Regulation of MHC class II antigen presentation by sorting of recycling HLA-DM/DO and class II within the multivesicular body

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 884-892

  Van Lith, M ^a   Van Ham, M ^a   Griekspoor, A ^a   Tjin, E ^a   Verwoerd, D ^a   Calafat, J ^a   Janssen, H ^a   Reits, E ^a   Pastoors, L ^a   Neefjes, J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DM ANTIGEN; HLA DO ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN PRESENTATION; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ELECTROPHORESIS; ENDOSOME; FLUORESCENCE ACTIVATED CELL SORTER; HUMAN; HUMAN CELL; IMMUNOELECTRON MICROSCOPY; INTERNALIZATION; LYSOSOME; MELANOMA CELL; PRIORITY JOURNAL;

EID: 0035879355     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.884     Document Type: Article

References (55)

1. MHC class II-associated invariant chain contains a sorting signal for endosomal compartments
2. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
3. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
4. Mediation by HLA-DM of dissociation of peptides from HLA-DR
5. Editing of the HLA-DR-peptide repertoire by HLA-DM
6. Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs
7. DOβ: A new β chain gene in HLA-D with a distinct regulation of expression
8. A novel class II MHC molecule with unusual tissue distribution
9. HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport
10. HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
11. Negative regulation by HLA-DO of MHC class II-restricted antigen processing
12. Altered antigen presentation in mice lacking H2-O
13. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
14. Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface
15. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route
16. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments
17. Molecular bases for the recognition of tyrosine-based sorting signals
18. Targeting of membrane proteins to endosomes and lysosomes
19. A lysosomal targeting signal in the cytoplasmic tail of the β chain directs HLA-DM to MHC class II compartments
20. Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB
21. HLA-DO is an intracellular class II molecule with distinctive thymic expression
22. Cellular distribution of a mixed MHC class II heterodimer between DRα and a chimeric DOβ chain
23. Two populations of la-like molecules on a human B cell line
24. Production and characterization of monoclonal antibodies recognizing the α-chain subunits of human Ia alloantigens
25. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells
26. A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex
27. HLA class II regulation and structure: Analysis with HLA-DR3 and HLA-DP point mutants
28. Association between HLA-DM and HLA-DR in vivo
29. Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments
30. Mutations in human dynamin block an intermediate stage in coated vesicle formation
31. Short cytoplasmic sequences serve as retention signals for transmembrane proteins in the endoplasmic reticulum
32. Lectin-induced retardation of subcellular organelles during preparative density gradient electrophoresis: Selective purification of plasma membranes
33. Nuclear targeting sequences: A consensus?
34. The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules
35. A role for HLA-DO as a co-chaperone of HLA-DM in peptide loading of MHC class II molecules
36. Functional HLA-DM on the surface of B cells and immature dendritic cells
37. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments
38. Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments
39. Different endocytic compartments are involved in the tight association of class II molecules with processed hen egg lysozyme and ribonuclease A in B cells
40. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms
41. Exploring the mechanisms of antigen processing by cell fractionation
42. Distinct antigen MHC class II complexes generated by separate processing pathways
43. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
44. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
45. Acceleration of intracellular targeting of antigen by the B-cell antigen receptor: Importance depends on the nature of the antigen-antibody interaction
46. Signals from the B lymphocyte antigen receptor regulate MHC class II containing late endosomes
47. Engagement of B cell receptor regulates the invariant chain-dependent MHC class II presentation pathway
48. A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
49. Functional characterization of a lysosomal sorting motif in the cytoplasmic tail of HLA-DOβ
50. Kinase activity controls the sorting of the epidermal growth factor receptor within the multivesicular body
51. HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
52. Differential expression of major histocompatibility complex class Ia, Ib, and II molecules on monocytes-derived dendritic and macrophagic cells
53. HLA-DM is present in one-fifth the amount of HLA-DR in the class II peptide-loading compartment where it associates with leupeptin-induced peptide (LIP)-HLA-DR complexes
54. Deficient peptide loading and MHC class II endosomal sorting in a human genetic immunodeficiency disease: The Chediak-Higashi syndrome
55. Enhanced interaction of HLA-DM with HLA-DR in enlarged vacuoles of hereditary and infectious lysosomal diseases