HLA-DM Is Present in One-Fifth the Amount of HLA-DR in the Class II Peptide-Loading Compartment Where It Associates with Leupeptin-Induced Peptide (LIP)-HLA-DR Complexes

Journal of Immunology

Volumn 157, Issue 12, 1996, Pages 5487-5495

  Schafer, Peter H ^a   Green, Jennifer M ^a,b   Malapati, Sunil ^a   Gu, Lin ^a   Pierce, Susan K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE ANTIGEN; H2 M ANTIGENS; H2-M ANTIGENS; HLA ANTIGEN CLASS 2; HLA D ANTIGEN; HLA DMB; HLA DR ANTIGEN; HLA-DMB; LEUPEPTIN; PEPTIDE; PEPTIDE FRAGMENT;

ARTICLE; B LYMPHOCYTE; CELL COMPARTMENTALIZATION; HUMAN; IMMUNOLOGY; INVARIANT CHAIN; MACROMOLECULE; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; SERODIAGNOSIS;

ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; B-LYMPHOCYTES; CELL COMPARTMENTATION; HISTOCOMPATIBILITY ANTIGENS CLASS II; HLA-D ANTIGENS; HLA-DR ANTIGENS; HUMANS; LEUPEPTINS; MACROMOLECULAR SUBSTANCES; PEPTIDE FRAGMENTS; PEPTIDES; PRECIPITIN TESTS; PROTEIN BINDING;

EID: 0030589330     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Fling, S., B. Arp, and D. Pious. 1994. HLA-DMA and -DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells. Nature 368:554.
2. Morris, P., J. Shaman, M. Attaya, M. Amaya, S. Goodman, C. Bergman, J. J. Monaco, and E. Mellins. 1994. An essential role for HLA-DM in antigen presentation by class II major histocompatibility molecules. Nature 368:551.
3. Ceman, S., J. W. Peterson, V. Pinet, and R. DeMars. 1994. Gene required for normal MHC class II expression and function is localized to approximately 45 kb of DMA in the class II region of the MHC. J. Immunol. 45:2865.
4. Sanderson, F., M. J. Kleijmeer, A. Kelly, D. Verwoerd, A. Tulp, J. J. Neefjes, H. J. Geuze, and J. Trowsdale. 1994. Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments. Science 266:1566.
5. Denzin, L., N. Robbins, C. Carboy-Newcomb, and P. Cresswell. 1994. Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells. Immunity 1:595.
6. Mellins, E., P. Cameron, M. Amaya, S. Goodman, D. Pious, and L. Smith. 1990. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 343:71.
7. Ceman, S., R. Rudersdorf, E. O. Long, and R. DeMars. 1992. MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability. J. Immunol. 149:754.
8. Riberdy, J., and P. Cresswell. 1992. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II artigen presentation. J. Immunol. 148: 2586.
9. Malnati, M. S., M. Marti, T. LaVaute, D. Jaraquemada, W. Biddison, R. DeMars, and E. O. Long. 1992. Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells. Nature 357:702.
10. Riberdy, J., R. Avva, H. Geuze, and P. Cresswell. 1994. Transport and intracellular distribution of MHC class II molecules and associated invariant chain in normal and antigen-processing mutant cell lines. J. Cell Biol. 125:1225.
11. Sloan, V. S., P. Cameron, G. Porter, M. Gammon, M. Amaya, E. Mellins, and D. M. Zaller. 1995. Mediation by HLA-DM of dissociation of peptides from HLA-DR. Nature 375:802.
12. Denzin, L. K., and P. Cresswell. 1995. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading. Cell 82:155.
13. Sherman, M. A., D. A. Weber, and P. E. Jensen. 1995. DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide. Immunity 3:197.
14. Karlsson, L., A. Peleraux, R. Lindstedt, M. Liljedahl, and P. Peterson. 1994. Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells. Science 266:1569.
15. Green, J. M., R. DeMars, X. Xu, and S. K. Pierce. 1995. The intracellular transport of MHC class II molecules in the absence of HLA-DM. J. Immunol. 155: 3759.
16. Pierre, P., L. K. Denzin, C. Hammond, J. R. Drake, S. Amigorena, P. Cresswell. and I. Mellman. 1996. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments. Immunity 4:229.
17. Ramachandra, L., S. Kovats, S. Eastman, and A. Y. Rudensky. 1996. Variation in HLA-DM expression influences conversion of MHC class II αβ: class II-associated invariant chain peptide complexes to mature peptide-bound class II αβ dimers in a normal B cell line. J. Immunol. 156:2196.
18. Qiu, Y., X. Xu, A. Wandinger-Ness, D. P. Dalke, and S. K. Pierce. 1994. Separation of subcellular compartments containing distinct functional forms of MHC class II. J. Cell Biol. 125:595.
19. Mellins, E., P. Cameron, M. Amaya, S. Goodman, D. Pious, L. Smith, and B. Arp. 1994. A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides. J. Exp. Med. 179:541.
20. Sanderson, F., C. Thomas, J. Neefjes, and J. Trowsdale. 1996. Association between HLA-DM and HLA-DR in vivo. Immunity 4:87.
21. DeMars, R., C. Chang, and R. Rudersdorf. 1983. Dissection of the D-region of the human major histocompatibility complex by means of induced mutations in a lymphoblastoid cell line. Hum. Immunol. 8:123.
22. DeMars, R., C. Chang, S. Shaw, P. J. Reitnauer, and P. M. Sondel. 1984. Homozygous deletions that simultaneously eliminate expressions of class I and class II antigens of EBV-transformed B-lymphoblastoid cells. I. Reduced proliferative responses of autologous and allogeneic T cells to mutant cells that have decreased expression of class II antigens. Hum. Immunol. 11:77.
23. Ceman, S., R. A. Rudersdorf, J. M. Peterson, and R. De Mars. 1995. DMA and DMB are the only genes in the class II region of the human MHC model for class II-associated antigen processing. J. Immunol. 154:2545.
24. Jelachich, M. L., M. J. Grusby, D. Clark, D. Tasch, E. Margoliash, and S. K. Pierce. 1984. Synergistic effects of antigen and soluble T-cell factors in B-lymphocyte activation. Proc. Natl. Acad. Sci. USA 81:5537.
25. Lampson, L. A., and R. Levy. 1980. Two populations of Ia-like molecules on a human B cell line. J. Immunol. 125:293.
26. Roche, P. A., M. S. Marks, and P. Cresswell. 1991. Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain. Nature 354:392.
27. Guy, K., V. Van Heyningen, B. B. Cohen, D. L. Deane, and C. M. Steel. 1982. Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains. Eur. J. Immunol. 12:942.
28. Xu, X., W. Song, H. Cho, Y. Qiu, and S. K. Pierce. 1995. Intracellular transport of invariant chain: MHC class II complexes to the peptide-loading compartment. J. Immunol. 155:2984.
29. Morton, P. A., M. L. Zachais, K. S. Giacoletto, J. A. Manning, and B. D. Schwartz. 1995. Delivery of nascent MHC class II-invariant chain complexes to lysosomal compartments and proteolysis of invariant chain by cysteine proteases precedes peptide binding in B-lymphoblastoid cells. J. Immunol. 154:137.
30. Marks, M. S., P. A. Roche, E. van Donselaar, L. Woodruff, P. J. Peters, and J. S. Bonifacino. 1995. A lysosomal targeting signal in the cytoplasmic tail of the β chain directs HLA-DM to MHC class II compartments. J. Cell Biol. 131:351.
31. Copier, J., M. J. Kleijmeer, S. Ponnambalam, V. Oorschot, P. Potter, J. Trowsdale, and A. Kelly. 1996. Targeting signal and subcellular compartments involved in the intracellular trafficking of HLA-DMB. J. Immunol. 157:1017.