The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects

Diabetologia

Volumn 43, Issue 11, 2000, Pages 1408-1416

  Schrauwen, P ^a   Schaart, G ^a   Saris, W H M ^a   Slieker, L J ^b   Glatz, J F C ^a   Vidal, H ^c   Blaak, E E ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b ELI LILLY AND COMPANY   (United States)

^c INSERM   (France)

Author keywords

Gene expression; Obesity; Type II diabetes; UCP2; UCP3; Very low calorie diet (VLCD); Western blotting

Indexed keywords

FATTY ACID BINDING PROTEIN; MESSENGER RNA; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ADULT; ARTICLE; CLINICAL ARTICLE; CORRELATION FUNCTION; HUMAN; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; WEIGHT REDUCTION; WESTERN BLOTTING;

ANTIBODY SPECIFICITY; BIOPSY; BODY MASS INDEX; CARRIER PROTEINS; DIABETES MELLITUS; DIABETES MELLITUS, TYPE 2; DIET, REDUCING; ENERGY INTAKE; ENERGY METABOLISM; GENE EXPRESSION; HUMANS; IMMUNOBLOTTING; ION CHANNELS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OBESITY; PROTEINS; RNA, MESSENGER; UNCOUPLING AGENTS; WEIGHT LOSS;

EID: 0033752878     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051547     Document Type: Article

References (41)

1. Molecular studies of the uncoupling protein
2. Uncoupling protein-3: A new member of the mitochondrial carrier family with tissue-specific expression
3. UCP3: An uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue
4. Linkage between markers in the vicinity of the uncoupling protein 2 gene and resting metabolic rate in humans
5. Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima Indians
6. Skeletal muscle UCP3 expression is a determinant of energy expenditure in Pima Indians
7. Uncoupling protein-2 messenger ribonucleic acid expression during very-low-calorie diet in obese premenopausal women
8. Tissue-dependent upregulation of rat uncoupling protein-2 expression in response to fasting or cold
9. Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: Is there a role for circulating free fatty acids?
10. Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature
11. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, β3-adrenergic agonists, and leptin
12. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans
13. Uncoupling protein-3 expression in skeletal muscle and free fatty acids in obesity
14. Elevated free fatty acids induce uncoupling protein 3 expression in muscle. A potential explanation for the effect of fasting
15. Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue
16. Post-Starvation gene expression of skeletal muscle uncoupling protein 2 and uncoupling protein 3 in response to dietary fat levels and fatty acid composition. A link with insulin resistance
17. Impaired free fatty acid utilization by skeletal muscle in non-insulin dependent diabetes mellitus
18. Plasma free fatty acid utilization and fatty acid binding protein content are diminished in forearm skeletal muscle of Type II diabetic subjects during overnight fasted conditions and during exercise
19. Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects
20. Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans
21. Uncoupling protein-3 gene expression: Reduced skeletal muscle mRNA in obese humans during pronounced weight loss
22. 13C]-palmitate oxidation rates in humans
23. A new correction factor for use in tracer estimations of plasma fatty acid oxidation
24. Increase in fat oxidation on a high-fat diet is accompanied by an increase in triglyceride-derived fatty acid oxidation
25. Diet, muscle glycogen and physical performance
26. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
27. mRNA expression of the long and short forms of uncoupling protein-3 in obese and lean humans
28. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
29. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
30. One-step enzyme-linked immunosorbent assay (ELISA) for plasma fatty acid-binding protein
31. The gross composition of the body
32. Human uncoupling proteins and obesity
33. The uncoupling proteins, a review
34. Weight loss leads to a marked decrease in non-resting energy expenditure in ambulatory human subjects
35. Changes in energy expenditure resulting from altered body weight
36. Fatty acid-binding protein and its relation to fatty acid oxidation
37. Impaired long-chain fatty acid utilization by cardiac myocytes isolated from mice lacking the heart-type fatty acid binding protein gene
38. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
39. Skeletal muscle UCP3 and UCP2 gene expression in response to inhibition of free fatty acid flux through mitochondrial beta-oxidation
40. On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein
41. Uncoupling protein 3 is reduced in skeletal muscle of NIDDM patients