Induction of differentiation accompanies inhibition of Cdk2 in a non-small cell lung cancer cell line

International Journal of Oncology

Volumn 15, Issue 1, 1999, Pages 161-166

  Szabo, Eva ^a  

^a Institute of Cancer Research   (United States)

Author keywords

Antisense Cdk2; Cdk inhibitors; Cdk2; Differentiation; Flavopiridol

Indexed keywords

CDK2 PROTEIN, HUMAN; CYCLIN D; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLINE; ENZYME INHIBITOR; FLAVONOID; FLAVOPIRIDOL; PIPERIDINE DERIVATIVE; PROTEIN SERINE THREONINE KINASE; PURINE DERIVATIVE; ROSCOVITINE; TUMOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL DIVISION; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; LUNG NON SMALL CELL CANCER; LUNG TUMOR; PATHOLOGY; SIGNAL TRANSDUCTION;

CARCINOMA, NON-SMALL-CELL LUNG; CDC2-CDC28 KINASES; CELL DIFFERENTIATION; CELL DIVISION; CYCLIN D1; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASES; CYCLINS; ENZYME INHIBITORS; FLAVONOIDS; G1 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; NEOPLASM PROTEINS; PIPERIDINES; PROTEIN-SERINE-THREONINE KINASES; PURINES; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033159624     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Kiyokawa H, Richon VM, Rifkind RA and Marks PA: Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol 14: 7195-7203, 1994.
2. Kranenberg O, de Groot RP, van deer Eb AJ and Zantema A: Differentiation of P19 EC cells leads to differential modulation of cyclin-dependent kinase activities and to changes in the cell cycle profile. Oncogenc 10: 87-95, 1995.
3. Missero C, Calautti E, Eckner R, Chim J, Tsai LH, Livingston D and Dotto GP: Involvement of the cell-cycle inhibitor CipI/WAF1 and the E1A-associatcd p300 protein in terminal differentiation. Proc Natl Acad Sci USA 92: 5451-5455, 1995.