Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila

Development

Volumn 129, Issue 8, 2002, Pages 1925-1933

  Shen, Baohe ^a   Manley, James L ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Drosophila; Pelle; Phosphorylation; Toll

Indexed keywords

MEMBRANE RECEPTOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; INSECT DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENZYME ACTIVATION; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, CELL SURFACE; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TRANSFECTION;

ANIMALIA; HEXAPODA; INSECTA; MAMMALIA;

EID: 0036336519     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (52)

1. Toll signaling pathways in the innate immune response
2. A conserved signaling pathway: The Drosophila toll-dorsal pathway
3. Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor
4. IRAK: A kinase associated with the interleukin-1 receptor
5. TRAF6 is a signal transducer for interleukin-1
6. The TMK1 gene from Arabidopsis codes for a protein with structural and biochemical characteristics of a receptor protein kinase
7. Cloning and characterization of ntTMK1 gene encoding a TMK1-homologous receptor-like kinase in tobacco
8. IL-1 receptor accessory protein is an essential component of the IL-1 receptor
9. Proteolytic processing of the Drosophila Spatzle protein by easter generates a dimeric NGF-like molecule with ventralising activity
10. The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila
11. An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators
12. The death domain: A module shared by proteins with diverse cellular functions
13. Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos
14. Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll
15. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex
16. Activation of the kinase Pelle by Tube in the dorsoventral signal transduction pathway of Drosophila embryo
17. Oligomerisation of Tube and Pelle leads to nuclear localisation of dorsal
18. Synergistic activation and repression of transcription by Drosophila homeobox proteins
19. The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
20. Recruitment of IRAK to the interteukin 1 receptor complex requires interleukin 1 receptor accessory protein
21. Signaling mechanisms in the antimicrobial host defense of Drosophila
22. Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
23. The Toll-receptor family and control of innate immunity
24. Mutant cells that do not respond to interleukin-1 (IL-1) reveal a novel role for IL-1 receptor-associated kinase
25. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase
26. Overexpression of an enzymically inactive interieukin-1-receptor-associated kinase activates nuclear factor-kappaB
27. Getting knotted: A model for the structure and activation of Spatzle
28. The complexity of Raf-1regulation
29. An early role of maternal mRNA in establishing the dorsoventral pattern in pelle mutant Drosophila embryos
30. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
31. Selective nuclear transport of the Drosophila morphogen dorsal can be established by a signaling pathway involving the transmembrane protein Toll and protein kinase A
32. Regulation of dorsal in cultured cells by Toll and tube: Tube function involves a novel mechanism
33. Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal
34. Signal transduction pathways activated by the IL-1 receptor family: Ancient signaling machinery in mammals, insects, and plants
35. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
36. Transcriptional responses to polypeptide ligands: The JAK-STAT pathway
37. Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo
38. Pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
39. Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube
40. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation
41. Regulation of the protein kinase Raf-1 by oncogenic Ras through phosphatidylinositol 3-kinase, Cdc42/Rac and Pak
42. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
43. Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo
44. The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway
45. Developmental and tissue-specific expression of mouse pelle-like protein kinase
46. Signal transduction by receptors with tyrosine kinase activity
47. Modulation of tumor necrosis factor and interleukin-1-dependent NF-kappaΒ activity by mPLK/IRAK
48. The ILI receptor accessory protein is responsible for the recruitment of the interleukin-1 receptor associated kinase to the IL1/IL1 receptor I complex
49. IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family
50. Ventralization of the Drosophila embryo by deletion of extracellular leucine-rich repeats in the Toll protein
51. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation