The proliferative effect of vascular endothelial growth factor requires protein kinase C-α and protein kinase C-ζ

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 1, 1999, Pages 178-185

  Wellner, Maren ^a   Maasch, Christian ^a   Kupprion, Christine ^a   Lindschau, Carsten ^a   Luft, Friedrich C ^a   Haller, Hermann ^a,b  

^a HUMBOLDT UNIVERSITY   (Germany)

^b FRANZ VOLHARD CLINIC   (Germany)

Author keywords

Cell proliferation; Cytosolic calcium; Endothelial cells; Isoforms; Protein kinase C; VEGF

Indexed keywords

ISOENZYME; PROTEIN KINASE C; VASCULOTROPIN;

ARTERY INTIMA PROLIFERATION; ARTICLE; CELL PROLIFERATION; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; GROWTH REGULATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM;

EID: 0032952924     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.1.178     Document Type: Article

References (44)

1. Neufeld G, Tessler S, Gitay Goren H, Cohen T, Levi BZ. Vascular endothelial growth factor and its receptors. Prog Growth Factor Res. 1994;5:89-97.
2. Tischer E, Mitchell R, Hartman T, Silva M, Gospodarowicz D, Fiddes JC, Abraham JA. The human gene for vascular endothelial growth factor: multiple protein forms are encoded through alternative exon splicing. J Biol Chem. 1991;266:11947-11954.
3. Senger DR, Brown LF, Claffey KP, Dvorak HF. Vascular permeability factor, tumor angiogenesis and stroma generation. Invasion Metastasis. 1994;14:385-394.
4. Connolly DT. Vascular permeability factor: a unique regulator of blood vessel function. J Cell Biochem. 1991;47:219-223.
5. de Vries C, Escobedo JA, Ueno H, Houck K, Ferrara N, Williams LT. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science. 1992;255:989-991.
6. Millauer B, Wizigmann Voos S, Schnurch H, Martinez R, Moller NP, Risau W, Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell. 1993;72:835-846.
7. Waltenberger J, Claesson Welsh L, Siegbahn A, Shibuya M, Heldin CH. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J Biol Chem. 1994;269: 26988-26995.
8. Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995;376:66-70.
9. Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF, Breitman ML, Schuh AC. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-66.
10. Kazlauskas A. Receptor tyrosine kinases and their targets. Curr Opin Genet Dev. 1994;4:5-14.
11. Enomoto T, Okamoto T. Sato JD. Vascular endothelial growth factor induces the disorganization of actin stress fibers accompanied by protein tyrosine phosphorylation and morphological change in Balb/C3T3 cells. Biochem Biophys Res Commun. 1994;202:1716-1723.
12. Guo D, Jia Q, Song HY, Warren RS, Donner DB. Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains: association with endothelial cell proliferation. J Biol Chem. 1995;270:6729-6733.
13. Bates DO, Curry FE. Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway. Am J Physiol. 1997;273:H687-H694.
14. Berk BC, Alexander RW, Brock TA, Gimbrone MA Jr, Webb RC. Vasoconstriction: a new activity for platelet-derived growth factor. Science. 1986;232:87-90.
15. Kohn EC, Alessandro R, Spoonster J, Wersto RW, Liotta LA. Angiogenesis: role of calcium-mediated signal transduction. Proc Natl Acad Sci USA. 1995;92:1307-1311.
16. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1993;258:607-614.
17. Montesano R, Pepper MS, Vassalli JD, Orci L. Modulation of angiogenesis in vitro. EXS. 1992;61:129-136.
18. Hu DE, Fan TP. Protein kinase C inhibitor calphostin C prevents cytokine-induced angiogenesis in the rat. Inflammation. 1995;19:39-54.
19. Nishizuka Y. The Albert Lasker Medical Awards: the family of protein kinase C signal transduction. JAMA. 1989;262:1826-1833.
20. Nishizuka Y. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 1988;334:661-665.
21. Haller H, Ziegler W, Lindschau C, Luft FC. Endothelial cell tyrosine kinase receptor and G-protein coupled receptor activation involves distinct protein kinase C isoforms. Arterioscler Thromb Vasc Biol. 1996; 16:678-686.
22. Haller H, Rieger M, Lindschau C, Kuhlmann M, Philipp S, Luft. FC. LDL increases Ca++ in human endothelial cells and augments thrombininduced cell signalling. J Lab Clin Med. 1994;124:708-714.
23. Haller H, Lindschau C, Quass P, Distler A, Luft FC. Nuclear calcium signalling is initiated by cytosolic calcium surges in vascular smooth muscle cells. Kidney Int. 1994;46:1653-1662.
24. Haller H, Baur E, Quass P, Behrend M, Lindschau C, Distler A, Luft FC. High glucose concentrations and protein kinase C isoforms in vascular smooth muscle cells. Kidney Int. 1995;47:1057-1067.
25. Kuriyama S, Ohuchi T, Yoshimura N, Honda Y. Growth factor-induced cytosolic calcium ion transients in cultured human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 1991;32:2882-2890.
26. Okamoto T, Asano T, Harada S, Ogata E, Nishimoto I. Regulation of transmembrane signal transduction of insulin-like growth factor II by competence type growth factors or viral ras p21. J Biol Chem. 1991;266: 1085-1091.
27. Takahashi T, Shibuya M. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-gamma pathway and partially induces mitotic signals in NIH3T3 fibroblasts. Oncogene. 1997;14: 2079-2089.
28. Lozano J, Berra E, Municio MM, Diaz-Meco MT, Dominguez I, Sanz L, Moscat J. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. J Biol Chem. 1994;269: 19200-19202.
29. Nanberg E, Morris C, Higgins T, Vara F, Rozengurt E. FGF stimulates protein kinase C in quiescent 3T3 cells without calcium mobilization or inositol phosphate accumulation. J Cell. Physiol. 1990;143:232-242.
30. Haller H, Lindschau C, Quass P, Distler A, Luft FC. Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-α. Circ Res. 1995;76:21-29.
31. Haller H, Lindschau C, Quass P, Luft FC, Distler A. Platelet-derived growth factor and angiotensin II induce different spatial distribution of protein kinase C-α and -β in vascular smooth muscle cells. Hypertension. 1994;23:848-852.
32. Leach KL, Powers EA, Ruff VA, Jaken S, Kaufmann S. Type 3 protein kinase C localization to the nuclear envelope of phorbol ester treated NIH 3T3 cells. J Cell Biol. 1989;109:685-695.
33. James G, Olson E. Deletion of the regulatory domain of protein kinase C-α exposes regions in the hinge and catalytic domains that mediate nuclear targeting. J Cell Biol. 1992;116:863-874.
34. Neri LM, Billi AM, Manzoli L, Rubbini S, Gilmour RS, Cocco L, Martelli AM. Selective nuclear translocation of protein kinase C alpha in Swiss 3T3 cells treated with IGF-I, PDGF and EGF. FEBS Lett. 1994; 347:63-68.
35. Irvine RF, Divecha N. Nuclear functions of protein kinase C. Semin Cell Biol. 1992;3:225-235.
36. Divecha N, Banfic H, Irvine RF. Inositides and the nucleus and inositides in the nucleus. Cell. 1993;74:405-407.
37. Tahayato A, Lefebvre P, Formstecher P, Dautrevaux M. A protein kinase C-dependent activity modulates retinoic acid-induced transcription. Mol Endocrinol. 1993;7:1642-1653.
38. Zhou W, Takuwa N, Kumada M, Takuwa Y, E2F1, B-myb and selective members of cyclin/cdk subunits are targets for protein kinase C-mediated bimodal growth regulation in vascular endothelial cells. Biochem Biophys Res Commun. 1994;199:191-198.
39. Zhou W, Takuwa N, Kumada M, Takuwa Y. Protein kinase C-mediated bidirectional regulation of DNA synthesis, RB protein phosphorylation, and cyclin-dependent kinases in human vascular endothelial cells. J Biol Chem. 1993;268:23041-23048.
40. Kosaka C, Sasaguri T, Masuda J, Zen K, Shimokado K, Yokota T. Ogata J. Protein kinase C-mediated inhibition of cyclin A expression in human vascular endothelial cells. Biochem Biophys Res Commun. 1993;193: 991-998.
41. Berra E, Diaz-Meco MT, Dominguez I, Municio MM, Sanz L, Lozano J, Chapkin RS, Moscat J. Protein kinase C zeta isoform is critical for mitogenic signal transduction. Cell. 1993;74:555-563.
42. Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT. Zeta PKC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem. 1994;269:10044-10049.
43. v integrins. Science. 1992;270:1500-1503.
44. Xia P, Aiello LP, Ishii H, Jiang ZY, Park DJ, Robinson GS, Takagi H, Newsome WP, Jirousek MR, King GL. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest. 1996;98: 2018-2026.