Cutting edge: Editing of recycling class II:Peptide complexes by HLA-DM

Journal of Immunology

Volumn 167, Issue 2, 2001, Pages 632-635

  Pathak, S S ^a   Lich, J D ^a   Blum, J S ^a  

^a Medical Science Building ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; HLA DM ANTIGEN; HLA DO ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; ENDOCYTOSIS; ENDOSOME; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035879199     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.2.632     Document Type: Article

References (30)

1. The biochemistry and cell biology of antigen processing and presentation
2. Assembly, transport and function of MHC class II molecules
3. Lonely MHC molecules seeking immunogenic peptides for meaningful relationships
4. Altered antigen presentation in mice lacking H2-O
5. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO
6. HLA-DM is localized to conventional and unconventional MHC class II-containing endocytic compartments
7. HLA-DM acts as a molecular chaperone and rescues empty HLA-DR molecules at lysosomal pH
8. HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cells
9. Extracellular antigen processing and presentation by immature dendritic cells
10. Functional HLA-DM on the surface of B cells and immature dendritic cells
11. Peptide loading onto recycling HLA-DR molecules occurs in early endosomes
12. Early endosomes and a late endocytic compartment generate different peptide-class II MHC complexes via distinct processing mechanisms
13. Peptide exchange in MHC molecules
14. Receptor-mediated endocytosis of antigens overcomes the requirement for HLA-DM in class II-restricted antigen presentation
15. Endocytic recycling is required for the presentation of an exogenous peptide via MHC class II molecules
16. Deficient antigen-presenting cell function in multiple genetic complementation groups of type II bare lymphocyte syndrome
17. Variation in HLA-DM expression influences conversion of MHC class II αβ: Class II-associated invariant chain peptide complexes to mature peptide-bound class II αβ dimers in a normal B cell line
18. 2-terminal domain
19. HLA-DM induces CLIP dissociation from MHC class II αβ dimers and facilitates peptide loading
20. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes
21. The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation
22. Antigen presentation mediated by recycling of surface HLA-DR molecules
23. The role of H2-O and HLA-DO in major histocompatibility complex class II-restricted antigen processing and presentation
24. Editing of the HLA-DR-peptide repertoire by HLA-DM
25. Vacuolar ATPase activity is required for endosomal carrier vesicle formation
26. Bafilomycins and concanamycins as inhibitors of V-ATPases and P-ATPases
27. HLA-DM: An in vivo facilitator of MHC class II peptide loading
28. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM
29. A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway
30. A lysosomal targeting signal in the cytoplasmic tail of the β chain directs HLA-DM to MHC class II compartments