Novel hexarelin analogs stimulate feeding in the rat through a mechanism not involving growth hormone release

European Journal of Pharmacology

Volumn 360, Issue 2-3, 1998, Pages 123-129

  Torsello, Antonio ^a   Luoni, Marina ^a   Schweiger, Francesca ^a   Grilli, Roberta ^a   Guidi, Margherita ^a   Bresciani, Elena ^a   Deghenghi, Romano ^b   Müller, Eugenio E ^a   Locatelli, Vittorio ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Ardana   (France)

Author keywords

Feeding; GH (growth hormone) secretion; GH (growth hormone) secretagogue; GHRP (growth hormone releasing peptide); Hexarelin

Indexed keywords

APPETITE STIMULANT; EP 41612; EP 41613; EP 41614; EP 41615; EP 41616; EP 50477; EP 50885; EP 50887; EP 51215; EP 51216; EP 51389; EP 51390; EP 60022; EP 60274; EP 60761; GROWTH HORMONE; HEXARELIN; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEEDING; GROWTH HORMONE RELEASE; MALE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; FEEDING BEHAVIOR; GROWTH HORMONE; GROWTH SUBSTANCES; MALE; OLIGOPEPTIDES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032491383     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00677-3     Document Type: Article

References (30)

1. Bowers C.Y. GH releasing peptides. Structure and kinetics. J. Pediatr. Endocrinol. 6:1993;21-31.
2. Bowers C.Y., Momany F.A., Reynolds G.A., Hong A. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology. 114:1984;1537-1545.
3. Bowers C.Y., Reynolds G.A., Durham D., Barrera C.M., Pezzoli S.S., Thorner M.O. Growth hormone (GH)-releasing peptide stimulates GH release in normal men and acts synergistically with GH-releasing hormone. J. Clin. Endocrinol. Metab. 70:1990;975-982.
4. Bowers C.Y., Sartor A.O., Reynolds G.A., Badger T.M. On the action of the growth hormone-releasing hexapeptide, GHRP. Endocrinology. 128:1991;2027-2035.
5. Bowers C.Y., Alster D.K., Frentz J.M. The growth hormone-releasing activity of a synthetic hexapeptide in normal men and short statured children after oral administration. J. Clin. Endocrinol. Metab. 74:1992;292-298.
6. Cella S.G., Locatelli V., De Gennaro V., Puggioni R., Pintor C., Müller E.E. Human pancreatic growth hormone (GH)-releasing hormone stimulates GH synthesis and release in infant rats, an in vivo study. Endocrinology. 116:1985;574-577.
7. Cella S.G., Locatelli V., De Gennaro V., Bondiolotti G.P., Pintor C., Loche S., Provezza M., Müller E.E. Epinephrine mediates the growth hormone-releasing effect of galanin in infant rats. Endocrinology. 122:1988;855-859.
8. Cozzi M.G., Zanini A., Locatelli V., Cella S.G., Müller E.E. Growth hormone releasing hormone and clonidine stimulate biosynthesis of growth hormone in neonatal pituitaries. Biochem. Biophys. Res. Commun. 138:1986;1223-1230.
9. Croom W.J., Leonard E.S., Baker P.K., Kraft L.A., Ricks C.A. The effects of synthetic growth hormone releasing hexapeptide BI 679 on serum growth hormone levels and production in lactating dairy cattle. J. Anim. Sci. 67:1984;109.
10. Deghenghi, R., 1996. Growth hormone releasing peptides. In: Bercu, B.B., Walker, R.F. (Eds.), Growth Hormone Secretagogues. Springer, New York, pp. 85-102.
11. Deghenghi R., Cananzi M.M., Torsello A., Battisti C., Müller E.E., Locatelli V. GH-releasing activity of hexarelin, a new growth hormone releasing peptide, in infant and adult rats. Life Sci. 54:1994;1321-1328.
12. Deghenghi R., Boutignon F., Luoni M., Grilli R., Guidi M., Locatelli V. Small peptides as potent releasers of growth hormone. J. Pediatr. Endocrinol. Metab. 8:1995;311-313.
13. Dickson S.L., Luckman S.M. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology. 138:1997;771-777.
14. Dickson S.L., Leng G., Robinson I.C.A.F. Systemic administration of growth hormone-releasing peptide activates hypothalamic arcuate neurons. Neurosci. Lett. 53:1993;303-307.
15. Dickson S.L., Leng G., Dyball R.E.J., Smith R.G. Central action of peptide and non-peptide growth hormone secretagogues in the rat. Neuroendocrinology. 61:1995;36-43.
16. Doscher M.E., Baker P.K., Kraft L.A., Ricks C.A. Effect of a synthetic growth hormone releasing hexapeptide (BI 679) and growth hormone releasing factor (GRF) on serum growth hormone levels in barrows. J. Anim. Sci. 59:1984;218.
17. Ghigo E., Arvat E., Gianotti L., Imbimbo B.P., Lenaerts V., Deghenghi R., Camanni F. Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, after intravenous, subcutaneous, intranasal, and oral administration in man. J. Clin. Endocrinol. Metab. 78:1994;693-698.
18. Guan X.M., Yu H., Palyha O.C., McKee K.K., Feighner S.D., Sirinathsinghji D.J., Smith R.G., Van der Ploegh L.H., Howard A.D. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res. Mol. Brain Res. 48:1997;23-29.
19. Hayashi S., Kaji H., Abe H., Chihara K. Effect of intravenous administration of growth hormone-releasing peptide on plasma growth hormone in patients with short stature. Clin. Pediatr. Endocrinol. 2(Suppl. 2):1993;69-74.
20. Howard A.D., Feighner S.D., Cully D.F., Arena J.P., Liberator P.A., Rosenblum C.I., Hamelin M.J., Hreniuk D.L., Palyha O.C., Anderson J., Paress P.S., Diaz C., Chou M., Liu K., McKee K.K., Pong S.S., Chaung L.Y., Elbrecht A., Dashkevicz M., Heavens R., Rigby M., Sirinathsinghji D.J.S., Dean D.C., Melillo D.G., Patchett A.A., Nargund R., Griffin P.R., DeMartino J.A., Gupta S.K., Schaeffer J.M., Smith R.G., Van der Ploeg L.H.T. Cloning of a G-protein coupled receptor for the growth hormone releasing peptide (GHRP-6) and non-peptidyl growth hormone secretagogues. Science. 273:1996;974-977.
21. Ilson B.E., Jorkasky D.K., Curnow R.T., Stote R.M. Effect of a new synthetic hexapeptide to selectively stimulate growth hormone release in healthy human subjects. J. Clin. Endocrinol. Metab. 69:1989;212-214.
22. Imbimbo B.P., Mant T., Edwards M., Amin D., Dalton N., Boutignon F., Lenaerts V., Wuthrich P., Deghenghi R. Growth hormone-releasing activity of hexarelin in humans. Eur. J. Clin. Pharmacol. 46:1994;421-425.
23. Kraft L.A., Baker P.K., Doscher M.E., Ricks C.A. Effect of a synthetic growth hormone releasing hexapeptide on serum growth hormone levels in steers. J. Anim. Sci. 59:1984;218.
24. Locke W., Kirgis H.D., Bowers C.Y., Abdoh A.A. Intracerebroventricular growth hormone-releasing peptide-6 stimulates eating without affecting plasma growth hormone responses in rats. Life Sci. 56:1995;1347-1352.
25. Malozowski S., Hao E.N., Ren S.G., Marin G., Liu L., Southers J.L., Merriam G.R. Growth hormone (GH) responses to the hexapeptide GH-releasing peptide and GH-releasing hormone (GHRH) in the cynomologus macaque: evidence for non-GHRH-mediated responses. J. Clin. Endocrinol. Metab. 73:1991;314-317.
26. Momany F.A., Bowers C.Y., Reynolds G.A., Chang D., Hong A., Newlander K. Design, synthesis and biological activity of peptides which release growth hormone in vitro. Endocrinology. 108:1981;31-39.
27. Okada K., Ishil S., Minami S., Sugihara H., Shibasaki T., Wakabayashi I. Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats. Endocrinology. 137:1996;5155-5158.
28. Pong S.S., Chaung L.Y.P., Dean D., Nargund R.P., Patchett A.A., Smith R.G. Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol. Endocrinol. 10:1996;57-61.
29. Vaccarino F.J., Bloom F.E., Rivier J., Vale W., Koob G.F. Stimulation of food intake in rats by centrally administered hypothalamic growth hormone-releasing factor. Nature. 314:1985;167-168.
30. 2 in rat, dogs, monkeys. Life Sci. 47:1990;29-36.