Sequential actions of BMP receptors control neural precursor cell production and fate

Genes and Development

Volumn 15, Issue 16, 2001, Pages 2094-2110

  Panchision, David M ^a   Pickel, James M ^a   Studer, Lorenz ^a,b   Lee, Sang Hun ^a,c   Turner, Patricia A ^a,d   Hazel, Thomas G ^a,e   McKay, Ronald D G ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c Hanyang University   (South Korea)

^d UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^e NeuralStem Biopharmaceuticals   (United States)

Author keywords

Bone morphogenetic protein; Development; Neural; Precursor cell; Receptor

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; RECEPTOR SUBTYPE; SONIC HEDGEHOG PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL FATE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GESTATION PERIOD; MALE; MITOSIS INHIBITION; MOUSE; NERVE CELL DIFFERENTIATION; NEURAL TUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENTIAL ANALYSIS; STEM CELL;

ANIMALS; APOPTOSIS; BONE MORPHOGENETIC PROTEIN RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; BONE MORPHOGENETIC PROTEINS; CELL COUNT; CELL DIFFERENTIATION; EMBRYO; EPITHELIAL CELLS; FEMALE; HEDGEHOG PROTEINS; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECEPTOR CROSS-TALK; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

ANIMALIA; ERINACEIDAE;

EID: 0035881809     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.894701     Document Type: Article

References (88)

1. Neural patterning in the vertebrate embryo
2. The importance of timing differentiation during limb muscle development
3. A molecular mechanism enabling continuous embryonic muscle growth: A balance between proliferation and differentiation
4. BMP-7 influences pattern and growth of the developing hindbrain of mouse embryos
5. The organizer factors Chordin and Noggin are required for mouse forebrain development
6. Expression of Pax-3 in the lateral neural plate is dependent on a Wnt-mediated signal from posterior nonaxial mesoderm
7. Bmp activity establishes a gradient of positional information throughout the entire neural plate
8. Combinatorial signaling through BMP receptor IB and GDF5: Shaping of the distal mouse limb and the genetics of distal limb diversity
9. Roles for Msx and Dlx homeoproteins in vertebrate development
10. The specification of neuronal identity by graded Sonic Hedgehog signalling
11. Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing
12. Neuron specificity of the neurofilament light promoter in transgenic mice requires the presence of DNA unwinding elements
13. Suppression of transforming growth factor-β-induced apoptosis through a phosphatidylinositol 3-kinase/Akt-dependent pathway
14. Differentiation-related mechanisms which suppress DNA replication
15. Teratogen-mediated inhibition of target tissue response to Shh signaling
16. Vnd/nkx, ind/gsh, and msh/msx: Conserved regulators of dorsoventral neural patterning?
17. Pattern formation: A new twist to BMP signalling
18. Measuring dimensions: The regulation of size and shape
19. Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis
20. Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos
21. Developmental control of cell cycle regulators: A fly's perspective
22. Gradient formation of the TGF-β homolog Dpp
23. Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
24. Induction and differentiation of the neural crest
25. Towards a greater understanding of the pathogenesis of holoprosencephaly
26. Ectopic bone morphogenetic proteins 5 and 4 in the chicken forebrain lead to cyclopia and holoprosencephaly
27. Neural crest apoptosis and the establishment of craniofacial pattern: An honorable death
28. Bone morphogenetic proteins promote astroglial lineage commitment by mammalian subventricular zone progenitor cells
29. The hem of the embryonic cerebral cortex is defined by the expression of multiple Wnt genes and is compromised in Gli3-deficient mice
30. Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex
31. The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-β
32. Enhanced expression of type I receptors for bone morphogenetic proteins during bone formation
33. Signaling of transforming growth factor-β family members through smad proteins
34. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
35. The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
36. Single factors direct the differentiation of stem cells from the fetal and adult central nervous system
37. POU transcription factors control expression of CNS stem cell-specific genes
38. Transcriptional mechanisms in the development of motor control
39. Unified nomenclature for the winged helix/forkhead transcription factors
40. Spinal cord neuronal precursors generate multiple neuronal phenotypes in culture
41. Signal transduction by bone morphogenetic proteins
42. Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues
43. BMP2-induced apoptosis is mediated by activation of the TAK1-38 kinase pathway that is negatively regulated by Smad6
44. Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smadl
45. Specificity of TGFβ signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans
46. Dpp receptor levels contribute to shaping the Dpp morphogen gradient in the Drosophila wing imaginal disc
47. Neuronal patterning by BMPs: A requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord
48. Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP
49. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm
50. A role for the roof plate and its resident TGFβ-related proteins in neuronal patterning in the dorsal spinal cord
51. The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo
52. Multiple roles of bone morphogenetic protein signaling in the regulation of cortical cell number and phenotype
53. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite
54. Developmental changes in progenitor cell responsiveness to bone morphogenetic proteins differentially modulate progressive CNS lineage fate
55. Morphogenesis of digits in the avian limb is controlled by FGFs, TGFβs, and noggin through BMP signaling
56. Control of digit formation by activin signalling
57. Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
58. Early cortical precursors do not undergo LIF-mediated astrocytic differentiation
59. Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4
60. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells
61. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells
62. A common neural progenitor for the CNS and PNS
63. p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/differentiation factor-5 in ATDC5 cells
64. Regulation of BMP/Dpp signaling during embryonic development
65. Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by a bmp2b/swirl pathway of genes
66. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway
67. In vivo analysis using variants of zebrafish BMPR-IA: Range of action and involvement of BMP in ectoderm patterning
68. BMPs are required at two steps of limb chondrogenesis: Formation of prechondrogenic condensations and their differentiation into chondrocytes
69. Bone morphogenetic proteins: From basic studies to clinical approaches
70. Alternative neural crest cell fates are instructively promoted by TGFβ superfamily members
71. Mice lacking Bmp6 function
72. In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
73. Transplantation of expanded mesencephalic precursors leads to recovery in parkinsonian rats
74. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
75. A BMP homolog acts as a dose-dependent regulator of body size and male tail patterning in Caenorhabditis elegans
76. Telencephalon-restricted expression of BF-1, a new member of the HNF-3/fork head gene family, in the developing rat brain
77. Dpp gradient formation in the Drosophila wing imaginal disc
78. Cell contact regulates fate choice by cortical stem cells
79. Antagonists go out on a limb
80. Bone morphogenetic protein type IB receptor is progressively expressed in malignant glioma tumours
81. XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway
82. The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb
83. Cell cycle regulators in neural stem cells and postmitotic neurons
84. Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression
85. Characterization of GDF-10 expression patterns and null mice
86. Developmental changes in progenitor cell responsiveness to cytokines
87. Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage