Dynamics of macrophage and T cell infection by HIV

Journal of Theoretical Biology

Volumn 196, Issue 1, 1999, Pages 101-113

  Wodarz, Dominik ^a   Lloyd, Alun L ^a   Jansen, Vincent A A ^a   Nowak, Martin A ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b INSTITUTE FOR ADVANCED STUDY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DYNAMICS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MATHEMATICAL MODEL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; RNA VIRUSES;

EID: 0033531206     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.1998.0816     Document Type: Article

References (60)

1. Anderson, R. M. & May, R. M. (1979). Population biology of infectious diseases: Part 1. Nature 280, 361-367.
2. Anderson, R. M. & May, R. M. (1991). Infectious Diseases of Humans. Dynamics and Control. Oxford: Oxford University Pres
3. Berger, E.A., Doms, R.W., Fenyo, E.M., Korber, B.T.M., Littman, D. R., Moore, J. P., Sattentau, Q. J., Schuitemaker, H., Sodroski, J. & Weiss, R. A. (1998). A new classification for HIV-1. Nature 391, 240.
4. Bertoletti, A., Sette, A., Chisari, F. V., Penna, A., Levrero, M., Decarli, M., Fiaccdori, F. & Ferrari, C. (1994). Natural variants of cytotoxic epitopes are T cell receptor antagonists for antiviral cytotoxic T cells. Nature 369, 407-410.
5. Biti, R., French, R. F., Young, J., Bennetts, B., Stewart, G. & Liang, T. (1997). HIV-1 infection in an individual homozygous for the CCR-5 deletion allele. Nature Med. 3, 252-253.
6. Borrow, P., Lewicki, H., Wei, X. P., Horwitz, M. S., Pfeffer, N., Meyers, H., Nelson, J.A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A. & Shaw, G. M. (1997). Antiviral pressure exerted by HIV-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Med. 3, 205-211.
7. Bukrinsky, M. I., Stanwick, T. L., Dempsey, M. P. & Stevenson, M. (1991). Quiescent lymphocytes - T as an inducible virus reservoir in HIV-1 infection. Science 254, 423-427.
8. Bukrinsky, M. I., Sharova, N., Dempsey, M. P., Stanwick, T. L., Bukrinskaya, A. G., Haggerty, S. & Stevenson, M. (1992). Active nuclear import of human immunodeficiency virus type-1 preintegration complexes. Proc. Nat. Acad. Sci. U.S.A. 89, 6580-6584.
9. Bukrinskaya, A. G., Ghorpade, A., Heinzinger, N. K., Smithgall, T. E., Lewis, R. E. & Stevenson, M. (1996). Phosphorylation-dependent human immunodeficiency virus type-1 infection and nuclear targeting of viral DNA. Proc. Nat. Acad. Sci. U.S.A. 93, 367-371.
10. Connor, R. I. & Ho, D. D. (1994). Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression. J. Virol. 68, 4400-4408.
11. Crowe, S. M. (1995). Role of macrophages in the pathogenesis of human immunodeficiency virus (HIV) infection. Aust. NZ. J. Med. 25, 777-783.
12. Dean, M., Carrington, M., Winkler, C., Huttley, G. A., Smith, M, W., Allikmets, R., Goedert, J. J., BuchBinder, S. P., Vittinghoff, E., Gomperts, E., Donfield, S., Vlahov, D., Kaslow, R., Saah, A., Rinaldo, C., Detels, R. & O'Brien S. J. (1996). Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273, 1856-1862.
13. DeBoer, R. J. & Boerlijst, M. C. B. (1994). Diversity and virulence thresholds in AIDS. Proc. Nat. Acad. Sci. U.S.A. 91, 544-548 .
14. DeBoer, R. J. & Perelson, A. S. (1998). Target cell limited and immune control models of HIV infection: A comparison. J. Theor. Biol. 190, 201-214.
15. Doms, R. W. & Moore, J. P. (1998). HIV-1 Coreceptor Use: A Molecular Window into Viral Tropism. WWW: http:///Perec/Desktop%20Folder/HIV- 1%20Coreceptor%20Use
16. Dragic, T., Litwin, V., Allaway, G. P., Martin, S. R., Huang, Y. X., Nagashima, K. A., Cayanan, C., Maddon, P. J., Koup, R. A., Moore, J. P. & Paxton, W. A. (1996). Nature 381, 667-673.
17. Emerman, M., Bukrinsky, M. & Stevenson, M. (1994). HIV infection of non-dividing cells - Reply. Nature 369, 108.
18. Essunger, P. & Perelson, A. S. (1994). Modelling HIV-infection of CD4(+) T cell subpopulations. J. Theor. Biol. 170, 367-391.
19. Feldherr, C. M. & Akin, D. (1993). Regulation of nuclear transport in proliferating and quiescent cells. Exp. Cell Res. 205, 179-186.
20. Fouchier, R. A. M., Meyaard, L., Brouwer, M., HovEnkamp, E. & Schuitemaker, H. (1996). Broader tropism and higher cytopathicity for CD4(+) T-cells of a syncyticum-inducing compared with a non-syncyticum-inducing HIV-1 isolate as a mechanism for accelerated CD4+ T cell decline in vivo. Virology 219, 87-95.
21. Goulder, P. J. R., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giagrande, P., Luzzi, G., Morgan, B., Edwards, A., McMichael, A. J. & Rowland-Jones, S. (1997). Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS. Nature Med. 3, 212-217.
22. Heinzinger, N. K., Burkrinsky, M. I., Haggerty, S. A., Ragland, A. M., Kewalramani, V., Lee, M. A., Gendelman, H. E., Ratner, L., Stevenson, M. & Emerman, M. (1994). The VPR protein of human immunodeficiency virus type-1 influences nuclear localisation of viral nucleic acids in non-dividing host cells. Proc. Nat. Acad. Sci. U.S.A. 91, 7311-7315.
23. Huang, Y. X., Paxton, W. A., Wolinsky, S. M., Neuman, A. U., Zhang, L. Q., He, T., Kang, S., Ceradini, D., Jin, Z. Q., Yazdanbakhsh, K., Kunstman, K., Erickson, D., Dragon, E., Landau, N. R., Phair, J., Ho, D. D. & Koup, R. A. (1996). The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med. 2, 1240-1243.
24. Jameson, S. C. & Bevan, M. J. (1995). T cell receptor antagonists and partial agonists. Immunity 2, 1-11.
25. Jameson, S. C., Carbone, F. R. & Bevan, M. J. (1993). Clone specific T-cell receptor antagonists of major histocompatibility complex class-1 restricted cytotoxic T cells. J. Exp. Med. 177, 1541-1550.
26. Kalams, S. A. & Walker, B. D. (1995). Cytotoxic T lymphocytes and HIV-1 related neurologic disorders. Curr. Top. Micobiol. Immunol. 202, 79-88.
27. Klenerman, P., Rowland-Jones, S., McAdam, S., Edwards, J., Daenke, S., Lalloo, D., Koppe, B., Rosenberg, W., Boyd, D., Edwards, A., Giangrande, P., Phillips, R. E. & McMichael, A. J. (1994). Cytotoxic T cell activity antagonized by naturally occurring HIV-1 gag variants. Nature 369, 403-407.
28. Klenerman, P., Meier, U. C., Phillips, R. E., & McMichael, A. J. (1995). The effects of natural altered peptide ligands on the whole blood cytotoxic T lymphocyte response to human immunodificiency virus. Europ. J. Immunol. 25, 1927-1931.
29. Klenerman, P., Phillips, R. E., Rinaldo, C. R., Wahl, L. M., Ogg, G., May, R. M., McMichael, A. J. & Nowak, M. A. (1996). Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection. Proc. Nat. Acad. Sci. U.S.A. 93, 15323-15328.
30. Lewis, P. F. & Emerman, M. (1994). Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J. Virol. 68, 510- 516.
31. Lewis, P., Hensel, M. & Emerman, M. (1992). Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J. 11, 3053-3058.
32. Liu, R., Paxton, W. A., Choe, S., Ceradini, D., Martin, S. R., Horuk, R., MacDonald, M. E., Stuhlmann, H., Koup, R. A. & Landau, N. R. (1996). Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply exposed individuals to HIV-1 infection. Cell 86, 367-377.
33. McAdam, S.N., Klenerman, P., Tussey, L. G., Rowland-Jones, S., Lalloo, D., Brown, A. L., Gotch, F. M. & McMichael, A. J. (1995). Immunogenic HIV variant peptides that bind to HLA-B8 but fail to stimulate cytotoxic T lymphocyte responses. J. Immunol. 155, 2729-2736.
34. McLean, A. R. (1992). Mathematical modelling of the immunization of populations. Rev. Med. Virol. 2, 141-152.
35. McLean, A. R. & Kirkwood, T. B. L. (1990). A model of human immunodeficiency virus infection in T helper cell clones. J. Theor. Biol. 147, 177-203.
36. Meier, U. C., Klenerman, P., Griffin, P., James, W., Koppe, B., Larder, B., McMichael, A. & Phillips, R. (1995). Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants. Science 270, 1360-1362.
37. Miller, D. G., Adam, M. A. & Miller, A. D. (1990). Gene-transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell. Biol. 10, 4239-4242.
38. Nowak, M. A. & Bangham, C. R. M. (1996). Population dynamics of immune responses to persistent viruses. Science 272, 74-79.
39. Nowak, M. A. & May, R. M. (1991). Mathematical biology of HIV infections - Antigenic variation and diversity threshold. Math. Biosci. 106, 1-21.
40. Nowak, M. A. & May, R. M. (1992). Coexistence and competition in HIV infections. J. Theor. Biol. 159, 329-342.
41. Nowak, M. A., Anderson, R. M., McLean, A. R., Wolfs, T. F. W., Goudsmit, J. & May, R. M. (1991). Antigenic diversity thresholds and the development of AIDS. Science 254, 963-969.
42. Nowak, M. A., May, R. M., Phillips, R. E., Rowland-Jones, S., Lalloo, D. G., McAdam, S., Klenerman, P., Koppe, B., Sigmund, K., Bangham, C. R. M. & McMichael, A. J. (1995). Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 375, 606-611.
43. Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O., Elvin, J. G., Rothbard, J. H., Bangham, C. R. M., Rizza, C. R. & McMichael, A. J. (1991). Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354, 453-459.
44. Rana, S., Besson, G., Cook, D. G., Rucker, J., Smyth, R. J., Yi, Y. J., Turner, J. D., Gua, H. H., Du, J. G., Peiper, S. C., Lavi, E., Samson, M., Libert, F., Liesnard, C., Vassart, G., Doms, R. W., Parmentier, M. & Collman, R. G. (1997). Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: Resistance to patient-derived and prototype isolates resulting from the delta CCR5 mutation. J. Virol. 71, 3219-3227.
45. Roe, T. Y., Reynolds, T. C., Yu, G. & Brown, P. O. (1993). Integration of murine leukemia virus DNA depends on mitosis. EMBO J. 12, 2099-2108.
46. Rudensey, L. M., Kimata, J. T., Benveniste, R. E. & Overbaugh, J. (1995). Progression to AIDS in Macaques is associated with changes in the replication, tropism, and cytopathic properties of the simian immunodeficiency virus variant population. Virology 207, 528-542.
47. Samson, M., Libert, F., Doranz, B. J., Rucker, J., Liesnard, C., Farber, C. M., Saragosti, S., LapoumerOulie, C., Cognaux, J., Forceille, C., Muyldermans, G., Verhofstede, C., Burtonboy, G., Georges, M., Imai, T., Rana, S., Yi, Y. J., Smyth, R. J., Collman, R. G., Doms, R. W., Vassart, G. & Parmentier, M. (1996). Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382, 722-725.
48. Schenzle, D. (1994). A model for AIDS pathogenesis. Statist. Med. 13, 2067-2079.
49. Schuitemaker, H. (1994). Macrophage-tropic HIV variants - Initiators of infection and AIDS pathogenesis. J. Leukocyte Biol. 56, 218-224.
50. Schuitemaker, H., Koot, M., Kootstra, M. A., Dercksen, M. W., Degoede, R. E. Y., van Steenwijk, R. P., Lange, J. M. A., Schattenkerk, J. K. M. E., Miedema, F. & Tersmette, M. (1992). Biological phenotype of human immunodeficiency virus type-1 clones at different stages of infection - Progression of disease is associated with a shift from monocytotropic to T-cell tropic virus populations. J. Virol. 66, 1354-1360.
51. Springett, G. M., Moen, R. C., Anderson, S., Blaese, R. M. & Anderson, W. F. (1989). Infection efficiency of lymphocytes-T with amphotropic retroviral vectors is cell cycle dependent. J. Virol. 63, 3865-3869.
52. Stevenson, M. (1996). Portals of entry - Uncovering HIV nuclear transport pathways. Trends Cell Biol. 6, 9-15.
53. Stevenson, M. & Gendelman, H. E. (1994). Cellular and viral determinants that regulate HIV-1 infection in macrophages. J. Leukocyte Biol. 56, 278-288.
54. Stevenson, M., Bukrinski, M. I., Gulizia, J., Haggerty, S., Dempsey, M. P, Sharova, N., Goldfarb, D., Lewis, P. & Emerman, M. (1994). Identification of factors which govern HIV-1 replication in non-dividing host cells. AIDS Res. Human Retroviruses 10, S82.
55. Stevenson, M., Bukrinskaya, A., Ghorpade, A., Heinzinger, N., Lewis, R., Ratner, L. & Ragland, A. (1995). Molecular basis for cell cycle dependent HIV replication. AIDS Res. Human Retroviruses 11, S87.
56. Weinberg, J. B., Matthews, T. J., Cullen, B. R. & Malim, M. H. (1991). Productive human immunodeficiency virus type-1 (HIV-1) infection of non-proliferating human monocytes. J. Exp. Med. 174, 1477-1482.
57. Wodarz, D. & Nowak, M. A. (1998). The effect of different immune responses on the evolution of virulent CXCR4 tropic HIV. Proc. Roy. Soc. Lond. B (in press).
58. Wodarz, D., Klenerman, P. & Nowak, M. A. (1998). Dynamics of cytotoxic T-lymphocyte exhaustion. Proc. Roy. Soc. Lond. B. 265, 191-203.
59. Van't Wout, A. B., Kootstra, N. A., Mulderkampinga, G. A., Albrechtvanlent, N., Scherpbier, H. J., Veenstra, J., Boer, K., Coutinho, R. A., Miedema, F. & Schuitemaker, H. (1994). Macrophage tropic variants initiate human immunodeficiency virus type-1 infection after sexual, parenteral, and vertical transmission. J. Clin. Invest. 94, 2060-2067.
60. Zhu, T. F., Mo, H, M., Wang, N., Nam, D. S., Cao, Y. Z., Koup, R. A. & Ho, D. D. (1993). Genotypic and phenotypic characterisation of HIV-1 in patients with primary infection. Science 261, 1179-1181.