Melatonin: Reducing molecular pathology and dysfunction due to free radicals and associated reactants

Neuroendocrinology Letters

Volumn 23, Issue SUPPL. 1, 2002, Pages 3-8

  Reiter, Russel J ^a   Tan, Duan Xian ^a   Allegra, Mario ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Antioxidant; Free radicals; Melatonin; Oxidative stress

Indexed keywords

ANTIOXIDANT; FREE RADICAL; HYDROGEN PEROXIDE; IRON; KYNURAMINE; LIPOPOLYSACCHARIDE; MELATONIN; REACTIVE OXYGEN METABOLITE; RECOMBINANT ERYTHROPOIETIN; SCAVENGER; TOXIN;

AGING; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; CELL DAMAGE; CONTROLLED STUDY; DISEASE SEVERITY; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; DRUG INFUSION; DRUG MECHANISM; GRAM NEGATIVE SEPSIS; HUMAN; ISCHEMIA; MACROMOLECULE; NEWBORN HYPOXIA; NEWBORN SEPSIS; NONHUMAN; OXIDATIVE STRESS; PATHOLOGY; RAT; REPERFUSION INJURY; REVIEW; SIDE EFFECT;

EID: 0036261347     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (69)

1. Oxidative damage in the central nervous system: Protection by melatonin
2. Actions of melatonin in the reduction of oxidative stress: A review
3. Melatonin: A potent, endogenous hydroxyl radical scavenger
4. Melatonin: Lowering the high price of free radicals
5. Significance of melatonin in antioxidative defense system: Reactions and products
6. Melatonin: Mechanisms and actions as an antioxidant
7. Antioxidative effect of melatonin in protection against cellular damage caused by ionizing radiation
8. Ototoxicity caused by cisplatin is ameliorated by melatonin and other antioxidants
9. Therapeutic effect of melatonin on carbon tetrachloride-induced acute liver injury in rats
10. Protective effect of melatonin in ischemic brain injury
11. Melatonin protects against stress-induced gastric lesions by scavenging the hydroxyl radical
12. Free radical-mediated molecular damage: Mechanisms for the protective actions of melatonin in the central nervous system
13. A novel melatonin metabolite, cyclic 3-hydroxymelatonin: A biomarker of melatonin interaction with hydroxyl radicals
14. Melatonin directly scavenges hydrogen peroxide: A potentially new metabolic pathway of melatonin biotransformation
15. 2-formyl-5-methoxykynuramine, a biogenic amine and melatonin metabolite, functions as a potent antioxidant
16. Individual and synergistic antioxidative actions of melatonin: Studies with vitamin E, vitamin C, glutathione and desferoxamine in rat liver homogenates
17. Nitrosation of melatonin by nitric oxide and peroxynitrite
18. Nitrosation of melatonin by nitric oxide: A computational study
19. 3+-EDTA: Comparison with glutathione and α-tocopherol
20. 2: Protection by melatonin and related molecules
21. Anti-carcinogenic actions of melatonin which involve antioxidative processes: Comparison with other antioxidants
22. 3
23. Melatonin versus vitamin E as a protective treatment against oxidative stress after extra-hepatic bile duct ligation in rats
24. Alzheimer's β protein mediated oxidative damage of mitochondrial DNA: Prevention by melatonin
25. Melatonin protects fetal rat brain against oxidative mitochondrial damage
26. Melatonin induced activity of the respiratory chain complexes I and IV can prevent mitochondrial damage induced by ruthenium red in vivo
27. Protective effect of melatonin against the 1-methyl-4-phenylpyridinium-induced inhibition of Complex I of the mitochondrial respiratory chain
28. Melatonin, mitochondria, and cellular bioenergetics
29. Protective effect of melatonin against α-naphthylisothiocyanate-induced liver injury in N1E-115 cells
30. Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatonin
31. Melatonin, a pineal secretory product with antioxidant properties, protects against cisplatin-induced nephrotoxicity in rats
32. Melatonin prevents endotoxin-induced circulatory failure in rats
33. Increased brain damage after stroke or excitotoxic seizures in melatonin-deficient rats
34. Augmentation of oxidative damage in life-long melatonin-deficient rats
35. Circadian variations in the rat serum total antioxidant status: Correlation with melatonin levels
36. Physiological levels of melatonin contribute to the antioxidant capacity of human serum
37. Melatonin: An antioxidant at physiological concentrations
38. Identification of melatonin in plants and its effects on plasma melatonin levels and binding to melatonin receptors in vertebrates
39. High levels of melatonin in seeds of edible plants: Possible function in germ tissue protection
40. Melatonin in plants
41. Effect of tryptophan administration on circulating melatonin levels of chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
42. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat
43. Identification of highly elevated levels in bone marrow: Its origin and significance
44. High physiological levels of melatonin in the bile of mammals
45. High melatonin concentrations in third ventricular cerebrospinal fluid are not due to Galen vein blood recirculation through he choroids plexus
46. Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of the chick
47. Melatonin stimulates glutathione peroxidase activity in human chorion
48. Rhythms of glutathione peroxidase and glutathione reductase in brain of chick: Their inhibition by light
49. Endogenous rhythms of melatonin, total antioxidant status and superoxide dismutase activity in several tissues of chick and their inhibition by light
50. Melatonin induces γ-glutamylcysteine synthase mediated by activator protein-1 in human vascular endothelial cells
51. Melatonin counteracts potentiation by homocysteine of KCl-induced vasoconstriction in human umbilical artery: Relation to calcium influx
52. Melatonin inhibits oxidative modification of low-density lipoprotein particles in normolipidemic post-menopausal women
53. Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats
54. Melatonin reduces dinitrobenzene sulfonic acid-induced colitis
55. Melatonin reduces both basal and bacterial lipopolysaccharide-induced lipid peroxidation
56. Lipopolysacchoride-induced hepatotoxicity is inhibited by the antioxidant melatonin
57. Effects of melatonin treatment in septic newborns
58. Increased levels of malondialdehyde and nitrite/nitrate in the blood of asphyxiated newborns: Reduction by melatonin
59. Melatonin prevents oxidative stress resulting from iron and erythropoietin administration
60. Monozygotic twins with Alzheimer's disease treated with melatonin: Case report
61. Melatonin treatment stabilizes chronobiologic and cognitive symptoms in Alzheimer's disease
62. Safety of melatonin in long-term use
63. Randomized, double-blind clinical trial, controlled with placebo, of the toxicology of chronic melatonin treatment
64. Strand scission in DNA induced by 5-hydroytryptamine (serotonin) in the presence of copper ions
65. Clinical trials of controlled-release melatonin in children with sleep-wake cyclic disorders
66. Maternal and developmental toxicity evaluation of melatonin administered orally to pregnant Sprague-Dawley rats
67. Fixed drug eruption due to melatonin
68. Melatonin and painful gynecomastia
69. The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice