Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis

Brain Research

Volumn 820, Issue 1-2, 1999, Pages 77-85

  Mitsuma, Norimasa ^a   Yamamoto, Masahiko ^a   Li, Mei ^a   Ito, Yasuhiro ^a   Mitsuma, Terunori ^b   Mutoh, Tatsuro ^c   Takahashi, Masahide ^a   Sobue, Gen ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

Author keywords

Amyotrophic lateral sclerosis; GDNFR ; MRNA; RET; Spinal cord motor neuron

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH FACTOR RECEPTOR; MESSENGER RNA; NEUROTROPHIC FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; AUTOPSY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IN SITU HYBRIDIZATION; MOTONEURON; NONHUMAN; ONCOGENE RET; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPINAL CORD VENTRAL HORN;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; DROSOPHILA PROTEINS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR RECEPTORS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MIDDLE AGED; MOTOR NEURONS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RET; RECEPTOR PROTEIN-TYROSINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPINAL CORD;

EID: 0033608408     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(98)01344-4     Document Type: Article

References (49)

1. Baloh R.H., Tansey M.G., Golden J.P., Creedon D.J., Heuckeroth R.O., Keck C.L., Zimonjic D.B., Popescu N.C., Johnson E.M. Jr., Milbrandt J. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 18:1997;793-802.
2. Baloh R.H., Gorodinsky A., Golden J.P., Tansey M.G., Keck C.L., Popescu N.C., Johnson Jr E.M., Milbrandt J. GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA. 95:1998;5801-5806.
3. Beck K.D., Valverde J., Alexi T., Poulsen K., Moffat B., Vandlen R.A., Rosenthal A., Heftl F. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature. 373:1995;339-341.
4. Burazin T.C.D., Gundlach A.L. Up-regulation of GDNFR-α and c-ret mRNA in facial motor neurons following facial nerve injury in the rat. Mol. Brain Res. 55:1998;331-336.
5. Calderó J., Prevette D., Mei X., Oakley R.A., Li L., Milligan C., Houenou L., Burek M., Oppenheim R.W. Peripheral target regulation of the development and survival of spinal sensory and motor neurons in the chick embryo. J. Neurosci. 18:1998;356-370.
6. Ceccherini I., Bocciardi R., Luo Y., Pasini B., Hofstra R., Takahashi M., Romeo G. Exon structure and flanking intronic sequences of the human RET proto-oncogene. Biochem. Biophys. Res. Commun. 196:1993;1288-1295.
7. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
8. Duberley R.M., Johnson I.P., Martin J.E., Anand P. RET-like immunostaining of spinal motoneurons in amyotrophic lateral sclerosis. Brain Res. 789:1998;351-354.
9. Elliott J.L., Snider W.D. Motor neuron growth factors. Neurology. 47:1996;S47-S53. Suppl 2.
10. GFRα Nomenclature Committee Nomenclature of GPI-linked receptors for the GDNF ligand family. Neuron. 19:1997;485-485.
11. Henderson C.E., Fardeau M. Neuronal growth factors: a hypothesis for the pathogenesis of the spinal muscular atrophies. Rev. Neurol. 144:1988;730-736.
12. Henderson C.E., Phillips H.S., Pollock R.A., Davies A.M., Lemeulle C., Armanini M., Simpson L.C., Moffet B., Vandlen R.A., Koliatsos V.E., Rosenthal A. GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science. 266:1994;1062-1064.
13. Ito Y., Yamamoto M., Li M., Doyu M., Tanaka F., Mutoh T., Mitsuma T., Sobue G. Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6α and gp130) in injured peripheral nerves. Brain Res. 793:1998;321-327.
14. Itoh T., Sobue G., Ken E., Mitsuma T., Takahashi A., Trojanowski J.Q. Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: system-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy. Acta Neuropathol. 83:1992;240-245.
15. Klein R.D., Sherman D., Ho W.H., Stone D., Bennett G.L., Moffat B., Vandlen R., Simmons L., Gu Q., Hongo J.A., Devaux B., Poulsen K., Armanini M., Nozaki C., Asai N., Goddard A., Phillips H., Henderson C.E., Takahashi M., Rosenthal A. A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature. 387:1997;717-721.
16. Koliatsos V.E., Clatterbuck R.E., Winslow J.W., Cayouette M.H., Price D.L. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron. 10:1993;359-367.
17. Kotzbauer P.T., Lampe P.A., Heuckeroth R.O., Golden J.P., Creedon D.J., Johnson Jr E.M., Milbrandt J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature. 384:1996;467-470.
18. Leigh P.N., Whitwell H., Garofalo O., Buller J., Swash M., Martin J.E., Gallo J.M., Weller R.O., Anderton B.H. Ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis: morphology, distribution, and specificity. Brain. 114:1991;775-788.
19. Lin L.F.H., Doherty D.H., Lile J.D., Bektesh S., Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science. 260:1993;1130-1132.
20. Milbrandt J., de Sauvage F., Fahrner T.J., Baloh R.H., Leitner M.L., Tansey M.G., Lampe P.A., Heuckeroth R.O., Kotzbauer P.T., Simburger K.S., Golden J.P., Davies J.A., Vejsada R., Kato A.C., Hynes M., Sherman D., Nishimura M., Wang L., Vandlen R., Moffat B., Klein R.D., Paulsen K., Gray C., Garces A., Henderson C.E., Phillips H.S., Johnson Jr E.M. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron. 20:1998;245-253.
21. Mufson E.J., Lavine N., Jaffar S., Kordower J.H., Quirion R., Saragovi H.U. Reduction in p140-TrkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp. Neurol. 146:1997;91-103.
22. Naveilhan P., ElShamy W.M., Ernfors P. Differential regulation of mRNAs for GDNF and its receptor Ret and GDNFR-α after sciatic nerve lesion in the mouse. Eur. J. Neurosci. 9:1997;1450-1460.
23. Ohiwa M., Murakami H., Iwashita T., Asai N., Iwata Y., Imai T., Funahashi H., Takagi H., Takahashi M. Characterization of Ret-Shc-Grb2 complex induced by GDNF, MEN 2A, and MEN 2B mutations. Biochem. Biophys. Res. Commun. 237:1997;747-751.
24. Oppenheim R.W., Houenou L.J., Johnson J.E., Lin L.F.H., Li L., Lo A.C., Newsome A.L., Prevette D.M., Wang S. Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature. 373:1995;344-346.
25. Pochon N.A., Menoud A., Tseng J.L., Zurn A.D., Aebischer P. Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. Eur. J. Neurosci. 9:1997;463-471.
26. trkB mRNA in amyotrophic lateral sclerosis. Brain Res. 621:1993;111-115.
27. Sendtner M., Kreutzberg G.W., Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature. 345:1990;440-441.
28. Sobue G., Yasuda T., Mitsuma T., Ross A.H., Pleasure D. Expression of nerve growth factor receptor in human peripheral neuropathies. Ann. Neurol. 24:1988;64-72.
29. Sobue G., Hashizume Y., Yasuda T., Mukai E., Kumagai T., Mitsuma T., Trojanowski J.Q. Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells. Acta Neuropathol. 79:1990;402-408.
30. Sobue G., Li M., Terao S., Aoki S., Ichimura M., Ieda T., Doyu M., Yasuda T., Hashizue Y., Mitsuma T. Axonal pathology in Japanese Guillain-Barré syndrome: a study of 15 autopsied cases. Neurology. 48:1997;1694-1700.
31. NGFR, trkA, trkB, and trkC) in human peripheral neuropathies. Neurochem. Res. 23:1998;821-829.
32. Tahira T., Ishizaka Y., Itoh F., Sugimura T., Nagao M. Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene. 5:1990;97-102.
33. Takahashi M., Cooper G.M. ret transforming gene encodes a fusion protein homologous to tyrosine kinase. Mol. Cell. Biol. 7:1987;1378-1385.
34. Takahashi M., Ritz J., Cooper G.M. Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell. 42:1985;581-588.
35. Terao S., Sobue G., Hashizume Y., Li M., Inagaki T., Mitsuma T. Age-related changes in human spinal ventral horn cells with special reference to the loss of small neurons in the intermediate zone: a quantitative analysis. Acta Neuropathol. 92:1996;109-114.
36. Tomac A., Lindqvist E., Lin L.F.H., Ögren S.O., Young D., Hoffer B.J., Olson L. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature. 373:1995;335-339.
37. Treanor J.J.S., Goodman L., Sauvage F.D., Stone D.M., Poulsen K.T., Beck C.D., Gray C., Armanini M.P., Pollock R.A., Hefti F., Phillips H.S., Goddard A., Moore M.W., Buj-Bello A., Davies A.M., Asai N., Takahashi M., Vandlen R., Henderson C.E., Rosenthal A. Characterization of a multicomponent receptor for GDNF. Nature. 382:1996;80-83.
38. Trojanowski J.Q., Walkenstein N., Lee V.M.Y. Expression of neurofilament subunits in neurons of the central and peripheral nervous system: an immunohistochemical study with monoclonal antibodies. J. Neurosci. 6:1986;650-662.
39. Trupp M., Arenas E., Fainzilber M., Nilsson A.S., Sieber B.A., Grigoriou M., Kilkenny C., Salazar-Grueso E., Pachnis V., Arumäe U., Sariola H., Saarma M., Ibáñez C.F. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature. 381:1996;785-789.
40. Trupp M., Belluardo N., Funakoshi H., Ibanez F. Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret proto-oncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci. 17:1997;3554-3567.
41. Tsuzuki T., Takahashi M., Asai N., Iwashita T., Matsuyama M., Asai J. Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues. Oncogene. 10:1995;191-198.
42. NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem. Res. 21:1996;929-938.
43. Yamamoto M., Sobue G., Yamamoto K., Terao S., Mitsuma T. Expression of glial cell line-derived growth factor mRNA in the spinal cord and muscle in amyotrophic lateral sclerosis. Neurosci. Lett. 204:1996;117-120.
44. M. Yamamoto, N. Mitsuma, Y. Ito, N. Hattori, M. Nagamatsu, M. Li, T. Mitsuma, G. Sobue, Expression of GDNF and GDNFR-α mRNAs in human peripheral neuropathies, Brain Res. (in press).
45. M. Yamamoto, N. Mitsuma, A. Inukai, Y. Ito, M. Li, T. Mitsuma, G. Sobue, Expression of GDNF and GDNFR-α mRNAs in muscles of motor neuron diseases, submitted.
46. Yan Q., Matheson C., Lopez O.T. In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature. 373:1995;341-344.
47. Widenfalk J., Nosrat C., Tomac A., Westphal H., Hoffer B., Olson L. Neurturin and glial cell line-derived neurotrophic factor receptor-β (GDNFR-β), novel proteins related to GDNF and GDNFR-α with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs. J. Neurosci. 17:1997;8506-8519.
48. World Federation of Neurology Research Group on Neuromuscular Diseases El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. J. Neurol. Sci. 124:1994;96-107. (Suppl).
49. Zhang B., Tu P., Abtahian F., Trojanowski J.Q., Lee V.M. Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J. Cell Biol. 139:1997;1307-1315.