Contribution of known and unknown susceptibility genes to early-onset diabetes in Scandinavia: Evidence for heterogeneity

Diabetes

Volumn 51, Issue 5, 2002, Pages 1609-1617

  Lindgren, Cecilia M ^a   Widén, Elisabeth ^b   Tuomi, Tiinamaija ^a,b   Li, Haiyan ^a   Almgren, Peter ^a   Kanninen, Timo ^a,c   Melander, Olle ^a   Weng, Jianping ^a   Lehto, Markku ^a   Groop, Leif C ^a,d  

^a Malmö University Hospital   (Sweden)

^b UNIVERSITY OF HELSINKI   (Finland)

^c Biocomputing Platforms Ltd Oy   (Finland)

^d Malmi University Hospital   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; INSULIN; MITOCHONDRIAL DNA;

ADULT; ALLELISM; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CELL HETEROGENEITY; CHROMOSOME 11Q; CHROMOSOME 18Q; CHROMOSOME 1P; CHROMOSOME 20Q; CHROMOSOME 21Q; CHROMOSOME 3P; CHROMOSOME 7Q; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC EPIDEMIOLOGY; GENETIC LINKAGE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; JUVENILE DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; MARKER GENE; PRIORITY JOURNAL; SCANDINAVIA; SINGLE STRAND CONFORMATION POLYMORPHISM;

EID: 0036319126     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.5.1609     Document Type: Article

References (54)

1. Metabolic and genetic characterization of prediabetic states: Sequence of events leading to non-insulin-dependent diabetes mellitus
2. Non-insulin-dependent diabetes mellitus - A collision between thrifty genes and an affluent society
3. Maturity-onset diabetes of the young: Clinical heterogeneity explained by genetic heterogeneity
4. Maternally inherited diabetes and deafness (MIDD): A distinct subtype of diabetes associated with a mitochondrial tRNA(Leu)(UUR) gene point mutation
5. Monogenic diabetes mellitus in youth: The MODY syndromes
6. Emerging epidemic of type 2 diabetes in youth
7. Characterization of the MODY3 phenotype: Early-onset diabetes caused by an insulin secretion defect
8. Molecular genetics of MODY in Germany
9. Mutations in the hepatocyte nuclear factor-4α gene in maturity-onset diabetes of the young (MODY1)
10. Gene for non-insulin-dependent diabetes mellitus (maturityonset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
11. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
12. Human glucokinase gene: Isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (type 2) diabetes mellitus
13. A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
14. Mutations in the hepatocyte nuclear factor-1α gene in maturity-onset diabetes of the young (MODY3)
15. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1
16. Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY
17. Mutation screening in 18 Caucasian families suggest the existence of other MODY genes
18. Genetic and clinical characterisation of maturity-onset diabetes of the young in Spanish families
19. Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes
20. High frequency of mutations in MODY and mitochondrial genes in Scandinavian patients with familial early-onset diabetes
21. Management of non-insulin-dependent diabetes mellitus in Europe: A consensus view
22. Metabolic consequences of a family history of NIDDM (the Botnia study): Evidence for sex-specific parental effects
23. Clinical and genetic characteristics of type 2 diabetes with and without GAD antibodies
24. Risk factors for NIDDM in white population: Paris prospective study
25. Predictors of progression from impaired glucose tolerance to NIDDM: An analysis of six prospective studies
26. The common PPARγ Pro 12Ala polymorphism is associated with decreased risk of type 2 diabetes
27. Hepatocyte nuclear factor-1 beta (MODY5) gene mutations in Scandinavian families with early-onset diabetes or kidney disease or both
28. Functional consequences of mutations in the MODY4 gene (IPF1) and coexistence with MODY 3 mutations
29. A distant upstream promoter of the HNF-4α gene connects the transcription factors involved in maturity-onset diabetes of the young
30. Parametric and nonparametric linkage analysis: A united multipoint approach
31. Genetic linkage analysis of complex genetic traits by using affected sibling pairs
32. Allegro, a new computer program for multipoint linkage analysis
33. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families
34. Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
35. Genetic linkage analysis in familial breast and ovarian cancer: Results from 214 families: The Breast Cancer Linkage Consortium
36. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes: Pima Diabetes Genes Group
37. Genomewide search for type 2 diabetes susceptibility genes in four American populations
38. Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI 3K
39. Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus
40. AMP-activated protein kinase - An archetypal protein kinase cascade?
41. Regulation of fatty acid and cholesterol metabolism by the AMP-activated protein kinase
42. Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy
43. The Finland-United States investigation of non-insulindependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes
44. New susceptibility locus for NIDDM is localized to human chromosome 20q
45. A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
46. A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
47. Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs
48. Exclusion of the hepatocyte nuclear factor 4α as a candidate gene for late-onset NIDDM linked with chromosome 20q
49. An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians
50. Genomewide scanning for type 2 diabetes susceptibility in Canadian Oji-Cree, using 190 microsatellite markers
51. Sequence and structure of a human glucose transporter
52. Isolation of a cDNA specifying subunit VIIb of human cytochrome c oxidase
53. Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes
54. Prevalence and incidence of non-insulin dependent diabetes mellitus