The role of t cell help for anti-viral CTL responses

Journal of Theoretical Biology

Volumn 211, Issue 4, 2001, Pages 419-432

  Wodarz, Dominik ^a   Jansen, Vincent A A ^b  

^a INSTITUTE FOR ADVANCED STUDY   (United States)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 2;

IMMUNE RESPONSE; VIRUS;

ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELL INTERACTION; CELLULAR IMMUNITY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; HELPER CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VIRUS IMMUNITY; VIRUS INFECTION; VIRUS LOAD;

MURINAE;

EID: 0035928858     PISSN: 00225193     EISSN: None     Source Type: Journal    
DOI: 10.1006/jtbi.2001.2358     Document Type: Article

References (33)

1. Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8 + effector T cell responses
2. Competition for antigenic sites during T cell proliferation: A mathematical interpretation of in vitro data
3. CD40L-defcient mice show deficits in antiviral immunity and have an impaired memory CD8 + CTL response
4. CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
5. CD4(+) T cell-mediated control of a gamma-herpesvirus in B cell-deficient mice is mediated by IFN-gamma
6. T cell repertoires and competitive exclusion
7. CD8 + T cells become nonresponsive (anergic) following activation in the presence of costimulation
8. Modeling T cell-antigen presenting cell interactions
9. Cytotoxic T lymphocytes in asymptomatic long-term nonprogressing HIV-1 infection. Breadth and specificity of the response and relation to in vivo viral quasispecies in a person with prolonged infection and low viral load
10. Strong cytotoxic T cell and weak neutralizing antibody responses in a subset of persons with stable nonprogressing HIV type 1 infection
11. Rapid turnover of plasma virions and Cd4 lymphocytes in HIV-1 infection
12. HLA alleles determine human T-lymphotropic virus-I (HTLV-I) proviral load and the risk of HTLV-I-associated myelopathy
13. Molecular mechanisms of lymphocyte-mediated cytotoxicity and their role in immunological protection and pathogenesis in vivo
14. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses
15. Levels of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte effector and memory responses decline after suppression of viremia with highly active antiretroviral therapy
16. Cytotoxic T lymphocytes and viral turnover in HIV type 1 infection
17. Containment of SIV infection: Cellular immune responses and protection from rechallenge following transient post-inoculation antiretroviral treatment
18. Control of SIV rebound through structured treatment interruptions during early infection
19. Population dynamics of immune responses to persistent viruses
20. A critical role for neutralizing-antibody-producing B cells, CD4(+) T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: Implications for adoptive immunotherapy of virus carriers
21. A conditioned dendritic cell can be a temporal bridge between a CD4 + T-helper and a T-killer cell
22. Vigorous HIV-1-specific CD4 + T cell responses associated with control of viremia
23. Immune control of HIV-1 after early treatment of acute infection
24. Control of viremia in simian immunodeficiency virus infection by CD8(+) lymphocytes
25. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
26. Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell- deficient mice
27. CD40 ligand is pivotal to efficient control of virus replication in mice infected with lymphocytic choriomeningitis virus
28. Early postinfection antiviral treatment reduces viral load and prevents CD4 + cell decline in HIV type 2-infected macaques
29. Viral dynamics in human-immunodeficiency-virus type-1 infection
30. Specific therapy regimes could lead to long-term control of HIV
31. Immune responses and viral phenotype: Do replication rate and cytopathogenicity influence virus load?
32. The dynamics of HTLV-1 and the CTL response
33. Transient antiretroviral treatment during acute SIV infection facilitates long-term control of the virus