Genetic linkage analysis of complex genetic traits by using affected sibling pairs

Biometrics

Volumn 54, Issue 4, 1998, Pages 1238-1246

  Hauser, Elizabeth R ^a   Boehnke, Michael ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Affected sibling pairs; Complex diseases; Genetic methods; Genetics; Identity by descent; Linkage analysis

Indexed keywords

AFFECTED SIBLING PAIR; COMPLEX DISEASE; GENETIC; GENETIC ANALYSIS; GENETIC LINKAGE; GENETIC METHODS; GENETIC TRAITS; HEART DISEASE; IDENTITY BY DESCENT; LINKAGE ANALYSIS;

ARTICLE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; GENETIC LINKAGE; GENETIC PREDISPOSITION; HUMAN; HYPERTENSION; PEDIGREE ANALYSIS; SIBLING;

EID: 0032433332     PISSN: 0006341X     EISSN: None     Source Type: Journal    
DOI: 10.2307/2533653     Document Type: Article

References (11)

1. Amos, C. I., Zhu, D. K., and Boerwinkle, E. (1996). Assessing genetic linkage and association with robust components of variance approaches. Annals of Human Genetics 60, 143-160.
2. Baum, L. E. (1972). An inequality and associated maximization technique in statistical estimation for probabilistic functions of Markov processes. Inequalities 3, 1-8.
3. Bernstein, F. (1931). Zur Grundlegung der Chromosomentheorie der Vererbung beim Menschen. Zeitschrift für induktive Abstammungs- und Vererbungslehre 54, 113-138.
4. Blackwelder, W. C. and Elston, R. C. (1985). A comparison of sib-pair linkage tests for disease susceptibility loci. Genetic Epidemiology 2, 85-97.
5. Blangero, J. and Almasy, L. (1997). Multipoint oligogenic linkage analysis of quantitative traits. Genetic Epidemiology 14, 959-964.
6. Cordell, H. J., Todd, J. A., Bennett, S. T., Kawaguchi, Y., and Farrall, M. (1995). Two-locus maximum lod score analysis of a multifactorial trait: Joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes. American Journal of Human Genetics 37, 920-934.
7. Dib, C., Faure, S., Fizames, C., et al. (1996). A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380, 152-154.
8. Elston, R. C. and Stewart, J. (1971). A general model for the genetic analysis of pedigree data. Human Heredity 21, 523-542.
9. Feingold, E. (1993). Markov processes for modeling and analyzing a new genetic mapping method. Journal of Applied Probability 30, 766-779.
10. Feingold, E., Brown, P. O., and Siegmund, D. (1993). Gaussian models for genetic linkage analysis using complete high-resolution maps of identity by descent. American Journal of Human Genetics 53, 234-251.
11. Fisher, R. A. (1934). The amount of information supplied by records of families as a function of the linkage in the population sampled. Annals of Eugenics 6, 66-70.