Selective pressure exerted by immunodominant HIV-1-specific cytotoxic T lymphocyte responses during primary infection drives genetic variation restricted to the cognate epitope

European Journal of Immunology

Volumn 29, Issue 11, 1999, Pages 3629-3635

  Soudeyns, Hugo ^a   Paolucci, Stefania ^b   Chappey, Colombe ^c   Daucher, Mary Beth ^b   Graziosi, Cecilia ^a   Vaccarezza, Mauro ^b   Cohen, Oren J ^b   Fauci, Anthony S ^b   Pantaleo, Giuseppe ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cytotoxic T lymphocyte; HIV 1; Viral escape mutation

Indexed keywords

VIRUS DNA; VIRUS ENVELOPE PROTEIN;

ANTIGEN RECOGNITION; ARTICLE; CASE REPORT; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; GENETIC SELECTION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; VIRUS IMMUNITY;

CELLS, CULTURED; EPITOPES, T-LYMPHOCYTE; HIV ENVELOPE PROTEIN GP120; HIV ENVELOPE PROTEIN GP41; HIV INFECTIONS; HIV-1; HUMANS; IMMUNODOMINANT EPITOPES; PROSPECTIVE STUDIES; T-LYMPHOCYTES, CYTOTOXIC; VARIATION (GENETICS);

EID: 0032703374     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199911)29:11<3629::AID-IMMU3629>3.0.CO;2-O     Document Type: Article

References (24)

1. Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M. and Oldstone, M. B., CTL activity associated with control of viremia in primary HIV-1 infection. J. Virol. 1995. 68: 6103-6110.
2. Koup, R. A., Safrit, J. T., Cao, Y., Andres, C. A., McLeod, G., Borkowsky, W., Farthing, C. and Ho, D. D., Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J. Virol. 1994. 68: 4650-4655.
3. Musey, L., Hughes, J., Schacker, T., Shea, T., Corey, L. and McElrath, M. J., Cytotoxic T cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. New Engl. J. Med. 1997. 337: 1267-1274.
4. + lymphocytes. Science 1999. 283: 857-860.
5. Soudeyns, H. and Pantaleo, G., The moving target: mechanisms of HIV persistence during primary infection. Immunol. Today 1999. 20: 446-450.
6. Price, D. A., Goulder, P. J. R., Klenerman, P., Sewell, A. K., Easterbrook, P. J., Troop, M., Bangham, C. R. M. and Phillips, R. E., Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc. Natl. Acad. Sci. USA 1997. 94: 1890-1895.
7. Borrow, P., Lewicki, H., Wei, X., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A. and Shaw, G. M., Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus. Nature Med. 1997. 3: 205-211.
8. Phillips, R. E., Rowland-Jones, S., Nixon, D. F., Gotch, F. M., Edwards, J. P., Ogunlesi, A. O., Elvin, J. G., Rothbard, J. A., Bangham, C. R. M., Rizza, C. R. and McMichael, A. J., Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 1991. 354: 453-459.
9. Brander, C., Hartman, K. E., Trocha, A. K., Jones, N. G., Johnson, R. P., Korber, B., Wentworth, P., Buchbinder, S. P., Wolinsky, S., Walker, B. D. and Kalams, S. A., Lack of strong immune selection pressure by the immunodominant, HLA-A*0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection. J. Clin. Invest. 1998. 101: 2559-2566.
10. Delwart, E. L., Pan, H., Sheppard, H. W., Wolpert, D., Neumann, A. U., Korber, B. and Mullins, J. I., Slower evolution of human immunodeficiency virus type 1 quasispecies during progression to AIDS. J. Virol. 1997. 71: 7498-7508.
11. + T cell clones during primary infection. Proc. Natl. Acad. Sci. USA 1997. 94: 9848-9853.
12. Pantaleo, G., Soudeyns, H., Demarest, J. F., Vaccarezza, M., Graziosi, C., Paolucci, S., Daucher, M., Cohen, O. J., Denis, F., Biddison, W., Sekaly, R.-P. and Fauci, A. S., Segregation of human immunodeficiency virus-specific cytotoxic T lymphocytes away from the predominant site of virus replication during primary infection. Eur. J. Immunol. 1997. 27: 3166-3173.
13. Chappey, C. and Hazout, S., A method for delineating structurally homogeneous regions in protein sequences. Comp. Applic. Biosci. 1992. 8: 255-260.
14. Korber, B. T. M., Brander, C., Walker, B. D., Koup, R., Moore, J. P., Haynes, B. F. and Myers, G. (Eds.) Human retroviruses and AIDS 1995. A compilation and analysis of nucleic acid and amino acid sequences. Los Alamos National Laboratory, Los Alamos 1995.
15. Nei, M. and Gojobori, T., Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Mol. Biol. Evol. 1986. 3: 418-426.
16. Klenerman, P., Rowland-Jones, S., McAdam, S., Edwards, J., Daenke, S., Lalloo, D., Köppe, B., Rosenberg, W., Boyd, D., Edwards, A., Giangrande, P., Phillips, R. E. and McMichael, A. J., Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 gag variants. Nature 1994. 369: 403-407.
17. Pantaleo, G., Demarest, J. F., Schacker, T., Vaccarezza, M., Cohen, O. J., Daucher, M., Graziosi, C., Schnittman, S. S., Quinn, T. J., Shaw, G. M., Perrin, L., Tambussi, G., Lazzarin, A., Sekaly, R.-P., Soudeyns, H., Corey, L. and Fauci, A. S., The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc. Natl. Acad. Sci. USA 1997. 94: 254-258.
18. Goulder, P. J., Phillips, R. E., Colbert, R. A., McAdam, S., Ogg, G., Nowak, M. A., Giangrande, P., Luzzi, G., Morgan, B., Edwards, A., McMichael, A. J. and Rowland-Jones, S., Late escape from an immunodominant cytotoxic T-lymphocytes response associated with progression to AIDS. Nature Med. 1997. 3: 212-217.
19. Nowak, M. A., May, R. M., Phillips, R. E., Rowland-Jones, S., Lalloo, D. G., McAdam, S., Klenerman, P., Köppe, B., Sigmund, K., Bangham, C. R. M. and McMichael, A. J., Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 1995. 375: 606-611.
20. Harrer, T., Harrer, E., Kalams, S. A., Barbosa, P., Trocha, A., Johnson, R. P., Elbeik, T., Feinberg, M. B., Buchbinder, S. P. and Walker, B. D., Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load. J. Immunol. 1996. 156: 2616-2623.
21. Moretta, A., Pantaleo, G., Moretta, L., Cerottini, J. C. and Mingari, M. C., Quantitative assessment of the pool size and subset distribution of cytolytic T lymphocytes within human resting or alloactivated peripheral blood T cell populations. J. Exp. Med. 1983. 157: 743-754.
22. Earl, P. L., Hugin, A. W. and Moss, B., Removal of cryptic poxvirus transcription termination signals from the human immunodeficiency virus type 1 envelope gene enhances expression and immunogenicity of a recombinant vaccinia virus. J. Virol. 1990. 64: 2448-2451.
23. Karacostas, V., Nagashima, K., Gonda, M. A. and Moss, B., Human immunodeficiency virus-like particles produced by a vaccinia virus expression vector. Proc. Natl. Acad. Sci. USA 1989. 86: 8964-8967.
24. Chakrabarti, S., Brechling, K. and Moss, B., Vaccinia virus expression vector: coexpression of betagalactosidase provides visual screening of recombinant virus plaques. Mol. Cell. Biol. 1985. 5: 3403-3409.