메뉴 건너뛰기




Volumn 19, Issue 2, 2002, Pages 76-84

Interleukin-12 inhibits eotaxin secretion of cultured primary lung cells and alleviates airway inflammation in vivo

Author keywords

Eotaxin; Interferon ; Interleukin 12; Lung cell culture

Indexed keywords

CYTOKINE; EOTAXIN; GAMMA INTERFERON; GAMMA INTERFERON ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 14; PLASMID DNA;

EID: 0036385403     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.2002.1950     Document Type: Article
Times cited : (19)

References (54)
  • 1
    • 0024467154 scopus 로고
    • Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes
    • Kobayashi M, Fitz L, Ryan M, Hewick RM, Clark SC, Chan S, Loudon R, Sherman F, Perussia B, Trinchieri G (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 170:827-845.
    • (1989) J Exp Med , vol.170 , pp. 827-845
    • Kobayashi, M.1    Fitz, L.2    Ryan, M.3    Hewick, R.M.4    Clark, S.C.5    Chan, S.6    Loudon, R.7    Sherman, F.8    Perussia, B.9    Trinchieri, G.10
  • 3
    • 0028281585 scopus 로고
    • Interleukin 12: A key modulator of immune function
    • Wolf SF, Sieburth D, Sypek J (1994) Interleukin 12: a key modulator of immune function. Stem Cells 12:154-168.
    • (1994) Stem Cells , vol.12 , pp. 154-168
    • Wolf, S.F.1    Sieburth, D.2    Sypek, J.3
  • 4
    • 0028013068 scopus 로고
    • Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohemopoietic progenitors in culture
    • Hirayama F, Katayama N, Neben S, Donaldson D, Nickbarg EB, Clark SC, Ogawa M (1994) Synergistic interaction between interleukin-12 and steel factor in support of proliferation of murine lymphohemopoietic progenitors in culture. Blood 83:92-98.
    • (1994) Blood , vol.83 , pp. 92-98
    • Hirayama, F.1    Katayama, N.2    Neben, S.3    Donaldson, D.4    Nickbarg, E.B.5    Clark, S.C.6    Ogawa, M.7
  • 5
    • 0027203303 scopus 로고
    • Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells
    • Jacobsen SE, Veiby OP, Smeland EB (1993) Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells. J Exp Med 178:413-418.
    • (1993) J Exp Med , vol.178 , pp. 413-418
    • Jacobsen, S.E.1    Veiby, O.P.2    Smeland, E.B.3
  • 8
    • 0028862097 scopus 로고
    • Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes
    • Miller MA, Skeen MJ, Ziegler HK (1995) Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. J Immunol 155:4817-4828.
    • (1995) J Immunol , vol.155 , pp. 4817-4828
    • Miller, M.A.1    Skeen, M.J.2    Ziegler, H.K.3
  • 9
    • 0028821825 scopus 로고
    • Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice
    • Gavett SH, O'Hearn DJ, Li X, Huang SK, Finkelman FD, Karp MW (1995) Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice. J Exp Med 182:1527-1536.
    • (1995) J Exp Med , vol.182 , pp. 1527-1536
    • Gavett, S.H.1    O'Hearn, D.J.2    Li, X.3    Huang, S.K.4    Finkelman, F.D.5    Karp, M.W.6
  • 10
    • 0033665039 scopus 로고    scopus 로고
    • Environmental factors favoring the allergen-specific Th2 response in allergic subjects
    • Piccinni MP, Maggi E, Romagnani S (2000) Environmental factors favoring the allergen-specific Th2 response in allergic subjects. Ann NY Acad Sci 917:844-852.
    • (2000) Ann NY Acad Sci , vol.917 , pp. 844-852
    • Piccinni, M.P.1    Maggi, E.2    Romagnani, S.3
  • 12
    • 0025008579 scopus 로고
    • The eosinophil and bronchial asthma: Current understanding
    • Gleich GJ (1990) The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 85:422-436.
    • (1990) J Allergy Clin Immunol , vol.85 , pp. 422-436
    • Gleich, G.J.1
  • 13
    • 0027715955 scopus 로고
    • The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo
    • Griffths-Johnson DA, Collins PD, Rossi AG, Jose PJ, Williams TJ (1993) The chemokine, eotaxin, activates guinea-pig eosinophils in vitro and causes their accumulation into the lung in vivo. Biochem Biophys Res Commun 197:1167-1172.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 1167-1172
    • Griffths-Johnson, D.A.1    Collins, P.D.2    Rossi, A.G.3    Jose, P.J.4    Williams, T.J.5
  • 14
    • 0030248686 scopus 로고    scopus 로고
    • Tissue-specific migration of lymphocytes: A key role for Th1 and Th2 cells?
    • Meeusen EN, Premier RR, Brandon MR (1996) Tissue-specific migration of lymphocytes: a key role for Th1 and Th2 cells? Immunol Today 17:421-424.
    • (1996) Immunol Today , vol.17 , pp. 421-424
    • Meeusen, E.N.1    Premier, R.R.2    Brandon, M.R.3
  • 15
    • 0032213360 scopus 로고    scopus 로고
    • Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels
    • Hofstra CL, Van Ark I, Hofman G, Kool M, Nijkamp FP, Van Oosterhout A J (1998) Prevention of Th2-like cell responses by coadministration of IL-12 and IL-18 is associated with inhibition of antigen-induced airway hyperresponsiveness, eosinophilia, and serum IgE levels. J Immunol 161:5054-5060.
    • (1998) J Immunol , vol.161 , pp. 5054-5060
    • Hofstra, C.L.1    Van Ark, I.2    Hofman, G.3    Kool, M.4    Nijkamp, F.P.5    Van Oosterhout, A.J.6
  • 18
    • 0029847440 scopus 로고    scopus 로고
    • Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways
    • Iwamoto I, Kumano K, Kurasawa K, Nakao A (1996) Interleukin-12 prevents antigen-induced eosinophil recruitment into mouse airways. Am J Respir Crit Care Med 154:1257-1260.
    • (1996) Am J Respir Crit Care Med , vol.154 , pp. 1257-1260
    • Iwamoto, I.1    Kumano, K.2    Kurasawa, K.3    Nakao, A.4
  • 19
    • 0031817368 scopus 로고    scopus 로고
    • Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice
    • Schwarze J, Hamelmann E, Cieslewicz G, Tomkinson A, Joetham A, Bradley K, Gelfand EW (1998) Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice. J Allergy Clin Immunol 102:86-93.
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 86-93
    • Schwarze, J.1    Hamelmann, E.2    Cieslewicz, G.3    Tomkinson, A.4    Joetham, A.5    Bradley, K.6    Gelfand, E.W.7
  • 20
    • 0031952393 scopus 로고    scopus 로고
    • Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity
    • Hogan SP, Foster PS, Tan X, Ramsay AJ (1998) Mucosal IL-12 gene delivery inhibits allergic airways disease and restores local antiviral immunity. Eur J Immunol 28:413-423.
    • (1998) Eur J Immunol , vol.28 , pp. 413-423
    • Hogan, S.P.1    Foster, P.S.2    Tan, X.3    Ramsay, A.J.4
  • 21
    • 0033543072 scopus 로고    scopus 로고
    • Systemic and local interferon γ gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice
    • Dow SW, Schwarze J, Heath TD, Potter TA, Gelfand EW (1999) Systemic and local interferon γ gene delivery to the lungs for treatment of allergen-induced airway hyperresponsiveness in mice. Human Gene Ther 10:1905-1914.
    • (1999) Human Gene Ther , vol.10 , pp. 1905-1914
    • Dow, S.W.1    Schwarze, J.2    Heath, T.D.3    Potter, T.A.4    Gelfand, E.W.5
  • 23
    • 0035873683 scopus 로고    scopus 로고
    • IL-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity
    • Walter DM, Wong CP, DeKruyff RH, Berry GJ, Levy S, Umetsu DT (2001) IL-18 gene transfer by adenovirus prevents the development of and reverses established allergen-induced airway hyperreactivity. J Immunol 15; 166:6392-6398.
    • (2001) J Immunol , vol.15 , Issue.166 , pp. 6392-6398
    • Walter, D.M.1    Wong, C.P.2    DeKruyff, R.H.3    Berry, G.J.4    Levy, S.5    Umetsu, D.T.6
  • 24
    • 0033230302 scopus 로고    scopus 로고
    • T helper1 cells and interferon γ regulate allergic airway inflammation and mucus production
    • Cohn L, Homer RJ, Niu N, Bottomly K (1999) T helper1 cells and interferon γ regulate allergic airway inflammation and mucus production. J Exp Med 189:1309-1317.
    • (1999) J Exp Med , vol.189 , pp. 1309-1317
    • Cohn, L.1    Homer, R.J.2    Niu, N.3    Bottomly, K.4
  • 25
    • 0031054101 scopus 로고    scopus 로고
    • Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: Nature of the cleaved fragment in relation to the structure and function of CD23
    • Schulz O, Sutton BJ, Beavil RL, Shi J, Sewell HF, Gould HJ, Laing P, Shakib F (1997) Cleavage of the low-affinity receptor for human IgE (CD23) by a mite cysteine protease: nature of the cleaved fragment in relation to the structure and function of CD23. Eur J Immunol 27:584-588.
    • (1997) Eur J Immunol , vol.27 , pp. 584-588
    • Schulz, O.1    Sutton, B.J.2    Beavil, R.L.3    Shi, J.4    Sewell, H.F.5    Gould, H.J.6    Laing, P.7    Shakib, F.8
  • 26
    • 0032127867 scopus 로고    scopus 로고
    • A mite subversive: Cleavage of CD23 and CD25 by Der p1 enhances allergenicity
    • Shakib F, Schulz O, Sewell H (1998) A mite subversive: cleavage of CD23 and CD25 by Der p1 enhances allergenicity. Immunol Today 19:313-316.
    • (1998) Immunol Today , vol.19 , pp. 313-316
    • Shakib, F.1    Schulz, O.2    Sewell, H.3
  • 27
    • 0029991462 scopus 로고    scopus 로고
    • The house dust mite allergen Der p 1 catalytically inactivates α1-antitrypsin by specific reactive center loop cleavage: A mechanism that promotes airway inflammation and asthma
    • Kalsheker NA, Deam S, Chambers L, Sreedharan S, Brocklehurst K, Lomas DA (1996) The house dust mite allergen Der p 1 catalytically inactivates α1-antitrypsin by specific reactive center loop cleavage: a mechanism that promotes airway inflammation and asthma. Biochem Biophys Res Commun 221:59-61.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 59-61
    • Kalsheker, N.A.1    Deam, S.2    Chambers, L.3    Sreedharan, S.4    Brocklehurst, K.5    Lomas, D.A.6
  • 28
    • 0033049930 scopus 로고    scopus 로고
    • Administration of IL-12 prevents mite Der p 1 allergen-IgE antibody production and eosinophils infiltration in animal model of airway inflammation
    • Lee YL, Fu CL, Ye YL, Chiang BL (1999) Administration of IL-12 prevents mite Der p 1 allergen-IgE antibody production and eosinophils infiltration in animal model of airway inflammation. Scand J Immunol 49:229-336.
    • (1999) Scand J Immunol , vol.49 , pp. 229-336
    • Lee, Y.L.1    Fu, C.L.2    Ye, Y.L.3    Chiang, B.L.4
  • 29
    • 0033027348 scopus 로고    scopus 로고
    • Administration of IL-12 exerts therapeutic instead of long-term preventive effect on Der p 1 allergen-Induced animal model of airway inflammation
    • Lee YL, Fu CL, Chiang BL (1999) Administration of IL-12 exerts therapeutic instead of long-term preventive effect on Der p 1 allergen-Induced animal model of airway inflammation. Immunology 97:232-240.
    • (1999) Immunology , vol.97 , pp. 232-240
    • Lee, Y.L.1    Fu, C.L.2    Chiang, B.L.3
  • 33
    • 0031445441 scopus 로고    scopus 로고
    • Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells
    • Ying S, Robinson DS, Meng Q, Rottman J, Kennedy R, Ringler DJ, Mackay CR, Daugherty BL, Springer MS, Durham SR, Williams TJ, Kay AB (1997) Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells. Eur J Immunol 27:3507-3516.
    • (1997) Eur J Immunol , vol.27 , pp. 3507-3516
    • Ying, S.1    Robinson, D.S.2    Meng, Q.3    Rottman, J.4    Kennedy, R.5    Ringler, D.J.6    Mackay, C.R.7    Daugherty, B.L.8    Springer, M.S.9    Durham, S.R.10    Williams, T.J.11    Kay, A.B.12
  • 34
    • 0033560126 scopus 로고    scopus 로고
    • Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production
    • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, Zhang Y, Elias JA (1999) Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest 103:779-788.
    • (1999) J Clin Invest , vol.103 , pp. 779-788
    • Zhu, Z.1    Homer, R.J.2    Wang, Z.3    Chen, Q.4    Geba, G.P.5    Wang, J.6    Zhang, Y.7    Elias, J.A.8
  • 35
    • 0033104696 scopus 로고    scopus 로고
    • Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells
    • Li L, Xia Y, Nguyen A, Lai YH, Feng L, Mosmann TR, Lo David (1999) Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells. J Immunol 162:2477-2487.
    • (1999) J Immunol , vol.162 , pp. 2477-2487
    • Li, L.1    Xia, Y.2    Nguyen, A.3    Lai, Y.H.4    Feng, L.5    Mosmann, T.R.6    Lo, D.7
  • 36
    • 0030668116 scopus 로고    scopus 로고
    • Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration
    • Song YK, Liu F, Chu S, Liu D (1997) Characterization of cationic liposome-mediated gene transfer in vivo by intravenous administration. Human Gene Ther 8:1585-1594.
    • (1997) Human Gene Ther , vol.8 , pp. 1585-1594
    • Song, Y.K.1    Liu, F.2    Chu, S.3    Liu, D.4
  • 37
    • 0027313072 scopus 로고
    • Systemic gene expression after intravenous DNA delivery into adult mice
    • Zhu N, Liggitt D, Liu Y, Debs R (1993) Systemic gene expression after intravenous DNA delivery into adult mice. Science 261:209-211.
    • (1993) Science , vol.261 , pp. 209-211
    • Zhu, N.1    Liggitt, D.2    Liu, Y.3    Debs, R.4
  • 38
    • 0031851486 scopus 로고    scopus 로고
    • Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery
    • Li S, Rizzo MA, Bhattacharya S, Huang L (1998) Characterization of cationic lipid-protamine-DNA (LPD) complexes for intravenous gene delivery. Gene Ther 5:930-937.
    • (1998) Gene Ther , vol.5 , pp. 930-937
    • Li, S.1    Rizzo, M.A.2    Bhattacharya, S.3    Huang, L.4
  • 39
    • 0030634166 scopus 로고    scopus 로고
    • Evidence for the increase in asthma worldwide
    • Woolcock AJ, Peat JK (1997) Evidence for the increase in asthma worldwide. Ciba Found Symp 206:122-134.
    • (1997) Ciba Found Symp , vol.206 , pp. 122-134
    • Woolcock, A.J.1    Peat, J.K.2
  • 40
    • 0028981432 scopus 로고
    • Allergen-stimulated interleukin-4 and interferon -production in primary culture: Responses of subjects with allergic rhinitis and normal controls
    • Imada M, Simons FE, Jay FT, Hayglass K (1995) Allergen-stimulated interleukin-4 and interferon -production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunology 85:373-380.
    • (1995) Immunology , vol.85 , pp. 373-380
    • Imada, M.1    Simons, F.E.2    Jay, F.T.3    Hayglass, K.4
  • 41
    • 0029047009 scopus 로고
    • Biology of disease: Interleukin-12, biology activity, therapeutic utility, and role in disease
    • Hendrzak JA, Brunda MJ (1995) Biology of disease: Interleukin-12, biology activity, therapeutic utility, and role in disease. Lab Invest 72:619-637.
    • (1995) Lab Invest , vol.72 , pp. 619-637
    • Hendrzak, J.A.1    Brunda, M.J.2
  • 43
    • 0029015978 scopus 로고
    • IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes
    • Marshall JD, Secrist H, DeKruyff RH, Wolf SF, Umetsu DT (1995) IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes. J Immunol 155: 111-117.
    • (1995) J Immunol , vol.155 , pp. 111-117
    • Marshall, J.D.1    Secrist, H.2    DeKruyff, R.H.3    Wolf, S.F.4    Umetsu, D.T.5
  • 45
    • 12944288317 scopus 로고    scopus 로고
    • Chemokine production by the BEAS-2B human brochial epithelial cells: Differential regulation of eotaxin, IL-8, and RANTES by Th2- and Th1-derived cytokines
    • Fujisawa T, Kato Y, Atsuta J, Terada A, Iguchi K, Kamiya H, Yamada H, Nakajima T, Miyamasu M, Hirai K (2000) Chemokine production by the BEAS-2B human brochial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by Th2- and Th1-derived cytokines. J Allergy Clin Immunol 105:126-133.
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 126-133
    • Fujisawa, T.1    Kato, Y.2    Atsuta, J.3    Terada, A.4    Iguchi, K.5    Kamiya, H.6    Yamada, H.7    Nakajima, T.8    Miyamasu, M.9    Hirai, K.10
  • 46
    • 0035879320 scopus 로고    scopus 로고
    • Functional expression of IL-12 receptor by human eosinophils: IL-12 promotes eosinophil apoptosis
    • Nutku E, Zhuang Q, Soussi-Gounni A, Aris F, Mazer BD, Hamid Q (2001) Functional expression of IL-12 receptor by human eosinophils: IL-12 promotes eosinophil apoptosis. J Immunol 167:1039-1046.
    • (2001) J Immunol , vol.167 , pp. 1039-1046
    • Nutku, E.1    Zhuang, Q.2    Soussi-Gounni, A.3    Aris, F.4    Mazer, B.D.5    Hamid, Q.6
  • 47
    • 0035865404 scopus 로고    scopus 로고
    • IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction
    • Wang S, Fan Y, Han X, Yang J, Bilenki L, Yang X (2001) IL-12-dependent vascular cell adhesion molecule-1 expression contributes to airway eosinophilic inflammation in a mouse model of asthma-like reaction. J Immunol 166:2741-2749.
    • (2001) J Immunol , vol.166 , pp. 2741-2749
    • Wang, S.1    Fan, Y.2    Han, X.3    Yang, J.4    Bilenki, L.5    Yang, X.6
  • 48
    • 0033862133 scopus 로고    scopus 로고
    • IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure
    • Zhao LL, Linden A, Sjostrand M, Cui ZH, Lotvall J (2000) IL-12 regulates bone marrow eosinophilia and airway eotaxin levels induced by airway allergen exposure. Allergy 55:749-756.
    • (2000) Allergy , vol.55 , pp. 749-756
    • Zhao, L.L.1    Linden, A.2    Sjostrand, M.3    Cui, Z.H.4    Lotvall, J.5
  • 49
    • 0001589215 scopus 로고    scopus 로고
    • The immunological role of respiratory tract epithelium
    • Cunningham R, Mahon BP (2001) The immunological role of respiratory tract epithelium. Mod Asp Immunobiol 1(5):204-209.
    • (2001) Mod Asp Immunobiol , vol.1 , Issue.5 , pp. 204-209
    • Cunningham, R.1    Mahon, B.P.2
  • 51
    • 0032032755 scopus 로고    scopus 로고
    • Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for genomic therapy
    • Lee YL, Tao MH, Chow YH, Chiang BL (1998) Construction of vectors expressing bioactive heterodimeric and single-chain murine interleukin-12 for genomic therapy. Human Gene Ther 9:457-465.
    • (1998) Human Gene Ther , vol.9 , pp. 457-465
    • Lee, Y.L.1    Tao, M.H.2    Chow, Y.H.3    Chiang, B.L.4
  • 52
    • 0035680992 scopus 로고    scopus 로고
    • Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma
    • Lee YL, Ye YL, Yu CI, Wu YL, Lai YL, Ku PH, Hong RL, Chiang BL (2001) Construction of single-chain interleukin-12 DNA plasmid to treat airway hyperresponsiveness in an animal model of asthma. Human Gene Ther 12:2065-2079.
    • (2001) Human Gene Ther , vol.12 , pp. 2065-2079
    • Lee, Y.L.1    Ye, Y.L.2    Yu, C.I.3    Wu, Y.L.4    Lai, Y.L.5    Ku, P.H.6    Hong, R.L.7    Chiang, B.L.8
  • 53
    • 4544320885 scopus 로고    scopus 로고
    • Animal models of airway sensitization
    • Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds), Wiley Press, New York
    • Hamelmann E, Gelfand EW (1999) Animal models of airway sensitization. Coligan JE, Kruisbeek AM, Margulies DH, Shevach EM, Strober W (eds) Current Protocols in Immunology, Wiley Press, New York, pp. 5.18.1-15.18.13.
    • (1999) Current Protocols in Immunology , pp. 5181-151813
    • Hamelmann, E.1    Gelfand, E.W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.