BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors

Development

Volumn 129, Issue 10, 2002, Pages 2459-2472

  Timmer, John R ^a   Wang, Charlotte ^a   Niswander, Lee ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Basic helix loop helix; Bone morphogenetic protein; Chick; Dorsal ventral patterning; Homeobox; Neural tube

Indexed keywords

BONE MORPHOGENETIC PROTEIN; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PAX6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL POPULATION; CELL TYPE; CHICKEN; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; GROWTH REGULATION; NERVE CELL; NERVE CELL DIFFERENTIATION; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL;

ANIMALIA; GALLUS GALLUS;

EID: 0036333281     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.129.10.2459     Document Type: Article

References (76)

1. BMPs as mediators of roof plate repulsion of commissural neurons
2. The origins of the neural crest. Part I: Embryonic induction
3. Control of cell pattern in the neural tube: Regulation of cell differentiation by dorsalin-1, a novel TGF beta family member
4. FGFs and BMP4 induce both Msx1-independent and Msx1-dependent signaling pathways in early tooth development
5. Msx1 antagonizes the myogenic activity of Pax3 in migrating limb muscle precursors
6. BMP type II receptor is required for gastrulation and early development of mouse embryos
7. FGF signalling controls the timing of Pax6 activation in the neural tube
8. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
9. PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development
10. Pax: Gene regulators in the developing nervous system
11. Expression of homeobox genes Msx-1 (Hox-7) and Msx-2 (Hox-8) during cardiac development in the chick
12. A Xenopus type I activin receptor mediates mesodermal but not neural specification during embryogenesis
13. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
14. BMP signalling in early Xenopus development
15. Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system
16. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
17. Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4
18. Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway
19. Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1
20. Sonic hedgehog: A common signal for ventral patterning along the rostrocaudal axis of the neural tube
21. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
22. Graded sonic hedgehog signaling and the specification of cell fate in the ventral neural tube
23. Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
24. Replication-competent retroviral vectors encoding alkaline phosphatase reveal spatial restriction of viral gene expression/transduction in the chick embryo
25. Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord
26. Crossinhibitory activities of Ngn1 and Math1 allow specification of distinct dorsal interneurons
27. The signalling molecule BMP4 mediates apoptosis in the rhombencephalic neural crest
28. Dynamic expression of the murine Achaete-Scute homologue Mash-1 in the developing nervous system
29. A series of normal stages in the development of the chick embryo. 1951
30. Progenitors of dorsal commissural interneurons are defined by MATH1 expression
31. Wnt expression patterns in chick embryo nervous system
32. Expression of slit-2 and slit-3 during chick development
33. Correct coordination of neuronal differentiation events in ventral forebrain requires the bHLH factor MASH1
34. The seven-transmembrane receptor smoothened cell-autonomously induces multiple ventral cell types
35. Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification
36. The specification of dorsal cell fates in the vertebrate central nervous system
37. Neuronal patterning by BMPs: A requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
38. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
39. A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord
40. Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites
41. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
42. Identification of neurogenin, a vertebrate neuronal determination gene
43. Xmsx-1 modifies mesodermal tissue pattern along dorsoventral axis in Xenopus laevis embryo
44. Pax3 and Pax7 are expressed in commissural neurons and restrict ventral neuronal identity in the spinal cord
45. Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants
46. Activin as a morphogen in Xenopus mesoderm induction
47. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
48. The mouse Dreher gene Lmx1a controls formation of the roof plate in the vertebrate CNS
49. Comparison of three nonviral transfection methods for foreign gene expression in early chicken embryos in ovo
50. Efficient selection for high-expression transfectants with a novel eukaryotic vector
51. Sequential actions of BMP receptors control neural precursor cell production and fate
52. Early specification of sensory neuron fate revealed by expression and function of neurogenins in the chick embryo
53. A sonic hedgehog-independent, retinoid-activated pathway of neurogenesis in the ventral spinal cord
54. Activin A inhibits Pax-6 expression and pertubs cell differentiation in the developing spinal cord in vitro
55. BMPs negatively regulate structure and function of the limb apical ectodermal ridge
56. Morphogen gradients: New insights from DPP
57. Epitope mapping of monoclonal antibodies to gag protein p19 of avian sarcoma and leukaemia viruses
58. Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis
59. Effects of Shh and Noggin on neural crest formation demonstrate that BMP is required in the neural tube but not ectoderm
60. The murine homeobox gene Msx-3 shows highly restricted expression in the developing neural tube
61. Neurogenin2 expression in ventral and dorsal spinal neural tube progenitor cells is regulated by distinct enhancers
62. Mice lacking Bmp6 function
63. Neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS
64. Establishment and maintenance of the border of the neural plate in the chick: Involvement of FGF and BMP activity
65. Xenopus msx1 mediates epidermal induction and neural inhibition by BMP4
66. Inhibition of floor plate differentiation by Pax3: Evidence from ectopic expression in transgenic mice
67. Topographic organization of embryonic motor neurons defined by expression of LIM homeobox genes
68. Pax-6, a murine paired box gene, is expressed in the developing CNS
69. Msx3: A novel murine homologue of the Drosophila msh homeobox gene restricted to the dorsal embryonic central nervous system
70. Effects of BMP-7 on mouse tooth mesenchyme and chick mandibular mesenchyme
71. GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex
72. Complementary and combinatorial patterns of Notch gene family expression during early mouse development
73. Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate
74. Requirement of Xmsx-1 in the BMP-triggered ventralization of Xenopus embryos
75. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
76. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage