Prognostic value of serum HIV-RNA levels at virologic steady state after seroconversion: Relation to CD4 cell count and clinical course of primary infection

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology

Volumn 16, Issue 2, 1997, Pages 93-99

  Pedersen, Court ^a   Katzenstein, Therese ^b   Nielsen, Claus ^c   Lundgren, Jens D ^d   Gerstoft, Jan ^b  

^a ODENSE UNIVERSITY HOSPITAL   (Denmark)

^b University of Copenhagen   (Denmark)

^c STATENS SERUM INSTITUT   (Denmark)

^d HVIDOVRE HOSPITAL   (Denmark)

Author keywords

CD4; Disease progression; HIV RNA; Natural history; Primary infection; Viral load

Indexed keywords

CD4 ANTIGEN; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; DISEASE COURSE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SEROCONVERSION; T LYMPHOCYTE SUBPOPULATION;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0030669517     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199710010-00004     Document Type: Article

References (27)

1. Pedersen C, Nielsen JO, Dickmeis E, Jordal R. Early progression to AIDS following primary HIV infection. AIDS 1989;3:45-7.
2. Buchbinder SP, Katz MH, Hessol NA, O'Malley Holmberg SD. Long-term HIV-1 infection without immunologic progression. AIDS 1994;8:1123-8.
3. Cao Y, Qin L, Zhang L, Safrit J, Ho DD. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. N Engl J Med 1995;332:201-8.
4. Pedersen C, Lindhardt BØ, Løkke Jensen B, et al. Clinical course of primary HIV infection: consequences for subsequent course of infection. Br Med J 1989;299:154-7.
5. 6/l, AIDS and death from AIDS. Br Med J 1994;309:1535-7.
6. Keet IPM, Krijnen P, Koot M, et al. Predictors of rapid progression to AIDS in HIV-1 seroconverters. AIDS 1993;7:51-7.
7. Veugelers PJ, Strathdee SA, Kaldor JM, et al. Incidence and prognostic significance of symptomatic primary HIV-1 infection in homosexual men [abstract Mo.C.324]. XI International Conference on AIDS, Vancouver, July 1996.
8. Katzenstein TL, Pedersen C, Nielsen C, Lundgren JD, Jakohsen PH, Gerstoft J. Longitudinal serum HIV RNA quantification: correlation to viral phenotype at seroconversion and clinical outcome. AIDS 1996;10:167-73.
9. Henrard DR, Phillips JF, Muenz LR, et al. Natural history of HIV-1 cell-free viremia. JAMA 199;274:554-8.
10. Havlir DV, Richman DD. Viral dynamics of HIV: implications for drug development and therapeutic strategies. Ann Intern Med 1996;124:984-94.
11. Mellors JW, Kingsley LA, Rinaldo CR Jr, et al. Quantification of HIV-1 RNA in plasma predicts outcome after seroconversion. Ann Intern Med 1995;122:573-9.
12. Jurriaans S, van Gemen B, Weverling GJ, et al. The natural history of HIV infection: Virus load and virus phenotype independent determinants of disease progression? Virology 1994;204:223-33.
13. Pedersen C, Kolby P, Sindrup JH, et al. Immunological studies in homosexual men with and without antibodies to human T-cell lymphotropic virus type III. Dan Med Bull 1986;33:270-2.
14. Centers for Disease Control. Revision of the CDC surveillance case definition of acquired immunodeficiency syndrome. MMWR CDC Surveill Summ 1987;36:1-14S.
15. Mellors JW, Rinaldo CR Jr, Gupta P, White RM, Todd JA, Kingsley LA. Prognosis in HIV-1 infection predicted by the quantity of virus in plasma. Science 1996;272:1167-70.
16. Pedersen C, Katzenstein T, Nielsen C, Lundgren JD, Gerstoft J. Events in early HIV infection determine the long term outcome of the infection [abstract Mo.B.1341]. XI International Conference on AIDS, Vancouver, July 1996.
17. Paola MA, Ercoli L, Galati V, et al. HIV-1 viral characteristics, serum neutralizing activity and disease progression in a group of HIV+ patients [abstract Tu.A.2088]. XI International Conference on AIDS, Vancouver, July 1996.
18. O'Brien, Hartigan P, Martin D, et al. Changes in plasma HIV-1 RNA and CD4-lymphocyte counts and the risk of progression to AIDS. N Engl J Med 1996;334:426-31.
19. Galetto-Lacour A, Yerly S, Peraeger TV, Baumberger C, Hirschel B, Perrin L, Swiss HIV cohort study group. Prognostic value of viremia in patients with long-standing human immunodeficiency virus infection. J Infect Dis 1996;173:13-88-93.
20. Mellors JW. Viral load and clinical outcome: a review of recent studies [abstract from Workshop Lecture 1]. HIV Drug Resistance Fifth International Workshop. Whistler, July 1996.
21. Pedersen C, Gerstoft J, Lundgren JD, et al. Development of AIDS and low CD4 cell counts in a cohort of 180 HIV seroconverters [abstract PO-B01-0862], IX International Conference on AIDS, Berlin, June 1993.
22. Ho DD. Viral counts in HIV infection. Science 1996;272:1124-5.
23. Ho DD, Neumann AU, Perelson AS, Chen W, Leonard JM, Markowitz M. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 1995;373:123-6.
24. Carpenter CCJ, Fischl M, Hammer SM, et al. Antiretroviral therapy for HIV infection in 1996: Recommendations of an international panel. JAMA 1996;276:146-54.
25. Rutherford GW, Lifson AR, Hessol NA, et al. Course of HIV-1 infection in a cohort of homosexual and bisexual men: an 11 year follow up study. Br Med J 1990;1183-8.
26. Bacchetti P, Moss AR. Incubation period of AIDS in San Fransisco. Nature 1989;338:251-3.
27. Giesecke J, Scalia-Tomba G, Håkansson C, Karlsson A, Lidman K. Incubation time of AIDS: progression of disease in a cohort of HIV-infected homo- and bisexual men with known dates of infection. Scand J Infect Dis 1990;22:407-11.