Angiotensin II regulates phosphorylation of translation elongation factor-2 in cardiac myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 281, Issue 1 50-1, 2001, Pages

  Everett, Allen D ^a,c   Stoops, Tamara D ^a   Nairn, Angus C ^b   Brautigan, David ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Mitogen activated protein kinase; Phosphoinositide 3 kinase; Protein phosphatase 2A; Protein translation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; ELONGATION FACTOR 2; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; RAPAMYCIN; TACROLIMUS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME ACTIVITY; HEART CELL CULTURE; HEART HYPERTROPHY; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RAT; TRANSLATION REGULATION;

EID: 0034809193     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2001.281.1.h161     Document Type: Article

References (39)

1. Cardiac action of angiotensin II: Role of an intracardiac renin-angiotensin system
2. Rapamycin inhibits α1-adrenergic receptor-stimulated cardiac myocyte hypertrophy but not activation of hypertrophy-associated genes. Evidence for involvement of p70 S6 kinase
3. A signaling pathway to translational control
4. Stimulation of the p38 mitogen-activated protein kinase pathway in neonatal rat ventricular myocytes by the G protein-coupled receptor agonists, endothelin-1 and phenylephrine: A role in cardiac myocyte hypertrophy?
5. An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues
6. Pressure overload induces severe hypertrophy in mice treated with cyclosporine, an inhibitor of calcineurin
7. A synthetic inhibitor of the mitogen-activated protein kinase cascade
8. Mechanism of action of the immunosuppressant rapamycin
9. 411 in vascular smooth muscle cells
10. Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin II-induced mitogen-activated protein kinase activation in vascular smooth muscle cells
11. 1 receptor gene regulation in cardiac myocytes and fibroblasts
12. Angiotensin II stimulates phosphorylation of the translational repressor 4E-binding protein 1 by a mitogen-activated protein kinase-independent mechanism
13. Akt signaling: Linking membrane events to life and death decisions
14. Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis
15. Mitogen-activated protein kinases in rat brain neuronal culture are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors
16. Calcineurin and cardiac hypertrophy
17. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
18. Cardiac hypertrophy
19. Calcineurin inhibition and cardiac hypertrophy
20. Regulation of protein synthesis of calcium
21. r 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2
22. Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
23. Angiotensin II induces activation of phosphatidylinositol 3-kinase in cardiomyocytes
24. eIF4E activity is regulated at multiple levels
25. Activity of protein phosphatases against initiation factor-2 and elongation factor 2
26. Differing effects of the protein phosphatase inhibitors okadaic acid and microcystin on translation in reticulocyte lysates
27. The tumor promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2
28. Rapamycin selectively inhibits angiotensin II-induced increase in protein sysnthesis in cardiac myocytes in vitro: Potential role of 70kD S6 kinase in angiotensin II-induced cardiac hypertrophy
29. 2+-dependent signaling
30. Protein phosphatases: Recent progress
31. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly and cardiac gene expression in ventricular hypertrophy
32. α1-adrenergic-stimulated hypertrophy in neonatal rat heart muscle cells
33. Phosphoinositide 3-kinases: A conserved family of signal transducers
34. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
35. Fostriecin, an anti-tumor antibiotic with inhibitory activity against serine/threonine protein phosphatases 1 (PP1) and 2A (PP2A), is highly selective for PP2A
36. Activation of mRNA translation in rat cardiac myocytes by insulin involves multiple rapamycin-sensitive steps
37. Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila
38. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes
39. Failure of calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats