Arginine-rich peptides are blockers of VR-1 channels with analgesic activity

FEBS Letters

Volumn 481, Issue 2, 2000, Pages 131-136

  Planells Cases, R ^a   Aracil, A ^b   Merino, J M ^c   Gallar, J ^b   Perez Paya E ^d   Belmonte, C ^b   Gonzalez Ros J M ^a   Ferrer Montiel, A V ^a  

^a MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^b INSTITUTO DE NEUROCIENCIAS   (Spain)

^c UNIVERSITY OF EXTREMADURA   (Spain)

^d UNIVERSITY OF VALENCIA   (Spain)

Author keywords

Capsaicin; Dynorphin; Ionic pore; Nociceptor; Non competitive antagonist; Pain

Indexed keywords

ARGININE DERIVATIVE; CAPSAICIN; DYNORPHIN; RECEPTOR BLOCKING AGENT; SYNTHETIC PEPTIDE; VANILLOID RECEPTOR;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EYE IRRITATION; MOUSE; NONHUMAN; OOCYTE; PAIN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; XENOPUS;

AMINO ACID SEQUENCE; ANALGESICS; ANIMAL; ARGININE; CAPSAICIN; DYNORPHINS; ELECTRIC CONDUCTIVITY; EYE; INHIBITORY CONCENTRATION 50; MICE; OOCYTES; PAIN; PEPTIDES; RECEPTORS, DRUG; SUPPORT, NON-U.S. GOV'T; XENOPUS LAEVIS;

EID: 0034666364     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01982-7     Document Type: Article

References (39)

1. Szolcsányi, J. (1993) in: Capsaicin in the Study of Pain (Wood, J.N., Ed.), pp. 1-23, Neuroscience Perspectives (Jenner, P., Series Ed.), Academic Press, New York.
2. Meyer, R.A., Campbell, J.N. and Raja, S. (1994) in: Textbook of Pain (Wall, P.D. and Melzack, R., Eds.), pp. 13-44, Churchill Livingstone, Edinburgh.
3. Szallasi A., Blumberg P.M. Pharmacol. Rev. 51:1999;159-211.
4. Campbell, E., Bevan, S. and Dray, A. (1993) in: Capsaicin in the Study of Pain (Wood, J.N., Ed.), pp. 255-273, Neuroscience Perspectives (Jenner, P., Series Ed.), Academic Press, New York.
5. Sterner O., Szallasi A. Trends Pharmacol. Sci. 20:1999;459-465.
6. Williams M., Kowaluk E.A., Arneric S.P. J. Med. Chem. 42:1999;1481-1500.
7. Caterina M.J., Schumacher M.A., Tominaga M., Rosen T.A., Levine J.D., Julius D. Nature. 389:1997;816-824.
8. Caterina M.J., Julius D. Curr. Opin. Neurobiol. 9:1999;525-530.
9. Tominaga M., Caterina M.J., Malmberg A.B., Rosen T.A., Gilvert H., Skinner K., Raumann B.E., Basbaum A.I., Julius D. Neuron. 21:1998;531-543.
10. Ritter, S. and Dinh, T.T. (1993) in: Capsaicin in the Study of Pain (Wood, J.N., Ed.), pp. 105-137, Neuroscience Perspectives (Jenner, P., Series Ed.), Academic Press, New York.
11. Caterina M.J., Leffler A., Malmberg A.B., Martin W.J., Trafton J., Petersen-Zeitz K.R., Koltzenburg M., Basbaum A.I., Julius D. Science. 288:2000;301-306.
12. Davis J.B., Gray J., Gunthorpe M.J., Hatcher J.P., Davey P.T., Overend P., Harries M.H., Latcham J., Clapham C., Atkinson K., Hughes S.A., Rance K., Grau E., Harper A.J., Pugh P.L., Rogers D.C., Bingham S., Randall A., Sheardown S.A. Nature. 405:2000;183-187.
13. Walpole, C.S.J. and Wrigglesworth, R. (1993) in: Capsaicin in the Study of Pain (Wood, J.N., Ed.), pp. 63-83, Neuroscience Perspectives (Jenner, P., Series Ed.), Academic Press, New York.
14. Dray A., Forbes C.A., Burgess G.M. Neurosci. Lett. 110:1990;52-59.
15. Fields B.G., Noble R.L. Int. J. Peptide Protein Res. 35:1990;161-214.
16. Ferrer-Montiel, A.V. and Montal, M. (1994) Methods: A Companion to Methods in Enzymology, Vol. 6, pp. 60-69.
17. Ferrer-Montiel A.V., Montal M. Methods Mol. Biol. 128:1999;167-178.
18. Ferrer-Montiel A.V., Sun W., Montal M. Proc. Natl. Acad. Sci. USA. 92:1995;8021-8025.
19. Levitzki, A. (1984) Receptors: A Quantitative Approach, pp. 1-142, Benjamin/Cummings, Menlo Park, CA.
20. Ferrer-Montiel A., Merino J.M., Planells-Cases R., Sun W., Montal M. Neuropharmacology. 37:1998;139-147.
21. González G.G., García de la Rubia P., Gallar J., Belmonte C. Invest. Ophthalmol. Vis. Sci. 34:1993;3329-3335.
22. de Castro F., Silos-Santiago I., Lopez de Armentia M., Barbacid M., Belmonte C. Eur. J. Neurosci. 10:1998;146-152.
23. Premkumar L.S., Auerbach A. Neuron. 16:1996;869-880.
24. Beck C., Wollmuth L.P., Seeburg P.H., Sakmann B., Kuner T. Neuron. 22:1999;559-570.
25. Ferrer-Montiel A., Merino J.M., Blondelle S.E., Pérez-Payá E., Houghten R.A., Montal M. Nature Biotechnol. 16:1998;286-291.
26. Seifert R., Eismann E., Ludwig J., Baumann A., Kaupp U.B. EMBO J. 18:1999;119-130.
27. Yang J., Ellinor P.T., Sather W.A., Zhang J.F., Tsien R.W. Nature. 366:1993;158-161.
28. Hille, B. (1992) Ionic Channels of Excitable Membranes, Sinauer Associates, Sunderland, MA.
29. Woodhull A.M. J. Gen. Physiol. 61:1973;687-708.
30. Zarei M.M., Dani J.A. J. Neurosci. 15:1995;1446-1454.
31. Kuner T., Schoepfer R. J. Neurosci. 16:1996;3549-3558.
32. Jancsó N., Jancsó-Gabor A., Szolcsányi J. Br. J. Pharmacol. Chemother. 32:1968;32-41.
33. Belmonte C., Giraldez F. J. Physiol. 321:1981;355-368.
34. Belmonte C., Gallar J., Pozo M.A., Rebollo I. J. Physiol. 437:1991;709-725.
35. Dickenson A.H., Dray A. Br. J. Pharmacol. 104:1991;1045-1049.
36. Liu L., Szallasi A., Simon S.A. Neuroscience. 84:1998;569-581.
37. Doyle D.A., Cabral J.M., Pfuetzner R.A., Kuo A., Gulbis J.M., Cohen S.L., Chait B.T., McKinnon R. Science. 280:1998;68-77.
38. Butelman E.R., Harris T.J., Pérez A., Kreek M.J. J. Pharmacol. Exp. Ther. 290:1999;678-696.
39. Ko M.C., Butelman E.R., Woods J.H. J. Pharmacol. Exp. Ther. 289:1999;378-385.