Vascular endothelial growth factor induces protein kinase C (PKC)-dependent Akt/PKB activation and phosphatidylinositol 3′-kinase-mediated PKCδ phosphorylation: Role of PKC in angiogenesis

Cell Biology International

Volumn 26, Issue 9, 2002, Pages 751-759

  Gliki, Georgia ^a   Wheeler Jones, Caroline ^b   Zachary, Ian ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b ROYAL VETERINARY COLLEGE   (United Kingdom)

Author keywords

Akt; Angiogenesis; Apoptosis; PKC; VEGF

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALPHOSTIN A; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE C DELTA; PROTEIN TYROSINE KINASE; RECEPTOR PROTEIN; ROTTLERIN; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; SIGNAL TRANSDUCTION; STIMULATION;

EID: 0036411819     PISSN: 10656995     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1065-6995(02)90926-1     Document Type: Article

References (46)

1. Abedi H, Zachary I, 1997. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells. J Biol Chem 272: 15442-15451.
2. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA, 1996. Mechanism of Activation of protein kinase B by Insulin and IGF-1. EMBO J 15: 6541-6551.
3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffne PR, Reese CB, Cohen P, 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261-269.
4. Alon T, Hemo I, Itin A, Pe'er J, Stone J, Keshet E, 1995. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nat Med 1: 1024-1028.
5. Burgering BM, Coffer PJ, 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602.
6. Chou MM, Hou W, Johnson J, Graham LK, Lee MH, Chen CS, Newton AC, Schaffhausen BS, Toker A, 1998. Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr Biol 8: 1069-1077.
7. Coffer PJ, Jin J, Woddgett JR, 1998. Protein Kinase B (c-Akt): a Multifunctional Mediator of Phosphatidylinositol 3-kinase Activation. Biochem d 335: 1-13.
8. Connolly DT, Olander JV, Heuvelman D, Nelson R, Monsell R, Siegel N, Haymore BE, Leimgruber R, Feder J, 1989. Human vascular permeability factor. Isolation from U937 cells, d Biol Chem 264: 20017-20024.
9. Davies SP, Reddy H, Caivano M, Cohen P, 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem d 351: 95-105.
10. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM, 1999. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605.
11. Dutil EM, Toker A, Newton AC, 1998. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK- 1). Curr Biol 8: 1366-1375.
12. Ferrara N, 1996. Vascular endothelial growth factor. Fur J Cancer 32A: 2413-2422.
13. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN, 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81: 727-736.
14. Gerber HP, McMurtrey A, Kowalski J, Yan M, Keyt BA, Dixit V, Ferrara N, 1998. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation, d Biol Chem 273: 30336-30343.
15. Gille H, Kowalski J, Yu L, Chen H, Pisabarro MT, Davis-Smyth T, Ferrara N, 2000. A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration. EMBO J 19: 4064-4073.
16. 2+. Biochem J 353: 503-512.
17. Gospodarowicz D, Abraham JA, Schilling J, 1989. Isolation and characterization of a vascular endothelial cell mitogen produced by pituitary-derived folliculo stellate cells. Proc Natl Acad Sci USA 86: 7311-7315.
18. Guo D, Jia Q, Song HY, Warren RS, Donner DB, 1995. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation. J Biol Chem 270: 6729-6733.
19. Jia H, Jezequel S, Lohr M, Shaikh S, Davis D, Soker S, Selwood D, Zachary I, 2001. Peptides encoded by Exon 6 of VEGF inhibit endothelial cell biological responses and angiogenesis induced by VEGF. Biochem Biophys Res Commun 283: 164-173.
20. Kobayashi E, Nakano H, Morimoto M, Tamaoki T, 1989. Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun 159: 548-553.
21. Konishi H, Kuroda S, Kikkawa U, 1994. The pleckstrin homology domain of RAC protein kinase associates with the regulatory domain of protein kinase C zeta. Biochem Biophys Res Commun 205: 1770-1775.
22. Laitinen M, Zachary I, Breier G, Pakkanen T, Hakkinen T, Luoma J, Abedi H, Risau W, Soma M, Laakso M, Martin JF, Yla-Herttuala S, 1997. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries. Hum Gene Ther 8: 17371744.
23. Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ, 1998. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science 281: 2042-2045.
24. Li W, Zhang J, Flechner L, Hyun T, Yam A, Franke TF, Pierce JH, 1999. Protein kinase C-α overexpression stimulates Akt activity and suppresses apoptosis induced by interleukin 3 withdrawal. Oncogene 18: 6564-6572.
25. Mao M, Fang X, Lu Y, Lpushin R, Bast RC, Mills GB, 2000. Inhibition of growth-factor-induced phosphorylation and activation of protein kinase B/Akt by atypical protein kinase C in breast cancer cells. Biochem J 352: 475-482.
26. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C, 1993. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. J Biol Chem 268: 9194-9197.
27. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z, 1999. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 13: 9-22.
28. Parekh DB, Katso RMT, Leslie NR, Downes CP, Procyc KJ, Waterfield MD, Parker PJ, 2000. β1-Integrin and PTEN control the phosphorylation of protein kinase C. Biochem J 352: 425-433.
29. Pertovarra L, Kaipainen A, Mustonen T, Orpana A, Ferrara N, Saksela O, Alitalo K, 1994. Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells. J Biol Chem 269: 6271-6274.
30. Risau W, 1997. Mechanisms of angiogenesis. Nature 386: 671-674.
31. Schreiber SL, 1991. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science 251: 283-287.
32. Soker S, Takashima H, Miao G, Neufeld G, Klagsbrun M, 1998. Neuropilin-1 is expressed by enothelial and tumour cells as an isoform-specific receptor for vascular endothelial growth factor. Cell 92.' 735-745.
33. Stavri G, Hong Y, Zachary I, Breier G, Baskerville P, Yla-Herttualla S, Risau W, Martin J, Erusalimsky J, 1995a. Hypoxia and platelet-derived growth factor-BB synergistically upregulate the expression of vascular endothelial growth factor in vascular smooth muscle cells. FEBS Lett 358:311-315.
34. Stavri G, Zachary I, Baskerville P, Martin J, Erusalimsky J, 1995b. Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Circulation 92: 5-8.
35. Stokoe D, Stephens LR, Copeland T, Gaffney PR, Reese CB, Painter GF, Holmes AB, McCormick F, Hawkins PT, 1997. Dual role of phosphatidylinositol 3,4,5trisphosphate in the activation of protein kinase B. Science 277: 567-570.
36. Takahashi T, Ueno H, Shibuya M, 1999. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18: 2221-2230.
37. Toullec D, Pianetti P, Coste H, Bellevergue P, Grandperret t, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamell L, Charon D, Kirilovsky J, 1991. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266: 1577115781.
38. Van Der Zee R, Murohara T, Luo Z, Zollmann F, Passeri J, Lekutat C, Isner JM, 1997. Vascular endothelial growth factor/vascular permeability factor augments nitric oxide release from quiescent rabbit and human vascular endothelium. Circulation 95: 1030-1037.
39. Vanhaesebroeck B, Alessi DR, 2000. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 346: 561-576.
40. Waltenberger J, Claesson-Welsh L, Siegbahn A, Shibuya M, Heldin CH, 1994. Different signal transduction properties of KDR and Flt 1, two receptors for vascular endothelial growth factor. J Biol Chem 269: 26988-26995.
41. Wellner M, Maasch C, Kupprion C, Lindschau C, Luft FC, Haller H, 1999. The proliferative effect of vascular endothelial growth factor requires protein kinase C-α and protein kinase C-ζ. Arterioscler Thromb Vasc Biol 19: 178-185.
42. 2 in endothelial cells via p42/p44 mitogen-activated protein kinase. FEBS Lett 420: 28-32.
43. Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL, 1996. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 98: 2018-2026.
44. Zachary I, Mathur A, Yla-Herttuala S, Martin JF, 2000. Vascular protection: a novel, non-angiogenic cardiovascular role for vascular endothelial growth factor. Arterioscler Thromb Vasc Biol 20: 1512-1520.
45. Zachary I, Gliki G, 2001. Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49:568-581.
46. Zheng W-H, Kar S, Quirion R, 2000. Stimulation of protein kinase C modulates insulin-like growth factor-l-induced Akt activation in PC12 Cells. J Biol Chem 275: 1337713385.