The dual role of CD4 T helper cells in the infection dynamics of HIV and their importance for vaccination

Journal of Theoretical Biology

Volumn 214, Issue 4, 2002, Pages 633-646

  Korthals Altes, H ^a,b,c   Wodarz, D ^a,b,c   Jansen, V A A ^a,b,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

HUMAN IMMUNODEFICIENCY VIRUS;

ARTICLE; CELL COUNT; CELL FUNCTION; CELL GROWTH; CELL INTERACTION; CELL STIMULATION; CELLULAR IMMUNITY; COMPARATIVE STUDY; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; GROWTH RATE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; MATHEMATICAL MODEL; PRIORITY JOURNAL; STEM CELL; TARGET CELL; VACCINATION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0036354175     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2483     Document Type: Article

References (73)

1. Effector cytotoxic T lymphocyte numbers induced by vaccination should exceed levels in chronic infection for protection from HIV
2. Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?
3. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
4. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons
5. CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8( + ) CTL response
6. CD40 ligand-mediated interactions are involved in the generation of memory CD8( + ) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
7. In vivo protective anti-HIV immune responses in non-human primates through DNA immunization
8. T lymphocyte responses in HIV-1 infection: Implications for vaccine development
9. Control of SHIV-89.6P-infection of cynomolgus monkeys by HIV-1 Tat protein vaccine
10. Virus phenotype switching and disease progression in HIV-1 infection
11. Interleukin-2 production used to detect antigenic peptide recognition by T-helper lymphocytes from asymptomatic HIV-seropositive individuals
12. T cell repertoires and competitive exclusion
13. Towards a general function describing T cell proliferation
14. On the definition and the computation of the basic reproduction ratio R0 in models for infectious diseases in heterogeneous populations
15. A functional and kinetic comparison of antiviral effector and memory cytotoxic T lymphocyte populations in vivo and in vitro
16. Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in Simian Immunodeficiency virus Env and Nef
17. Early suppression of SIV replication by CD8 + nef-specific cytotoxic T cells in vaccinated macaques
18. Immunization with live attenuated simian immunodeficiency virus induces strong type 1 T helper responses and beta-chemokine production
19. Pre-clinical development of a multi-CTL epitope-based DNA prime MVA boost vaccine for AIDS
20. Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen
21. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV- 1 infection - Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load
22. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection
23. The B-cell response in lymphoid-tissue of mice immunized with various antigenic forms of the Influenza-virus Hemagglutinin
24. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
25. Association between virus-specific cytotoxic T-lymphocyte and helper responses in human immunodeficiency virus type 1 infection
26. Enhanced T-cell immunogenicity and protective efficacy of a human immunodeficiency virus type 1 vaccine regimen consisting of consecutive priming with DNA and boosting with recombinant fowlpox virus
27. Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer lymphocytes-T
28. On the role of antigen in maintaining cytotoxic T-cell memory
29. On the role of antigen in maintaining cytotoxic T-cell memory
30. Human immunodeficiency virus infection of helper T cell clones. Early proliferative defects despite intact antigen-specific recognition and interleukin 4 secretion
31. Viral dynamics of acute HIV-1 infection
32. Dendritic cells need T cell help to prime cytotoxic T cell responses to strong antigens
33. T cell responses to HIV
34. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma
35. Plasma viral load and CD4( + ) lymphocytes as prognostic markers of HIV-1 infection
36. Immunological abnormalities in human immunodeficiency virus (HIV)-infected asymptomatic homosexual men. HIV affects the immune system before CD4 + T helper cell depletion occurs
37. Selection of virus variants and emergence of virus escape mutants after immunization with an epitope vaccine
38. Type 1 CD4( + ) T-cell help is required for induction of antipeptide multispecific cytotoxic T lymphocytes by a lipopeptidic vaccine in rhesus macaques
39. Early and persistent human immunodeficiency virus type 1 (HIV-1)-specific T helper dysfunction in blood and lymph nodes following acute HIV-1 infection
40. Viral dynamics of primary viremia and antiretroviral therapy in simian immunodeficiency virus infection
41. Virus-specific MHC class II-restricted TCR-transgenic mice: Effects on humoral and cellular immune responses after viral infection
42. Early highly active antiretroviral therapy for acute HIV-1 infection preserves immune function of CD8 + and CD4 + T lymphocytes
43. Prognostic value of serum HIV-RNA levels at virologic steady state after seroconversion: Relation to CD4 cell count and clinical course of primary infection
44. Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
45. HIV-1-specific CD4 + T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression
46. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection
47. A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell
48. Neutralizing antibody-independent containment of immunodeficiency virus challenges by DNA priming and recombinant pox virus booster immunizations
49. HIV type 1-specific helper T cells: A critical host defense
50. Vigorous HIV-1-specific CD4 + T cell responses associated with control of viremia
51. Characterization of HIV-1-specific T-helper cells in acute and chronic infection
52. Recombinant modified vaccinia virus Ankara-simian immunodeficiency virus gag pol elicits cytotoxic T lymphocytes in rhesus monkeys detected by a major histocompatibility complex class I/peptide tetramer
53. Selective pressure exerted by immunodominant HIV-1-specific cytotoxic T lymphocyte responses during primary infection drives genetic variation restricted to the cognate epitope
54. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice
55. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus
56. Lymphocyte-proliferative responses to HIV antigens as a potential measure of immunological reconstitution in HIV disease
57. Normal human CD4 + memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis
58. Determination of antigen-specific memory/effector CD4 + T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency
59. DNA vaccines for emerging infectious diseases: What if?
60. The role of T cell help for anti-viral CTL responses
61. Evolutionary dynamics of HIV-induced subversion of the immune response
62. Specific therapy regimes could lead to long-term immunological control of HIV
63. Immune responses and viral phenotype: Do replication rate and cytopathogenicity influence viral load?
64. Dynamics of macrophage and T cell infection by HIV
65. Transient antiretroviral treatment during acute simian immunodeficiency virus infection facilitates long-term control of the virus
66. The role of antigen-independent persistence of memory cytotoxic T lymphocytes
67. A new theory of cytotoxic T-lymphocyte memory: Implications for HIV treatment
68. Immunogenicity of a human immunodeficiency virus (HIV) polytope vaccine containing multiple HLA A2 HIV CD8( + ) cytotoxic T-cell epitopes
69. Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys
70. Therapeutic vaccination against chronic viral infection: The importance of cooperation between CD4( + ) and CD8( + ) T cells
71. On immunological memory