Peptides encoded by exon 6 of VEGF inhibit endothelial cell biological responses and angiogenesis induced by VEGF

Biochemical and Biophysical Research Communications

Volumn 283, Issue 1, 2001, Pages 164-173

  Jia, Haiyan ^a   Jezequel, Sylvie ^a   Löhr, Marianne ^b   Shaikh, Shaheda ^b   Davis, Dana ^b   Soker, Shay ^c   Selwood, David ^b   Zachary, Ian ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Apoptosis; ERK; KDR; Migration; Neuropilin 1; Prostacyclin

Indexed keywords

ANGIOGENESIS INHIBITOR; BASIC FIBROBLAST GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPILIN; PROSTACYCLIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN[11-22]; VASCULOTROPIN[121-132]; VASCULOTROPIN[125-136]; VASCULOTROPIN[129-140]; VASCULOTROPIN[133-144];

ANGIOGENESIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; CROSS LINKING; ENDOTHELIUM CELL; ENZYME ACTIVITY; EXON; HUMAN; HUMAN CELL; MITOGENESIS; PRIORITY JOURNAL; RECEPTOR BINDING;

SUIDAE;

EID: 0034794764     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4761     Document Type: Article

References (39)

1. Role of vascular endothelial growth factor in the regulation of angiogenesis
2. Vascular endothelial growth factor (VEGF) and its receptors
3. The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
4. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
5. VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix
6. Basic fibroblast growth factor upregulates the expression of vascular endothelial growth factor in vascular smooth muscle cells. Synergistic interaction with hypoxia
7. Fibroblast growth factor-2
8. Tumor angiogenesis: Past, present and the near future
9. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases
10. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)
11. A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain
12. Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1
13. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases
14. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
15. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells
16. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
17. Neuropilin-1 is a placenta growth factor-2 receptor
18. Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1
19. Signaling via vascular endothelial growth factor receptors
20. Signal relays in the VEGF system
21. VEGF gene transfer reduces intimal thickening via increased production of nitric oxide in carotid arteries
22. Vascular endothelial growth factor stimulates prostacyclin production and activation of cytosolic phospholipase A2 in endothelial cells via p42/p44 mitogen-activated protein kinase
23. 2-
24. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
25. Functions of the VEGF receptor-1 (FLT-1) in the vasculature
26. Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site
27. Identification of vascular endothelial growth factor determinants for binding KDR and FLT-1 receptors. Generation of receptor-selective VEGF variants by site-directed mutagenesis
28. Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain
29. Cell release of bioactive fibroblast growth factor 2 by exon 6-encoded sequence of vascular endothelial growth factor
30. Expression of vascular permeability factor/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis
31. Angiogenesis in cancer, vascular, rheumatoid and other disease
32. Enhancement of tumor growth and vascular density by transfection of vascular endothelial cell growth factor into MCF-7 human breast carcinoma cells
33. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis
34. Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor121
35. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
36. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
37. Quantitation and prognostic value of breast cancer angiogenesis: Comparison of microvessel density, Chalkley count, and computer image analysis
38. Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation by a peptide corresponding to the exon 7-encoded domain of VEGF165
39. The role of syndecan cytoplasmic domain in basic fibroblast growth factor-dependent signal transduction