HLA-DM, HLA-DO and tapasin: Functional similarities and differences

Current Opinion in Immunology

Volumn 14, Issue 1, 2002, Pages 22-29

  Brocke, Pascale ^a   Garbi, Natalio ^a   Momburg, Frank ^a   Hämmerling, Günter J ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CALRETICULIN; CHAPERONE; HLA DM ANTIGEN; HLA DO ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OXIDOREDUCTASE; PEPTIDE; TAPASIN;

ANTIBODY AFFINITY; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTATION; ANTIGEN STRUCTURE; B LYMPHOCYTE ACTIVATION; CATALYST; CELL COMPARTMENTALIZATION; CELL SURFACE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; DENDRITIC CELL; ENDOSOME; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MODEL; NONHUMAN; PROTEIN FUNCTION; REVIEW;

EID: 0036467491     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(01)00294-1     Document Type: Review

References (75)

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13. Crystal structure of mouse H2-M
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40. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules
41. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells
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51. The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation
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53. The nature of the MHC class I peptide loading complex
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57. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line .220
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65. HLA-B polymorphism affects interactions with multiple endoplasmic reticulum proteins
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67. d molecules share common tapasin dependencies as determined using a novel epitope tag
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69. Quantitative and qualitative influences of tapasin on the class I peptide repertoire
70. TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man
71. ER60/ERp57 forms disulfide-bonded intermediates with MHC class I heavy chain
72. Ligand-exchange of MHC class II proteins is triggered by H-bond donor groups of small molecules
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75. Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers