Two years of growth hormone (GH) treatment increases bone mineral content and density in hypopituitary patients with adult-onset GH deficiency

Journal of Clinical Endocrinology and Metabolism

Volumn 81, Issue 8, 1996, Pages 2865-2873

  Johannsson, Gudmundur ^a   Rosén, Thord ^a   Bosaeus, Ingvar ^a   Sjöström, Lars ^a   Bengtsson, Bengt Åke ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; GROWTH HORMONE; HUMAN GROWTH HORMONE; OSTEOCALCIN; PARATHYROID HORMONE; PROCOLLAGEN;

ADULT; AGED; ARTICLE; BODY HEIGHT; BODY WEIGHT; BONE DENSITY; BONE MASS; BONE METABOLISM; BONE MINERAL; BONE REMODELING; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; GROWTH HORMONE DEFICIENCY; HORMONE SUBSTITUTION; HUMAN; HYPOGONADOTROPIC HYPOGONADISM; HYPOPITUITARISM; LUMBAR SPINE; MALE; PRIORITY JOURNAL;

ADULT; AGED; BLOOD; BONE AND BONES; BONE DENSITY; BONE REMODELING; DENSITOMETRY, X-RAY; FEMALE; GROWTH HORMONE; HUMANS; HYPOPITUITARISM; MALE; MIDDLE AGED; SEX CHARACTERISTICS; TIME FACTORS;

EID: 0029812889     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.81.8.2865     Document Type: Article

References (49)

1. Rappaport R, Czerichow P. 1993 Disorders of growth hormone and prolactin secretion. In: Bertrand J, Rappaport R, Sizonenko PC, eds. Pediatric endocrinology: physiology, pathophysiology and clinical aspects, 2nd ed. Baltimore: Williams and Wilkins: 220 - 241.
2. De Boer H, Blok GJ, Van Lingen A, Teule GJJ, Lips P, Van Der Veen EA. 1994 Consequences of childhood-onset growth hormone deficiency of adult bone mass. J Bone Miner Res. 9:1319 - 1326.
3. Kaufman JM, Taelman P, Vermeulen A, Vandeweghe M. 1992 Bone mineral status in growth hormone-deficient males with isolated and multiple pituitary deficiencies of childhood onset. J Clin Endocrinol Metab. 74:118 - 123.
4. Holmes SJ, Economou G, Whitehouse RW, Adams JE, Shalet SM. 1994 Reduced bone mineral density in patients with adult onset growth hormone deficiency. J Clin Endocrinol Metab. 78:669 - 674.
5. Johansson AG, Burman P, Westermark K, Ljunghall S. 1992 The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor I. J Intern Med. 232:447 - 452.
6. Rosén T, Hansson T, Granhed H, Szücs J, Bengtsson B-Å. 1993 Reduced bone mineral content in adult patients with growth hormone deficiency. Acta Endocrinol (Copenh). 129:201 - 208.
7. Rosén T, Wilhelmsen L, Landin-Wilhelmsen K, Lappas G, Lindsledt G, Bengtsson B-Å. Increased fracture rate in growth hormone deficient adults [Abstract p2 - 251]. Proc of the 77th Annual Meet of The Endocrine Soc. 1995.
8. Schlemmer A, Johansen JS, Pedersen SA, Jørgensen JOL, Hassanger C, Christiansen C. 1991 The effects of growth hormone (GH) therapy on urinary pyridinoline cross-links in GH-deficient adults. Clin Endocrinol (Oxf). 35:471 - 476.
9. Johansen JS, Pedersen SA, Jørgensen JOL, et al. 1990 Effects of growth hormone (GH) on plasma bone Gla protein in GH-deficient adults. J Clin Endocrinol Metab. 70:916 - 919.
10. Binnerts A, Swart GR, Wilsson JHP, et al. 1992 The effects of growth hormone administration in growth hormone deficient adults on bone, protein, carbohydrate and lipid homeostasis, as well as on body composition. Clin Endocrinol (Oxf). 37:79 - 87.
11. Vandeweghe M, Taelman P, Kaufman JM. 1993 Short and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males. Clin Endocrinol (Oxf). 39:409 - 415.
12. Bengtsson B-Å, Edén S, Lönn L, et al. 1993 Treatment of adults with growth hormone (GH) deficiency with recombinant human GH. J Clin Endocrinol Metab. 76:309 - 317.
13. Beshyah SA, Thomas E, Kyd P, Sharp P, Fairney A, Johnston DG. 1994 The effect of growth hormone replacement therapy in hypopituitary adults on calcium and bone metabolism. Clin Endocrinol (Oxf). 40:383 - 391.
14. Degerblad M, Elgindy N, Hall K, Sjöberg H-E, Thorén M. 1992 Potent effect of recombinant human growth hormone on bone mineral density and body composition in adults with panhypopituitarism. Acta Endocrinol (Copenh). 126:387 - 393.
15. O'Halloran DJ, Agathocles T, Whitehouse RW, Holmes SJ, Adams JE, Shalet SM. 1993 Increased bone density after recombinant human growth hormone (GH) therapy in adults with isolated GH deficiency. J Clin Endocrinol Metab. 76:1344 - 1348.
16. Holmes SJ, Whitehouse RW, Swindell R, Economou G, Adams JE, Shalet SM. 1995 Effect of growth hormone replacement on bone mass in adult onset growth hormone deficiency. Clin Endocrinol (Oxf). 42:627 - 633.
17. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, et al. 1994 Serum insulinlike growth factor I in a random population sample of men and women: relationship to age, sex, smoking habits, coffee consumption and physical activity, blood pressure and concentrations of plasma lipids, fibrinogen, parathyroid hormone and osteocalcin. Clin Endocrinol (Oxf). 41:351 - 357.
18. Mazess RB, Barden HS, Bisek JP, Hanson J. 1990 Dual-energy x-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr. 51:1106 - 1112.
19. Recker RR, Davies KM, Hinders SM, Heaney RP, Stegman MR, Kimmel DB. 1992 Bone gain in young adult women. JAMA. 268:2403 - 2408.
20. Whitehead H, Boreman C, Mcllrath EM, et al. 1992 Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clin Endocrinol (Oxf). 36:45 - 52.
21. Beshyah SA, Kyd P, Thomas E, Fairney A, Johnston DG. 1995 The effects of prolonged growth hormone replacement on bone metabolism and bone mineral density in hypopituitary adults. Clin Endocrinol (Oxf). 42:249 - 254.
22. Degerblad M, Bengtsson B-Å, Bramnert M, et al. 1995 Reduced bone mineral density in adults with growth hormone (GH) deficiency: increased bone turnover during 12 months of GH substitution therapy. Eur J Endocrinol. 133:180 - 188.
23. Wood AJJ. 1992 The prevention and treatment of osteoporosis. N Engl J Med. 327:620 - 627.
24. Heaney RP. 1994 The bone-remodeling transient: implications for the interpretation of clinical studies of bone mass change. J Bone Miner Res. 9:1515 - 1523.
25. Holmes SJ, Whitehouse RW, Economou G, O'Halloran DJ, Adams JE, Shalet SM. 1995 Further increase in forearm cortical bone mineral content after discontinuation of growth hormone replacement. Clin Endocrinol (Oxf). 42:3 - 7.
26. Svendsen OL, Hassager C, Skødt V, Christiansen C. 1995 Impact of soft tissue on invivo accuracy of bone mineral measurements in the spine, hip, and forearm: a human cadaver study. J Bone Miner Res. 10:868 - 873.
27. Aloia JF, Roginsky MS, Jowsey J, Dombrowski CS, Shukla KK, Cohn SH. 1972 Skeletal metabolism and body composition in acromegaly. J Clin Endocrinol Metab. 35:543 - 551.
28. Kassem M, Blum W, Ristelli J, Moskilde L, Eriksen EF. 1993 Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro. Calcif Tissue Int. 52:222 - 226.
29. Nilsson A, Swolin D, Enerbäck S, Ohlsson C. 1995 Expression of functional growth hormone receptors in cultured human osteoblast-like cells. J Clin Endocrinol Metab. 80:3483 - 3488.
30. Lewinson D, Shenzer P, Hochberg Z. 1993 Growth hormone involvement in the regulation of tartrate-resistant acid phosphatase-positive cells that are active in cartilage and bone resorption. Calcif Tissue Int. 52:216 - 221.
31. Manolagas SC, Jilka RL. 1995 Bone marrow, cytokines, and bone remodeling. N Engl J Med. 332:305 - 311.
32. Lieberman SA, Holloway L, Marcus R, Hoffman AR. 1994 Interactions of growth hormone and parathyroid hormone in renal phosphate, calcium, and calcitriol metabolism and bone remodeling in postmenopausal women. J Bone Miner Res. 9:1723 - 1728.
33. Spencer EM, Tobiassen O. 1981 The mechanism of the action of growth hormone on vitamin D metabolism in the rat. Endocrinology. 108:1064 - 1070.
34. Spanos E, Barret D, Maclntyre I, Pike J, Safilial EF, Haussler MR. 1978 Effect of growth hormone on vitamin D metabolism. Nature. 273:246 - 247.
35. 3 and calcium to prevent hip fractures in elderly women. N Engl J Med. 327:1637 - 1642.
36. Aloia JF, Vaswani AN, Yeh JK, Cohn SH. 1988 Premenopausal bone mass is related to physical activity. Arch Intern Med. 148:121 - 123.
37. Block JE, Genant HK, Black D. 1986 Greater verebral bone mineral mass in exercising young men. West J Med. 145:39 - 42.
38. Inzucchi SE, Robbins RJ. 1994 Effects of growth hormone on human bone biology. J Clin Endocrinol Metab. 79:691 - 694.
39. Mȧrd G, Lundin K, Borg G, Jonsson B, Lindberg A. 1994 Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: combined data from 12 European placebo-controlled clinical trials. Endocrinol Metab. 1(Suppl A):43 - 49.
40. Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH. 1991 Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. J Appl Physiol. 70:695 - 700.
41. Dalsky GP, Stocke KS, Ehsani AA, Slatopolsky E, Lee WC, Birge Jr SJ. 1988 Weight-bearing exercise training and lumbar bone mineral content in postmenopausal women. Ann Intern Med. 108:824 - 828.
42. Eriksen EF, Brixen K, Charles P. 1995 New markers of bone metabolism: clinical use in metabolic bone disease. Eur J Endocrinol. 132:251 - 263.
43. Kotzman H, Bernecker P, Hübsch P, et al. 1993 Bone mineral density and parameters of bone metabolism in patients with acromegaly. J Bone Miner Res. 8:459 - 465.
44. Stepan JJ, Lachman M, Zverlna J, Pacovsky V, Baylink DJ. 1989 Castrated men exhibit bone loss: effect of calcitonin treatment on biochemical indices of bone remodeling. J Clin Endocrinol Metab. 69:523 - 527.
45. Smith EP, Boyd J, Frank GR, et al. 1994 Estrogen resistance caused by mutation in the estrogen-receptor gene in a man. N Engl J Med. 331:1056 - 1061.
46. Tothill P, Avenell A. 1994 Errors in dual-energy x-ray absorptiometry of the lumbar spine owing to fat distribution and soft tissue thickness during weight change. Br J Radiol. 67:71 - 75.
47. Rosén T, Johannsson C, Hallgren P, Caidahl C, Bosaeus I, Bengtsson B-Ȧ. 1994 Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults. Endocrinol Metab. 1:55 - 66.
48. Melton III LJ, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL. 1993 Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res. 8:1227 - 1233.
49. Cummings SR, Black DM, Nevitt MC, et al. 1993 Bone density at various sites for prediction of hip fracture. Lancet. 341:72 - 75.