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Volumn 266, Issue 1437, 1999, Pages 2523-2530

Virus phenotype switching and disease progression in HIV-1 infection

Author keywords

HIV 1; Mathematical model; Non syncitium inducing; Phenotype switch; Syncytium inducing

Indexed keywords

ARTICLE; DISEASE COURSE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE SYSTEM; MATHEMATICAL MODEL; PHENOTYPE; PRIORITY JOURNAL; TARGET CELL;

EID: 0033596278     PISSN: 09628452     EISSN: 14712970     Source Type: Journal    
DOI: 10.1098/rspb.1999.0955     Document Type: Article
Times cited : (28)

References (61)
  • 4
    • 0031298109 scopus 로고    scopus 로고
    • HIV entry and tropism: The chemokine receptor connection
    • Berger, E. A. 1997 HIV entry and tropism: the chemokine receptor connection. AIDS 11, S3 S16.
    • (1997) AIDS , vol.11
    • Berger, E.A.1
  • 6
    • 0031000756 scopus 로고    scopus 로고
    • Human immunodeficiency virus drug therapy and virus load
    • Bonhoeffer, S., Coffin, J. M. & Xovvak, M. A. 1997 Human immunodeficiency virus drug therapy and virus load. J. Viral. 71, 3275 3278.
    • (1997) J. Virol. , vol.71 , pp. 3275-3278
    • Bonhoeffer, S.1    Coffin, J.M.2    Nowak, M.A.3
  • 7
    • 0029553403 scopus 로고
    • Viral resistance: A major challenge in managing HIV disease
    • Boucher, C. A. B. & Reedjik, M. 1995 Viral resistance: a major challenge in managing HIV disease. J. Biol. Regul. Homeo. Agents 9, 91 94.
    • (1995) J. Biol. Regul. Homeo. Agents , vol.9 , pp. 91-94
    • Boucher, C.A.B.1    Reedjik, M.2
  • 8
    • 0028146788 scopus 로고
    • Cryptic nature of envelope V3 region epitopes protects primary monocylotropic human-immunodeficiency-virus type-1 from antibody neutralization
    • Bouhabib, D. C., Roderiquez, G., Oravecz, T., Berman, P. W., Lusso, P. & Norcross, M. A. 1994 Cryptic nature of envelope V3 region epitopes protects primary monocylotropic human-immunodeficiency-virus type-1 from antibody neutralization. J. Virol. 68, 6006 6013.
    • (1994) J. Virol. , vol.68 , pp. 6006-6013
    • Bouhabib, D.C.1    Roderiquez, G.2    Oravecz, T.3    Berman, P.W.4    Lusso, P.5    Norcross, M.A.6
  • 9
    • 0026054892 scopus 로고
    • Quiescent lymphocytes-T as an inducible virus reservoir in HIV-1 infection
    • Bukrinsky, M. I., Stanwick, T. L., Dempsey, M. P. & Stevenson, M. 1991 Quiescent lymphocytes-Tas an inducible virus reservoir in HIV-1 infection. Science 254, 423-427.
    • (1991) Science , vol.254 , pp. 423-427
    • Bukrinsky, M.I.1    Stanwick, T.L.2    Dempsey, M.P.3    Stevenson, M.4
  • 10
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin, J. M. 1995 HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy. Science 267, 483 489.
    • (1995) Science , vol.267 , pp. 483-489
    • Coffin, J.M.1
  • 11
    • 0027409934 scopus 로고
    • Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type-1 infected individuals
    • Connor, R. I., Mohri, H., Cao, Y. & Ho, D. D. 1993 Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type-1 infected individuals. J. Virol. 67, 1772 1777.
    • (1993) J. Virol. , vol.67 , pp. 1772-1777
    • Connor, R.I.1    Mohri, H.2    Cao, Y.3    Ho, D.D.4
  • 12
    • 0028798332 scopus 로고
    • Syncytium inducing (SI) phenotype suppression at seroconversion after intramuscular inoculation of a non-syncytium inducing/SI phenotypically mixed human immunodeficiency population
    • Cornelissen, M. (and 10 others) 1995 Syncylium inducing (SI; phenotype suppression at scroconversion after intramuscular inoculation of a non-syncytium inducing/SI phenotypically mixed human immunodeficiency population. J. Virol. 69, 1810 1818.
    • (1995) J. Virol. , vol.69 , pp. 1810-1818
    • Cornelissen, M.1
  • 13
    • 0026702003 scopus 로고
    • Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncitium-inducing phenotype: Analysis by single amino acid substitution
    • De Jong, J. J., De Ronde, A., Keulen, W., Tersmette, M. & Goudsmit, J. 1992 Minimal requirements for the human immunodeficiency virus type 1 V3 domain to support the syncitium-inducing phenotype: analysis by single amino acid substitution. J. Viral. 66, 6777 6780.
    • (1992) J. Virol. , vol.66 , pp. 6777-6780
    • De Jong, J.J.1    De Ronde, A.2    Keulen, W.3    Tersmette, M.4    Goudsmit, J.5
  • 14
    • 0029805203 scopus 로고    scopus 로고
    • Host factors and the pathogenesis of HIV-induced disease
    • Fauci, A. S. 1996 Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529 534.
    • (1996) Nature , vol.384 , pp. 529-534
    • Fauci, A.S.1
  • 15
    • 0026606727 scopus 로고
    • Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type1 gpl20 molecule
    • Fouchier, R. A. M., Groenink, M., Kootstra, N. A., Tersmette, M., Huisman, H. G., Miedema, F. & Schuitemaker, H. 1992 Phenotype-associated sequence variation in the third variable domain of the human immunodeficiency virus type1 gpl20 molecule. J. Virol. 66, 3183-3187.
    • (1992) J. Virol. , vol.66 , pp. 3183-3187
    • Fouchier, R.A.M.1    Groenink, M.2    Kootstra, N.A.3    Tersmette, M.4    Huisman, H.G.5    Miedema, F.6    Schuitemaker, H.7
  • 16
    • 0029891862 scopus 로고    scopus 로고
    • Broader tropism and higher cytopathicity for CD4+ T-cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolates a mechanism for accelerated CD4+ T cell decline in vivo
    • Fouchier, R. A. M., Meyaard, L., Brouwer, M., Hovenkamp, K. & Schuitemaker, H. 1996 Broader tropism and higher cytopathicity for CD4+ T-cells of a syncytium-inducing compared to a non-syncytium-inducing HIV-1 isolates a mechanism for accelerated CD4+ T cell decline in vivo. Virology 219, 87 95.
    • (1996) Virology , vol.219 , pp. 87-95
    • Fouchier, R.A.M.1    Meyaard, L.2    Brouwer, M.3    Hovenkamp, E.4    Schuitemaker, H.5
  • 18
    • 16944366524 scopus 로고    scopus 로고
    • Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS
    • Goulder, P. J. R. (and 11 others) 1997 Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS, .Nature Med. 3, 212-217.
    • (1997) Nature Med. , vol.3 , pp. 212-217
    • Goulder, P.J.R.1
  • 19
    • 0033011115 scopus 로고    scopus 로고
    • CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue
    • Grivel, J.-C. & Margolis, L, B. 1999 CCR5-and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue. ,Nature Med. 5, 344 346.
    • (1999) Nature Med. , vol.5 , pp. 344-346
    • Grivel, J.-C.1    Margolis, L.B.2
  • 20
    • 0026069628 scopus 로고
    • Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type-1 clones derived from a single individual
    • Groenink, K. M., Fouchier, R. A. M., De Goede, R. R. V, De Wolf, K, Gruters, R. A., Cuypers, T. M., Huisman, H. G. & Tersmette, M. 1991 Phenotypic heterogeneity in a panel of infectious molecular human immunodeficiency virus type-1 clones derived from a single individual. J. Virol. 65, 1968-1975.
    • (1991) J. Virol. , vol.65 , pp. 1968-1975
    • Groenink, K.M.1    Fouchier, R.A.M.2    De Goede, R.E.Y.3    De Wolf, F.4    Gruters, R.A.5    Cuypers, T.M.6    Huisman, H.G.7    Tersmette, M.8
  • 21
    • 0030293534 scopus 로고    scopus 로고
    • Dynamics of viral variants in HIV-1 nef and specific cytotoxic T lymphocytes in vivo
    • Haas, G. fand 12 others; 1996 Dynamics of viral variants in HIV-1 nef and specific cytotoxic T lymphocytes in vivo. J. Immunol. 157, 4212-4221.
    • (1996) J. Immunol. , vol.157 , pp. 4212-4221
    • Haas, G.1
  • 22
    • 0030593031 scopus 로고    scopus 로고
    • Toward an understanding of the correlates of protective immunity to HIV infection
    • Haynes, B. F., Pantaleo, G. & Fauci, A. S. 1996 Toward an understanding of the correlates of protective immunity to HIV infection. Science 271, 324-328.
    • (1996) Science , vol.271 , pp. 324-328
    • Haynes, B.F.1    Pantaleo, G.2    Fauci, A.S.3
  • 23
    • 0032505065 scopus 로고    scopus 로고
    • Apoptosis of CD8+ T cells is mediated by macrophages through interaction with HIV gpl20 with chemokine receptor CXCR4
    • Herhein, G., Mahlknecht, U, Batliwalla, F., Gregersen, P., Pappas, T., Butler, J., O'Brien, W A. & Verdin, E. 1998 Apoptosis of CD8+ T cells is mediated by macrophages through interaction with HIV gpl20 with chemokine receptor CXCR4. Nature 395, 189 194.
    • (1998) Nature , vol.395 , pp. 189-194
    • Herbein, G.1    Mahlknecht, U.2    Batliwalla, F.3    Gregersen, P.4    Pappas, T.5    Butler, J.6    O'Brien, W.A.7    Verdin, E.8
  • 24
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho, D. D., Neumann, A. U., Perelson, A. S., Chen, W., Leonard, J. M. & Markowitz, M. 1995 Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123 126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1    Neumann, A.U.2    Perelson, A.S.3    Chen, W.4    Leonard, J.M.5    Markowitz, M.6
  • 25
    • 0032418812 scopus 로고    scopus 로고
    • The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
    • Kalams, S. A. & Walker, B. D. 1998 The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J. Exp. Med. 188, 2199-2204.
    • (1998) J. Exp. Med. , vol.188 , pp. 2199-2204
    • Kalams, S.A.1    Walker, B.D.2
  • 27
    • 19144365480 scopus 로고    scopus 로고
    • Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection
    • Koot, M., van't Wout, A. B., Kootstra, N. A., De Goede, R. E., Tersmette, M. & Schuitemaker, H. 1996 Relation between changes in cellular load, evolution of viral phenotype, and the clonal composition of virus populations in the course of human immunodeficiency virus type 1 infection. J. Inject. Dis. 173, 349 354.
    • (1996) J. Infect. Dis. , vol.173 , pp. 349-354
    • Koot, M.1    Van't Wout, A.B.2    Kootstra, N.A.3    De Goede, R.E.4    Tersmette, M.5    Schuitemaker, H.6
  • 28
    • 0032929247 scopus 로고    scopus 로고
    • Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis
    • Root, M., Van Leeuwen, R., De Goede, R. E., Keet, I. P., Danner, S., Eeftinck Schattenkerk, J. K., Reiss, P., Tersmette, M., Lange, J. M. & Schuitemaker, H. 1999 Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis. J. Infect. Dis. 179, 254-258.
    • (1999) J. Infect. Dis. , vol.179 , pp. 254-258
    • Koot, M.1    Van Leeuwen, R.2    De Goede, R.E.3    Keet, I.P.4    Danner, S.5    Eeftinck Schattenkerk, J.K.6    Reiss, P.7    Tersmette, M.8    Lange, J.M.9    Schuitemaker, H.10
  • 29
    • 0028337166 scopus 로고
    • Temporal association of cellular immune-responses with the initial control of viremia in primary human-immunodeficiency-virus type-1 syndrome
    • Knup, R. A., Safrit, J. T., Cao, Y. Z., Andrews, C. A., McLeod, G., Borkowsky, W, Farthing, C. & Ho, D. D. 1994 Temporal association of cellular immune-responses with the initial control of viremia in primary human-immunodeficiency-virus type-1 syndrome. J. Viral. 68, 4650 4655.
    • (1994) J. Virol. , vol.68 , pp. 4650-4655
    • Koup, R.A.1    Safrit, J.T.2    Cao, Y.Z.3    Andrews, C.A.4    McLeod, G.5    Borkowsky, W.6    Farthing, C.7    Ho, D.D.8
  • 31
    • 0025891987 scopus 로고
    • CD8+ cell anti-HIV activity correlates with the clinical state of the infected individuals
    • Mackewicz, C. E., Ortega, H. W. & Levy, J. A. 1991 CD8+ cell anti-HIV activity correlates with the clinical state of the infected individuals. J. Clin. Invest. 87, 1462 1466.
    • (1991) J. Clin. Invest. , vol.87 , pp. 1462-1466
    • Mackewicz, C.E.1    Ortega, H.W.2    Levy, J.A.3
  • 32
    • 0025226583 scopus 로고
    • A model of human immunodeficiency virus infection in T helper cell clones
    • McLean, A. R. & Kirkwood, T. B. L. 1990 A model of human immunodeficiency virus infection in T helper cell clones. J. Theor. Biol. 147, 177 203.
    • (1990) J. Theor. Biol. , vol.147 , pp. 177-203
    • McLean, A.R.1    Kirkwood, T.B.L.2
  • 33
    • 0026574212 scopus 로고
    • Models of interaction between HIV and other pathogens
    • McLean, A. R. & Nowak, M. A. 1992 Models of interaction between HIV and other pathogens. J. Theor. Biol. 155, 69 86.
    • (1992) J. Theor. Biol. , vol.155 , pp. 69-86
    • McLean, A.R.1    Nowak, M.A.2
  • 36
    • 0028168943 scopus 로고
    • Changing virus-host inter-actions in the course of HIV-1 infection
    • Miedema, F. (and 10 others) 199-1-Changing virus-host inter-actions in the course of HIV-1 infection. Immunol. Rev. 140, 35-72.
    • (1994) Immunol. Rev. , vol.140 , pp. 35-72
    • Miedema, F.1
  • 37
    • 0024991185 scopus 로고
    • Transition dynamics of HIV disease in a cohort of African prostitutes: A Markov model approach
    • Nagelkerke, N. J., Plummer, F. A., Holton, D., Anzala, A. O., Manji, F., Ngugi, K. N. & Moses, S. 1990 Transition dynamics of HIV disease in a cohort of African prostitutes: a Markov model approach. AIDS 4, 743 747.
    • (1990) AIDS , vol.4 , pp. 743-747
    • Nagelkerke, N.J.1    Plummer, F.A.2    Holton, D.3    Anzala, A.O.4    Manji, F.5    Ngugi, E.N.6    Moses, S.7
  • 38
    • 0025871325 scopus 로고
    • Mathematical biology of HIV infections - Antigenic variation and diversity thresholds
    • Nowak, M. A. & May, R. M. 1991 Mathematical biology of HIV infections - antigenic variation and diversity thresholds. Math. Biosci. 106, 1 21.
    • (1991) Math. Biosci. , vol.106 , pp. 1-21
    • Nowak, M.A.1    May, R.M.2
  • 40
    • 7144227284 scopus 로고    scopus 로고
    • Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
    • Ogg, G. S. (and 14 others) 1998 Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science 279, 2103 2106.
    • (1998) Science , vol.279 , pp. 2103-2106
    • Ogg, G.S.1
  • 41
    • 0031662093 scopus 로고    scopus 로고
    • Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasi-species
    • Osirowski, M. A., Krakauer, D. C., Li, Y., Justement, S. J., Learn, G., Ehler L. A., Stanley, S. K., Nowak, M. A. & Fauci, A. S. 1998 Effect of immune activation on the dynamics of human immunodeficiency virus replication and on the distribution of viral quasi-species. J. Virol. 72, 7772-7784.
    • (1998) J. Virol. , vol.72 , pp. 7772-7784
    • Ostrowski, M.A.1    Krakauer, D.C.2    Li, Y.3    Justement, S.J.4    Learn, G.5    Ehler, L.A.6    Stanley, S.K.7    Nowak, M.A.8    Fauci, A.S.9
  • 42
    • 0029820873 scopus 로고    scopus 로고
    • Immunopathogenesis of HIV infection
    • Pantaleo, G. & Fauci, A. S. 1996 Immunopathogenesis of HIV infection. A. Rer. Micrombiol. 50, 825 -854.
    • (1996) A. Rev. Micrombiol. , vol.50 , pp. 825-854
    • Pantaleo, G.1    Fauci, A.S.2
  • 43
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, viral generation time
    • Perelson, A. S., Neumann, A. U., Markowitz, M., Leonard, J. M. & Ho, D. D. 1996 HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, viral generation time. Science 271, 1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 44
    • 0028131190 scopus 로고
    • Keynote address: Variations in the natural history of HIV infection
    • Phair, J. P. 1994 Keynote address: variations in the natural history of HIV infection. AIDS Res. Hum. Retroviruses. 10, 883-885.
    • (1994) AIDS Res. Hum. Retroviruses , vol.10 , pp. 883-885
    • Phair, J.P.1
  • 45
    • 0029095585 scopus 로고
    • Virologic characterization of primary human immunodeficiency virus type 1 infection in a health care worker following needlestick injury
    • 995
    • Pratt, R. D., Shapiro, J. F., McKinney, N., Kwok, S. & Speetor, S. A. I995 Virologic characterization of primary human immunodeficiency virus type 1 infection in a health care worker following needlestick injury. J. Inject. Dis. 172, 851-854.
    • (1995) J. Infect. Dis. , vol.172 , pp. 851-854
    • Pratt, R.D.1    Shapiro, J.F.2    McKinney, N.3    Kwok, S.4    Spector, S.A.5
  • 47
    • 84944372866 scopus 로고
    • Serologic and immunologic studies in patients with AIDS in North America and Africa. The potential role of infectious agents as cofactors in human immunodeficiency virus infection
    • Quinn, T. C., Piot, P., McCormick, J. R., Feinsod, F. M., Tuelman, H., Kapita, B., Stevens, W. & Fauci, A. S. 1987 Serologic and immunologic studies in patients with AIDS in North America and Africa. The potential role of infectious agents as cofactors in human immunodeficiency virus infection. J. Am. Med. Assoc. 257, 2617 2621.
    • (1987) J. Am. Med. Assoc. , vol.257 , pp. 2617-2621
    • Quinn, T.C.1    Piot, P.2    McCormick, J.B.3    Feinsod, F.M.4    Taelman, H.5    Kapita, B.6    Stevens, W.7    Fauci, A.S.8
  • 48
    • 0032568196 scopus 로고    scopus 로고
    • The frequency of resistant mutant virus before antiviral therapy
    • Ribeiro, R. M., Bonhoeffer, S. & Nowak, M. A. 1998 The frequency of resistant mutant virus before antiviral therapy. AIDS 12, 461-465.
    • (1998) AIDS , vol.12 , pp. 461-465
    • Ribeiro, R.M.1    Bonhoeffer, S.2    Nowak, M.A.3
  • 49
    • 85020796682 scopus 로고    scopus 로고
    • HIV drug resistance - An overview
    • Richman, D. D. 1996 HIV drug resistance - an overview. AIDS 10, S121.
    • (1996) AIDS , vol.10
    • Richman, D.D.1
  • 51
    • 0032089101 scopus 로고    scopus 로고
    • HIV type 1-specific helper T-cells: A critical host defense
    • Rosenberg, F. S. & Walker, B. 13. 1998 HIV type 1-specific helper T-cells: a critical host defense. AIDS Res. Hum. Retroviruses 14, S143-S147.
    • (1998) AIDS Res. Hum. Retroviruses , vol.14
    • Rosenberg, E.S.1    Walker, B.D.2
  • 53
    • 0029101841 scopus 로고
    • The immunology of primary HIV infection - Which immune responses control HIV replication
    • Safrit, J. T. & Koup, R. A. 1995 The immunology of primary HIV infection - which immune responses control HIV replication, Curr. Opin. Immunol. 7, 456 461.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 456-461
    • Safrit, J.T.1    Koup, R.A.2
  • 54
    • 0026600926 scopus 로고
    • Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
    • Schuitemaker, H., Koot, M., Kootstra, N. A., Dereksen, M. W., de Goede, R. E., van Steenwijk, R. P., Lange, J. M., Schattenkerk, J. K., Miedema, F. & Tersmette, M. 1992 Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J. Virol. 66, 1354 1360.
    • (1992) J. Virol. , vol.66 , pp. 1354-1360
    • Schuitemaker, H.1    Koot, M.2    Kootstra, N.A.3    Dereksen, M.W.4    De Goede, R.E.5    Van Steenwijk, R.P.6    Lange, J.M.7    Schattenkerk, J.K.8    Miedema, F.9    Tersmette, M.10
  • 55
    • 0030050591 scopus 로고    scopus 로고
    • Portals of entry - Uncovering HIV nuclear transport pathways
    • Stevenson, M. 1996 Portals of entry - uncovering HIV nuclear transport pathways. Trends Cell Biol. 6, 9 15.
    • (1996) Trends Cell Biol. , vol.6 , pp. 9-15
    • Stevenson, M.1
  • 56
    • 0024536114 scopus 로고
    • Evidence for a role of virulent human immunodeficiency virus (HIV) variants in pathogenesis of acquired immunodeficiency syndrome: Studies on sequential HIV isolates
    • Tersmette, M., Gruters, R. A., De Wolf, F., Dde Goede, R. E. Y, Lange, J. M. A., Sehellekens, P. T. A., Goudsmit, J., Huisman, H. G. & Miedema, F. 1989 Evidence for a role of virulent human immunodeficiency virus (HIV) variants in pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates. J. Virol. 63, 2118 2125.
    • (1989) J. Virol. , vol.63 , pp. 2118-2125
    • Tersmette, M.1    Gruters, R.A.2    De Wolf, F.3    De Goede, R.E.Y.4    Lange, J.M.A.5    Schellekens, P.T.A.6    Goudsmit, J.7    Huisman, H.G.8    Miedema, F.9
  • 58
    • 0028811974 scopus 로고
    • Viral dynamics in human immunodeficiency type-1 infection
    • Wei, X. (and 11 others) 1995 Viral dynamics in human immunodeficiency type-1 infection. Nature 373, 117-122.
    • (1995) Nature , vol.373 , pp. 117-122
    • Wei, X.1
  • 59
    • 0032558927 scopus 로고    scopus 로고
    • The effect of different immune responses on the evolution of virulent CXCR4-tropic HIV
    • Wodarz, D. & Novvak, M. A. 1998 The effect of different immune responses on the evolution of virulent CXCR4-tropic HIV Proc. R. Sac. Lond. B 265, 2149 2158.
    • (1998) Proc. R. Sac. Lond. B , vol.265 , pp. 2149-2158
    • Wodarz, D.1    Nowak, M.A.2
  • 61
    • 0027422278 scopus 로고
    • Genotypic and phenotypic characterization of HIV-1 patients with primary infection
    • Zhu, T., Mo, H., Wang, N., Nam, D., Cao, Y, Koup, R. & Ho, D. D. 1993 Genotypic and phenotypic characterization of HIV-1 patients with primary infection. Science 261, 1179-1181.
    • (1993) Science , vol.261 , pp. 1179-1181
    • Zhu, T.1    Mo, H.2    Wang, N.3    Nam, D.4    Cao, Y.5    Koup, R.6    Ho, D.D.7


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