Circular minidefensins and posttranslational generation of molecular diversity

Journal of Leukocyte Biology

Volumn 70, Issue 3, 2001, Pages 461-464

  Leonova, Larisa ^a,c   Kokryakov, Vladimir N ^c,d   Aleshina, Galina ^c   Hong, Teresa ^a   Nguyen, Tung ^a   Zhao, Chengquan ^a,e   Waring, Alan J ^a   Lehrer, Robert I ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ST PETERSBURG STATE UNIVERSITY   (Russian Federation)

^d INSTITUTE OF EXPERIMENTAL MEDICINE   (Russian Federation)

^e DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Antimicrobial; Defensins; Innate immunity; Peptides; RTD

Indexed keywords

DEFENSIN;

ARTICLE; MOLECULAR BIOLOGY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN PURIFICATION; PROTEIN STRUCTURE; RHESUS MONKEY; TANDEM REPEAT;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW; CLONING, MOLECULAR; DEFENSINS; DISULFIDES; HUMANS; MACACA MULATTA; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; PEPTIDES, CYCLIC; POLYMERASE CHAIN REACTION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RNA, MESSENGER; SEQUENCE HOMOLOGY, AMINO ACID; VARIATION (GENETICS);

EID: 0034841161     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Solution structure of bovine neutrophil beta-defensin-12: The peptide fold of the beta-defensins is identical to that of the classical defensins
2. The human beta defensin-1 and alpha-defensins are encoded by adjacent genes: Two peptide families with differing disulfide topology share a common ancestry
3. Gallinacin-3, an inducible epithelial beta-defensin in the chicken
4. A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated alphadefensins
5. Purification of cysteine-rich bioactive peptides from leukocytes by continuous acid-ureapolyacrylamide gel electrophoresis
6. Ultrasensitive assays for endogenous antimicrobial polypeptides
7. HBTU activation for automated Fmoc solid-phase peptide synthesis
8. Isolation and characterization of human defensin cDNA clones
9. The gene encoding the HNP-4 precursor contains a recent 86-base duplication and is located on chromosome 8
10. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiplewavelength spectrophotometry