β1-Integrin and PTEN control the phosphorylation of protein kinase C

Biochemical Journal

Volumn 352, Issue 2, 2000, Pages 425-433

  Parekh, D B ^a   Katso, R M T ^a   Leslie, N R ^a   Downes, C P ^a   Procyk, K J ^a   Waterfield, M D ^a   Parker, P J ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Adherence; Phosphatidylinositol 3 kinase; Phosphoinositide phosphatase; Tumour suppressor

Indexed keywords

BETA1 INTEGRIN; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE C; ISOENZYME; PHOSPHATASE; PRKCD PROTEIN, HUMAN; PROTEIN KINASE C DELTA; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ALLOSTERISM; ARTICLE; BLADDER CARCINOMA; CARCINOMA CELL; CELL CULTURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN INTERACTION; TUMOR SUPPRESSOR GENE; CELL LINE; ENZYME ACTIVATION; HUMAN; METABOLISM; PHOSPHORYLATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTIGENS, CD29; CELL LINE; ENZYME ACTIVATION; HUMANS; ISOENZYMES; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASE C-DELTA; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0034537553     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3520425     Document Type: Article

References (39)

1. Modulation of growth tactor responsiveness of murine mammary carcinoma cells by cell matrix interactions: Correlation of cell proliferation and spreading
2. Activation of Rac and Cdc42 by integrins mediates cell spreading
3. Multiple pathways control protein kinase C phosphorylation
4. Protein kinase C isotypes controled by phosphoinositide 3-kinase through the protein kinase PDK1
5. Regulation of protein kinase C ζ by PI 3-kinase and PDK-1
6. Regulation of conventional protein kinase C isozymes by phosphoinositide-dependent kinase 1 (PDK-1)
7. Rapamycin-sensitive phosphorylation of PKC on a carboxyterminal site by an atypical PKC complex
8. The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
9. mTOR controls one of two kinase pathways acting upon nPKCδ and nPKCε
10. PTEN: A tumour suppressor that functions as a phospholipid phosphatase
11. Calcium phosphate-mediated gene transfer: A highly efficient transfection system for slably transfoming cells with plasmid DNA
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. Activation of multiple interleukin-1β converting enzyme homologues in cytosol and nuclei of HL-60 cells during eloposide-induced apoptosis
14. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
15. A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry
16. Phosphorylation of protein kinase C-α on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase-resistant state
17. PTEN gene and integrin signaling in cancer
18. The expression profile for the tumour suppressor gone PTEN and associated polymorphic markers
19. PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase/Akt cell survival pathway
20. The lipid phosphatase activity of PTEN is critical for its tumor supressor function
21. Biosynthesis and post-translational modifications of protein kinase C in human breast cancer cells
22. Studies on the phosphorylation of protein kinase C-α
23. Determination of in vivo phosphorylation sites in protein kinase C
24. Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
25. Regulation of profein kinase C
26. Phosphorylation of threonine-638 critically controls the dephosphorylation and inactivation of protein kinase C-α
27. The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
28. 12-O-Tetradecanoylphorbol-13-acetate-induced dephosphorylation of protein kinase Cα correlates with the presence of a membrane associated protein phosphatase 2A heterotrimer
29. Integrins, oncogenes, and anchorage independence
30. Signalling by integrin receptors
31. Integrins and anoikis
32. Matrix adhesion and Ras transformation both activate a phospholnositide 3-DH kinase and protein kinase B/Akt cellular survival pathway
33. Akt phcophorylation of BAD couples survival signals to the cell-intrinsic death machinery
34. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
35. Loss of protein kinase C function induces an apoptotic response
36. Focal adhesion kinase in integrin-mediated signaling
37. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
38. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
39. Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B