary cultures of rat hepatocytes: Effect of physicochemical and hormonal manipulations. Endocrinology, 136, 4754-4761.
9. Low, S.C., Assaad, S.N., Rajan, V., Chapman, K.E., Edwards, C.R.W. & Seckl, J.R. (1993) Regulation of 11 β -hydroxysteroid dehydrogenase by sex steroids in vivo; further evidence for the existence of a second dehydrogenase in rat kidney. Journal of Endocrinology, 139, 27-35.
10. Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Tracher, D.F. & Turner, R.C. (1985) Homeostasis model of assessment; insulin resistance and β cell function from plasma glucose and insulin concentrations in man. Diabetologia, 28, 412-419.
11. Moore, A., Aitken, R., Burke, C., Gaskell, S., Groom, G., Holder, G. et al. (1985) Cortisol assays: guidelines for the provision of clinical biochemistry service. Annals Clinical Biochemistry, 22, 435-454.
12. Palermo, M., Shackelton, C.H.L., Manero, F. & Stewart, P.M. (1996) Urine free cortisone and the assessment of 11 β hydroxysteroid dehydrogenase activity in man. Clinical Endocrinology, 45, 605-611.
13. Raven, P.W. & Taylor, N.F. (1995) Steroid metabolism in healthy men and women. Journal of Endocrinology, 147 (Suppl. 2), 100.
14. Riddle, M.C. & McDaniel, P.A. (1993) Acute reduction of renal 11 β-hydroxysteroid dehydrogenase activity by several antinatriuretic stimuli. Metabolism: Clinical and experimental, 42, 1370-1374.
15. Rodin, A., Thakker, H., Taylor, N. & Clayton, R. (1994) Hyperandrogenism in polycystic ovarian syndrome: evidence for dysregulation of 11 β hydroxysteroid dehydrogenase. New England Journal of Medicine, 330, 460-465.
16. Seckl, J.R. (1993) 11 β -hydroxysteroid dehydrogenase isoforms and their implication for blood pressure regulation. European Journal of Clinical Investigation., 23, 589-601.
17. Seckl, J.R. (1995) The syndrome of apparent mineralocorticoid excess and deficiency of 11 b-hydroxysteroid dehydrogenase. Clinical Endocrinology, 43, 247-248.
18. Takeda, Y., Miyamori, I., Yoneda, T., Ito, Y. & Takeda, R. (1994) Expression of 11β hydroxysteroid dehydrogenase mRNA in rat vascular smooth muscle cells. Life Science, 54, 281-285.
19. Walker, B.R. & Edwards, C.R.W. (1991) II-β hydroxysteroid dehydrogenase and enzyme mediated receptor protection: life after liquorice? Clinical Endocrinology, 35, 281-289.
20. Weaver, J.U., Kelly, W.F., Bilous, R.W., Donovan, S.J. & Wood, P.J. (1995b) Capillary cortisol measurements in assessment of hydrocortisone replacement therapy in hypopituitary adults. Journal of Endocrinology, 144 (Suppl. 1), 290.
21. Weaver, J.U., Kelly, W.F., Summerfield, G.P., Langstaff, J., Conn, D., Richardson, S., Fordham, J.N., Bates, J., Pitcher, O., Laker, M.F., Bilous, R.W. & Wood, P.J. (1995c) The effect of unbound plasma cortisol on plasma fibrinogen and other putative risk factors for ischaemic heart disease in hypopituitary adults. Journal of Endocrinology, 144 (Suppl. 1), 291.
22. Weaver, J.U., Monson, J.P., Noonan, K., John, W.G., Edwards, A., Evans, K.A. & Cunningham, J. (1995a) The effect of low dose recombinant human Growth Hormone replacement on regional fat distribution, insulin sensitivity and cardiovascular risk factors in hypopituitary adults. Journal of Clinical Endocrinology and Metabolism, 80, 153-159.
23. Weaver, J.U., Thaventhiran, L., Noonan, K., Burrin, J.M., Taylor, N.F., Norman, M.R. & Monson, J.P. (1994) The effect of growth hormone replacement on cortisol metabolism and glucocorticoid sensitivity in hypopituitary adults. Clinical Endocrinology, 41, 639-648.