Genetics of chronic lymphocytic leukemia: Genomic aberrations and VH gene mutation status in pathogenesis and clinical course

Leukemia

Volumn 16, Issue 6, 2002, Pages 993-1007

  Stilgenbauer, S ^a   Bullinger, L ^a   Lichter, P ^a   Dohner H ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

ATM; CLL; Genomic aberrations; p53; VH mutation status

Indexed keywords

ALKYLATING AGENT; ATM PROTEIN; BIOLOGICAL MARKER; CD38 ANTIGEN; FLUDARABINE; IMMUNOGLOBULIN HEAVY CHAIN;

CANCER GENETICS; CANCER STAGING; CANCER SURVIVAL; CHROMOSOME 11Q; CHROMOSOME 13Q; CHROMOSOME 17P; CHROMOSOME DELETION; CHROMOSOME DELETION 11; CHROMOSOME DELETION 13; CHROMOSOME DELETION 17; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL FEATURE; CONTROLLED STUDY; CYTOGENETICS; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE COURSE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE IDENTIFICATION; GENE MUTATION; GENETIC RISK; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMOGENESIS; LYMPHADENOPATHY; MOLECULAR GENETICS; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW; RISK ASSESSMENT; TREATMENT FAILURE;

EID: 0036275343     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.leu.2402537     Document Type: Review

References (186)

1. Clustering of aberrations to specific chromosomes in human neoplasms
2. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities
3. Cytogenetic findings and survival in B-cell chronic lymphocytic leukemia. Second IWCCLL compilation of data on 662 patients
4. Genomic aberrations and survival in chronic lymphocytic leukemia
5. Cellular origin of human B-cell lymphomas
6. The pathogenesis of chronic lymphocytic leukemia: Analysis of the antibody repertoire
7. Chronic lymphocytic leukemia B cells express restricted sets of mutated and unmutated antigen receptors
8. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
9. H genes are associated with a more aggressive form of chronic lymphocytic leukemia
10. B-cell activation of peripheral blood lymphocytes from patients with chronic lymphocytic leukaemia
11. Human chronic lymphocytic leukemia: Karyotypes in different lymphocyte populations
12. Chromosome abnormalities of leukaemic B lymphocytes in chronic lymphocytic leukaemia
13. Extra chromosome 12 in chronic lymphocytic leukaemia
14. Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation
15. Cytogenetic and molecular abnormalities in chronic lymphocytic leukaemia
16. Detection of trisomy 12 in chronic lymphoid leukemias using fluorescence in situ hybridization
17. In vitro activation of leukaemia B cells by interleukin-4 and antibodies to CD40
18. Cytogenetic and immunologic characterization of mitotic cells in chronic lymphocytic leukemia
19. Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors
20. Detection of complete and partial chromosome gains and losses by comparative genomic in situ hybridization
21. Detection of amplified genomic sequences by reverse chromosome painting using genomic tumor DNA as probe
22. Comparative genomic hybridization in chronic B-cell leukemias reveals a high incidence of chromosomal gains and losses
23. Is non-isotopic in situ hybridization finally coming of age?
24. Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: Diagnosis of trisomy 18 with probe L1.84
25. Chromosome aberrations in B-cell chronic lymphocytic leukemia: Reassessment based on molecular cytogenetic analysis
26. H mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
27. Chromosomes and causation of human cancer and leukemia. XLV. Chromosome patterns in stimulated lymphocytes of chronic lymphocytic leukemia
28. Prognostic importance of cytogenetic abnormalities in patients with chronic lymphocytic leukemia
29. Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia
30. Prognostic information from cytogenetic analysis in chronic B-lymphocytic leukemia and leukemic immunocytoma
31. The most common chromosome change in 86 chronic B cell or T cell tumors: A 14q32 translocation
32. Clonal chromosome abnormalities in chronic lymphocytic leukemia patients revealed by TPA stimulation of whole blood cultures
33. Cytogenetic studies in chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia: A progress report
34. Chromosome abnormalities in B cell chronic lymphocytic leukemia and their clinical correlations
35. Correlation of chromosome abnormalities with laboratory features and clinical course in B-cell chronic lymphocytic leukaemia
36. Chromosome abnormalities involving band 13q14 in hematologic malignancies
37. Chromosome 13 - A new marker for B-cell chronic lymphocytic leukemia
38. Frequent clonal abnormalities of chromosome band 13q14 in B-cell chronic lymphocytic leukemia: Multiple clones, subclones, and nonclonal alterations in 82 Midwestern patients
39. Chromosome abnormalities in chronic lymphocytic leukemia revealed by TPA as a mitogen
40. A new characteristic karyotypic anomaly in lymphoproliferative disorders
41. Nonrandom chromosome abnormalities in lymphoma
42. A 14;19 translocation in B-cell chronic lymphocytic leukemia: A new recurring chromosome aberration
43. bcl-1, t(11;14), and mantle cell-derived lymphomas
44. Genomic aberrations in the CLL3 trial of the German CLL Study Group (GCLLSG): Deletion 11q23 indentifies patients with molecular disease persitstence after autologous high dose therapy
45. Incidence and corralation of genomic aberrations with clinical and biological risk factors in B-CLL stage Binet-A within the CLL1 trial of the GCLLSG
46. Karyotypic evolution in B-cell chronic lymphocytic leukemia
47. Karyotypic evolution in CLL. Identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease
48. Secondary abnormalities of chromosome 6q in B-cell chronic lymphocytic leukemia: A sequential study of karyotypic instability in 51 patients
49. Clonal evolution in B-CLL: Acquisition of deletions involving 6q21, 11q22 and 17p13 (TP53) associated with disease progression
50. Chronic lymphocytic leukemia cells with allelic deletions at 13q14 commonly have one intact RB1 gene: Evidence for a role of an adjacent locus
51. Evidence for a new tumour suppressor locus (DBM) in human B-cell neoplasia telomeric to the retinoblastoma gene
52. Retinoblastoma gene deletions in B-cell chronic lymphocytic leukemia
53. High frequency of monoallelic retinoblastoma gene deletion in B-cell chronic lymphoid leukemia shown by interphase cytogenetics
54. Molecular cytogenetic analysis of Rb-1 deletions in chronic B-cell leukemias
55. Frequent homozygous deletions of the D13S25 locus in chromosome region 13q14 defines the location of a gene critical in leukaemogenesis in chronic B-cell lymphocytic leukaemia
56. Deletion cartography around the D13S25 Locus in B cell chronic lymphocytic leukemia
57. Heterogeneity of deletions involving RB-1 and the D13S25 locus in B-cell chronic lymphocytic leukemia revealed by FISH
58. 13q deletions in lymphoid malignancies
59. Minimal region of loss at 13q14 in B-cell chronic lymphocytic leukemia
60. Cloning and gene mapping of the chromosome 13q14 region deleted in chronic lymphocytic leukemia
61. Cloning of two candidate tumor suppressor genes within a 10 kb region on chromosome 13q14, frequently deleted in chronic lymphocytic leukemia
62. Construction of a 780-kb PAC, BAC, and cosmid contig encompassing the minimal critical deletion involved in B cell chronic lymphocytic leukemia at 13q14.3
63. Detailed molecular delineation of 13q14.3 loss in B-cell chronic lymphocytic leukemia
64. Expressed sequences as candidates for a novel tumor suppressor gene at band 13q14 in B-cell chronic lymphocytic leukemia and mantle cell lymphoma
65. Exclusion of Leu1 and Leu2 genes as tumor suppressor genes in 13q14.3-deleted B-CLL
66. The candidate gene for B-cell chronic lymphocytic leukemia localized at 13q14.3, BCMSUN, has an independently expressed homolog on 1p22-p31, BCMSUN-like
67. B-cell neoplasia associated gene with multiple splicing (BCMS): The candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions
68. Trisomy 12 defines a group of CLL with atypical morphology: Correlation between cytogenetic, clinical and laboratory features in 544 patients
69. In B-cell chronic lymphocytic leukaemia chromosome 17 abnormalities and not trisomy 12 are the single most important cytogenetic abnormalities for the prognosis: A cytogenetic and immunophenotypic study of 480 diagnosed patients
70. Cytogenetic analysis of B cell chronic lymphoid leukemias classified according to morphologic and immunophenotypic (FAB) criteria
71. Karyotypic evolution in CLL. Identification of a new sub-group of patients with deletions of 11q and advanced or progressive disease
72. Deletions at 11q identify a subset of patients with typical CLL who show consistent disease progression and reduced survival
73. Analysis of deletions of the long arm of chromosome 11 in hematologic malignancies with fluorescence in situ hybridization
74. Molecular cytogenetic delineation of a novel critical genomic region in chromosome bands 11q22.2-q23.1 in lymphoproliferative disorders
75. A radiation hybrid map of 506 STS markers spanning human chromosome 11
76. Discontinuous deletions at 11q23 in B cell chronic lymphocytic leukemia
77. ATM: From gene to function
78. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor
79. Atm-deficient mice: A paradigm of ataxia telangiectasia
80. Biallelic mutations in the ATM gene in T-prolymphocytic leukemia
81. Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia
82. Deficiency of the ATM protein defines an aggressive subgroup of B-cell chronic lymphocytic leukemia
83. ATM mutations in B-cell chronic lymphocytic leukemia
84. Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia
85. Somatic ATM mutations indicate a pathogenic role of ATM in B-cell chronic lymphocytic leukemia
86. Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage
87. p53 dysfunction in B-cell chronic lymphocytic leukemia: Inactivation of ATM as an alternative to TP53 mutation
88. Molecular characterisation of deletion at 11q22.1-23.3 in mantle cell lymphoma
89. Molecular characterization of 11q deletions points to a pathogenic role of the ATM gene in mantle cell lymphoma
90. Mantle cell lymphoma is characterized by inactivation of the ATM gene
91. 11 q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
92. Chromosome aberrations in B-cell chronic lymphocytic leukemia. Pathogenetic and clinical implications
93. Cytogenetic mapping of the duplicated segment of chromosome 12 in lymphoproliferative disorders
94. Molecular Analysis of chromosome 12 in chronic lymphocytic leukemia
95. Trisomy 12 in chronic lymphocytic leukemia: An interphase cytogenetic study
96. Detection of trisomy 12 in chronic lymphocytic leukemia by fluorescence in situ hybridization to interphase cells: A simple and sensitive method
97. Mosaicism of trisomy 12 in chronic lymphocytic leukemia detected by non-radioactive in situ hybridisation
98. Fluorescence in situ hybridization and cytogenetic studies of trisomy 12 in chronic lymphocytic leukemia
99. Trisomy 12 in chronic lymphocytic leukemia detected by fluorescence in situ hybridization: Analysis by stage, immunophenotype, and morphology
100. Trisomy 12 is uncommon in typical chronic lymphocytic leukaemias
101. Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridization
102. Trisomy 12 and lymphoplasmacytoid lymphocytes in chronic leukemic B-cell disorders
103. Amplification of multiple regions of chromosome 12, including 12q13-15, in chronic lymphocytic leukaemia
104. FISH identifies different types of duplications with 12q13-15 as the commonly involved segment in B-cell lymphoproliferative malignancies characterized by partial trisomy 12
105. Matrix-based comparative genomic hybridization: Biochips to screen for genomic imbalances
106. High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays
107. Extra chromosome 12 and prognosis in chronic lymphocytic leukaemia
108. The sequential analysis of trisomy 12 in B-cell chronic lymphocytic leukaemia
109. Long-term follow-up of trisomy 12 by FISH in chronic lymphocytic leukemia
110. p53 mutations in human lymphoid malignancies: Association with Burkitt lymphoma and chronic lymphocytic leukemia
111. Mutations of the p53 gene in B-cell chronic lymphocytic leukemia: A report on 39 cases with cytogenetic analysis
112. p53 gene mutation in B-cell chronic lymphocytic leukemia is associated with drug resistance and is independent of MDR1/MDR3 gene expression
113. Analysis of alterations of oncogenes and tumor suppressor genes in chronic lymphocytic leukemia
114. p53 gene deletion predicts for poor survival and non-response to therapy with purine analogs in chronic B-cell leukemias
115. p53 aberrations in B-CLL predict survival and are associated with in vivo resistance to therapy
116. Detection and characterization of p53 abnormalities in chronic lymphocytic leukemia (CLL)
117. Campath-1H in refractory B-CLL - Complete remission despite p53 gene mutation
118. Cytogenetic deletion maps of hematologic neoplasms: Circumstantial evidence for tumor suppressor loci
119. 6q deletions define distinct clinico-pathologic subsets of non-Hodgkin's lymphoma
120. Clinical and morphologic features of B-cell small lymphocytic lymphoma with del(6)(q21q23)
121. 6q deletions in acute lymphoblastic leukemia and non-Hodgkin's lymphomas
122. Indcidence and clinical significance of 6q deletions in B-cell chronic lymphocytic leukemia
123. A 3-cM commonly deleted region in 6q21 in leukemias and lymphomas delineated by fluorescence in situ hybridization
124. Prognostic value of chromosomal abnormalities in follicular lymphoma
125. PRAD1, a candidate BCL1 oncogene: Mapping and expression in centrocytic lymphoma
126. Characterization of a candidate bcl-1 gene
127. PRAD-1/Cyclin D1 gene overexpression in chronic lymphoproliferative disorders: A highly specific marker of mantle cell lymphoma
128. Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation
129. Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation
130. An additional breakpoint in the BCL-1 locus associated with the t(11;14)(q13;q32) translocation of B-lymphocytic malignancy
131. A search for bcl1, bcl2, and c-myc oncogene rearrangements in chronic lymphocytic leukemia
132. Association of bcl-1 rearrangements with lymphocytic lymphoma of intermediate differentiation
133. Oncogene rearrangements in chronic B-cell leukemia
134. Phenotypic markers and BCL1 rearrangements in B-cell chronic lymphocytic leukemia: A cancer and leukemia group B study
135. Variant translocation of the bcl-2 gene to Ig in a chronic lymphocytic leukemia
136. Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia
137. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
138. Lack of 5′bcl2 rearrangements in B-cell leukemia
139. BCL2 translocations in leukemias of mature B cells
140. BCL3 rearrangements and t(14;19)(q32;q13) in lymphoproliferative disorders
141. Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia
142. Identification of a transcriptional unit adjacent to the breakpoint in the 14;19 translocation of chronic lymphocytic leukemia
143. BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: A molecular and cytogenetic study
144. The proto-oncogene bcl-3 encodes an I kappa B protein
145. The role of immunoglobulin translocations in the pathogenesis of B-cell malignancies
146. Deletions and rearrangement of CDKN2 in lymphoid malignancy
147. p16 gene homozygous deletions in acute lymphoblastic leukemia
148. Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies
149. CDKN2 gene deletion is not found in chronic lymphoid leukemias of B- and T-cell origin, but is frequent in acute lymphoblastic leukemia
150. Automated genomic profiling using microarray-based hybridization (Matrix-CGH) - A powerful technique for the detection of DNA-amplifications in aggressive lymphoma
151. Automated genomic profiling in chronic lymphocytic leukemia using microarray-based hybridization (Matrix-CGH)
152. Lack of detectable somatic hypermutation in the V region of the Ig H chain gene of a human chronic B lymphocytic leukemia
153. Ig V region gene expression in small lymphocytic lymphoma with little or no somatic hypermutation
154. B cells of chronic lymphatic leukemia express V genes in unmutated form
155. Immunoglobulin (Ig) VH gene usage in B-CLL patients: Different VH gene profiles in unmutated compared to mutated CLL and normal controls
156. Ig VH1 genes expressed in B cell chronic lymphocytic leukemia exhibit distinctive molecular features
157. Analysis of VDJ rearrangement structure and VH mutation status in chronic lymphocytic leukemia
158. Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes
159. Differential rates of somatic hypermutation in V(H) genes among subsets of chronic lymphocytic leukemia defined by chromosomal abnormalities
160. + chronic lymphocytic leukemia B cells: A multiple time point analysis
161. Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
162. Cloning of bcl-6, the locus involved in chromosome translocations affecting band 3q27 in B-cell lymphoma
163. The POZ domain: A conserved protein-protein interaction motif
164. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma
165. Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma
166. The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
167. BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci
168. Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes
169. Nonimmunoglobulin gene hypermutation in germinal center B cells
170. BCL-6 mutations are associated with immunoglobulin variable heavy chain mutations in B-cell chronic lymphocytic leukemia
171. Identification of three subgroups of B cell chronic lymphocytic leukemia based upon mutations of BCL-6 and IgV genes
172. Somatic mutation of bcl-6 genes can occur in the absence of V(H) mutations in chronic lymphocytic leukemia
173. The characteristics of the ongoing mutations in the CD79 genes of B-CLL clones are not typical of Ig V gene hypermutation
174. Analysis of somatic mutation in five B cell subsets of human tonsil
175. Immunoglobulin V genes and CD38 expression in CLL
176. CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia
177. Updated data on V gene mutation status and CD38 expression in CLL
178. VH mutation status, CD38 expression level, genomic aberrations, and survival in chronic lymphocytic leukemia
179. H mutation status and conventional cytogenetics
180. Expression of unmutated VH genes is a detrimental prognostic factor in chronic lymphocytic leukemia
181. Unmutated VH gene status retains its adverse prognostic influence after autologous stem cell transplantation (SCT) for chronic lymphocytic leukemia (CLL)
182. CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia
183. Clinical significance of CD38 expression in chronic lymphocytic leukemia
184. CDNA microarray gene expression analysis of B-cell chronic lymphocytic leukemia proposes potential new prognostic markers involved in lymphocyte trafficking
185. Relation of gene expression phenotype to immunoglobulin mutation genotype in B cell chronic lymphocytic leukemia
186. Gene expression profiling of B cell chronic lymphocytic leukemia reveals a homogeneous phenotype related to memory B cells