Central nervous system inflammation and neurological disease in transgenic mice expressing the CC chemokine CCL21 in oligodendrocytes

Journal of Immunology

Volumn 168, Issue 3, 2002, Pages 1009-1017

  Chen, Shu Cheng ^a   Leach, Michael W ^a   Chen, Yuetian ^a   Cai, Xiao Yan ^a   Sullivan, Lee ^a   Wiekowski, Maria ^a   Dovey Hartman, B J ^a   Zlotnik, Albert ^a   Lira, Sergio A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE;

ANIMAL TISSUE; ARTICLE; ATAXIA; ENCEPHALITIS; HISTOPATHOLOGY; IMMUNE RESPONSE; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; TRANSGENIC MOUSE; TREMOR;

EID: 0036467417     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.168.3.1009     Document Type: Article

References (67)

1. Cellular immune reactivity within the CNS
2. T-lymphocyte entry into the central nervous system
3. Immunologic mechanisms and therapy in multiple sclerosis
4. Pathology and pathogenesis of demyelinating diseases
5. The immune response in viral encephalitis
6. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
7. Lymphocyte homing and homeostasis
8. Chemokines and chemokine receptors in T-cell development
9. Chemokines
10. Recent advances in chemokines and chemokine receptors
11. Neutrophil infiltration, glial reaction, and neurological disease in transgenic mice expressing the chemokine N51/KC in oligodendrocytes
12. Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1
13. Chemokine expression in murine experimental allergic encephalomyelitis
14. Chemokines in immune-mediated inflammation of the central nervous system
15. Dynamic regulation of α- and β-chemokine expression in the central nervous system during mouse hepatitis virus-induced demyelinating disease
16. C10 is a novel chemokine expressed in experimental inflammatory demyelinating disorders that promotes recruitment of macrophages to the central nervous system
17. Identification and characterization of a novel β chemokine containing six conserved cysteines
18. Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13
19. Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension
20. Identification of a new mouse β-chemokine, thymus-derived chemotactic agent 4. With activity on T lymphocytes and mesangial cells
21. A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes
22. The role of chemokines in the microenvironmental control of T versus B cell arrest in Peyer's patch high endothelial venules
23. A lymphocyte-specific CC chemokine, secondary lymphoid tissue chemokine (SLC), is a highly efficient chemoattractant for B cells and activated T cells
24. The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3β are potent chemoattractants for in vitro- and in vivo-derived dendritic cells
25. 6-C-kine (SLC), a lymphocyte adhesion-triggering chemokine expressed by high endothelium, is an agonist for the MIP-3β receptor CCR7
26. The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3
27. Species specificity of the CC chemokine 6Ckine signaling through the CXC chemokine receptor CXCR3: Human 6Ckine is not a ligand for the human or mouse CXCR3 receptors
28. Chemokines and the arrest of lymphocytes rolling under flow conditions
29. Secondary lymphoid-tissue chemokine (SLC) stimulates integrin αδβ7-mediated adhesion of lymphocytes to mucosal addressin cell adhesion molecule-1 (MAdCAM-1) under flow
30. Identification through bioinformatics of two new macrophage proinflammatory human chemokines. MIP-3a and MIP-3β
31. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7
32. CKβ-11/macrophage inflammatory protein-3β/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells
33. Chemokines and the homing of dendritic cells to the T cell areas of lymphoid organs
34. Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse
35. The reduced expression of 6Ckine in the plt mouse results from the deletion of one of two 6Ckine genes
36. Gene duplication at the chemokine locus on mouse chromosome 4: Multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-I ligand chemokine genes in the plt mutation
37. A novel mutant gene involved in T-lymphocyte-specific homing into peripheral lymphoid organs on mouse chromosome 4
38. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
39. Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression
40. Factor influencing production frequency of transgenic mice
41. An upstream region in the sperm receptor gene directs the expression of firefly luciferase to growing oocytes of transgenic mice
42. Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone
43. Genetic models for CNS inflammation
44. EBI1-ligand chemokine (ELC) attracts a broad spectrum of lymphocytes: Activated T cells strongly up-regulate CCR7 and efficiently migrate toward ELC
45. Cutting edge: Identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK
46. Identification and molecular characterization of rat CXCR3: Receptor expression and interferon-inducible protein-10 binding are increased in focal stroke
47. Ischemia-induced neuronal expression of the microglia attracting chemokine secondary lymphoid-tissue chemokine (SLC)
48. CXCR3 expression in human central nervous system diseases
49. Purification of human eosinophil-derived neurotoxin
50. Neurotoxicity of human eosinophils
51. Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis
52. Early eosinophil infiltration into the optic nerve of mice with experimental allergic encephalomyelitis
53. Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes
54. Transgenic mouse model for central nervous system demyelination
55. Dysmyelination in class I MHC transgenic mice
56. Targeted CNS expression of interferon-γ in transgenic mice leads to hypomyelination, reactive gliosis, and abnormal cerebellar development
57. Overexpression of 2′,3′-cyclic nucleotide 3′-phosphodiesterase in transgenic mice alters oligodendrocyte development and produces aberrant myelination
58. Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice
59. Primary demyelination in transgenic mice expressing interferon-γ
60. Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice
61. Lymphocyte migration into brain modeled in vitro: Control by lymphocyte activation, cytokines and antigen
62. Adhesion of lymphocytes to cerebral microvascular cells: Effects of interferon-γ, turnout necrosis factor and interleukin-1
63. Spontaneous inflammatory demyelinating disease in transgenic mice showing central nervous system-specific expression of tumor necrosis factor α
64. Immune surveillance in the injured nervous system: T-lymphocytes invade the axotomized mouse facial motor nucleus and aggregate around sites of neuronal degeneration
65. Cutting edge: Ectopic expression of the chemokine TCA4/SLC is sufficient to trigger lymphoid neogenesis
66. Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice