Major histocompatibility complex class I expression in oligodendrocytes induces hypomyelination in transgenic mice

Journal of Neuroscience Research

Volumn 44, Issue 2, 1996, Pages 165-173

  Power, C ^a,c   Kong, P A ^a   Trapp, B D ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WINNIPEG   (Canada)

Author keywords

hypomyelination; MHC Class I; oligodendrocytes; transgenic mice

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MYELIN BASIC PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASTROCYTE; BRAIN; CONTROLLED STUDY; MICROGLIA; MOUSE; MYELIN SHEATH; MYELINATION; NONHUMAN; OLIGODENDROGLIA; PERIKARYON; PRIORITY JOURNAL; PROMOTER REGION; SPINAL CORD; TRANSGENIC MOUSE;

AGING; ANIMALS; BRAIN; DEMYELINATING DISEASES; GENES, MHC CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MICE; MICE, TRANSGENIC; MYELIN BASIC PROTEINS; OLIGODENDROGLIA; PROMOTER REGIONS (GENETICS); SPINAL CORD;

EID: 0029961665     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960415)44:2<165::AID-JNR9>3.0.CO;2-B     Document Type: Article

References (38)

1. Allison J, Campbell IL, Morahan G, Mandel TE, Harrison LC, Miller JFAP (1988): Diabetes in transgenic mice resulting from over-expression of class I histocompatibility molecules in pancreatic beta cells. Nature 333:529-533.
2. Andersson M, Paabo S. Nilsson T, Peterson PA (1985): Impaired intracellular transport of class I MHC antigens as a possible means for adenoviruses to evade immune surveillance. Cell 43:215-222.
3. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC (1987): The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512-518.
4. Brinster RL, Chen HY, Trumbauer ME, Yagle MK, Palmiter RD (1985) Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci USA 82:4438-4442.
5. Currier RD, Eldridge R (1982): Possible risk factors in multiple sclerosis as found in a national twin study. Arch Neurol 39:140-144.
6. Due C, Simonsen M, Olsson L (1986): The major histocompatibility complex class I heavy chain as a structural subunit of the human cell membrane insulin receptor: implications for the range of biological functions of histocompatibility antigens. Proc Natl Acad Sci USA 83:6007-6011.
7. Foran DR, Peterson AC (1992): Myelin acquisition in the central nervous system of the mouse revealed by an MBP-Lac Z transgene. J Neurosci 12:4890-4897.
8. Gow A, Friedrich VL, Lazzanni RA (1992): Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expression. J Cell Biol 119:605-616.
9. Hammer RE, Maika SD, Richardson JA, Tang J, Taurog JD (1990): Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human b2m an animal model of HLA-B27-associated human disorders. Cell 63:1099-1112.
10. Hayes C, Kelly D, Murayama S, Komiyama A, Suzuki K, Popko B (1992): Expression of the Neu oncogene under the transcriptional control of the myelin basic protein gene in transgenic mice: generation of transformed glial cells. J Neurosci Res 31:175-187.
11. Jackson MR, Cohen-Doyle MF, Peterson PA, Williams DB (1994): Regulation of MHC class I transport by the molecular chaperone, calnexin. Science 263:384-390.
12. Kagawa T, Ikenaka K, Inoue Y, Kuriyama S, Tsujii T, Nakao J. Nakajima K, Aruga J, Okano H, Mikoshiba K (1994): Glial cell degeneration and hypomyelmation caused by overexpression of myelin proteolipid protein gene. Neuron 13:427-442.
13. Koller BH, Marrack P, Kappler JW, Smithies O (1990): Normal development of mice deficient in b-2M, MHC class I proteins, and CD8 + cells. Science 248:1227-1230.
14. Li X, Bartlett WP (1991): Developmental expression of glial fibrillary acidic protein and glutamine synthetase mRNAs in normal and jimpy mice. Mol Brain Res 9:313-317.
15. Lo D, Burkly LC, Widera G, Cowing C, Flavell RA, Palmiter RD, Brinster RL (1988): Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells. Cell 53:159-168.
16. Macklin WB, Trapp BD, Kagawa T, Ikenaka K (1995): Hypomyelination in transgenic mice with multiple copies of the myelin proteolipid protein gene. J Neurochem 64:S86A.
17. Mauerhoff T, Pujol-Bonrell R, Mirakian R, Bottazzo GF (1988): Differential expression and regulation of major histocompatibility complex (MHC) products in neural and glial cells of the human fetal brain. J Neuroimmunol 18:271-289.
18. McFarlin DE. McFarland HF (1982): Multiple sclerosis. N Engl J Med 307:1183-1188.
19. Mucke L, Oldstone MBA (1992): The expression of major histocompatibility complex (MHC) class I antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (LCMV). J Neuroimmunol 36:193-198.
20. Power CP, Kong PA, Crawford TO, Wesselingh S, Glass JD, McArthur JC, Trapp BD (1993): Cerebral white matter changes in acquired immunodeficiency syndrome dementia: alterations in the blood-brain barrier. Ann Neurol 34:339-350.
21. Readhead C, Popko B, Takahashi N, Shine HD, Saavedra A, Sidman RL, Hood L (1987): Expression of a myelin basic protein gene in shiverer transgenic mice: Correction of the dysmyelinating phynotype. Cell 48:703-712.
22. Readhead C, Schneider A, Griffiths I, Nave K-A (1994): Premature arrest of myelin formation in transgenic mice with increased proteolipid protein gene dosage. Neuron 12:583-595.
23. dml mice. Ann Neurol 33:208-212.
24. Roitt IM (1991): ''Essential Immunology." Oxford: Blackwell Scientific, p 51.
25. Sarvetnick N. Liggitt D, Pitts SL, Hansen SE, Stewart TA (1988): Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52:773-782.
26. Schiffmann R, Moller JR, Trapp BD. Shih HH-L, Farrer RG, Katz DA, Alger JR, Parker CC, Hauer PE, Kaneski CR, et al. (1994): Childhood ataxia with diffuse central nervous system hypomyelination. Ann Neurol 35:331-340.
27. Steinman L, Rosenbaum JT, Sriram S. McDevitt HO (1981): In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis. Proc Natl Acad Sci USA 78:7111-7114.
28. Steinmetz M, Hood L (1983): Genes of the major histocompatibility complex in mouse and man. Science 222:727-733.
29. Suzumura A, Lavi E, Weiss SR, Silberberg DH (1986a): Coronavirus infection induces H-2 antigen expression on oligodendrocytes and astrocytes. Science 232:991-993.
30. Suzumura A, Silberberg DH, Lisak RP (1986b): The expression of MHC antigens on oligodendrocytes: induction of polymorphic H-2 expression by lymphokines. J Neuroimmunol 11:179-190.
31. Trapp BD, Small JA, Pulley M, Khoury G, Scangos GA (1988): Dysmyelination in transgenic mice containing JC virus early region. Ann Neurol 28:38-48.
32. Trapp BD, Andrews SB, Cootauco C, Quarles RH (1989): The myelin-associated glycoprotein is enriched in multivesicular bodies and periaxonal membranes of actively myelinating oligodendrocytes. J Cell Biol 109:2417-2426.
33. Turnley AM, Miller JFAP, Bartlett PF (1991a): Regulation of MHC molecules on MBP positive oligodendrocytes in mice by IFN-gamma and TNF-alpha. Neurosci Lett 123:45-48.
34. Turnley AM, Morahan G, Okano H, Bernard O, Mikoshiba K, Allison J, Bartlett PF, Miller JFAP (1991b): Dysmyelination in transgenic mice resulting from expression of class I histocompatibility molecules in oligodendrocytes. Nature 353:566-569.
35. Woodroofe MN, Bellamy AS, Feldmann M, Davison AN, Cuzner ML (1986): Immunocytochemical characterization of the immune reaction in the central nervous system in multiple sclerosis: possible role for microglia in lesion growth. J Neurol Sci 74: 135-152.
36. Yoshioko T, Feigenbaum L, Jay G (1991): Transgenic mouse model for central nervous system demyelination. Mol Cell Biol 11: 5479-5486.
37. Zeller NK, Hunkoler MJ, Campagnoni AT, Sprague J, Lazzarini RA (1984): Characterization of mouse myelin basic protein messenger RNAs with a myelin basic protein cDNA clone. Proc Natl Acad Sci USA 81:18-22.
38. Zijlstra M, Bix M, Simister NE, Loring JM, Raulet DH, Jaennisch R (1990): b-2 microglobulin deficient mice lack CED4-8+ cytolytic T cells. Nature 344:742-746.