The TGF-β-Smad network: Introducing bioinformatic tools

Trends in Genetics

Volumn 18, Issue 2, 2002, Pages 96-103

  Kloos, Dorothee U ^a   Choi, Claudia ^a   Wingender, Edgar ^a  

^a BIOBASE GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; SMAD PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

AMINO ACID SEQUENCE; BIOINFORMATICS; DATA BASE; GENE TARGETING; HUMAN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0036468236     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(02)02556-8     Document Type: Review

References (79)

1. Nomenclature: Vertebrate mediators of TGFβ family signals
2. Controlling TGF-beta signalling
3. Phosphorylation of Ser465 and Ser467 (SSXS-motif) in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signalling
4. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
5. Signal transduction by bone morphogenetic proteins
6. Positive and negative regulation of TGF-beta signalling
7. ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signalling
8. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
9. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
10. Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components
11. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
12. Structural basis of Smad2 recognition by the Smad anchor for receptor activation
13. A structural basis for mutational inactivation of the tumour suppressor Smad4
14. Human Smad3 and Smad4 are sequence-specific transcription activators
15. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine receptors
16. Formation of a stable heterodimer between Smad2 and Smad4
17. Characterization of functional domains within Smad4/DPC4
18. Crystal structure of a transcriptionally active Smad4 fragment
19. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signalling
20. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
21. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
22. Characterization of a bone morphogenetic protein-responsive Smad binding element
23. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
24. Interaction of Smad complexes with tripartite DNA-binding sites
25. A transcriptional partner for MAD proteins in TGF-β signalling
26. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
27. TGF-β-stimulated cooperation of smad proteins with the coactivators CBP/p300
28. A Smad transcriptional corepressor
29. Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
30. Mutations in the Smad4/DPC4 gene in juvenile polyposis
31. DPC4 gene in various tumor types
32. MADR2 maps to 18q21 and encodes a TGFβ-regulated protein that is functionally mutated in colorectal carcinoma
33. Somatic in vivo alterations of the JV18-1 gene at 18q1 in human lung cancers
34. Mad-related genes in the human
35. Mutations in the tumor suppressors Smad2 and Smad4 inactivated transforming growth factor β signaling by targeting Smads to the ubiquitin-proteasome pathway
36. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
37. Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme
38. Specific sequence motif of 8-Cys repeats of TGF-beta binding proteins, LTBPs, creates a hydrophobic interaction surface for binding of small latent TGF-beta
39. Transforming growth factor-beta: Pleiotropic role in the regulation of hematopoiesis
40. Specificity, diversity, and regulation in TGF-β superfamily signalling
41. Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKBP12
42. The TGFbeta receptor activation process. An inhibitor- to substrate-binding switch
43. The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation
44. SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor
45. Interaction between Smad anchor for receptor activation and Smad3 is not essential for TGF-beta/Smad3-mediated signalling
46. Nucleocytoplasmic shuttling of smad1 conferred by its nuclear localization and nuclear export signals
47. Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus
48. Importin beta mediates nuclear translocation of Smad3
49. Transforming growth factor-beta induces nuclear import of Smad3 in an importin-beta1 and Ran-dependent manner
50. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
51. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
52. Inhibition of transforming growth factor-beta/Smad signalling by the interferon-gamma/STAT pathway
53. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors
54. Interplay of signal mediators of decapentaplegic (Dpp): Molecular characterization of mothers against dpp, Medea, and daughters against dpp
55. Smad7 and Smad6 differentially modulate transforming growth factor β-induced inhibition of embryonic lung morphogenesis
56. Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells
57. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
58. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation
59. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-beta signalling
60. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
61. Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation
62. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
63. Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1
64. Calmodulin differentially modulates Smad1 and Smad2 signalling
65. Inactivation of smad-transforming growth factor beta signalling by Ca(2+)-calmodulin-dependent protein kinase II
66. Regulation of Smad signaling by protein kinase C
67. The TRANSFAC system on gene expression regulation
68. MatInd and MatInspector - New fast and sensitive tools for detection of consensus matches in nucleotide sequence data
69. Transcription regulatory region analysis using signal detection and fuzzy clustering
70. TRANSCompel: A database on composite regulatory elements providing combinatorial transcriptional regulation
71. Recognition of NFATp/AP-1 Composite Elements within genes induced upon the activation of immune cells
72. The TRANSPATH signal transduction database: A knowledge base on signal transduction networks
73. DIP: The database of interacting proteins: 2001 Update
74. BIND - The biomolecular interaction network database
75. The modularity of biological regulatory networks
76. Structural and functional characterization of the transforming growth factor-beta-induced Smad3/c-Jun transcriptional cooperativity
77. Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
78. Smad2 and Smad3 positively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
79. Smad1 and Smad4 are components of the bone morphogenetic protein-4 (BMP-4)-induced transcription complex of the Xvent-2B promoter