Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation

Journal of Molecular Biology

Volumn 299, Issue 2, 2000, Pages 369-378

  Linder, B ^a   Newman, R ^b   Jones, L K ^a   Debernardi, S ^a   Young, B D ^a   Freemont, P ^b   Verrijzer, C P ^c   Saha, V ^a  

^a London School of Medicine and Dentistry   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c LEIDEN UNIVERSITY   (Netherlands)

Author keywords

AT hooks; Chromatin; LAP PHD finger; NLS; Protein protein interaction

Indexed keywords

PROTEIN DERIVATIVE;

ARTICLE; BIOCHEMISTRY; CHROMATIN; HUMAN; HUMAN CELL; LEUKEMOGENESIS; NUCLEAR LOCALIZATION SIGNAL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

EID: 0034595504     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3766     Document Type: Article

References (39)

1. The PHD finger: Implications for chromatin-mediated transcriptional regulation
2. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
3. AT-hook motifs identified in a wide variety of DNA-binding proteins
4. Specific recognition of cruciform DNA by nuclear protein HMG1
5. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein
6. The HRX proto-oncogene product is widely expressed in human tissues and localizes to nuclear structures
7. A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia
8. The t(10;11) translocation in acute myeloid leukemia (M5) consistently fuses the leucine zipper motif of AF10 onto the HRX gene
9. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
10. Reversal of intrinsic DNA bends in the IFN beta gene enhancer by transcription factors and the architectural protein HMG I(Y)
11. Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster
12. The t(4;11) chromosome translocation of human acute leukaemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene
13. Adenoviral E1A-associated protein p300 is involved in acute myeloid leukemia with t(11;22)(q23;q13)
14. Co-operative DNA binding by GAGA transcription factor requires the conserved BTB/POZ domain and reorganises promoter topology
15. A C4HC3 zinc finger motif
16. Expression pattern and cellular distribution of the murine homologue of AF10
17. A novel human gene, WSTF, is deleted in Williams syndrome
18. Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs
19. The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences
20. The bromodomain of Gcn5p interacts in vitro with specific residues in the N terminus of histone H4
21. Cloning of the ALL-1 fusion partner, the AF-6 gene, involved in acute myeloid leukemias with the t(6;11) chromosome translocation
22. Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia
23. The AT-DNA-binding domain of mammalian high mobility group I chromosomal proteins: A novel peptide motif for recognizing DNA structure
24. Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix
25. AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: Altered sub-cellular distribution of mutants lacking the PHD zinc fingers
26. Two interdependent basic domains in nucleoplasmin nuclear targeting-sequence: Identification of a class of bipartite nuclear targeting sequence
27. The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins
28. Translocations, fusion genes, and acute leukemia
29. Semper: Distortion compensation, selective averaging, 3D reconstruction and transfer function correction in a highly programmable system
30. Locking in stable states of gene expression: Transcriptional control during Drosophila development
31. The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX
32. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3)
33. WHSC1, a 90 kb SET domain-containing gene, expressed in early development and homologous to a Drosophila dysmorphy gene maps in the Wolf-Hirschhorn syndrome critical region and is fused to IgH in t(4;14) multiple-myeloma
34. Sars are cis DNA elements of chromosome dynamics - Synthesis of a sar repressor protein
35. The high mobility group protein HMG I(Y) is required for F-kappa B-dependent virus induction of the human IFN-beta gene
36. BR140, a novel zinc-finger protein with homology to the TAF250 subunit of TFIID
37. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias
38. Chromosome abnormalities in leukaemia: The 11q23 paradigm
39. Altered Hox expression and segmental identity in Mll-mutant mice