Tapasin enhances peptide-induced expression of H2-M3 molecules, but is not required for the retention of open conformers

Journal of Immunology

Volumn 167, Issue 4, 2001, Pages 2097-2105

  Lybarger, L ^a   Yu, Y Y L ^a   Chun, T ^a   Wang, C R ^a   Grandea III, A G ^a   Van Kaer, L ^a   Hansen, T H ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; TAPASIN;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CELL SURFACE; ENDOPLASMIC RETICULUM; LIGAND BINDING; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0035882013     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.4.2097     Document Type: Article

References (52)

1. Mechanisms of MHC class I-restricted antigen processing
2. The role of tapasin in MHC class 1 antigen assembly
3. The peptide-loading complex and ligand selection during the assembly of HLA class I molecules
4. Dependence of peptide binding by MHC class I molecules on their interaction with TAP
5. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes
6. Impaired assembly yet normal trafficking of MHC class I molecules in tapasin mutant mice
7. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
8. Evidence for successive peptide binding and quality control stages during MHC class I assembly
9. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
10. Soluble tapasin restores MHC class I expression and function in the tapasin-negative cell line 220
11. Distinct functions of tapasin revealed by polymorphism in MHC class I peptide loading
12. d molecules share common tapasin dependencies as determined using a novel epitope tag
13. Retention of empty MHC class I molecules by tapasin is essential to reconstitute antigen presentation in invertebrate cells
14. Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules
15. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
16. MHC class I molecules compete in the endoplasmic reticulin for access to transporter associated with antigen processing
17. MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains
18. Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction
19. HLA-B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in mechanisms of HLA class I peptide loading
20. H2-M3, a full-service class Ib histocompatibility antigen
21. d major histocompatibility complex class I chimera
22. The majority of H2-M3 is retained intracellularly in a peptide-receptive state and traffics to the cell surface in the presence of N-formylated peptides
23. Ham-2 corrects the class I antigen-processing defect in RMA-S cells
24. The alloreactive T cell response against the class lb molecule H2-M3 is specific for high affinity peptides
25. Identification of an H2-M3-restricted Listeria epitope: Implications for antigen presentation by M3
26. Definition and transfer of a serological epitope specific for peptide-empty forms of MHC class I
27. d class I major histocompatibility complex molecules determines their antigenic structure
28. Transfer and expression of three cloned non-HLA-A, -B, -C class I major histocompatibility complex genes in mutant lymphoblastoid cells
29. A Listeria monocytogenes pentapeptide is presented to cytolytic T lymphocytes by the H2-M3 MHC class Ib molecule
30. Maternally transmitted histocompatibility antigen of mice: A hydrophobic peptide of a mitochondrially encoded protein
31. ds: Sequence motif, quantitative binding, and molecular modeling of the complex
32. Solid phase peptide synthesis: The synthesis of a tetrapeptide
33. d antigen, the product of the third polymorphic locus of the mouse major histocompatibility complex
34. TAP associates with a unique class I conformation, whereas calnexin associates with multiple class I forms in mouse and man
35. 2-microglobulin complexes associate with TAP transporters before peptide binding
36. 2-microglobulin antibody and its use in the genetic and biochemical analysis of major hisotcompatibility antigens
37. Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies
38. Identification of T cell epitopes: Rapid isolation of class I-presented peptides from viable cells by mild acid elution
39. Exogenous peptides enter the endoplasmic reticulum of TAP-deficient cells and induce the maturation of nascent MHC class I molecules
40. d in cell lysates and at the cell surface
41. Effect of TAP on the generation and intracellular trafficking of peptide-receptive major histocompatibility complex class I molecules
42. Direct delivery of exogenous MHC class 1-molecule binding oligopeptides to the endoplasmic reticulin of viable cells
43. Interaction of MHC class I molecules with the transporter associated with antigen processing
44. Kinetics and affinity of reactions between antigen-specific T cell receptor and peptide-MHC complexes
45. High-affinity reactions between antigen-specific T cell receptors and peptides associated with allogeneic and syngeneic major histocompatibility complex class I proteins
46. d molecules at the cell surface
47. d molecules and of GFP-TAP1 reports on the assembly and retention of these molecules in the endoplasmic reticulin
48. Selective export of MHC class I molecules from the ER after their dissociation from TAP
49. Heat shock proteins come of age: Primitive functions acquire new roles in an adaptive world
50. Induction of ovalbumin-specific cytotoxic T cells by in vivo peptide immunization
51. MHC class I expression and transport in a calnexin-deficient cell line
52. Assembly, peptide loading, and transport of MHC class I molecules in a calnexin-negative cell line